Integrated network pharmacology reveals the mechanism of action of Xianlinggubao prescription for inflammation in osteoarthritis by Jingyi Hou, Yubo Li, Yu Zhang, Ning Yang, Bin Chen, Guiyun Ma, Naiqiang Zhu

“…PPI network analysis revealed that XLGB may alleviate OA inflammation by modulating key genes, including COX-2, IL-1β, TNF, IL-6, and MMP-9. …”
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Revealing the impact of gut microbiota-derived metabolites on depression through network pharmacology by Si Su, Tengarile A, Ruhan A, Riga Wu, Lisi Wei, La Ta, Wenfeng Huo, Lijun Tong, Jing Zhang, Rilebagen Hu, Li Li

“…A microbiota–metabolite–target–signal pathway–disease network was constructed using Cytoscape 3.9.1, revealing 15 metabolites associated with the IL-17, TLR, and PI3K-Akt signalling pathways. …”
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Comprehensive genomic and phenotypic analyses reveal the genetic basis of fruit quality in litchi by Qian Yan, Junting Feng, Jiezhen Chen, Yingjie Wen, Yonghua Jiang, Yingxiao Mai, Kan Huang, Hailun Liu, Hongsen Liu, Fachao Shi, Yanwei Hao, Changhe Cai, Canye Yu, Liangxi Ou, Rui Xia

“…We then analyze the population structure and reveal four main subgroups within the population. …”
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Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication by Yarou Gao, Ge Liu, Yirui Ma, Yue Su, Xiaoqin Lian, Lefang Jiang, Jiaxin Ke, Xingjian Zhu, Mingxin Zhang, Yang Yu, Qun Peng, Wei Zhao, Wei Zhao, Xulin Chen

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Dynamic human liver proteome atlas reveals functional insights into disease pathways by Lili Niu, Philipp E Geyer, Rajat Gupta, Alberto Santos, Florian Meier, Sophia Doll, Nicolai J Wewer Albrechtsen, Sabine Klein, Cristina Ortiz, Frank E Uschner, Robert Schierwagen, Jonel Trebicka, Matthias Mann

“…Bioinformatic analysis reveals that half of hepatocyte protein mass is comprised of enzymes and 23% of mitochondrial proteins, twice the proportion of other liver cell types. …”
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Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice by Shijia Liu, Haijian Sun, Zijing Du, Shuai Lu, Chenwen Wang, Ye Zhang, Zichen Luo, Lu Wang, Zhimin Fan, Peng Wei, Yujiao Yan, Junzhi Zhang, Shusheng Yin, Tongtong Liu, Qiongzi He, Xi Guo, Kang Ding, Jingjie Zhou, Haibing Hua, Chengli Yu, Weichen Xu, Jinjun Shan, Yongming Li, Yi Xu, Xiaotao Shen, Gang Cao, Wei Zhou

“…In this study, metabolomics and proteomics analysis for multi-center cohorts reveal that both serum arginine levels and the rate-limiting enzyme argininosuccinate synthetase 1 (ASS1) are significantly elevated in UC patients. …”
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Regional homogeneity patterns reveal the genetic and neurobiological basis of State-Trait Anxiety by Yuanhao Li, Su Yan, Jia Li, Yuanyuan Qin, Li Li, Nanxi Shen, Yan Xie, Dong Liu, Jicheng Fang, Tian Tian, Wenzhen Zhu

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Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide by Jiandong Wang, Xue Zhang, Yi Wu, Yi Wu, Qianfei Wei, Lingshan Yan, Youli Yu, Yanan Guo, Zhengqin Yu, Pan Wang, Xiaonan Yang

“…The integrated examination of transcriptomic and metabolomic data revealed that the glycerophospholipid metabolic pathway stands out as the most significant among all metabolic pathways. …”
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Novel cVEMP procedure reveals sexual dimorphism in peak to trough latency by Max Gattie, Max Gattie, Elena V. M. Lieven, Karolina Kluk

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Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastoma by Jiukun Hu, Xiaohan Sa, Yue Yang, Yuwen Han, Jie Wu, Minxuan Sun, Shaheryar Shafi, Nafees Ahmad, Sami Siraj, Jiao Yang, Yuanshuai Zhou

“…Single cell trajectory analysis reveals a pseudotime trajectory, indicating the differentiation of glioblastoma stem cells (GSCs) toward ECs. …”
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Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick. by Angélique Igel-Egalon, Mohammed Moudjou, Davy Martin, Alexandra Busley, Tina Knäpple, Laetitia Herzog, Fabienne Reine, Nad'a Lepejova, Charles-Adrien Richard, Vincent Béringue, Human Rezaei, Human Rezaei

“…To achieve progress on this issue, we correlated the PrPSc quaternary structural transition from three distinct prion strains during unfolding and refolding with their templating activity. We reveal the existence of a mesoscopic organization in PrPSc through the packing of a highly stable oligomeric elementary subunit (suPrP), in which the strain structural determinant (SSD) is encoded. …”
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Plasma lipidomic analysis reveals distinct lipid alterations in patients with pulmonary tuberculosis by Chunfa Zhang, Mingya Cai, Huangjie Cai, Xiaoyang Chen

“…Correlation analysis revealed weak-to-moderate associations of select lipids with age and glucose, but minimal or no correlation with BMI, sex, or smoking, indicating that lipidomic alterations are primarily disease-driven. …”
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Satellite Observations Reveal Widespread Color Variations in Global Lakes Since the 1980s by Xiaoyi Shen, Chang‐Qing Ke, Zheng Duan, Yu Cai, Haili Li, Yao Xiao

“…Green lakes (495–560 nm) were more prevalent in densely populated middle‐latitude regions, while most red and yellow colors (≥560 nm) were located in the Southern Hemisphere. Our findings reveal distinct temporal patterns of lake color changes, with the majority of global lakes shifted toward shorter wavelengths. …”
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Observational and Genetic Evidence Reveals the Effect of Serum Lipid Levels on COPD Risk by Jia G, Guo T, Liu L, He C

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Comparative genomics reveals key adaptive mechanisms in pathogen host-niche specialization by Menglu Zhang, Longxi Han, Caizhi Liao, Weiheng Su, Weiheng Su, Chunlai Jiang, Chunlai Jiang

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SAGE2Splice: unmapped SAGE tags reveal novel splice junctions. by Byron Yu-Lin Kuo, Ying Chen, Slavita Bohacec, Ojvind Johansson, Wyeth W Wasserman, Elizabeth M Simpson

“…Nine of these 12 candidates were validated by RT-PCR and sequencing, and among these, four revealed previously uncharacterized exons. Thus, SAGE2Splice provides a new functionality for the identification of novel transcripts and exons. …”
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Longitudinal Metabolomics Reveals Metabolic Dysregulation Dynamics in Patients with Severe COVID-19 by Ryo Uchimido, Kenjiro Kami, Hiroyuki Yamamoto, Ryo Yokoe, Issei Tsuchiya, Yoko Nukui, Yuki Goto, Mariko Hanafusa, Takeo Fujiwara, Kenji Wakabayashi

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Arctic speleothems reveal nearly permafrost-free Northern Hemisphere in the late Miocene by Anton Vaks, Andrew Mason, Sebastian F. M. Breitenbach, Alena Giesche, Alexander Osinzev, Irina Adrian, Aleksandr Kononov, Stuart Umbo, Franziska A. Lechleitner, Marcelo Rosensaft, Gideon M. Henderson

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Metagenome-assembled genomes reveal novel diversity and atypical sources of a superbug by Rafael López-Sánchez, Alejandro Aguilar-Vera, Santiago Castillo-Ramírez

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Transcriptome analysis reveals defense responses of alfalfa seedling roots to Sclerotium rolfsii by Shizhen Jia, Shizhen Jia, Zhencuo Dan, Zhencuo Dan, He Li, He Li, Yuhan Guo, Yuhan Guo, Lei Jia, Lei Jia, Ailing Yu, Ailing Yu, Huitong Zhan, Huitong Zhan, Xiangjun Liu, Xiangjun Liu, Teng Gao, Teng Gao, Yun Shi, Yun Shi, Zeng-Yu Wang, Zeng-Yu Wang, Lili Cong, Lili Cong, Lili Cong

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