Investigating the effect of Arvcf reveals an essential role on regulating the mesolimbic dopamine signaling-mediated nicotine reward by Yan Wang, Zhongli Yang, Xiaoqiang Shi, Haijun Han, Andria N. Li, Bin Zhang, Wenji Yuan, Yan-Hui Sun, Xiao-Ming Li, Hong Lian, Ming D. Li

“…Subsequently, our SnRNA-seq analysis revealed that Arvcf was directly involved in dopamine biosynthesis in VTA dopaminergic neurons. …”
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Design and characterization of G-quadruplex RNA aptamers reveal RNA-binding by KDM5 lysine demethylases by Johanna Luige, Thomas Conrad, Alexandros Armaos, Annita Louloupi, Anna Vincent, David Meierhofer, Michael Gajhede, Gian Gaetano Tartaglia, Ulf Andersson Vang Ørom

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Genomic and immunological profiling reveals novel prognostic biomarkers for limited-stage small cell lung cancer by Ye Li, Xiaolong Ma, Zhiyi Wan, Pengfei Bao, Enli Zhang, Lihua Liu, Shunchang Jiao, Shengjie Sun

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Kidney cancer PDOXs reveal patient‐specific pro‐malignant effects of antiangiogenics and its molecular traits by Lidia Moserle, Roser Pons, Mar Martínez‐Lozano, Gabriela A Jiménez‐Valerio, August Vidal, Cristina Suárez, Enrique Trilla, José Jiménez, Inés de Torres, Joan Carles, Jordi Senserrich, Susana Aguilar, Luis Palomero, Alberto Amadori, Oriol Casanovas

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Metagenomic Characterization of Poultry Cloacal and Oropharyngeal Swabs in Kenya Reveals Bacterial Pathogens and Their Antimicrobial Resistance Genes by Philip M. Panyako, Sheila C. Ommeh, Stephen N. Kuria, Jacqueline K. Lichoti, Johns Musina, Venugopal Nair, Vish Nene, Muhammad Munir, Samuel O. Oyola

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Revealing field-driven distorted conical spiral phase in a weakly anisotropic double helical antiferromagnet by Ki Won Jeong, Jae Min Hong, Jae Yeon Seo, Sunghyun Lim, Kyungsun Moon, Mi Kyung Kim, Nara Lee, Young Jai Choi

“…Visualizations of spin textures reveal that an in-plane magnetic field transforms the DH ground state into a distorted conical spiral (DCS) state, challenging previous simplistic depictions of conical spirals. …”
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Striatal cell-type–specific molecular signatures reveal potential therapeutic targets in a model of dystonia by Kaitlyn M. Roman, Ashok R. Dinasarapu, Suraj Cherian, Xueliang Fan, Yuping Donsante, Nivetha Aravind, C. Savio Chan, H.A. Jinnah, Ellen J. Hess

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Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration by Christabel Thembela Dube, Hamish T. J. Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Jeremy A. Herrera, Ivona Baricevic-Jones, Richard D. Unwin, Danny Chan, Kanna Gnanalingham, Judith A. Hoyland, Stephen M. Richardson

“…Additionally, correlational analyses were conducted to define similarities and differences between tissue and plasma protein changes in individuals with mild and severe IVD degeneration. Results Our data revealed that the abundance of 31 proteins was significantly increased in severe degenerated IVD tissues compared to mild. …”
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Nasolabial Ulcerated Placard Revealing a Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell Lymphoma by J. B. Ntihebuwayo, F. Hali, A. Kerouach, H. Rachadi, S. Chiheb, F. Marnissi

“…Clinical examination revealed submandibular lymph nodes. The specimen analysis associated with anatomoclinical manifestation was concluded for a primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma. …”
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Integrated metabolomics and transcriptomics reveal differences in terpenoids and the molecular basis among the roots of three Bupleurum species by Dong Wen, Hongliang Ji, Mei Rong, Yang Liu, Jiemei Jiang, Xinwei Guo, Zhihui Gao, Yanhong Xu, Jianhe Wei

“…Results Metabolomics results revealed that Bmar contained more saikosaponins than Bchi and Bsco. …”
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Underwater paleontology inside cenotes reveals the Miocene-Pliocene fish diversity in the Yucatan Peninsula, southeast Mexico. by Kleyton M Cantalice, Hugo E Salgado-Garrido, Erick Sosa-Rodríguez, Kay Vilchis-Zapata, Gerardo González-Barba, Underwater Archaeological Atlas project

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Positions of cysteine residues reveal local clusters and hidden relationships to Sequons and Transmembrane domains in Human proteins by Manthan Desai, Bingyun Sun

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Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia by Isabella C. Galvão, Manuela Lemoine, Lauana A. Messias, Patrícia A.O.R.A. Araújo, Jaqueline C. Geraldis, Clarissa L. Yasuda, Marina K.M. Alvim, Enrico Ghizoni, Helder Tedeschi, Fernando Cendes, Fabio Rogerio, Iscia Lopes-Cendes, Diogo F.T. Veiga

“…In this study, we performed multi-omics single-nuclei profiling to map the chromatin accessibility and transcriptome landscapes of FCD type II, generating a comprehensive multimodal single-nuclei dataset comprising 61,525 cells from 11 clinical samples of lesions and controls. Our findings revealed profound chromatin, transcriptomic, and cellular alterations affecting neuronal and glial cells in FCD lesions, including the selective loss of upper-layer excitatory neurons, significant expansion of oligodendrocytes and immature astrocytic populations, and a distinct neuronal subpopulation harboring dysmorphic neurons. …”
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Revealing nanostructures in high-entropy alloys via machine-learning accelerated scalable Monte Carlo simulation by Xianglin Liu, Kai Yang, Yongxiang Liu, Fanli Zhou, Dengdong Fan, Zongrui Pei, Pengxiang Xu, Yonghong Tian

“…We apply SMC-GPU to explore nanostructure evolution in two high-entropy alloys, FeCoNiAlTi and MoNbTaW, revealing diverse morphologies including nanoparticles, 3D-connected NPs, and disorder-stabilized phases. …”
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Morphological and Phylogenetic Analyses Reveal Dictyostelids (Cellular Slime Molds) Colonizing the Ascocarp of <i>Morchella</i> by Wen-Shu Hu, Lin-Lin Jiang, Pu Liu, Xiao-Yan Zhang, Wei Wei, Xi-Hui Du

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Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. by Demetris Pillas, Clive J Hoggart, David M Evans, Paul F O'Reilly, Kirsi Sipilä, Raija Lähdesmäki, Iona Y Millwood, Marika Kaakinen, Gopalakrishnan Netuveli, David Blane, Pimphen Charoen, Ulla Sovio, Anneli Pouta, Nelson Freimer, Anna-Liisa Hartikainen, Jaana Laitinen, Sarianna Vaara, Beate Glaser, Peter Crawford, Nicholas J Timpson, Susan M Ring, Guohong Deng, Weihua Zhang, Mark I McCarthy, Panos Deloukas, Leena Peltonen, Paul Elliott, Lachlan J M Coin, George Davey Smith, Marjo-Riitta Jarvelin

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Single-cell and bulk transcriptome profiling reveals RNA-binding protein regulatory programs in cervical cancer by Shasha Yang, Jingjing Zeng, Yong Wang, Yudi Tan, Li Yu, Jinkong Wei, Yuying Wei, Yuxuan Jin, Junying Chen

“…Immunohistochemical experiments revealed that TIPARP expression was down-regulated in HPV + cervical cancer(p = 0.033). …”
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Pesticide exposome reveals oxidative stress and immune response disruptions in occupationally exposed women with breast cancer by Juliana Maria Bitencourt de Morais Valentim, Luciana Pizzatti, Carolina Coradi, Isabella Cristina Cazagranda, Bruna Fadel, Beatriz Geovana Leite Vacario, Shaiane Carla Gaboardi, Matheus Iago Oliveira Coletto, Rodrigo Kern, Wander Rogério Pavanelli, Daniel Rech, Maria Luiza Ferreira dos Santos, Leonardo Foti, Allan Henrique Depieri Cataneo, Guilherme Ferreira Silveira, Juliano Bordignon, Fábio Rodrigues Ferreira Seiva, Carolina Panis

“…High-throughput proteomic analyses of plasma revealed distinct protein expression profiles between the groups, primarily associated with inflammation, oxidative stress, and immune deregulation. …”
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An integrated physiology and proteomics analysis reveals the response of wheat grain to low temperature stress during booting by Anmin Zhang, Zihong Li, Qirui Zhou, Jiawen Zhao, Yan Zhao, Mengting Zhao, Shangyu Ma, Yonghui Fan, Zhenglai Huang, Wenjing Zhang

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Brain network analysis reveals hemispheric aberrant topology in patients with idiopathic REM sleep behavior disorder by Yi Sun, Lifeng Qian, Biwen Wu, Hongru Sun, Jing Hu, Sangsheng Zhu, Jiaye Cai, Huaying Cai, Ximiao Jiang, Yu Sun

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