Machine learning approach for revealing the nickel grade and recovery optimization in reduction process of laterite ores by Vuri Ayu Setyowati, Fakhreza Abdul

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Time-resolved connectivity reveals the “how” and “when” of brain networks reconfiguration during face processing by Antonio Maffei, Paola Sessa

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Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications by Chunxiao Cheng, Yuanjiao Liu, Lingyun Sun, Jiayao Fan, Xiaohui Sun, Ju-Sheng Zheng, Lin Zheng, Yimin Zhu, Dan Zhou

“…Cross-ancestry metabolome-wide analysis further revealed four shared potential causal metabolites, highlighting the potential protective role of creatine for T2D. …”
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Development of swimming speed-based biomarker reveals interactive toxicity of TCEP and TCPP in amphibian larvae by Xin-Dan Cao, Zi-Ying Wang, Wen-Qi Xie, Jia-Jun Hao, Yi-Ge Xie, Zi-Yong Xiang, Guo-Hua Ding

“…Using an information-theoretic approach, we revealed an interaction pattern: high TCEP concentrations significantly diminished TCPP's effects on swimming speed. …”
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Subtype-specific atypical B cell profiles in myasthenia gravis reveal distinct immunopathological pathways by Patricia M. Sikorski, Henry J. Kaminski, Angela Vincent, Taylor Bauman, Leslie Jacobson, Linda L. Kusner

“…Functionally, CD11c+ B cells from MuSK-MG exhibited greater ASC differentiation and autoantibody production.DiscussionMG subtypes exhibit distinct atBC profiles linked to immunopathology and disease onset. These findings reveal subtype-specific pathways that regulate atBCs and highlight their potential as therapeutic targets in both IgG1-3- and IgG4-mediated autoimmunity.…”
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Mendelian randomization reveals immune cell composition as a key determinant of cervical cancer prognosis by Yangyang Chen, Dongdong Zhong

“…These observations were also further supported by additional analyses, such as scatter plots and linear regression models, which revealed further nuances in the intricate relationship between the immune microenvironment and the disease. …”
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Integrative bioinformatics analysis and experimental validation reveals key genes and regulatory mechanisms in the development of gout by Ye Yuan, Zhiqiang Gao, Jianhong Chen, Yuejing Liu, Jingguo Zhou

“…Immune infiltration revealed significant upregulation of M2 macrophages, activated mast cells, activated NK cells, and γδ T cells in gout samples. …”
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An in vitro model of the epithelial airway reveals a key function for EHF in lung homeostasis and disease by Laetitia Pinte, Marta Vila-Gonzalez, Eleanor C. Williams, Erika Causa, Ricardo Fradique, Tekle Pauzaite, Charlotte Passemar, Silvia Becca, Christopher Gribben, Shiqi Ye, Maha Al-Thani, Fabian Bachinger, Floris J. M. Roos, James A. Nathan, Irina Mohorianu, Andres Floto, Pietro Cicuta, Ludovic Vallier

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Proteomic and phosphoproteomic profilings reveal distinct cellular responses during Tilapinevirus tilapiae entry and replication by Tuchakorn Lertwanakarn, Matepiya Khemthong, Piyathip Setthawong, Narumon Phaonakrop, Sittiruk Roytrakul, Sekkarin Ploypetch, Win Surachetpong

“…Results Our findings revealed significant alterations in protein expression and phosphorylation states, highlighting distinct responses between the cell lines. …”
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A reporter assay in lamprey embryos reveals both functional conservation and elaboration of vertebrate enhancers. by Hugo J Parker, Tatjana Sauka-Spengler, Marianne Bronner, Greg Elgar

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Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. by Li-Jun Ma, Ashraf S Ibrahim, Christopher Skory, Manfred G Grabherr, Gertraud Burger, Margi Butler, Marek Elias, Alexander Idnurm, B Franz Lang, Teruo Sone, Ayumi Abe, Sarah E Calvo, Luis M Corrochano, Reinhard Engels, Jianmin Fu, Wilhelm Hansberg, Jung-Mi Kim, Chinnappa D Kodira, Michael J Koehrsen, Bo Liu, Diego Miranda-Saavedra, Sinead O'Leary, Lucila Ortiz-Castellanos, Russell Poulter, Julio Rodriguez-Romero, José Ruiz-Herrera, Yao-Qing Shen, Qiandong Zeng, James Galagan, Bruce W Birren, Christina A Cuomo, Brian L Wickes

“…Expanded families of cell-wall synthesis enzymes, essential for fungal cell integrity but absent in mammalian hosts, reveal potential targets for novel and R. oryzae-specific diagnostic and therapeutic treatments.…”
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JMY powers dendritogenesis and is regulated by CaM revealing a general, critical principle in neuromorphogenesis by Maja Kühne, Anna-Lena Zepernick, Britta Qualmann, Michael Manfred Kessels, Maryam Izadi-Seitz

“…Here, we identify the WH2 domain-based actin nucleator JMY as target of the calcium sensor calmodulin, reveal that JMY is critical for dendritic arbor formation and unravel that JMY’s molecular mechanisms employed in dendritic arborization are depended on Arp2/3 complex interaction, Arp2/3 complex activity and functionality of JMY’s WH2 domains, i.e. on JMY’s abilities to promote actin filament formation. …”
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Combining patient-lesion and big data approaches to reveal hippocampal contributions to spatial memory and navigation by Sara Pishdadian, Antoine Coutrot, Lauren Webber, Michael Hornberger, Hugo Spiers, R. Shayna Rosenbaum

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TO THE POSSIBILITY OF REVEALING OF SIDE EFFECTS OF METRONIDAZOLE (0,5% INFUSION SOLUTION, 100 ML) IN EXPERIMENT by A. G. Yushkov, N. A. Shulgina, A. A. Gushchina, G. G. Yushkov, M. M. Rasulov, V. V. Benemanskiy, M. M. Boon

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Multi-omics analysis reveals the core microbiome and biomarker for nutrition degradation in alfalfa silage fermentation by Yuan Wang, Yunlei Sun, KeXin Huang, Yu Gao, Yufan Lin, Baojie Yuan, Xin Wang, Gang Xu, Luiz Gustavo Nussio, Fuyu Yang, Kuikui Ni

“…This study integrated large-scale microbial culturing with high-throughput sequencing to thoroughly examine the microbial community structure in alfalfa silage and explored the potential pathways of nutritional degradation via metagenomic analysis. The findings revealed an enriched microbial diversity in silage, indicated by the identification of amplicon sequence variants. …”
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Corrigendum: High-dose fluorescein reveals unusual confocal endomicroscope imaging of low-grade glioma by Evgenii Belykh, Naomi R. Onaka, Xiaochun Zhao, Irakliy Abramov, Jennifer M. Eschbacher, Peter Nakaji, Mark C. Preul

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Correction: Super pan-genome reveals extensive genomic variations associated with phenotypic divergence in Actinidia by Xiaofen Yu, Minghao Qu, Pan Wu, Miao Zhou, Enhui Lai, Huan Liu, Sumin Guo, Shan Li, Xiaohong Yao, Lei Gao

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Direct mosquito feedings on dengue-2 virus-infected people reveal dynamics of human infectiousness. by Louis Lambrechts, Robert C Reiner, M Veronica Briesemeister, Patricia Barrera, Kanya C Long, William H Elson, Alfonso Vizcarra, Helvio Astete, Isabel Bazan, Crystyan Siles, Stalin Vilcarromero, Mariana Leguia, Anna B Kawiecki, T Alex Perkins, Alun L Lloyd, Lance A Waller, Uriel Kitron, Sarah A Jenkins, Robert D Hontz, Wesley R Campbell, Lauren B Carrington, Cameron P Simmons, J Sonia Ampuero, Gisella Vasquez, John P Elder, Valerie A Paz-Soldan, Gonzalo M Vazquez-Prokopec, Alan L Rothman, Christopher M Barker, Thomas W Scott, Amy C Morrison

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Integrated analysis reveals prognostic value of HLA-I LOH in triple-negative breast cancer by Yi Xiao, Xi Jin, Yi-Zhou Jiang, Zhi-Ming Shao, Yi-Fan Zhou, Gen-Hong Di

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Unveiling the Subterranean Symphony: A Comprehensive Study of Cave Fungi Revealed Through National Center for Biotechnology Sequences by Željko Savković, Slađana Popović, Miloš Stupar

“…Finally, cutting-edge molecular technologies and better sampling methods are revealing hitherto undiscovered fungal diversity in caves worldwide.…”
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