Comparative proteomics reveals mechanisms that underlie insecticide resistance in Culex pipiens pallens Coquillett. by Chongxing Zhang, Qiqi Shi, Tao Li, Peng Cheng, Xiuxia Guo, Xiao Song, Maoqing Gong

“…Finally, midgut differential protein expression profiles were analyzed, and 62 proteins were selected for verification of differential expression using iTRAQ and parallel reaction monitoring strategy, respectively. iTRAQ profiles of adaptation selection to three insecticide strains combined with midgut profiles revealed that multiple insecticide resistance mechanisms operate simultaneously in resistant insects of Culex pipiens pallens. …”
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AI-driven automated discovery tools reveal diverse behavioral competencies of biological networks by Mayalen Etcheverry, Clément Moulin-Frier, Pierre-Yves Oudeyer, Michael Levin

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Druggable proteins of Alistipes reveal promising antimicrobial targets against chronic intestinal inflammation by Saman Sohail, Ayesha Wisal, Sobia Rana, Rao Muhammad Abid Khan, Asad Ullah, Farooq-Ahmad Khan, Muhammad Irfan, Muhammad Imran, Paulo V. S. D. Carvalho, Renato Rozental, Farzana Shaheen, Farzana Shaheen, Syed Shah Hassan, Syed Shah Hassan

“…The 3D structures of the selected targets (LpxA and KdsB) revealed good druggability scores. The top hits (ZINC85530940, ZINC05161112, ZINC95911713, and ZINC05566415) for both targets showed maximum H-bond interactions. …”
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Integrated lipidomics and microbiomics reveal the quality changes of fresh yak tenderloin during storage by Feiyan Yang, Xudong He, Xin Wen, Guangfan Qu, Hanzhi Zhang, Zhang Luo, Shuguo Sun

“…Integrated analysis revealed that microbial metabolites interact with lipids, resulting in a deterioration of meat quality. …”
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High-Dose Fluorescein Reveals Unusual Confocal Endomicroscope Imaging of Low-Grade Glioma by Evgenii Belykh, Naomi R. Onaka, Xiaochun Zhao, Irakliy Abramov, Jennifer M. Eschbacher, Peter Nakaji, Mark C. Preul

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A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription by Zhang Weisheng, Jun Nakayama, Yukino Inomata, Shigeki Higashiyama, Toru Hiratsuka

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Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia. by Daniel R Schrider, Julien Ayroles, Daniel R Matute, Andrew D Kern

“…We developed a novel machine learning framework, called FILET (Finding Introgressed Loci via Extra-Trees) capable of revealing genomic introgression with far greater power than competing methods. …”
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Genome-wide association and functional follow-up reveals new loci for kidney function. by Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A Böger, Christian Fuchsberger, Matthias Olden, Ming-Huei Chen, Adrienne Tin, Daniel Taliun, Man Li, Xiaoyi Gao, Mathias Gorski, Qiong Yang, Claudia Hundertmark, Meredith C Foster, Conall M O'Seaghdha, Nicole Glazer, Aaron Isaacs, Ching-Ti Liu, Albert V Smith, Jeffrey R O'Connell, Maksim Struchalin, Toshiko Tanaka, Guo Li, Andrew D Johnson, Hinco J Gierman, Mary Feitosa, Shih-Jen Hwang, Elizabeth J Atkinson, Kurt Lohman, Marilyn C Cornelis, Åsa Johansson, Anke Tönjes, Abbas Dehghan, Vincent Chouraki, Elizabeth G Holliday, Rossella Sorice, Zoltan Kutalik, Terho Lehtimäki, Tõnu Esko, Harshal Deshmukh, Sheila Ulivi, Audrey Y Chu, Federico Murgia, Stella Trompet, Medea Imboden, Barbara Kollerits, Giorgio Pistis, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Tamara B Harris, Lenore J Launer, Thor Aspelund, Gudny Eiriksdottir, Braxton D Mitchell, Eric Boerwinkle, Helena Schmidt, Margherita Cavalieri, Madhumathi Rao, Frank B Hu, Ayse Demirkan, Ben A Oostra, Mariza de Andrade, Stephen T Turner, Jingzhong Ding, Jeanette S Andrews, Barry I Freedman, Wolfgang Koenig, Thomas Illig, Angela Döring, H-Erich Wichmann, Ivana Kolcic, Tatijana Zemunik, Mladen Boban, Cosetta Minelli, Heather E Wheeler, Wilmar Igl, Ghazal Zaboli, Sarah H Wild, Alan F Wright, Harry Campbell, David Ellinghaus, Ute Nöthlings, Gunnar Jacobs, Reiner Biffar, Karlhans Endlich, Florian Ernst, Georg Homuth, Heyo K Kroemer, Matthias Nauck, Sylvia Stracke, Uwe Völker, Henry Völzke, Peter Kovacs, Michael Stumvoll, Reedik Mägi, Albert Hofman, Andre G Uitterlinden, Fernando Rivadeneira, Yurii S Aulchenko, Ozren Polasek, Nick Hastie, Veronique Vitart, Catherine Helmer, Jie Jin Wang, Daniela Ruggiero, Sven Bergmann, Mika Kähönen, Jorma Viikari, Tiit Nikopensius, Michael Province, Shamika Ketkar, Helen Colhoun, Alex Doney, Antonietta Robino, Franco Giulianini, Bernhard K Krämer, Laura Portas, Ian Ford, Brendan M Buckley, Martin Adam, Gian-Andri Thun, Bernhard Paulweber, Margot Haun, Cinzia Sala, Marie Metzger, Paul Mitchell, Marina Ciullo, Stuart K Kim, Peter Vollenweider, Olli Raitakari, Andres Metspalu, Colin Palmer, Paolo Gasparini, Mario Pirastu, J Wouter Jukema, Nicole M Probst-Hensch, Florian Kronenberg, Daniela Toniolo, Vilmundur Gudnason, Alan R Shuldiner, Josef Coresh, Reinhold Schmidt, Luigi Ferrucci, David S Siscovick, Cornelia M van Duijn, Ingrid Borecki, Sharon L R Kardia, Yongmei Liu, Gary C Curhan, Igor Rudan, Ulf Gyllensten, James F Wilson, Andre Franke, Peter P Pramstaller, Rainer Rettig, Inga Prokopenko, Jacqueline C M Witteman, Caroline Hayward, Paul Ridker, Afshin Parsa, Murielle Bochud, Iris M Heid, Wolfram Goessling, Daniel I Chasman, W H Linda Kao, Caroline S Fox

“…Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. …”
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Resistify: A Novel NLR Classifier That Reveals Helitron-Associated NLR Expansion in Solanaceae by Moray Smith, John T Jones, Ingo Hein

“…Applying Resistify in combination with tools to identify transposable elements to a panel of Solanaceae genomes reveals a previously undescribed association between NLRs and Helitron transposable elements.…”
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An approximate likelihood method reveals ancient gene flow between human, chimpanzee and gorilla by Galtier, Nicolas

“…Analysis of coding and non-coding data in primates illustrates the potential of the approach and reveals that a substantial fraction of the human/chimpanzee/gorilla phylogenetic conflict is due to ancient gene flow. …”
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Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. by Anna L Swan, Christine Schütt, Jan Rozman, Maria Del Mar Muñiz Moreno, Stefan Brandmaier, Michelle Simon, Stefanie Leuchtenberger, Mark Griffiths, Robert Brommage, Piia Keskivali-Bond, Harald Grallert, Thomas Werner, Raffaele Teperino, Lore Becker, Gregor Miller, Ala Moshiri, John R Seavitt, Derek D Cissell, Terrence F Meehan, Elif F Acar, Christopher J Lelliott, Ann M Flenniken, Marie-France Champy, Tania Sorg, Abdel Ayadi, Robert E Braun, Heather Cater, Mary E Dickinson, Paul Flicek, Juan Gallegos, Elena J Ghirardello, Jason D Heaney, Sylvie Jacquot, Connor Lally, John G Logan, Lydia Teboul, Jeremy Mason, Nadine Spielmann, Colin McKerlie, Stephen A Murray, Lauryl M J Nutter, Kristian F Odfalk, Helen Parkinson, Jan Prochazka, Corey L Reynolds, Mohammed Selloum, Frantisek Spoutil, Karen L Svenson, Taylor S Vales, Sara E Wells, Jacqueline K White, Radislav Sedlacek, Wolfgang Wurst, K C Kent Lloyd, Peter I Croucher, Helmut Fuchs, Graham R Williams, J H Duncan Bassett, Valerie Gailus-Durner, Yann Herault, Ann-Marie Mallon, Steve D M Brown, Philipp Mayer-Kuckuk, Martin Hrabe de Angelis, IMPC Consortium

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Adipocyte mitochondria in dairy cows reveals constraints in growth and signals adaptive metabolic responses by Elvira Gagniuc, Adina-Mihaela Pîrvu, Dumitru-Iulian Nastac, Paul A. Gagniuc, Mihaela Gherghiceanu, Manuella Militaru

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An in vivo “turning model” reveals new RanBP9 interactions in lung macrophages by Yasuko Kajimura, Shuxin Dong, Anna Tessari, Arturo Orlacchio, Alexandra Thoms, Maria Concetta Cufaro, Federica Di Marco, Foued Amari, Min Chen, Shimaa H. A. Soliman, Lara Rizzotto, Liwen Zhang, Damu Sunilkumar, Joseph M. Amann, David P. Carbone, Amer Ahmed, Giuseppe Fiermonte, Mike A. Freitas, Alessia Lodi, Piero Del Boccio, Lino Tessarollo, Dario Palmieri, Vincenzo Coppola

“…This work provides the first lung specific RanBP9-associated interactome in physiological conditions and reveals that RanBP9 and the CTLH complex could be key regulators of macrophage bioenergetics and immune functions.…”
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Optical genome mapping reveals novel structural variations in an autism spectrum disorder cohort by Yunjia Zhang, Wai-Tong Chien, Judy Yuet-Wa Chan, Tsz-Yan Cheung, Zhiqian He, Kai-Hang Yip, Dorothy Fung-Ying Chan, Josephine Shuk-Ching Chong, Mary Miu-Yee Waye, Sek-Ying Chair, Ting-Fung Chan

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A diagnostic framework to reveal future clean water scarcity in a changing climate by Shanlin Tong, Rui Xia, Jie Chen, Wenpan Li, Yan Chen, Chong-Yu Xu

“…Based on scenario simulations, the results further reveal that mitigation measures for clean water scarcity are mainly affected by natural factors in near and far futures. …”
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Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition by Ana V. Almeida, Kathrine T. Jensen, Seandean L. Harwood, Martin H. Jørgensen, Nadia S. Nielsen, Ida B. Thøgersen, Jan J. Enghild, Gregers R. Andersen

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Nutrigenomic and Nutritional Analyses Reveal the Effects of Pelleted Feeds on Asian Seabass (Lates calcarifer). by Si Yan Ngoh, Daniel Tan, Xueyan Shen, Purushothaman Kathiresan, Junhui Jiang, Woei Chang Liew, Natascha May Thevasagayam, Hsiao Yuen Kwan, Jolly M Saju, Sridatta R S Prakki, Chin Heng Goh, Hong Ching Wong, Tai Teck Chan, Miklós Mézes, László Orbán

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Revealing Spatial Patterns of Dockless Shared Micromobility: A Case Study of Košice, Slovakia by Štefan Gábor, Ladislav Novotný, Loránt Pregi

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Exhalation metabolomics: A new force in revealing the impact of ozone pollution on respiratory health by Chen Tao, Peter Mettke, Yaru Wang, Xue Li, Ligang Hu

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Magnification Bias Reveals Severe Contamination in Hubble Frontier Field Photo-z Catalogs by Jiashuo Zhang, Jeremy Lim, Tom Broadhurst, Sung Kei Li, Man Cheung Li, Giorgio Manzoni, Rogier Windhorst

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