Morpho-phylogenetic evidence reveals four novel species of Coniella (Diaporthales, Schizoparmaceae) from southern China by Duhua Li, Zixu Dong, Qiyun Liu, Yaling Wang, Zhaoxue Zhang, Xiuguo Zhang, Jiwen Xia

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Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias by Anke Schumann, Ainhoa Martinez-Pizarro, Eva Richard, Christoph Schell, Anna Laura Kössinger, Karina A. Zeyer, Stefan Tholen, Oliver Schilling, Michael Barry, Björn Neubauer, Michael Köttgen, Luciana Hannibal, Lourdes R. Desviat, Ute Spiekerkötter

“…Our investigations revealed altered mitochondrial networks shifted towards fission and a marked reduction of mitophagy. …”
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Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype by James J. Fink, Nathaniel Delaney-Busch, Ryan Dawes, Evanthia Nanou, Christopher Folts, Karthiayani Harikrishnan, Chris Hempel, Hansini Upadhyay, Trinh Nguyen, Himali Shroff, David Stoppel, Steven J. Ryan, Jane Jacques, Jennifer Grooms, Elizabeth Berry-Kravis, Mark F. Bear, Luis A. Williams, David Gerber, Mark Bunnage, Brinley Furey, Graham T. Dempsey

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2bRAD-M reveals differences in microbial communities between Modic changes and disc herniation by Fang Yang, Jingtao Zhang, Junpu Zha, Guolei Zhang, Jia Li, Wei Du, Lin Liu, Jun Di

“…A functional annotation analysis showed that differentially abundant taxa between the Modic change and herniated disc groups could be assigned to 4093 COGs (Clusters of Orthologous Groups) and 342 related signaling pathways.ConclusionThis study represents the first application of 2bRAD-M to Modic changes and disc herniation, revealing significant differences in microbial taxa between the two groups. …”
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Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities by Bart Kolendowski, Sylvia Cheng, Yudith Ramos Valdes, Trevor G. Shepherd, Gabriel E. DiMattia

“…Using the 105C and KOC-7c human ovarian clear cell carcinoma (OCCC) cell lines, which have distinct proliferative phenotypes as spheroids but the same prototypical OCCC gene mutation profile of constitutively activated AKT signaling with the loss of ARID1A, we revealed therapeutic targets that efficiently kill cells in spheroids. …”
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Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression by Vinayak Vinayak, Ramin Basir, Rosela Golloshi, Joshua Toth, Lucas Sant’Anna, Melike Lakadamyali, Rachel Patton McCord, Vivek B. Shenoy

“…Conclusively, our simulations reveal that heterochromatin domain boundaries regulate gene expression and epigenetic memory. …”
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Breaking the DNA by soft X-rays in the water window reveals the scavenging and temporal behaviour of ·OH radicals by Luděk Vyšín, Przemyslaw Wachulak, Věra Hájková, Marie Davídková, Henryk Fiedorowicz, Andrzej Bartnik, Libor Juha

“…Abstract A laser-plasma source emitting photons with energies in the water window spectral range has been used to reveal the radiation chemical yields of single-strand breaks in plasmid DNA as a function of ·OH radical scavenger concentration. …”
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Large-scale genomic analysis reveals significant role of insertion sequences in antimicrobial resistance of Acinetobacter baumannii by Fei Xie, Lifeng Wang, Song Li, Long Hu, Yanhua Wen, Xuming Li, Kun Ye, Zhimei Duan, Qi Wang, Yuanlin Guan, Ye Zhang, Qiqi Shi, Jiyong Yang, Han Xia, Lixin Xie

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A multi-task deep neural network reveals inflowing river impacts for predictive lake management by Han Yan, Haoyang Fu, Zhuo Chen, An-Ran Liao, Mo-Yu Shen, Yi Tao, Yin-Hu Wu, Hong-Ying Hu

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Sequence-based GWAS reveals genes and variants associated with predicted methane emissions in French dairy cows by Solène Fresco, Marie-Pierre Sanchez, Didier Boichard, Sébastien Fritz, Pauline Martin

“…Functional annotation revealed potential candidate genes, in particular FASN, DGAT1, ACSS2, and KCNIP4, which could be involved in biological pathways possibly related to methane production. …”
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COMBINED ANALYSIS OF LINKAGE AND WHOLE EXOME SEQUENCING REVEALS CIC AS A CANDIDATE GENE FOR ISOLATED DYSTONIA by Barış Salman, Emrah Yücesan, Bedia Samancı, Başar Bilgiç, Haşmet Ayhan Hanağası, İbrahim Hakan Gürvit, Uğur Özbek, Sibel Aylin Uğur İşeri

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Electrically modulated photothermal force microscopy for revealing molecular conformation changes during polarization switching at the nanoscale by Songyou Yao, He Jiang, Jiaxuan Wen, Da Shu, Chang Xu, Wenpeng Zhu, Xiaoyue Zhang, Yue Zheng

“…By characterizing electrodriven ferroelectric switching in edge-on poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) lamellae, ePTFM reveals not only the evolution of polarization but also in situ chemical correlations. …”
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Identification of Genetic Loci for Grain Traits and Disease Resistance Reveals a Potential Trade-Off in Rice by Yulin Jia, Melissa H. Jia, Heather Box

“…Another TGW locus (qTGW3.3) and a grain length locus (qLNG3.3) were mapped at qBLAST3 on chromosome 3. These results reveal potential trade-offs between disease resistance and productivity, which are important for breeders to develop high-yielding and disease-resistant rice varieties. …”
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Population genomics of sika deer reveals recent speciation and genetic selective signatures during evolution and domestication by Huamiao Liu, Bo Zhu, Tianjiao Wang, Yimeng Dong, Yan Ju, Yang Li, Weilin Su, Ranran Zhang, Shiwu Dong, Hongliang Wang, Yongna Zhou, Yanmin Zhu, Lei Wang, Zhengyi Zhang, Pei Zhao, Shuyan Zhang, Rui Guo, E. A, Yuwen Zhang, Xin Liu, Hidetoshi B. Tamate, Qiqi Liang, De Ma, Xiumei Xing

“…Conclusion Population genomic analyses revealed that the continental and Japanese lineages represent distinct phylogenetic species. …”
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Author Correction: In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons by Wanjie Wu, Yingzhu He, Yujun Chen, Yiming Fu, Sicong He, Kai Liu, Jianan Y. Qu

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Author Correction: Late Paleolithic whale bone tools reveal human and whale ecology in the Bay of Biscay by Krista McGrath, Laura G. van der Sluis, Alexandre Lefebvre, Anne Charpentier, Ana S. L. Rodrigues, Esteban Álvarez-Fernández, François Baleux, Eduardo Berganza, François-Xavier Chauvière, Morgane Dachary, Elsa Duarte Matías, Claire Houmard, Ana B. Marín-Arroyo, Marco de la Rasilla Vives, Jesus Tapia, François Thil, Olivier Tombret, Leire Torres-Iglesias, Camilla Speller, Antoine Zazzo, Jean-Marc Pétillon

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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

“…Gene distribution patterns across the plant kingdom revealed that ZAR1 and ZRK emerged after the divergence of most angiosperms from Amborella and before the split of magnoliids, monocots, and eudicots. …”
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GFP fusions of Sec-routed extracellular proteins in Staphylococcus aureus reveal surface-associated coagulase in biofilms by Dominique C. S. Evans, Amanda B. Khamas, Lisbeth Marcussen, Kristian S. Rasmussen, Janne K. Klitgaard, Birgitte H. Kallipolitis, Janni Nielsen, Daniel E. Otzen, Mark C. Leake, Rikke L. Meyer

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Transcriptome and hormones metabolome joint analyses reveal the key molecular mechanism of Sweetpotato storage roots sprouting by Fan Ding, Xue Zou, Heling Fan, Li-ping Rao, Jian Sun, Qiang Li

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Metabolomics combined with metagenomics analysis reveals the potential mechanism of Zhejiang psyllium polysaccharides against hyperuricemia in rats by Dan Wu, Jingjie Niu, Jianping Hu, Hao Wang, Haixue Kuang

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