Metabolic profiling reveals first evidence of fumigating drug plant Peganum harmala in Iron Age Arabia by Barbara Huber, Marta Luciani, Ahmed M. Abualhassan, Daniel Giddings Vassão, Ricardo Fernandes, Thibaut Devièse

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A new late Pleistocene fossil crocodile from Sudan reveals hidden diversity of Crocodylus in Africa by Khalafallah Salih, Johannes Müller, Ali Eisawi, Faysal Bibi

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Granger causality connectivity analysis of persistent atrial fibrillation dynamics reveals posterior wall mechanistic insights by Joseph Barker, MRes, Arunashis Sau, PhD, Nikesh Bajaj, PhD, Alex Jenkins, MPhys, Alex Sharp, MRCP, Xili Shi, PhD, Xinyang Li, PhD, Nabeela Karim, PhD, Balvinder Handa, PhD, Richard Chambers, MSc, Timothy Betts, PhD, Nicholas S. Peters, MD, FHRS, Tom Wong, MD, Fu Siong Ng, PhD, FHRS

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Multi-omics and network pharmacology reveal Huayu-Tongbi decoction reduced arthritis-related bone erosion by Bozhen Chen, Lu Yang, Houchun Wang, Peng Yu, Mengyang Ma, Meiqi Chen, Yingyan Zhou, Jiaqi Wu, Huasheng Liang, Maojie Wang, Runyue Huang, Yiting He, Qingchun Huang, Xiaohong He

“…In vitro multi-omics study revealed the decoction’s effect and underlying mechanisms in osteoclastic differentiation. …”
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Identification of an immunodominant region on a group A Streptococcus T-antigen reveals temperature-dependent motion in pili by Jeremy M. Raynes, Paul G. Young, Natalie Lorenz, Jacelyn M.S. Loh, Reuben McGregor, Edward N. Baker, Thomas Proft, Nicole J. Moreland

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Quantitative proteomics reveals pregnancy prognosis signature of polycystic ovary syndrome women based on machine learning by Yuanyuan Wu, Cai Liu, Jinge Huang, Fang Wang

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Bioinformatics‑Based Analysis Reveals Diagnostic Biomarkers and Immune Landscape in Atopic Dermatitis by Yang M, Zhang X, Zhou C, Du Y, Zhou M, Zhang W

“…Potential microRNA (miRNA)-messenger RNA (mRNA) and miRNA-long non-coding RNA (lncRNA) interactions were predicted using miRanda and TargetScan tools.Results: We identified 381 DEGs (217 upregulated, 164 downregulated). GO analysis revealed enrichment in skin barrier formation, epidermal development, and inflammatory response. …”
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Novel machine‐learning bioinformatics reveal distinct metabolic alterations for enhanced colorectal cancer diagnosis and monitoring by Rui Xu, Hyein Jung, Fouad Choueiry, Shiqi Zhang, Rachel Pearlman, Heather Hampel, Ning Jin, Jieli Li, Jiangjiang Zhu

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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism by Jie An, Inna Astapova, Guofang Zhang, Andrew L. Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J. Muehlbauer, Tabitha George, Joseph Brozinick, Mark A. Herman, Christopher B. Newgard

“…Integrated transcriptomic and metabolomic analyses in rats with GalNac-siRNA-mediated suppression of ChREBP expression in liver reveal other ChREBP functions. GalNac-siChREBP treatment reduces expression of genes involved in coenzyme A (CoA) biosynthesis, with lowering of CoA and short-chain acyl-CoA levels. …”
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Quantitative proteomics analysis reveals the tolerance of wheat to salt stress in response to Enterobacter cloacae SBP-8. by Rajnish Prakash Singh, Ashish Runthala, Shahid Khan, Prabhat Nath Jha

“…A broader comparison of the proteome of wheat plant under different treatments revealed that changes in some of the metabolic pathway may be involved in stress adaption in response to PGPR inoculation. …”
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Common bean pan-genome reveals abundant variation patterns and relationships of stress response genes and pathways by Xu Wang, Ming Yan, Shanshan Cui, Fang Li, Qingqing Zhao, Qingnan Wang, Bin Jiang, Yixin Huang, Yang Sun, Xiangdong Kong

“…Transcriptome analysis of multiple biotic and abiotic stresses reveals that gene expression patterns are organ-, stress-, and gene conservation-specific. …”
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Revealing the Oxygen Transport Challenges in Catalyst Layers in Proton Exchange Membrane Fuel Cells and Water Electrolysis by Huiyuan Li, Shu Yuan, Jiabin You, Congfan Zhao, Xiaojing Cheng, Liuxuan Luo, Xiaohui Yan, Shuiyun Shen, Junliang Zhang

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Taxonomic and functional diversities reveal different fish assemblage dynamics of stow net fishery in Haizhou Bay by Guangjie Fang, Yazhou Zhang, Haolin Yu, Chuanxi Chen, Jun Liang, Yanli Tang

“…In summary, the taxonomic and functional diversities revealed inconsistent statuses and trends of fish assemblages, with an evident decreasing trend in the non-target fish group requiring special attention. …”
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Commentary: Electromagnetic navigation with nonintubated thoracoscopic wedge resection: Summating novelties to reveal truthsCentral Message by Matthew Egyud, MD, Bryan M. Burt, MD

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Blood virome profiling reveals subtype-specific viral signatures and reduced diversity in non-Hodgkin lymphoma by Shaokun Pan, Wang Li, Xingyue Zhao, Huijie Wang, Jing Liu, Wen Zhang, Chenglin Zhou, Youhua Xie

“…Bioinformatic analysis identified 45 viral families, revealing subtype-specific viromic signatures. BCL exhibited a dominance of Anelloviridae, which accounted for 86% of eukaryotic viruses, compared with only 3% in controls, correlating with immunosuppression. …”
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Chromosome-level genome assembly reveals adaptive evolution of the invasive Amazon sailfin catfish (Pterygoplichthys pardalis) by Yunyun Lv, Yanping Li, Miao Fang, Yi Liu, Yuanyuan Wang, Yexin Yang, Yuanchao Zou, Qiong Shi, Xidong Mu

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Non-Targeted Metabolomics Reveals Tobacco Metabolites Associated with Roasted Tobacco Quality Under Organic Substitution by Feng Tian, Li Zhang, Lina Niu, Xinglong Fan, Yongliang Han, Yuanshang Liu, Jiancai Qian, Shihang Huang, Xixian Ou, Qiang Li

“…Among these, certain pathways such as alanine, aspartate, and glutamate metabolism, D-amino acid metabolism, purine metabolism, tryptophan metabolism, and galactose metabolism were up-regulated, whereas other pathways such as starch and sucrose metabolism, betalain biosynthesis, and biosynthesis of unsaturated fatty acids were down-regulated and significantly enriched with differential metabolites. This study revealed the significant differences in the metabolite composition under different fertilization conditions, with a strong correlation between metabolites and tobacco quality indices. …”
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Targeted plasma metabolomics reveals potential biomarkers of the elderly with mild cognitive impairment in Qingdao rural area by Yuchi Meng, Murong Cheng, Hongyan Qu, Zhenxue Song, Ling Zhang, Yuanjun Zeng, Dongfeng Zhang, Suyun Li

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Revealing Anisotropic Growth of Liraglutide Oligomers by Native Ion Mobility Mass Spectrometry and Molecular Dynamics Simulation by Zhenyu Xi, Syuan-Ting Kuo, Xiao Cong, Xin Yan, David H. Russell

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Multi-omics reveals the mechanism of quality discrepancy between Gayal (Bos frontalis) and yellow cattle beef by Lin Han, Runqi Fu, Chunjia Jin, Huan Gao, Binlong Fu, Qian Li, Ye Yu, Min Qi, Jiawei Zhang, Shengyong Mao, Jing Leng

“…Transcriptomic analysis of the psoas major (PM) muscle revealed significant changes in genes linked to muscle development, amino acid metabolism, and lipid metabolism. …”
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