Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery by Azene Tesfaye

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TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family by Philip Schmiege, Dawid Jaślan, Michael Fine, Nidish Ponath Sadanandan, Alexandra Hatton, Nadia Elghobashi-Meinhardt, Christian Grimm, Xiaochun Li

“…Here, we present six cryo-EM structures of human TRPML2 in distinct states revealing that the π-bulge of the S6 undergoes a π-α transition upon agonist binding, highlighting the remarkable role of the π-bulge in ion channel regulation. …”
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Integrative Taxonomy of Costa Rican Tetrigidae (Orthoptera) Reveals Eight New Species by Niko Kasalo, Daniel H. Janzen, Winnie Hallwachs, Allison Brown, Martin Husemann, Mathias Vielsäcker, Tomislav Domazet-Lošo, Damjan Franjević, Madan Subedi, Domagoj Bogić, Josip Skejo

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Metabolomics and transcriptomics reveal the quality formation mechanism during the processing of black tea by Mingjin Li, Hao Xu, Hongyu Chen, Fengjiao Ding, Qinji Li, Ziqiong Liu, Feiquan Wang, Xiaoli Jia, Yang Wu, Yun Sun, Shan Jin

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Integrated transcriptomic and metabolomic analyses reveal heterosis for meat quality of Neijiang pigs by Haifeng Dan, Haifeng Dan, Haifeng Dan, Chengming Liu, Chengming Liu, Chengming Liu, Huiling Zhang, Huiling Zhang, Huiling Zhang, Mailin Gan, Mailin Gan, Mailin Gan, Yan Wang, Yan Wang, Yan Wang, Lei Chen, Lei Chen, Lei Chen, Ye Zhao, Ye Zhao, Ye Zhao, Bin Liu, Kangping Zhu, Lili Niu, Lili Niu, Lili Niu, Li Zhu, Li Zhu, Li Zhu, Linyuan Shen, Linyuan Shen, Linyuan Shen

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Cosmic Rays and the Askaryan Effect Reveal Subsurface Structure and Buried Ice on the Moon by E. S. Costello, R. R. Ghent, A. Romero‐Wolf, P. W. Gorham, P. G. Lucey, C. J. Tai Udovicic, P. Linton, A. Ludwig, K. McBride, C. Miki, E. Oberla, J. Rolla, A. Jung

“…Our simulations show that the radio emissions and reflections could reveal ice layers as thin as 10 cm and buried under regolith as deep as 9 m. …”
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Integrating single-cell and spatial transcriptomics reveals the cellular heterogeneity of vestibular schwannoma by Wenqi Dong, Yuchen Jin, Lingkang Dong, Yumeng Jiang, Zhuangzhuang Li, Maoxiang Xu, Jingjing Wang, Feng Liu, Dongzhen Yu

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Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. by Ernest Diez Benavente, Zoe Ward, Wilson Chan, Fady R Mohareb, Colin J Sutherland, Cally Roper, Susana Campino, Taane G Clark

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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…We identified genes that are thus far unique to S. molnari, which reveal their evolutionary novelty and likely role as adaptations to specific host niches. …”
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Double Materiality in Sustainability Reporting: Revealing ESG-SDGs Connections for Businesses’ Awareness by Camelia Iuliana Lungu, Chirața Caraiani, Andreea Mădălina Bojan, Cornelia Dascălu, Raluca Andreea Achim

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Single-cell sequencing reveals the role of SALL4 in cervical cancer development by Bao Tonghui, Li Wufen, Qi Lin

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Deep phosphoproteomics of Klebsiella pneumoniae reveals HipA-mediated tolerance to ciprofloxacin. by Payal Nashier, Isabell Samp, Marvin Adler, Fiona Ebner, Lisa Thai Lê, Marc Göppel, Carsten Jers, Ivan Mijakovic, Sandra Schwarz, Boris Macek

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Endogenous expression of inactive lysine deacetylases reveals deacetylation-dependent cellular mechanisms. by Tasha B Toro, Elena V Skripnikova, Kiara E Bornes, Kun Zhang, Terry J Watt

“…Engineered HT1080 cells expressing inactive KDA6 or KDAC8 domains remained viable and exhibited enhanced acetylation on known substrate proteins. RNA-seq analysis revealed that many changes in gene expression were observed when KDACs were inactivated, and that these gene sets differed significantly from knockdown and knockout cell lines. …”
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Spatial transcriptomics reveals regionally altered gene expression that drives retinal degeneration by Ulrike Schumann, Lixinyu Liu, Riemke Aggio-Bruce, Adrian V. Cioanca, Artur Shariev, Michele C. Madigan, Krisztina Valter, Jiayu Wen, Riccardo Natoli

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Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress by Juliette Humeau, Allan Sauvat, Giulia Cerrato, Wei Xie, Friedemann Loos, Francesca Iannantuoni, Lucillia Bezu, Sarah Lévesque, Juliette Paillet, Jonathan Pol, Marion Leduc, Laurence Zitvogel, Hugues de Thé, Oliver Kepp, Guido Kroemer

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Single-Cell RNA Sequencing Reveals Immunosuppressive Mechanisms of MDSCs in Lung Cancer by Liu Ziming

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Molecular evolution of toothed whale genes reveals adaptations to echolocating in different environments by L. Magpali, E. Ramos, A. Picorelli, L. Freitas, M. F. Nery

“…Results Our comparative analysis across 37 odontocete species revealed patterns of accelerated evolution within coastal and riverine lineages, supporting the hypothesis that shallow habitats pose specific selective pressures to sonar propagation, which are not found in the deep ocean. …”
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Structure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid. by Neil J Ball, Giuseppe Nicastro, Moumita Dutta, Dominic J Pollard, David C Goldstone, Marta Sanz-Ramos, Andres Ramos, Erik Müllers, Kristin Stirnnagel, Nicole Stanke, Dirk Lindemann, Jonathan P Stoye, William R Taylor, Peter B Rosenthal, Ian A Taylor

“…Further in vitro and functional virological assays reveal that residues making inter-domain NtDCEN-CtDCEN interactions are required for PFV capsid assembly and that intact capsid is required for PFV reverse transcription. …”
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Revealing the dynamics of a local Alpine windstorm using large-eddy simulations by N. Krieger, H. Wernli, M. Sprenger, C. Kühnlein

“…Overall, our semi-idealized LESs in complex and steep terrain reveal the three-dimensional structure and the mechanism of the local windstorm. …”
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Space-based inversion reveals underestimated carbon monoxide emissions over Shanxi by Xiaolu Li, Jason Blake Cohen, Pravash Tiwari, Liling Wu, Shuo Wang, Qin He, Hailong Yang, Kai Qin

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