Proximity extension assay reveals serum inflammatory biomarkers in two amyotrophic lateral sclerosis cohorts by Yujing Chen, Sujuan Sun, Ninglu Gao, Zetai Bai, Wenfei Yu, Bing Zhao, Yan Yun, Xiaohan Sun, Pengfei Lin, Wei Li, Yuying Zhao, Chuanzhu Yan, Shuangwu Liu

“…In conclusion, our study revealed a consistent and replicable serum inflammatory profile and developed a biomarker panel that can differentiate ALS patients from HCs in two cohorts, which may play an important role in advancing our current understanding of the inflammatory process and identifying novel therapeutic strategies for ALS patients.…”
Get full text

Eye Tracking Reveals Physical Therapist Decision Making While Evaluating Standing Balance Performance by Emma Nigrelli, Wendy Carender, Kathleen H. Sienko, Leia Stirling

Get full text

Spatial Metabolomics Reveals the Effects of Dietary Capsaicin Intervention on Interscapular Adipose Tissue Metabolome in Mice by Haoqing Yang, Peiying Zheng, Jiamiao Hu, Zhongjing Lin, Natthida Sriboonvorakul, Shaoling Lin

“…A KEGG pathway analysis further revealed these changes were associated with key characteristics of beige energy metabolism pathways, such as thermogenesis, glycerol phospholipid metabolism, and pentose phosphate pathway. …”
Get full text

Comparative transcriptome analysis reveals key genes and signaling pathways mediated by salicylic acid in potato by Aie Chen, Beini Zhang, Huijie Wang, Jiangqing Wang, Ji Wei, Yuxin Jia, Hongyang Wang

“…Moreover, transcriptomic data revealed the robust induction of detoxification-related enzymes under SA treatment, including 19 glutathione S-transferases and 30 cytochrome P450 genes. …”
Get full text

Rank revealing‐based tensor completion using improved generalized tensor multi‐rank minimization by Wei Z. Sun, Peng Zhang, Bo Zhao

“…A rank‐decreasing method is derived to reveal the tensor rank in order to avoid the troublesome user defined hyper‐parameter selection. …”
Get full text

Transcriptional landscape and chromatin accessibility reveal key regulators for liver regenerative initiation and organoid formation by Jiabei Lian, Yachun An, Wenjing Wei, Yao Lu, Xiyu Zhang, Gongping Sun, Haiyang Guo, Longjin Xu, Xuena Chen, Huili Hu

“…Comprehensive integration of RNA sequencing and ATAC sequencing reveals that ATF3 representing “Initiation_on” TF and ONECUT2 representing “Initiation_off” TF transiently modulate the occupancy of target promoters to license liver cells for regeneration. …”
Get full text

Comparative analysis of dorsal and tail skin reveals region-dependent heterogeneity in axolotl skin regeneration by Lieke Yang, Qian Chen, Jinman Li, Yan Hu, Yaoxin Liu, Binbin Lu, Shuaibin Pei, Tingyi Huang, Yanmei Liu, Ji-Feng Fei

“…Developmental trajectory studies reveal prolonged retention of a hypodifferentiated state in tail skin, contrasting with early stratification in dorsal tissue. …”
Get full text

Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…Furthermore, our analysis revealed significant interactions between cells at different stages of PDAC and identified three promising therapeutic agents (XR-11576, Ixabepilone, and AMONAFIDE) based on correlated genes. …”
Get full text

Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein. by Freya Klepsch, Peter Chiba, Gerhard F Ecker

Get full text

Gut metagenomic characteristics of ADHD reveal low Bacteroides ovatus-associated host cognitive impairment by Yan Li, Haiting Sun, Yufen Huang, Anqi Yin, Linjuan Zhang, Jiao Han, Yixuan Lyu, Xiangzhao Xu, Yifang Zhai, Huan Sun, Ping Wang, Jinyang Zhao, Silong Sun, Hailong Dong, Feng Zhu, Qiang Wang, Luis Augusto Rohde, Xuefeng Xie, Xin Sun, Lize Xiong

Get full text

Multi-omics reveals EGCG’s anti-calcification effects associated with gut microbiota and metabolite remodeling by Yating Zhang, Yating Zhang, Zihan Tang, Zihan Tang, Junwen Zhu, Ruochi Zhao, Shuangshuang Wang, Shuangshuang Wang

“…Gut microbiota analysis revealed EGCG-mediated restoration of alpha diversity and taxonomic shifts, including reversal of Spirochaetota, Desulfobacterota, and Actinobacteriota abundances at the phylum level (*P<0.05); marked changes in Clostridia_UCG_014, Desulfovibrionales, Christensenellales, Erysipelotrichales, Oscillospirales, and Spirochaetales at the order level (*P<0.05); and normalization of Treponema, unclassified Treponema, and Lactobacillus johnsonii at the genus/species level (*P<0.05). …”
Get full text

Revealing genetic determinants of photosynthesis-related traits in citrus via genome-wide association studies by Xuesong Wang, Ryan Traband, Yoko Hiraoka, Sergio Pietro Ferrante, Lei Yu, Qiong Jia, Sarah Wang, Zixian Wang, Aleyda Acosta Rangel, Tatiane O. Vieira, Tracy L. Kahn, Mikeal L Roose, Louis Santiago, Zhenyu Jia

“…Pairwise correlation analysis revealed clusters of interrelated traits organized into four distinct groups. …”
Get full text

Transcriptome profiling reveals insight into the cold response of perennial ryegrass genotypes with contrasting freezing tolerance by Akhil Reddy Pashapu, Gražina Statkevičiūtė, Ferenz Sustek-Sánchez, Mallikarjuna Rao Kovi, Odd Arne Rognli, Cecilia Sarmiento, Nils Rostoks, Kristina Jaškūnė

Get full text

Network pharmacology and molecular docking reveal the potential inner mechanism between sensitive skin and hyperpigmentation by Jianhua Zhang, Shichao Liu, Wenjiao Guo, Zhiyun Du, Li Lin

“…The combination of PPI network, KEGG and GO analysis revealed the key role of tyrosinase and immune-mediated inflammation in pigmentation on sensitive skin. …”
Get full text

Molecular Barcoding Reveal the Existence of Mole Crabs Emerita emeritus in North Coast of Central Java by Dian Bhagawati, Elly Tuti Winarni, Agus Nuryanto

“…This study aimed to figure out the existence of mole crabs in the northern coast of Central Java as revealed from the cytochrome c oxidase 1 (COI) barcoding. …”
Get full text

High Optical-to-X-Ray Polarization Ratio Reveals Compton Scattering in BL Lacertae’s Jet by Iván Agudo, Ioannis Liodakis, Jorge Otero-Santos, Riccardo Middei, Alan Marscher, Svetlana Jorstad, Haocheng Zhang, Hui Li, Laura Di Gesu, Roger W. Romani, Dawoon E. Kim, Francesco Fenu, Herman L. Marshall, Luigi Pacciani, Juan Escudero Pedrosa, Francisco José Aceituno, Beatriz Agís-González, Giacomo Bonnoli, Víctor Casanova, Daniel Morcuende, Vilppu Piirola, Alfredo Sota, Pouya M. Kouch, Elina Lindfors, Callum McCall, Helen E. Jermak, Iain A. Steele, George A. Borman, Tatiana S. Grishina, Vladimir A. Hagen-Thorn, Evgenia N. Kopatskaya, Elena G. Larionova, Daria A. Morozova, Sergey S. Savchenko, Ekaterina V. Shishkina, Ivan S. Troitskiy, Yulia V. Troitskaya, Andrey A. Vasilyev, Alexey V. Zhovtan, Ioannis Myserlis, Mark Gurwell, Garrett Keating, Ramprasad Rao, Sincheol Kang, Sang-Sung Lee, Sanghyun Kim, Whee Yeon Cheong, Hyeon-Woo Jeong, Emmanouil Angelakis, Alexander Kraus, Dmitry Blinov, Siddharth Maharana, Rumen Bachev, Jenni Jormanainen, Kari Nilsson, Vandad Fallah Ramazani, Carolina Casadio, Antonio Fuentes, Efthalia Traianou, Clemens Thum, José L. Gómez, Lucio Angelo Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno, Raffaella Bonino, Alessandro Brez, Niccolò Bucciantini, Fiamma Capitanio, Simone Castellano, Elisabetta Cavazzuti, Chien-Ting Chen, Stefano Ciprini, Enrico Costa, Alessandra De Rosa, Ettore Del Monte, Niccolò Di Lalla, Alessandro Di Marco, Immacolata Donnarumma, Victor Doroshenko, Michal Dovčiak, Steven R. Ehlert, Teruaki Enoto, Yuri Evangelista, Sergio Fabiani, Riccardo Ferrazzoli, Javier A. García, Shuichi Gunji, Kiyoshi Hayashida, Jeremy Heyl, Wataru Iwakiri, Philip Kaaret, Vladimir Karas, Fabian Kislat, Takao Kitaguchi, Jeffery J. Kolodziejczak, Henric Krawczynski, Fabio La Monaca, Luca Latronico, Simone Maldera, Alberto Manfreda, Frédéric Marin, Andrea Marinucci, Francesco Massaro, Giorgio Matt, Ikuyuki Mitsuishi, Tsunefumi Mizuno, Fabio Muleri, Michela Negro, Chi-Yung Ng, Stephen L. O’Dell, Nicola Omodei, Chiara Oppedisano, Alessandro Papitto, George G. Pavlov, Abel L. Peirson, Matteo Perri, Melissa Pesce-Rollins, Pierre-Olivier Petrucci, Maura Pilia, Andrea Possenti, Juri Poutanen, Simonetta Puccetti, Brian D. Ramsey, John Rankin, Ajay Ratheesh, Oliver J. Roberts, Carmelo Sgrò, Patrick Slane, Paolo Soffitta, Gloria Spandre, Douglas A. Swartz, Toru Tamagawa, Fabrizio Tavecchio, Roberto Taverna, Yuzuru Tawara, Allyn F. Tennant, Nicholas E. Thomas, Francesco Tombesi, Alessio Trois, Sergey S. Tsygankov, Roberto Turolla, Jacco Vink, Martin C. Weisskopf, Kinwah Wu, Fei Xie, Silvia Zane

Get full text

P34 | ADJUDIN-INDUCED MODEL IN RATS REVEALS HIPPO SIGNALING PATHWAY ACTIVITY IN THE TESTIS

Get full text

Metagenomic analysis reveals the novel role of vaginal Lactobacillus iners in Chinese healthy pregnant women by Xudong Wang, Qingru Jiang, Xiaohui Tian, Wei Chen, Junrui Mai, Gan Lin, Yingfang Huo, Haiyang Zheng, Dandan Yan, Xiaohong Wang, Tian Li, Yu Gao, Xiangyu Mou, Wenjing Zhao

“…We conducted vaginal metagenomic analysis, examining species, functional pathways, and genes, and utilized correlation and LEfSe analyses to link microbiota to health conditions. Results revealed that healthy participants exhibited higher levels of Lactobacillus iners, with its abundance associated with tetrahydrofolate biosynthesis pathways. …”
Get full text

Transcriptome and Endogenous Hormones Reveal the Regulatory Mechanism of Flower Development in <i>Camellia azalea</i> by Jian Xu, Fan Yang, Ruimin Nie, Wanyue Zhao, Fang Geng, Longqing Chen

“…Further analysis of the dynamic trends of five endogenous hormone contents and plant hormone signal transduction genes revealed significant differences in the requirements of endogenous hormones, such as gibberellins and indoleacetic acid, by <i>C. azalea</i> at distinct growth stages. …”
Get full text

Integrative Analysis of Clinical and Bioinformatics Databases to Reveal the Role of Peripheral Innate Immunity in Kawasaki Disease by Hongjun Ba, Lili Zhang, Huimin Peng, Jixun Lin, Youzhen Qin, Yao Wang

“…Microarray data revealed that activation of the innate immune response contributed to KD development and progression. …”
Get full text