Time-series metabolomic analysis revealed altered metabolism of cynomolgus monkeys after injecting exosomes by Xinmei Hu, Cancan Wang, Yu Xiao, Peng Jiang, Dongxing Huang, Liang-cheng Li, Zhongquan Qi

Get full text

An Overview of 20 Years of Pisco Spirit Research: Trends and Gaps Revealed by a Systematic Review by Erick Saldaña, Jennifer Alvarez, Jaime Laqui-Estaña, Karina Eduardo, Juan D. Rios-Mera, César Augusto Napa-Almeyda, Jhony Mayta-Hancco

Get full text

On Epistemological Boundaries of Turbulence Modeling Revealed through Stokes’ Reserved Stance on Reynolds’ RANS Equations by ZHANG Xiao-feng

“…[Objective] This study reveals the epistemological rationale underlying George Gabriel Stokes’ cautious and reserved stance in his review of Osborne Reynolds’ groundbreaking 1895 paper proposing the Reynolds-Averaged Navier-Stokes (RANS) equations. …”
Get full text

Residue-Specific Structural and Dynamical Coupling of Protein and Hydration Water Revealed by Molecular Dynamics Simulations by Shuai Wang, Jun Gao, Xiakun Chu

“…Here, we employ all-atom molecular dynamics simulations to investigate this relationship across four representative proteins. Our results reveal that protein residues with greater flexibility or solvent exposure are surrounded by more disordered hydration water, akin to bulk water, whereas rigid and buried non-polar residues are associated with structurally ordered hydration shells. …”
Get full text

Comprehensive transcriptome and proteome analysis revealed the molecular mechanisms of melatonin priming and waterlogging response in peach by Xianbin Gu, Linghong Lu, Jing Gao, Fei Fan, Genhua Song, Huiqin Zhang

Get full text

Whole-genome resequencing revealed the genetic diversity and body weight-related genes of Gannan yak by Minghao Zhang, Minghao Zhang, Chun Huang, Chun Huang, Qi Bao, Tong Wang, Tong Wang, Xiaoming Ma, Xiaoming Ma, Guangyao Meng, Guangyao Meng, Xuelan Zhou, Xuelan Zhou, Qingbo Zheng, Qingbo Zheng, Min Chu, Min Chu, Chunnian Liang, Chunnian Liang, Xian Guo, Xian Guo, Pengjia Bao, Pengjia Bao, Ping Yan, Ping Yan

“…Initial analyses of runs of homozygosity (ROH), nucleotide diversity, and linkage disequilibrium (LD) decay among the six yak breeds revealed that Gannan yaks exhibited the lowest ROH, the highest nucleotide diversity, and the fastest LD decay, indicating rich genetic diversity. …”
Get full text

Klippel–Feil syndrome revealed by post-traumatic neck pain: Case report and literature review by Salma El Kadiri, MD, Ibtissam El Bqaq, MD, Hind Qajia, MD, Zyneb Izi, MD, Latifa Chat, PhD, Mohammed Jiddane, PhD, Firdaous Touarsa, PhD, Siham El Haddad, PhD

“…A brain computed tomography scan performed to evaluate these symptoms revealed incomplete fusion of two cervical vertebrae (C2-C3), leading to a diagnosis of KFS. …”
Get full text

Diffusible Signal Factors and <i>Xylella fastidiosa</i>: A Crucial Mechanism Yet to Be Revealed by Letizia Portaccio, Marzia Vergine, Mariarosaria De Pascali, Luigi De Bellis, Andrea Luvisi

Get full text

Possible cross‑talk between atrial fibrillation and obstructive sleep apnea revealed by transcriptomic analysis by Xinmiao Chen, Yi Li, Yao Liu

“…Immunoassay infiltration analysis revealed elevated levels of activated macrophages in both OSA and AF samples. …”
Get full text

Effects of age-associated regional changes in aortic stiffness on human hemodynamics revealed by computational modeling. by Federica Cuomo, Sara Roccabianca, Desmond Dillon-Murphy, Nan Xiao, Jay D Humphrey, C Alberto Figueroa

“…Using the best available biomechanical data, our results for PWV compare well to findings reported for large population studies while rendering a higher resolution description of evolving local and global metrics of aortic stiffening. Our results reveal similar spatio-temporal trends between stiffness and its surrogate metrics, except PWV, thus indicating a complex dependency of the latter on geometry. …”
Get full text

Skeletal ossification of Middle Triassic pachypleurosaur Keichousaurus hui (Reptilia: Sauropterygia) revealed by zinc distribution by Yi-nuo Wang, Da-yong Jiang, Ryosuke Motani, Ming-tao Yao, Cheng Ji, Zuo-yu Sun, Min Zhou

“…A comparative analysis of juvenile and subadult specimens reveals distinct patterns of Zn enrichment, reflecting differential bone development across ontogenetic stages. …”
Get full text

An Aligned Sub-Neptune Revealed with MAROON-X and a Tendency Toward Alignment for Small Planets by Alex S. Polanski, Ian J. M. Crossfield, Andreas Seifahrt, Jacob L. Bean, Jonathan Brande, Karen A. Collins, David R. Coria, Akihiko Fukui, Norio Narita, Julian Stürmer, Steven Giacalone, David Kasper

Get full text

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP. by Umaimainthan Palendira, Carol Low, Anna Chan, Andrew D Hislop, Edwin Ho, Tri Giang Phan, Elissa Deenick, Matthew C Cook, D Sean Riminton, Sharon Choo, Richard Loh, Frank Alvaro, Claire Booth, H Bobby Gaspar, Alessandro Moretta, Rajiv Khanna, Alan B Rickinson, Stuart G Tangye

Get full text

The Mechanism of Omicron Variant‐Associated Cardiac Injury in Rhesus Macaques Was Revealed by Proteomic and Phosphoproteomic Analyses by Tao Ding, Ya‐Nan Zhou, Jiang‐Feng Liu, Shuai‐Yao Lu, Jun‐Tao Yang

Get full text

Effects of Different Drying Methods on the Quality of Forest Ginseng Revealed Based on Metabolomics and Enzyme Activity by Junjia Xing, Xue Li, Wenyu Dang, Limin Yang, Lianxue Zhang, Wei Li, Yan Zhao, Jiahong Han, Enbo Cai

“…This study investigated the effects of traditional hot air drying (HAD) and the self-developed negative-pressure circulating airflow-assisted desiccator drying (PCAD) method on the quality of FG using metabolomics and enzyme activity. The results revealed that the enzyme activities of dried FG were reduced considerably. …”
Get full text

Mendelian randomization analysis revealed that albuminuria is the key factor affecting socioeconomic status in CKD patients by Jianbo Qing, Lijuan Zhang, Changqun Li, Yafeng Li

“…Our univariable MR analysis revealed a significant causal relationship between high levels of albuminuria and lower income (OR = 0.84, 95% CI: 0.73–0.96, p = 0.013), with no significant pleiotropy detected. …”
Get full text

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping by Inês De Magalhaes Pinheiro, John R. D. Dawson, Nicolas Calo, Marianne Paolini-Bertrand, Kalyana Bharati Akondi, Gavin Tan, Tracy M. Handel, Irina Kufareva, Oliver Hartley

Get full text

Morphological characteristics and phylogenetic analyses revealed five new species (Basidiomycota) from Southwestern China by Ali Yang, Lu Wang, Yongjun Hu, Yingtao Jiang, Guiying Shi, Changlin Zhao

“…Phylogenetic analyses performed based on the ITS+nLSU rDNA gene regions with the maximum likelihood, maximum parsimony, and Bayesian inference methods revealed that five new species belong to the genera Conferticium, Dendrocorticiopsis, Eichleriella, Gloeohypochnicium, and Punctularia. …”
Get full text

Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal Polyp by Padmakar Bardapurkar, Mangesh Londhe, Sushama G. Gurwale, Pranjali Nibe, Prachi Chouhan

“…A per rectal examination revealed a protruding mass, leading to a diagnosis of a pedunculated rectal mass. …”
Get full text

Insights into metabolic changes during epidermal differentiation as revealed by multiphoton microscopy with fluorescence lifetime imaging by Monika Malak, Chen Qian, Jeemol James, Syam Nair, Julie Grantham, Marica B. Ericson

“…Analysis of MPM-FLIM images acquired at 750 nm and 900 nm excitation revealed a decreased relative fraction of intracellular NADH and FAD after high calcium treatment, consistent with increased oxidative phosphorylation. …”
Get full text