Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation by Njenga R. Kamau, Michelle R. Tamplin, Chu-Yu Lee, Eric D. Axelson, Isabella M. Grumbach, Michael S. Petronek

“…The data refinement revealed that the most represented system was the olfactory system (8/18 regions, 44%). …”
Get full text

Immunogenic cell death signature predicts survival and reveals the role of VEGFA + Mast cells in lung adenocarcinoma by Meng Zhang, Guowei Zhou, Yantao Xu, Benliang Wei, Qian Liu, Guanxiong Zhang, Ruimin Chang

“…Moreover, utilizing single-cell RNA sequencing, we revealed the role of mast cells in the TME with the highest IRS. …”
Get full text

Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease by Zhen Zhu, Guangxin Luan, Song Wu, Yiyi Song, Shuang Shen, Kaiyue Wu, Shengnan Qian, Weiping Jia, Jun Yin, Tao Ren, Jianping Ye, Li Wei

“…Further GSEA analysis and GSVA scoring revealed that mitophagy and other key mitochondrial perturbation events, such as ROS production, apoptosis, membrane potential, adenosine triphosphate (ATP) synthesis, and mitochondrial dynamics, were involved in the protective mechanism of losartan on PT cells, thereby improving mitochondrial homeostasis. …”
Get full text

Genome-wide DNA methylation profiling reveals a novel hypermethylated biomarker PRKCB in gastric cancer by Leyan Li, Xiao Fei, Huan Wang, Sihai Chen, Xinbo Xu, Huajing Ke, Yanan Zhou, Yi Hu, Cong He, Chuan Xie, Nonghua Lu, Jianping Liu, Yin Zhu, Nianshuang Li

“…DNA methylome analysis further revealed 4432 differentially-methylated probes (DMPs), with the gene PRKCB exhibited the most prominent average DNA methylation disparity (mean Δβ = 0.353). …”
Get full text

Development of convergent adaptations reveal highly conserved early ontogenetic skull shape in fishes with amphibious vision by Philipp Thieme, Vivian Fischbach, Ioannis Papadakis, Timo Moritz

“…While cross sections reveal that the eyes develop required morphological adaptations for simultaneous amphibious vision in larval life stages, the restructuring of the neurocranium which causes the dorsolateral relocation of the eyes occurs only during late juvenile development. …”
Get full text

MaxEnt model reveals northward and elevational expansion of climate suitability for Camellia oleifera growth in China by Xiaojun Wang, Shumei Xiao, Guangxu Liu, Mingying Quan, Chunxia Zhang

Get full text

Randomised trial reveals a mismatch between preferences for and hormonal responses to anthropogenic light colour temperatures by Solène Guenat, Jörg Haller, Nicole Bauer

Get full text

Correction: Untargeted lipidomics reveals unique lipid signatures of extracellular vesicles from porcine colostrum and milk

Get full text

Revealing the Intrinsic Correlation between Cu Scales and Free Radical Chain Reactions in the Regulation of Catalytic Behaviour by Haifeng Zhang, Zilong Zhang, Jingyi Yan, Siyang Wang, Xubin Huang, Fangmin Zuo, Ao Li, Fengkai Gao, Haidan Lin, Bolin Wang

“…Accelerated ageing experiments were conducted to reveal variations in copper scales and deterioration in insulation properties. …”
Get full text

Mathematical model linking telomeres to senescence in Saccharomyces cerevisiae reveals cell lineage versus population dynamics by Anaïs Rat, Veronica Martinez Fernandez, Marie Doumic, Maria Teresa Teixeira, Zhou Xu

Get full text

Bioinformatics analysis based on microarray data reveals molecular crosstalk and immune relationship between sarcopenia and atherosclerosis by Jinghong Yang, Jun Zhong, Yimin Du, Jialin Liu, Zhong Li, Yanshi Liu

Get full text

Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development by Yuma Takano, Jun Suzuki, Kotaro Nomura, Gento Fujii, Junko Zenkoh, Hitomi Kawai, Yuta Kuze, Yukie Kashima, Satoi Nagasawa, Yuka Nakamura, Motohiro Kojima, Katsuya Tsuchihara, Masahide Seki, Akinori Kanai, Daisuke Matsubara, Takashi Kohno, Masayuki Noguchi, Akihiro Nakaya, Masahiro Tsuboi, Genichiro Ishii, Yutaka Suzuki, Ayako Suzuki

“…The detailed examination of each case, as well as the subsequent computational analyses based on the observed diverse profiles, reveals that significant changes in the phenotypic appearances of tumor cells are frequently associated with changes in immune cell features. …”
Get full text

Mendelian randomization studies of gastric cancer reveal potential risk factors, promising biomarkers and therapeutic targets by Maowei He, Yanting Duan, Yuanyan Zhang, Chao Qian, Jiawei Jin

Get full text

Multi-omics study reveals differential expression and phosphorylation of autophagy-related proteins in autism spectrum disorder by Eden Deri, Shashank Kumar Ojha, Maryam Kartawy, Igor Khaliulin, Haitham Amal

“…Our multi-omics study reveals differential expression and phosphorylation of autophagy-related proteins in ASD but further investigation is needed to prove the full involvement of autophagy in ASD. …”
Get full text

Transcription factor networks and novel immune biomarkers reveal key prognostic and therapeutic insights in ovarian cancer by Aiqin Zhao, Sufang Zhou, Xiaoyi Yang, Haiying Lu, Dan Zou, Xuan Zhang, Li Liu

Get full text

Serum metabolites characterize hepatic phenotypes and reveal shared pathways: results from population-based imaging by Juliane Maushagen, Johanna Nattenmüller, Ricarda von Krüchten, Barbara Thorand, Annette Peters, Wolfgang Rathmann, Jerzy Adamski, Christopher L. Schlett, Fabian Bamberg, Rui Wang-Sattler, Susanne Rospleszcz

Get full text

Transcriptomic and network toxicology approaches reveal potential mechanisms of DEHP induced intrahepatic cholestasis during pregnancy by Lun Zhang, Qianqian Huang, Yun Yu, Yue Jiang, Mengzhen Hou, Wenkang Tao, Cheng Zhang, Jianqing Wang

“…Subsequent analyses employing STRING and cytoscape software revealed five core targets: EGFR, STAT3, JUN, FOS, and HSP90AA1. …”
Get full text

Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplication. by Karin Voordeckers, Chris A Brown, Kevin Vanneste, Elisa van der Zande, Arnout Voet, Steven Maere, Kevin J Verstrepen

Get full text

Interpretable Machine Learning Reveals the Crucial Role of Water Availability in Regulating Thermal Optimality of Terrestrial Ecosystems by Arman Ahmadi, Kanishka Mallick, Koong Yi, Dennis Baldocchi

Get full text

Gene expression profile of anoikis reveals new subtypes of liver cancer and discovery of therapeutic targets and biomarkers by Yajing Zhu, Pan Zhang

Get full text