Single-cell RNA-sequencing reveals predictive features of response to pembrolizumab in Sézary syndrome by Tianying Su, George E. Duran, Alexa C. Kwang, Nirasha Ramchurren, Steven P. Fling, Youn H. Kim, Michael S. Khodadoust

“…We observed intrapatient Sézary cell heterogeneity including subclonal segregation of a coding mutation and copy number variation. Our study reveals differential effects of pembrolizumab in both malignant and healthy T cells. …”
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Comparative EEG reveals general and conspecific vocalization sensitivities in evolutionarily distant mammal species by Boglárka Morvai, Marianna Boros, Elodie Ferrando, Lilla Magyari, Attila Andics

“…ERP differences between conspecific vocalizations and any other sounds were identified in all three species, in later time windows (humans: 468–552 and 572–640 ms, dogs: 314–506 ms; pigs: 254–436 ms), perhaps reflecting categorical processing. These findings reveal that general and conspecific vocalization sensitivities are served by evolutionarily conserved, temporally and functionally distinct neural mechanisms.…”
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Pan-cancer analysis reveals dual roles of HES6 in cancer immunity and prognosis by Ying Sun, Peiru Liu, Dongyang Lv, Defu Yang, Shiyu Qiao, Jing Liu, Ying Yan, Wenping Wang

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Untargeted metabolomics reveals quinic acid as the kiwifruit component that affects brain activity in mice. by Claudio Marcello Marzo, Martino Bianconi, Mauro Commisso, Sofia Gambini, Cristiano Chiamulera, Linda Avesani, Stefano Negri, Flavia Guzzo

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Pan-cancer analysis reveals immunological and prognostic significance of CCT5 in human tumors by Md. Zabir Ahmed, Md Mohtasim Billah, Jannatul Ferdous, Shoriful Islam Antar, Abdullah Al Mamun, Md. Jubayer Hossain

“…Immune infiltration analysis revealed a strong correlation between CCT5 and different immune cells. …”
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In silico analysis reveals distinct changes in markers of epithelial to mesenchymal transition in glioma subtypes by Nives Pećina-Šlaus, Alja Zottel, Željko Škripek, Borna Puljko, Fran Dumančić, Anja Bukovac, Ivana Jovčevska, Anja Kafka

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Revealing Ecological Values in Traditional Sasak Bale Tani for Culturally-Rooted Design Innovation by Dendi Sigit Wahyudi

“…Employing a qualitative method involving literature review, field observation, and spatial analysis, this research offers a novel contribution by systematically mapping ecological parameters within vernacular Sasak architecture, an area still underrepresented in current architectural discourse. The findings reveal how traditional Sasak layouts promote ecological sustainability, social harmony, and climate-responsive agricultural architecture. …”
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Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency by Delaney Kaper, Uroš Radović, Per-Olof Bergh, August Qvist, Marcus Henricsson, Jan Borén, Marc Pilon

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Serum lipidomics analysis reveals yolk sac absorption differences in newly hatched chicks by Qiqi Han, Yao Zhang, Youying Chen, Ze Wang, Shu Chen, Dongli Li, Wenbin Li, Aiqiao Liu, Yuming Guo, Zengpeng Lv

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Learning Methods to Combine Linguistic Indicators: Improving Aspectual Classification and Revealing Linguistic Insights by Eric V. Siegel, Kathleen R. McKeown

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A unique case report revealing the elusive clinical phenomenon of meningitis retention syndrome by Sajal Gupta, Kishan Raj K, Prashanth Adiga K

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Single-cell sequencing reveals transcriptional dynamics regulated by ERα in mouse ovaries. by Qicai Hu, Yiqian Gui, Congcong Cao, Jun Xie, Huiru Tang

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Exploration of Hiptage (Malpighiaceae) diversity in Vietnam reveals a new species with wingless fruits by Mai Thi Xuan Lam, Marie-Stella Jagou, Giang Quoc Van, Florent Martos, Truc Thi Ngoc Nguyen, Truong Van Do, Rafael Felipe de Almeida, Hoa Dang Tran, Khoa Dang Tran, Giang Thi Nguyen, Dong Phuong Tran, Ky Huynh, Jean-Noël Rivière, Mathieu Rouget, Diep Quang Dinh, Anh Tuan Le, Xuan Thi Trinh, Jean-Philippe Deguine, Pierre Lefeuvre

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Structures of Native Doublet Microtubules from Trichomonas vaginalis Reveal Parasite-Specific Proteins by Alexander Stevens, Saarang Kashyap, Ethan H. Crofut, Shuqi E. Wang, Katherine A. Muratore, Patricia J. Johnson, Z. Hong Zhou

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High-parameter immunophenotyping reveals distinct immune cell profiles in pruritic dogs and cats by Erin McDonald, Eric Kehoe, Darcy Deines, Mary McCarthy, Brie Wright, Susan Huse

“…These animals were categorized based on pruritic behavior or routine check-ups (non-pruritic controls).ResultsUnsupervised clustering revealed various immune cell populations, including T-cell subsets distinguished by CD62L expression and distinct monocyte subsets. …”
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Integrative Genomic and Cytogenetic Analyses Reveal the Landscape of Typical Tandem Repeats in Water Hyacinth by Liqing Feng, Ying Zhuang, Dagang Tian, Linwei Zhou, Jinbin Wang, Jingping Fang

“…Our study used integrated genomic and cytogenetic analyses of this allotetraploid species to characterize five representative tandem repeats, revealing distinct genomic distribution patterns and copy number polymorphisms. …”
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Joint genetic analysis using variant sets reveals polygenic gene-context interactions. by Francesco Paolo Casale, Danilo Horta, Barbara Rakitsch, Oliver Stegle

“…Our model retrieves a larger number of interactions than alternative methods and reveals that up to 20% of cases show context-specific configurations of causal variants. …”
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A meta-analysis reveals earthworms as mutualists rather than predators of soil microorganisms by Manuel Blouin, Aïssa Robin, Lysandre Amans, Frédérique Reverchon, Isabelle Barois, Patrick Lavelle

“…Comparing microbial abundance in earthworm casts to control units without earthworms revealed effect sizes two- to three-fold greater (for bacteria and fungi, respectively) than when using the soil surrounding earthworm casts as a control. …”
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Metagenomic Analysis Reveals the Effects of Microplastics on Antibiotic Resistance Genes in Sludge Anaerobic Digestion by Zhonghong Li, Donghai Yuan

“…Network correlation analysis further revealed that plasmids represent the predominant category of MGEs involved in the HGT of ARGs. …”
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Revealing the Circulation Patterns Most Conducive to Regional Heatwave in Southeast Asia and the Mechanisms Behind by Yang Lyu, Jingyu Wang, Xiefei Zhi, Shoupeng Zhu, Hugh Zhang, Joshua Lee, Yi Fan, Yan Ji, Edward Park, Xianfeng Wang

“…In addition to these common high‐pressure patterns, a low‐pressure dominant pattern is identified, characterized by two enhanced low‐pressure systems over the Tibetan Plateau and mid‐latitude Western Pacific, which deplete a considerable amount of moisture, resulting in diminished cloud cover and rapid warming across continental SEA. Further analysis reveals that all patterns are significantly modulated by Madden Jullian Oscillation (MJO) activities, each showing distinct peak occurrences in different MJO phases, with further links to ENSO and the Indian Ocean Dipole.…”
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