Chemoprofiling of Himantoglossum robertianum (Loisel.) P. Delforge leaves reveals predominance of gastrodigenin and structurally related compounds by Ilaria Chiocchio, Antonio De Agostini, Manuela Mandrone, Pierluigi Cortis, Clarissa Tarozzi, Ferruccio Poli, Cinzia Sanna

“…The active metabolites were present in all the natural populations, where only slight variations in their concentration were revealed. Conclusion Mapping the metabolome of H. robertianum leaves has provided new insights into the study of orchids, including diagnostic signals for rapid identification of gastrodigenin-like compounds directly from the 1H NMR profile of a crude extract. …”
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Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts by Rhowell Navarro Tiozon, Rhowell Navarro Tiozon, Erstelle Pasion-Uy, Saleh Alseekh, Saleh Alseekh, Kristel June D. Sartagoda, Shem Gempesaw, Joel H. G. Tolentino, Alisdair R. Fernie, Alisdair R. Fernie, Nese Sreenivasulu

“…Further, we employed Genome-wide association studies (GWAS), gene-set analysis, and targeted association analysis to identify the candidate genes linked to these lipids.ResultsThe genetic analyses revealed 72 candidate genes involved in the regulation of these accumulating lipids in PRS. …”
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Arctic zircon U-Pb ages reveal multiphase glaciations in East Siberia during the late Quaternary by Han Feng, Zhengquan Yao, Xuefa Shi, Zhongshi Zhang, Huayu Lu, Hanzhi Zhang, Yanguang Liu, Xin Shan, Jiang Dong, Linsen Dong, Gongxu Yang, Limin Hu, Yuri Vasilenko, Anatolii Astakhov, Alexander Bosin

“…Here, we present a provenance study using 10,111 detrital zircon U-Pb ages from circum-Arctic shelf sediments and central Arctic IRD. Our results reveal that a prominent ~90–110 Ma zircon peak serves as a distinctive fingerprint for East Siberian-sourced sediments. …”
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Silent predators: Revealing the parasites of Himalayan musk deer (Moschus leucogaster) in Manaslu Conservation Area, Nepal by Bishnu Achhami, Shila Gurung, Sujan Deshar, Sapana Khaiju, Lekha Kumari Thapa, Sabita Gurung

“…Non-invasive sampling of 52 fresh fecal pellets from Kaltal (n = 28) and Mugumba (n = 24) revealed a high prevalence (94.2 %) of gastrointestinal parasites including two nematodes (Pneumocaulus sp. and Strongyle) and one parasitic protist (Eimeria sp.). …”
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TMT-based quantitative proteomics reveals the effects of electromagnetic field and freezing preservation techniques on mutton quality by Xing Lei, Wei Su, Rongmei Zhou, Yingchun Mu

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Basal Xenobot transcriptomics reveals changes and novel control modality in cells freed from organismal influence by Vaibhav P. Pai, Léo Pio-Lopez, Megan M. Sperry, Patrick Erickson, Parande Tayyebi, Michael Levin

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Multi-Omics Analysis Reveals the Negative Effects of High-Concentrate Diets on the Colonic Epithelium of Dumont Lambs by Shufang Li, Hairong Wang, Boyang Li, Henan Lu, Jianxin Zhao, Aiwu Gao, Yawen An, Jinli Yang, Tian Ma

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Transcriptome profiling of two rice varieties reveals their molecular responses under high night-time temperature. by Wardah K Mustahsan, Yuya Liang, Abdul R Mohammed, Charles D Johnson, Endang M Septiningsih, Lee Tarpley, Michael J Thomson

“…Furthermore, transcriptomic data revealed distinct responsive mechanisms in Antonio and Colorado in response to both HNT and 1-MCP. …”
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Neonatal mouse model reveals pathogenesis of Shanxi Tick Virus 2 isolated from Haemaphysalis longicornis by Fan Li, Reichen Wang, Bangshuai Zhang, Guangjun Jin, Jingdong Song, Weimin Gou, Changyuan Sun, Qikai Yin, De Li, Kai Nie, Qianqian Cui, Shihong Fu, Songtao Xu, Qiang Wei, Huanyu Wang

“…Electron microscopy revealed that SXTV2 particles are enveloped, surface-spiked, pleomorphic, and approximately 100 nm in diameter. …”
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50 Years of Antibody Numbering Schemes: A Statistical and Structural Evaluation Reveals Key Differences and Limitations by Zirui Zhu, Katherine S. Olson, Thomas J. Magliery

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Integrated Analysis of Cuproptosis Regulators Reveals Prognostic Significance and Therapeutic Targets in IDH1 Mutant Glioma by Yuxuan Luan, Yong Meng, Chunming Sun, Ruixin Wu, Qimeng Chang, Yilin Wang, Minfeng Shu

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Combining Experimental Validation and Network Pharmacology to Reveal the Action Mechanism of Panax Notoginseng-Radix Salviae on Atherosclerosis by Song N, Zhang X, Yin H, Zhang L, Li C, Li J, Li Y, Wu J

“…Mechanistic studies further revealed that PN-RS inhibited the JAK2-STAT3 signaling pathway and reduced the concentrations of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1).Conclusion: These findings suggest that PN-RS could be a promising treatment for atherosclerosis, applicable across diverse populations. …”
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Whole-genome sequencing reveals patterns of runs of homozygosity underlying genetic diversity and selection in domestic rabbits by Xinxin Ping, Yuan Chen, Hui Wang, Zhuoya Jin, Qianting Duan, Zhanjun Ren, Xianggui Dong

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Correction: State of knowledge for invasive green iguanas in Florida reveals negative impacts and pervasive research needs by Natalie M. Claunch, Paulina M. Jones, Emily S. Khazan, Bryan M. Kluever

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Modelling quiescence exit of neural stem cells reveals a FOXG1-FOXO6 axis by Kirsty M. Ferguson, Carla Blin, Claudia Garcia-Diaz, Harry Bulstrode, Raul Bardini Bressan, Katrina McCarten, Steven M. Pollard

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Integrative taxonomy reveals cryptic diversity within the Euphorbia nicaeensis alliance (Euphorbiaceae) in the central Balkan Peninsula by Angela Sharovikj Ivanova, Angela Sharovikj Ivanova, Peter Schönswetter, Mitko Kostadinovski, Michael H. J. Barfuss, Renata Ćušterevska, Božo Frajman

“…We uncovered cryptic lineages in the central Balkan Peninsula, where the description of two new species, diploid E. balcanica, and tetraploid E. skopjensis was necessary. In addition, we revealed high diversity, partly related to polyploidisations, among the populations from the eastern Balkan and Pontic steppes, likely pertaining to different species. …”
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Joint Genomic and Transcriptomic Analysis Reveals Candidate Genes Associated with Plumage Color Traits in Matahu Ducks by Pengwei Ren, Liu Yang, Muhammad Zahoor Khan, Yadi Jing, Meixia Zhang, Chao Qi, Xin Zhang, Xiang Liu, Zhansheng Liu, Shuer Zhang, Mingxia Zhu

“…The functional enrichment of these genes revealed several key signaling pathways, including those related to cGMP-PKG, cAMP, PI3K-Akt, and MAPK. …”
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Transcriptome analysis reveals regulatory mechanism of methyl jasmonate-induced monoterpenoid biosynthesis in Mentha arvensis L. by Tingting Huang, Wenjin Men, Ariuntungalag Myanganbayar, Undarmaa Davaasambuu

“…KEGG enrichment analysis revealed that “Monoterpenoid biosynthesis” was among the most significantly enriched metabolic pathways. …”
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Hyperspectral reflectance imaging and spectral component analysis techniques to reveal distinct color patterns on plant leaves by Shalini Krishnamoorthi, Daisuke Urano

“…This protocol details step-by-step procedures for hyperspectral image acquisition, correction of uneven lighting, and spectral component analysis to reveal distinct and sometimes previously undetectable features on leaves. …”
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Integration of multi-omics quantitative trait loci evidence reveals novel susceptibility genes for Alzheimer’s disease by Jinyang Gao, Xiaochan Bi, Wenjing Jiang, Yanqing Wang

“…For ACE, our analyses across methylation, expression, and protein levels revealed an overall odds ratio (OR) indicating a protective effect against AD. …”
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