A pharmaco‐epistasis strategy reveals a new cell size controlling pathway in yeast by Fabien Moretto, Isabelle Sagot, Bertrand Daignan‐Fornier, Benoît Pinson

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Network propagation of rare variants in Alzheimer's disease reveals tissue-specific hub genes and communities. by Marzia Antonella Scelsi, Valerio Napolioni, Michael D Greicius, Andre Altmann, Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Alzheimer’s Disease Sequencing Project (ADSP)

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Integrated multi-omics reveals metabolic determinants of CRAB ST2 airway infection progression by DingYun Feng, JianXia Zhou, Logen Liu, Ying Li, RongHua Zhong, WenBin Wu, WenZheng Zheng, TianTuo Zhang

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Full-waveform inversion reveals diverse origins of lower mantle positive wave speed anomalies by Thomas L. A. Schouten, Lars Gebraad, Sebastian Noe, Anna J. P. Gülcher, Solvi Thrastarson, Dirk-Philip van Herwaarden, Andreas Fichtner

“…Abstract Determining Earth’s structure is paramount to unravel its interior dynamics. Seismic tomography reveals positive wave speed anomalies throughout the mantle that spatially correlate with the expected locations of subducted slabs. …”
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CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to oxidative stress by Ilaria Maurizio, Emanuela Ruggiero, Irene Zanin, Marta Conflitti, Giulia Nicoletto, Roberta Provvedi, Sara N. Richter

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Deep mutational scanning of the multi-domain phosphatase SHP2 reveals mechanisms of regulation and pathogenicity by Ziyuan Jiang, Anne E. van Vlimmeren, Deepti Karandur, Alyssa Semmelman, Neel H. Shah

“…Here, we perform deep mutational scanning on full-length SHP2 and the isolated phosphatase domain to dissect mechanisms of dysregulation. Our analysis reveals mechanistically diverse mutational effects and identifies key intra- and inter-domain interactions that contribute to SHP2 activity, dynamics, and regulation. …”
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A Screen of Traditional Chinese Medicinal Plant Extracts Reveals 17 Species with Antimicrobial Properties by Garrett L. Ellward, Macie E. Binda, Dominika I. Dzurny, Michael J. Bucher, Wren R. Dees, Daniel M. Czyż

“…<b>Results:</b> Intriguingly, our results reveal 17 plant species with potent antimicrobial properties effective primarily against gram-positive organisms, including <i>Streptococcus aureus</i> and <i>epidermidis</i>. …”
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Geospatial and modelling analyses reveal diverse tick and tick-associated microbes in the East African Community by Abakundana Nsenga Ariston Gabriel, Xiao-Yang Wang, Guo-Yao Zu, Pei-Yu Zhen, Laila Jamil, Shi-Jing Shen, Cheng Li, Ntakirutimana Theoneste, Lin Zhao, Wu-Chun Cao

“…The predictive model identified suitable habitats for four dominant tick species, with certain species flourishing under ideal conditions, such as elevation, temperature, and vegetation. Our study revealed that ticks might affect broader areas where they have never been previously reported. …”
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In Silico Characterization of Sirtuins in Acetic Acid Bacteria Reveals a Novel Phylogenetically Distinctive Group by Igor Jugović, Janja Trček

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Transcriptomic–proteomic analysis reveals the regulatory mechanisms of Alfalfa (Medicago sativa) in response to Fusarium acuminatum by Zhidan Shi, Zhidan Shi, Hongxia Sun, Lifen Hao, Yongqing Yang, Chen Guo, Haiyan Huangfu, Hongli Huo, Lili Zhao, Jiuru Huangfu, Haijun Ding, Yongyu Fang, Ziqin Li, Yiding Niu

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Characterization of Medusavirus encoded histones reveals nucleosome-like structures and a unique linker histone by Chelsea M. Toner, Nicole M. Hoitsma, Sashi Weerawarana, Karolin Luger

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Genome-guided isolation of the hyperthermophilic aerobe Fervidibacter sacchari reveals conserved polysaccharide metabolism in the Armatimonadota by Nancy O. Nou, Jonathan K. Covington, Dengxun Lai, Xavier Mayali, Cale O. Seymour, Juliet Johnston, Jian-Yu Jiao, Steffen Buessecker, Damon Mosier, Alise R. Muok, Nicole Torosian, Allison M. Cook, Ariane Briegel, Tanja Woyke, Emiley Eloe-Fadrosh, Nicole Shapiro, Scott G. Bryan, Savannah Sleezer, Joshua Dimapilis, Cristina Gonzalez, Lizett Gonzalez, Marlene Noriega, Matthias Hess, Ross P. Carlson, Lan Liu, Meng-Meng Li, Zheng-Han Lian, Siqi Zhu, Fan Liu, Xian Sun, Beile Gao, Ritesh Mewalal, Miranda Harmon-Smith, Ian K. Blaby, Jan-Fang Cheng, Peter K. Weber, Gabriela Grigorean, Wen-Jun Li, Anne E. Dekas, Jennifer Pett-Ridge, Jeremy A. Dodsworth, Marike Palmer, Brian P. Hedlund

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Three-Dimensional Culture Modelling Reveals Divergent Mycobacterium tuberculosis Virulence and Antimicrobial Treatment Response by Magdalena K. Bielecka, Liku B. Tezera, Elena Konstantinopoulou, Nicola Casali, Orestis L. Katsamenis, Ximena Gonzalo, Francis Drobniewski, Paul T. Elkington

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Optogenetic cleavage of the Miro GTPase reveals the direct consequences of real-time loss of function in Drosophila. by Francesca Mattedi, Ethlyn Lloyd-Morris, Frank Hirth, Alessio Vagnoni

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All-optical mapping reveals distributed suppression of cortical sensory responses after optogenetic silencing by Manuel Ambrosone, Elena Montagni, Francesco Resta, Tommaso Ulivi, Lorenzo Curti, Federica Polverini, Giacomo Mazzamuto, Guido Mannaioni, Alessio Masi, Francesco Saverio Pavone, Anna Letizia Allegra Mascaro

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Integration of transcriptome and DNA methylome analysis reveals the molecular mechanism of taproot yield heterosis in radish by Xiaoli Zhang, Liang Xu, Yan Wang, Wei Zhang, Xinyu Zhang, Junhui Dong, Jiali Ying, Lun Wang, Yinbo Ma, Liwang Liu

“…Proliferating cell nuclear antigen immunolocalization revealed significant inhibition of vascular cambium activity in both the hybrids and parental lines. …”
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Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype by Xinzhi Xu, Tianwen Qiu, Kexin Sun, Xue Han, Junxia Huang, Xiuyuan Wang, Jianchao Ge, Ji Yang

“…Results Proteomic data revealed the inflammatory signature of DM, with GO and KEGG enrichment analyses identifying chemotaxis-related pathways. …”
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Correction: Genetic Diversity within Schistosoma haematobium: DNA Barcoding Reveals Two Distinct Groups

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Transcriptome-based WGCNA reveals the molecular regulation of xylem plasticity in acclimation to drought and rewatering in mulberry by Yue Tian, Yue Tian, Zeyang Zhai, Zeyang Zhai, Yujie Yang, Yujie Yang, Kaixin Zhang, Kaixin Zhang, Sang Ma, Sang Ma, Jialing Cheng, Jialing Cheng, Li Liu, Li Liu, Xu Cao, Xu Cao

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Genome‐Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat by Zhirong Wang, Yuqi He, Mengyu Zhao, Xiang‐Qian Liu, Hao Lin, Yaliang Shi, Kaixuan Zhang, Guijie Lei, Dili Lai, Tong Liu, Xiaoyang Peng, Jiayue He, Wei Li, Xiangru Wang, Sun‐Hee Woo, Muriel Quinet, Alisdair R. Fernie, Xin‐Yuan Huang, Meiliang Zhou

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