Multi-omics analysis of epigenetic dysregulation reveals clinical heterogeneity and evaluates the immunotherapeutic potential of lung adenocarcinoma by Yuqing Ren, Zaoqu Liu, Yi Yue, Siyuan Weng, Hongxia Jia, Jing Li, Ping Li, Chunya Lu, Xinwei Han, Guojun Zhang

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Molecular dynamics simulations reveal key roles of the LIF receptor in the assembly of human LIF signaling complex by Bo Gao, Hanrui Liu, Mengkai Zhu, Shun Zhang, Meiniang Wang, Yijun Ruan, Yue Zheng

“…Structural studies have revealed how LIF forms a functional signaling complex. …”
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Self-control design reveals varied lactation and metabolic responses to rumen-protected methionine in dairy cows by Zi-Hai Wei, Shu-Lin Liang, Feng-Fei Gu, Jane Wamatu, Hui-Zeng Sun

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Revealing major macroeconomic growth factors for an emerging economy: evidence from half-century of economic resilience by Mehedi Hasan, Md. Obidul Haque, Md. Saddam Hossain, Md. Ahsan Habib, Mohammad Bin Amin, Md. Atikur Rahaman, Judit Oláh

“…Using an autoregressive distributed lag (ARDL) bounds testing approach, the study leverages 50 years of time-series data to explore the dynamic relationships between these macroeconomic factors and economic growth. The findings reveal that FDI, government consumption, and trade openness significantly boost economic growth, while inflation and exchange rate appreciation exert negative effects. …”
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The integrated analysis of transcriptomics and metabolomics reveals the effects of tea polyphenols on lipid metabolism in lion-head geese by Zhiqi Fu, Chunpeng Liu, Tao Zeng, Yuchuan Wang, Yuwen Liang, Na Ao, Lizhi Lu, Jing Fu

“…Moreover, the combined analysis revealed a strong positive correlation between ANGPTL4 and the organic compounds of steroidal saponins, such as Glucoconvallasaponin B, and negative correlations with glycerophospholipid metabolites, such as LysoPC (P-16:0). …”
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Transcriptional meta-analysis and immune cell profiles reveal altered neutrophil dynamics in chronic atrial fibrillation by Elijah Stone, Jude Taylor, Amy Li, Craig S. McLachlan

“…Immune cell analysis revealed altered abundances in five cell types in persistent AF, particularly an increase in neutrophils, which was not observed in permanent AF. …”
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Tourist brownfields in French Polynesia - Revealing a destination crisis and a form of resistance to international tourism by Philippe Bachimon

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Transcriptome and Small-RNA Sequencing Reveals the Response Mechanism of <i>Brassica napus</i> to Waterlogging Stress by Xianshuai Song, Lan Ge, Kaifeng Wang, Nian Wang, Xinfa Wang

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Single‐Cell RNA Sequencing Reveals the Critical Role of SEC16B in Lung Metastasis of Osteosarcoma by Shangyu Liu, Haijun Tang, Shanhang Li, Jian Guan, Yangjie Cai, Hening Li, Weijie Yan, Wei Dai, Danting Xiao, Zhuan Zou, Wenyu Feng, Xinli Zhan, Yun Liu, Juliang He

“…By intersecting lung metastasis‐related genes identified via hdWGCNA analysis with differentially expressed genes from bulk RNA sequencing, SEC16B was identified as the key gene influencing lung metastasis. qRT‐PCR results revealed that SEC16B expression was significantly downregulated in OS cell lines. …”
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ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2. by Gaynor Miller, Monica Neilan, Ruth Chia, Nabeia Gheryani, Natalie Holt, Annabelle Charbit, Sara Wells, Valter Tucci, Zuzanne Lalanne, Paul Denny, Elizabeth M C Fisher, Michael Cheeseman, Graham N Askew, T Neil Dear

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Multielement Imaging Reveals the Diagenetic Features and Varied Water Redox Conditions of a Lacustrine Dolomite Nodule by Yuke Liu, Wenyuan He, Jinyou Zhang, Zhenwu Liu, Fazi Chen, Huajian Wang, Yuntao Ye, Yitong Lyu, Zhiyong Gao, Zhichao Yu, Lina Bi, Shuichang Zhang

“…The final imaging data graphically revealed dynamic variation of elemental distributions, including elements enriched in dolomite (e.g., Ca, Mg, Fe, and Mn), clastic quartz (Si), and clay minerals (e.g., Al and K) and redox-sensitive trace elements (e.g., Cr, Mo, V, and U). …”
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Chromosome‐scale Salvia hispanica L. (Chia) genome assembly reveals rampant Salvia interspecies introgression by Julia Brose, John P. Hamilton, Nicholas Schlecht, Dongyan Zhao, Paulina M. Mejía‐Ponce, Arely Cruz‐Pérez, Brieanne Vaillancourt, Joshua C. Wood, Patrick P. Edger, Salvador Montes‐Hernandez, Guillermo Orozco deRosas, Björn Hamberger, Angélica Cibrian‐Jaramillo, C. Robin Buell

“…We sequenced and analyzed the genomes of 20 Chia accessions with differing seed color and geographic origin revealing population structure within S. hispanica and interspecific introgressions of Salvia species. …”
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RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats by Sebastien Riquier, Samuel Carthy, Graham M. Hughes, Frederic Touzalin, Wilfried Haerty, Zixia Huang, Emma C. Teeling

“…Our network analysis revealed significant variation in immune status among a subset of individuals, potentially due to pathogenic conditions. …”
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Revealing the Ecstasy of Communication upon using Tik Tok: A Virtual Ethnography in Palopo City, Indonesia by Wahyuni Husain, Saifur Rahman, Intan Soliha Ibrahim, Achmad Sulfikar

“…Data were analyzed using reduction techniques, presentation, and drawing conclusions. The results reveal that TikTok usage is prevalent among students, with daily use averaging over three hours per day. …”
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AI-driven MRI analysis reveals brain atrophy patterns in benign relapsing-remitting multiple sclerosis by M. Niiranen, M. Niiranen, P. Bendel, P. Bendel, J. Koikkalainen, J. Lötjönen, T. Selander, E. Solje, E. Solje, P. Hartikainen, S. Simula, R. Vanninen, R. Vanninen, A. M. Portaankorva

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Prediction of target genes and functional types of cis-regulatory modules in the human genome reveals their distinct properties by Sisi Yuan, Pengyu Ni, Zhengchang Su

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Single cell dissection reveals SFRP2+ fibroblasts amplifying inflammatory responses in oral lichen planus by Juehua Cheng, Juehua Cheng, Juehua Cheng, Jia Liu, Jia Liu, Jia Liu, Yuchi Zhu, Yuchi Zhu, Yuchi Zhu, Jingjing Yang, Jingjing Yang, Jingjing Yang, Yanlin Geng, Yanlin Geng, Yanlin Geng, Yuan Fan, Yuan Fan, Yuan Fan

“…Besides, SFRP2+ Wnt5a+ fibroblasts were located around CD8+ T cells in the superficial layer of the lymphocyte infiltration zone.ConclusionsOur findings reveal the heterogeneity and pathogenic mechanisms of fibroblasts in OLP, providing new insights into the cellular drivers of chronic inflammation in OLP.…”
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Revealing Mucilage Event-Linked Community Composition in the Sea of Marmara from eDNA Metabarcoding Data by Onur Doğan, Anıl Doğan Örün, Raşit Bilgin, Melek İşinibilir

“…To overcome this problem, we used environmental DNA (eDNA) metabarcoding approaches to reveal the species-level resolution of community composition. …”
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Transcriptomic and proteomic analysis reveals the mechanism of chicken cecum response to Salmonella enterica serovar Enteritidis inoculation by Yuanmei Wang, Liying Liu, Yanan Zhao, Yanru Ren, Xiuxiu Miao, Yaning Dong, Lewen Liu, Xianyao Li

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Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis by Changying Jing, Changying Jing, Yaqi Sun, Yaqi Sun, Hongsheng Bi, Junguo Guo, Cong Ren, Jike Song, Beibei Wang, Qingmei Tian, Dadong Guo, Pengjuan He, Lijie Li, Xiaofeng Xie

“…Finally, in vivo experiments provided evidence confirming that QHRGF was identified as the key target of the anti-inflammatory effect of uveitis.ConclusionIn conclusion, this research revealed that QHRGF can be used to treat uveitis through multiple components and targets. …”
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