In vivo structure profiling reveals human cytosolic and mitochondrial tRNA structurome and interactome in response to stress by Noah Peña, Yichen Hou, Christopher P. Watkins, Sihao Huang, Wen Zhang, Christopher D. Katanski, Tao Pan

“…We also identify cytosolic and mitochondrial tRNA structure and interaction changes upon arsenite treatment, a type of oxidative stress that induces translational reprogramming, which is consistent with global translation repression in both compartments. Our results reveal variations of tRNA structurome and dynamic interactome that have functional consequences in translational regulation.…”
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Meta-Analysis of Abbreviated MRI Scanning Reveals a High Specificity and Sensitivity in Detecting Breast Cancer by Bei Zhou, Weiguang He, Jasmine Kaur, Qingxia Cai, Audesh Bhat, Qiang Liu

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Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate. by Jatin Narula, Aileen M Smith, Berthold Gottgens, Oleg A Igoshin

“…Taken together our analysis not only reveals new insights into hematopoietic stem cell regulatory network functionality but also provides a novel and widely applicable strategy to incorporate experimental measurements into dynamical network models.…”
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An integrated model of multiple-condition ChIP-Seq data reveals predeterminants of Cdx2 binding. by Shaun Mahony, Matthew D Edwards, Esteban O Mazzoni, Richard I Sherwood, Akshay Kakumanu, Carolyn A Morrison, Hynek Wichterle, David K Gifford

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Metabolic flux analysis of glioblastoma neural stem cells reveals distinctive metabolic phenotypes in ketogenic conditions by Anna Rushin, Aleezeh Shaikh, Callie Hardin, Loic P. Deleyrolle, Matthew E. Merritt

“…Flux analysis using a detailed metabolic modeling approach revealed three unique metabolic phenotypes in the patient GBMs that correlated with cell viability. …”
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Phylogenetic analysis of Mycobacterium bovis reveals animal and zoonotic tuberculosis spread between Morocco and European countries. by Hind Yahyaoui Azami, Claudia Perea, Tod Stuber, Mohammed Bouslikhane, Jaouad Berrada, Hamid Aboukhassib, Alberto Oscar Allepuz Palau, Ana C Reis, Mónica V Cunha, Tyler C Thacker, Suelee Robbe-Austerman, Liliana C M Salvador, Frederick D Quinn

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Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumors by Céline Patte, Roxane M. Pommier, Anthony Ferrari, Felicia Fei-Lei Chung, Maria Ouzounova, Pauline Moullé, Mathieu Richaud, Rita Khoueiry, Maëva Hervieu, Silvia Breusa, Marion Allio, Nicolas Rama, Laura Gérard, Valérie Hervieu, Gilles Poncet, Tanguy Fenouil, Vincent Cahais, Anne-Sophie Sertier, Anne Boland, Delphine Bacq-Daian, Benjamin Ducarouge, Julien C. Marie, Jean-François Deleuze, Alain Viari, Jean-Yves Scoazec, Colette Roche, Patrick Mehlen, Thomas Walter, Benjamin Gibert

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Germline variants analysis of Chinese breast cancer patients reveals numerous alterations in homologous recombination genes by Zhaoyun Jiang, Bing Xu, Bo Sun, Beibei Yang, Su Lu, Mengjian Li, Juan Zhang, Liqiang Qi, Qixi Wu

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Transcriptomic analysis reveals molecular mechanism by which Chinese olive fruit prolongs lifespan of Caenorhabditis elegans by Yuanxin Miao, Yan Xu, Jia Gao, Xu Ai, Rui Duan, Rong Li

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Radar-measured passerine vertical speeds reveal a migratory switch near a major barrier by Yuval Werber, Nir Sapir

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Integrative Metagenomic Analyses Reveal Gut Microbiota-Derived Multiple Hits Connected to Development of Diabetes Mellitus by Sehad N. Alarifi, Essam Jamil Alyamani, Mohammed Alarawi, Azzam A. Alquait, Mohammed A. Alolayan, Ahmad M. Aldossary, Randa A. Abd EL-Rahman, Rashid Mir

“…Results: Our findings revealed significant differences in microbial composition between the two groups. …”
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Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

“…Annotation of in vitro cell types with reference to in vivo development reveals diverse mesendoderm lineage cell types including lateral plate and paraxial mesoderm, neural crest, and primitive gut. …”
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Single-cell sequencing of peripheral blood mononuclear cells reveals immune landscape of monkeypox patients with HIV by Yamin Liu, Xinhua Liu, Jingjing Wang, Ying Xie, Jing Guo, Zhiqiang Liu, Ying Li, Bei Jiang, Jingya Wang

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Integrative Modeling of Urinary Metabolomics and Metal Exposure Reveals Systemic Impacts of Electronic Waste in Exposed Populations by Fiona Hui, Zhiqiang Pang, Charles Viau, Gerd U. Balcke, Julius N. Fobil, Niladri Basu, Jianguo Xia

“…Both linear and nonlinear models revealed distinct sets of exposure-responsive compounds, highlighting diverse biological responses. …”
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Comparative proteomic analyses reveal the proteome response to short-term drought in Italian ryegrass (Lolium multiflorum). by Ling Pan, Zhongfu Yang, Jianping Wang, Pengxi Wang, Xiao Ma, Meiliang Zhou, Ji Li, Nie Gang, Guangyan Feng, Junming Zhao, Xinquan Zhang

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Proteomic screening of human targets of viral microRNAs reveals functions associated with immune evasion and angiogenesis. by Amelia M Gallaher, Sudipto Das, Zhen Xiao, Thorkell Andresson, Philippe Kieffer-Kwon, Christine Happel, Joseph Ziegelbauer

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Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis by Pritam Sukul, Dagmar-Christiane Fischer, Celine Broderius, Simon Grzegorzewski, Anja Rahn, Thomas Mittlmeier, Bernd Kreikemeyer, Daniel A. Reuter, Jochen K. Schubert, Wolfram Miekisch

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Next-Generation Sequencing Reveals the Potential Role of RET Protooncogene in Metastasis Progression in Medullary Thyroid Cancer by Maurice Klein, Anna Julia Claudia Klein, Arnold M. Raem, Nicklas Garrelfs, Henrike J. Fischer, Frank Hölzle, Kai Wermker

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High‐Throughput Proteoform Imaging for Revealing Spatial‐Resolved Changes in Brain Tissues Associated with Alzheimer's Disease by Yue Sun, Dan Liu, Yu Liang, Xue Yang, Xinxin Liu, Baofeng Zhao, Zhen Liang, Yukui Zhang, Lihua Zhang

“…The obtained proteoform images reveals differential expression of individual proteoforms across the brain regions, and distinct spatial distribution patterns of various proteoforms generated from a single gene. …”
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Revealing the unspoken battle: limited awareness of PMDD and Its invisible consequences on women's well-being in Pakistan by Muhammad Shahzad, Mahnoor Saeed, Farah Shahzad, Rabia, Ali Hassan

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