Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs by Lei Liu, Guoqiang Yi, Yilong Yao, Yuwen Liu, Jiang Li, Yalan Yang, Mei Liu, Lingzhao Fang, Delin Mo, Longchao Zhang, Yonggang Liu, Yongchao Niu, Liyuan Wang, Xiaolu Qu, Zhangyuan Pan, Lei Wang, Muya Chen, Xinhao Fan, Yun Chen, Yongsheng Zhang, Xingzheng Li, Zhen Wang, Yijie Tang, Hetian Huang, Pengxiang Yuan, Yuying Liao, Xinjian Li, Zongjun Yin, Di Liu, Dongjie Zhang, Quanyong Zhou, Wangjun Wu, Jicai Jiang, Yahui Gao, George E. Liu, Lixian Wang, Yaosheng Chen, Kui Li, Martien A. M. Groenen, Zhonglin Tang

“…Analysis of selective domestication revealed BRCA1 associated with enhanced adipocyte growth and fat deposition, and ABCA3 linked to an alleviated immune response and reduced lung injury. …”
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Revealing the spatiotemporal dynamics of protein fouling on micropatterned ultrafiltration membranes by in-situ visualization by Anna Malakian, Scott M. Husson

“…CLSM images were compared with filtration data to reveal the effect of pattern geometry on protein fouling. …”
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Olink proteomics reveals TNFRSF9 as a biomarker for abdominal aortic aneurysms by Runze Chang, Heng Wang, Chuanlong Lu, Jinshan Chen, Yaling Li, Maolin Qiao, Siqi Gao, Lizheng Li, Keyi Fan, Ruijing Zhang, Honglin Dong

“…The ELISA results were consistent with the Olink proteomics results, and the receiver operating characteristic (ROC) curve analysis revealed that the binding of TNFRSF9 and IL-6 has high diagnostic value (Olink AUC = 0.9056; ELISA AUC = 0.950). …”
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Revealing the mechanisms of warfarin-induced vascular calcification through metabolomics and network toxicology by Zhijiao Zhang, Zhijiao Zhang, Pengyan Jia, Pengyan Jia, Chunqi Feng, Chunqi Feng, Juan Xu, Jingmin Zhang, Niuniu Bai, Weihong Chen, Weihong Chen, Weiqi Gao, Weiqi Gao, Weiqi Gao

“…Network toxicology analysis, molecular docking, and experimental validation showed that warfarin may induce VC by modulating the targets AKT1, TP53, and HSP90AA1, thereby influencing the PI3K-AKT signaling pathway. This study reveals the potential molecular mechanisms underlying warfarin-induced VC, laying a foundation for further mechanistic investigations and providing important insights for the rational clinical application of warfarin.…”
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Single-Cell RNA Sequencing Reveals an Atlas of Meihua Pig Testis Cells by Mao Zhang, Yiming Yan, Guoliang Peng, Shuang Gao, Hongyi Li, Yuan Li

“…Functional enrichment analysis revealed that the differentially expressed genes (DEGs) in testicular somatic cells were enriched in the pathways of Ribosome, Oxidative phosphorylation, Protein processing in endoplasmic reticulum, Retrograde endocannabinoid signaling, Cellular senescence and Insulin signaling. …”
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Beyond buzzwords: NLP reveals common threads in sustainable and circular construction discourse by Shakarim Aubakirov, Alexandr Pak, Iskander Akhmetov, Aidana Tleuken, Huseyin Atakan Varol, Assel Akzhalova, Ferhat Karaca

“…These methods are used to analyze a dataset of 480 academic articles focusing on sustainability and circular economy in the construction sector. Our analysis revealed that circular construction is more specific and practical, emphasizing resource efficiency, waste management, and industry-specific processes, targeting the operational aspects of recycling and resource recovery. …”
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RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection. by Isabelle Derré, Marc Pypaert, Alice Dautry-Varsat, Hervé Agaisse

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Pig models reveal the interplay between fatty acids and cytokines in skeletal muscle by Fernanda Nery Ciconello, Christopher Keith Tuggle, Julia Dezen Gomes, Bruna Pereira Martins da Silva, Mariah de Castro Durval, Camila Sabino de Oliveira, Lucas Echevarria Nascimento, Luciana Sales Freitas, James Eugene Koltes, Aline Silva Mello Cesar

“…Functional enrichment analysis and hub gene identification revealed several key genes involved in immune function and fatty acid metabolism. …”
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Past conservation efforts reveal which actions lead to positive outcomes for species by Ashley T. Simkins, William J. Sutherland, Lynn V. Dicks, Craig Hilton-Taylor, Molly K. Grace, Stuart H. M. Butchart, Rebecca A. Senior, Silviu O. Petrovan

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Improving asthma care in children: revealing needs and bottlenecks through in-depth interviews by Casper E. W. Gijsen, Carolien van Rossem, Jean W. M. Muris, Marieke W. P. van Horck, Edward Dompeling

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Revealing heterogeneity in mild cognitive impairment based on individualized structural covariance network by Xiaotong Wei, Ronglong Xiong, Ping Xu, Tingting Zhang, Junjun Zhang, Zhenlan Jin, Ling Li

“…Finally, correlation analysis and functional annotation further revealed that the affected edges were related to cognitive performance and implicated in memory and emotion terms. …”
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Soundscape analysis reveals fine ecological differences among coral reef habitats by Juan Carlos Azofeifa-Solano, Miles J.G. Parsons, Rohan Brooker, Robert McCauley, Daniel Pygas, William Feeney, Steve Simpson, Sophie L. Nedelec, Eve M. Croxford, Mark Meekan, Christine Erbe

“…Benthic composition analysis identified two distinct healthy habitat types: one dominated by branching corals and another without a dominant coral growth form. Acoustic analysis revealed these habitats also had unique nighttime soundscapes, driven by amplitude (loudness) and uniformity (sound diversity) differences linked to fish and invertebrate activity. …”
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Comment on “Bibliometric analysis reveals the research hotspots and trends of nasopharyngeal carcinoma immunotherapy” by Hua Zhao, Jiayue Xu, Kun Xu, Yuejun Zhou

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Integrative indexes reveal the tolerance of winter wheat to different overwinter freezing injury by Lu Wu, Lu Wu, Weidong Yu, Chen Cheng, Liping Feng, Jintao Yan, Dawei Zheng, Feiyun Yang

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Single cell proteomics reveals proteome heterogeneity in iPSC-derived cardiomyocytes by Lizhuo Ai, Aleksandra Binek, Vladimir Zhemkov, Ali Haghani, Simion Kreimer, Edo Israely, Madelyn Arzt, Arun Sharma, Clive Svendsen, Jennifer Van Eyk

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Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells by Silvia Stingele, Gabriele Stoehr, Karolina Peplowska, Jürgen Cox, Matthias Mann, Zuzana Storchova

“…Furthermore, using the quantitative data we investigated the changes of cellular pathways in response to aneuploidy. This analysis revealed specific and uniform alterations in pathway regulation in cells with extra chromosomes. …”
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Gastric metastasis and peritoneal carcinosis revealing primary breast cancer: an unusual presentation by Shema Ayadi, Souhir Monastiri, Amine Ben Safta, Mehdi Hammami, Imen Samaali, Mehdi Kammoun, Ahlem Blel, Raoudha Aloui, Yosra Zaimi, Leila Mouelhi

“…Initial investigations were inconclusive, prompting laparoscopic peritoneal biopsies which revealed independent cell proliferation. Subsequently, a second look upper digestive endoscopy showed multiple gastric ulcerations suggestive of gastric carcinoma. …”
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Comparative Transcriptome Analysis in Eggplant Reveals Selection Trends during Eggplant Domestication by Qingzhen Wei, Liming Du, Wuhong Wang, Tianhua Hu, Haijiao Hu, Jinglei Wang, Karine David, Chonglai Bao

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Novel Classification of Peroneal Tendon Disease Reveals Cellular and Molecular Phenotypes of the Tenosvnovium by Julia Matthias MD, Michael A. David PhD, Sara E. Buckley DO, Daniel J. Ross MD, Nathaniel Zona BA, Michael A. Hewitt B.A., Joshua Metzl MD, Daniel K. Moon MD, MS, MBA, Courtney Grimsrud MD, Douglas J. Adams PhD, Michael Zuscik PhD, Kenneth Hunt MD

“…PTD4 was associated with increased leukocyte activation and chemotaxis (Fig 1E). DH revealed increased cellular density (i.e., hypercellularity) with PTD4 (Figure 1B, C). …”
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Evolutionary modeling reveals that value-oriented knowledge creation behaviors reinvent jobs by Yihang Cheng, Zhaoqi Yang, Yuan Cheng, Yong Ge, Hengshu Zhu

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