Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy by Fangzhou He, Jiuhui Xu, Fanwei Zeng, Boyang Wang, Yi Yang, Jie Xu, Xin Sun, Tingting Ren, Xiaodong Tang

“…Conclusions Our integrative analysis revealed that the MIF/CD74 axis is a promising target for the treatment of Ewing sarcoma and provides a rationale for this novel immunotherapy.…”
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Correlative X-ray imaging to reveal the dissolution of nanoparticles and nutrient transport in plant foliar fertilization by Chengpeng Wu, Emil V. Kristensen, Francesco Minutello, Augusta Szameitat, Søren Husted, Rajmund Mokso

“…Finally, micro-computed tomography integrates these findings into a complete three-dimensional digital representation of the plant’s microstructure, revealing regions of apparent densification associated with NP accumulation. …”
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Chromosome 21 scan in Down syndrome reveals DSCAM as a predisposing locus in Hirschsprung disease. by Anne-Sophie Jannot, Anna Pelet, Alexandra Henrion-Caude, Asma Chaoui, Marine Masse-Morel, Stacey Arnold, Damien Sanlaville, Isabella Ceccherini, Salud Borrego, Robert M W Hofstra, Arnold Munnich, Nadège Bondurand, Aravinda Chakravarti, Françoise Clerget-Darpoux, Jeanne Amiel, Stanislas Lyonnet

“…At last, we provide the functional rationale to the involvement of DSCAM by network analysis and assessment of SOX10 regulation. Our results reveal the involvement of DSCAM as a HSCR susceptibility locus, both in Down syndrome and HSCR isolated cases. …”
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Machine learning-based integration reveals reliable biomarkers and potential mechanisms of NASH progression to fibrosis by Jiahui Feng, Zheng Gong, Jialing Yang, Yuting Mo, Fengqian Song

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Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology. by Nikita Komarov, Cornelia Fritsch, G Larisa Maier, Johannes Bues, Marjan Biočanin, Clarisse Brunet Avalos, Andrea Dodero, Jae Young Kwon, Bart Deplancke, Simon G Sprecher

“…We propose that further investigations, across the animal kingdom, may reveal higher sensory complexity than currently anticipated.…”
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Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes. by Jennifer E Ho, Martin G Larson, Anahita Ghorbani, Susan Cheng, Ming-Huei Chen, Michelle Keyes, Eugene P Rhee, Clary B Clish, Ramachandran S Vasan, Robert E Gerszten, Thomas J Wang

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HaptiKart: An engaging videogame reveals elevated proprioceptive bias in individuals with autism spectrum disorder. by Daniel E Lidstone, Mohit Singhala, Liam J Wang, Jeremy D Brown, Stewart H Mostofsky

“…HaptiKart provides a highly scalable approach for measuring sensory-motor bias, revealing that individuals with ASD show elevated proprioceptive bias, correlating with autism severity. …”
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Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR by Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal

“…Our mutagenesis studies reveal that selective M5 PAMs bind outside previously characterized M5 mAChR allosteric sites. …”
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A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity. by Vanina Guernier, Cyrille Goarant, Jackie Benschop, Colleen L Lau

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Changes in goose hypothalamus under different photocycles: RNA-Seq reveals new pathways and molecules by Yuyan FENG, Jie LIU, Xiaojing CHEN, Binbin GUO, Mingming LEI, Huanxi ZHU, Yingdong NI

“…The RNA-seq results revealed that compared with the SP group, the LPS group showed 24 significantly upregulated genes, and 9 significantly downregulated genes. …”
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tRNA signatures reveal a polyphyletic origin of SAR11 strains among alphaproteobacteria. by Katherine C H Amrine, Wesley D Swingley, David H Ardell

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Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis by Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang

“…The correlation of specific intact N-glycopeptides with the clinical features of SSc patients was analyzed. The results revealed a notable increase in the levels of 6 intact N-glycopeptides (IgG2-N3H3F1, IgG2-N3H4F1, IgG2-N4H4F1, IgG2-N4H5F1, IgG2-N5H4F1, and IgG2-N5H5F1) and a decrease in the levels of another set of 6 intact N-glycopeptides (IgG1-N4H3F1, IgG2-N3H6F1A1, IgG2-N4H4F1A1, IgG2-N5H3F1, IgG3-N4H3F1, and IgG3-N4H4F1). …”
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Raman micro-spectroscopy reveals the metabolic alterations in primary prostate tumor tissues of patients with metastases by Xiaoguang Shao, Bo Liu, Hongyang Qian, Qihan Zhang, Yinjie Zhu, Shupeng Liu, Heng Zhang, Jiahua Pan, Wei Xue

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Quantitative image analysis reveals distinct structural transitions during aging in Caenorhabditis elegans tissues. by Josiah Johnston, Wendy B Iser, David K Chow, Ilya G Goldberg, Catherine A Wolkow

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Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastoma by Can Xu, Jin Yang, Huan Xiong, Xiaoteng Cui, Yuhao Zhang, Mingjun Gao, Lei He, Qiuyue Fang, Changxi Han, Wei Liu, Yangyang Wang, Jin Zhang, Ying Yuan, Zhaomu Zeng, Ruxiang Xu

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Revealing the Karomah and Contributions of Kyai Basyirun: A Study of Oral Literature and Social Transformation in Malang by Nadia Nabila, Kholiq

“…This research aims to reveal the character that Kyai Basyirun has and his work towards the people of Karangsuko Malang. …”
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A pangenome reveals LTR repeat dynamics as a major driver of genome evolution in Chenopodium by Kate E. Jaggi, Karol Krak, Helena Štorchová, Bohumil Mandák, Ashley Marcheschi, Alexander Belyayev, Eric N. Jellen, John Sproul, David Jarvis, Peter J. Maughan

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Network pharmacology and experimental verification reveal the mechanism of Qingfei Tongluo mixture in treating pulmonary fibrosis by Ying Zhou, Wenlong Wang, Wanping Zhu, Tingting Cai, Nannan Wang, Xia Liu, Wenmin Wang, Kequn Chai

“…Network pharmacology and experimental verification reveal the mechanism of Qingfei Tongluo mixture in treating pulmonary fibrosis. …”
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XRISM Reveals Low Nonthermal Pressure in the Core of the Hot, Relaxed Galaxy Cluster A2029 by XRISM Collaboration, Marc Audard, Hisamitsu Awaki, Ralf Ballhausen, Aya Bamba, Ehud Behar, Rozenn Boissay-Malaquin, Laura Brenneman, Gregory V. Brown, Lia Corrales, Elisa Costantini, Renata Cumbee, Maria Diaz Trigo, Chris Done, Tadayasu Dotani, Ken Ebisawa, Megan E. Eckart, Dominique Eckert, Satoshi Eguchi, Teruaki Enoto, Yuichiro Ezoe, Adam Foster, Ryuichi Fujimoto, Yutaka Fujita, Yasushi Fukazawa, Kotaro Fukushima, Akihiro Furuzawa, Luigi Gallo, Javier A. García, Liyi Gu, Matteo Guainazzi, Kouichi Hagino, Kenji Hamaguchi, Isamu Hatsukade, Katsuhiro Hayashi, Takayuki Hayashi, Natalie Hell, Edmund Hodges-Kluck, Ann Hornschemeier, Yuto Ichinohe, Manabu Ishida, Kumi Ishikawa, Yoshitaka Ishisaki, Jelle Kaastra, Timothy Kallman, Erin Kara, Satoru Katsuda, Yoshiaki Kanemaru, Richard Kelley, Caroline Kilbourne, Shunji Kitamoto, Shogo Kobayashi, Takayoshi Kohmura, Aya Kubota, Maurice Leutenegger, Michael Loewenstein, Yoshitomo Maeda, Maxim Markevitch, Hironori Matsumoto, Kyoko Matsushita, Dan McCammon, Brian McNamara, François Mernier, Eric D. Miller, Jon M. Miller, Ikuyuki Mitsuishi, Misaki Mizumoto, Tsunefumi Mizuno, Koji Mori, Koji Mukai, Hiroshi Murakami, Richard Mushotzky, Hiroshi Nakajima, Kazuhiro Nakazawa, Jan-Uwe Ness, Kumiko Nobukawa, Masayoshi Nobukawa, Hirofumi Noda, Hirokazu Odaka, Shoji Ogawa, Anna Ogorzalek, Takashi Okajima, Naomi Ota, Stephane Paltani, Robert Petre, Paul Plucinsky, Frederick S. Porter, Katja Pottschmidt, Kosuke Sato, Toshiki Sato, Makoto Sawada, Hiromi Seta, Megumi Shidatsu, Aurora Simionescu, Randall Smith, Hiromasa Suzuki, Andrew Szymkowiak, Hiromitsu Takahashi, Mai Takeo, Toru Tamagawa, Keisuke Tamura, Takaaki Tanaka, Atsushi Tanimoto, Makoto Tashiro, Yukikatsu Terada, Yuichi Terashima, Yohko Tsuboi, Masahiro Tsujimoto, Hiroshi Tsunemi, Takeshi Tsuru, Hiroyuki Uchida, Nagomi Uchida, Yuusuke Uchida, Hideki Uchiyama, Yoshihiro Ueda, Shinichiro Uno, Jacco Vink, Shin Watanabe, Brian J. Williams, Satoshi Yamada, Shinya Yamada, Hiroya Yamaguchi, Kazutaka Yamaoka, Noriko Yamasaki, Makoto Yamauchi, Shigeo Yamauchi, Tahir Yaqoob, Tomokage Yoneyama, Tessei Yoshida, Mihoko Yukita, Irina Zhuravleva, Tommaso Bartalesi, Stefano Ettori, Roman Kosarzycki, Lorenzo Lovisari, Tom Rose, Arnab Sarkar, Ming Sun, Prathamesh Tamhane

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Cryptophyte diversity and assembly mechanisms reveal ecological discontinuities in a river-estuary-coast continuum by Changyun Wang, Yao Liu, Zhuyin Tong, Shujie Cai, Yichong Wang, Nengwang Chen, Bangqin Huang, Wupeng Xiao

“…This finding suggests that cryptophytes may follow different ecological rules compared to macrozoobenthos, perhaps because of the complex habitat heterogeneity and the dynamic mixing of freshwater and marine species in estuaries. Our analyses also revealed significant ecological discontinuities along the continuum, particularly at the estuarine interface, where deterministic processes, such as salinity-driven selection, become more influential in community assembly across habitat boundaries. …”
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