Inflammation-profiling reveals activated pathways and biomarkers with predictive potential in oligoarticular juvenile idiopathic arthritis by Xingzhao Wen, Cecilia Aulin, Erik Sundberg, Erik Sundberg, Heshuang Qu, André Struglics, Anne-Sophie Merritt, Erik Melén, Maria Altman, Maria Altman, Helena Erlandsson Harris, Helena Erlandsson Harris

“…Comparative analysis revealed 13 proteins specific to oJIA. Correlations were found between DEPs in oJIA SF and clinical parameters (cJADAS-71, pain, health impact score). …”
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Comparative genomic analysis of enterobacterial clinical isolates reveals differences in resistome and stress signaling pathway by Sarah Sonbol, Nahla A. Hussein

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Time-series metatranscriptomics reveals differential salinity effects on the methanogenic food web in paddy soil by Xi Zhou, Xin Li, Qicheng Bei, Xingjie Wu, Guihua Xu, Xiuzhu Dong, Werner Liesack, Zhenling Cui, Fusuo Zhang, Jingjing Peng

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Structural characterization of the ABC transporter DppABCDF in Escherichia coli reveals insights into dipeptide acquisition. by Panpan Li, Manfeng Zhang, Yihua Huang

“…Unlike the reported heterotrimeric Mycobacterium tuberculosis DppBCD translocator, the E. coli DppBCDF translocator is a heterotetramer, with a [4Fe-4S] cluster at the C-terminus of each ATPase subunit. Structural studies reveal that ATPγS/AMPPNP-bound DppBCDF adopts an inward-facing conformation, similar to that of apo-DppBCDF, with only one ATPγS or AMPPNP molecule bound to DppF. …”
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Comprehensive analysis of alternative splicing in Rosa roxburghii Tratt reveals its role in flavonoid synthesis by Yanlin An, Jiahua Wu, Yani Chen, Shize Li, Shize Li

“…In addition, qRT-PCR analysis revealed that the expression level of basic helix-loop-helix (bHLH) transcription factor AS transcript was higher than its full-length transcript, and it was highly expressed in FR1 and significantly correlated with flavonoids.DiscussionOur research identified AS events in different tissues of chestnut rose and revealed their important functions in flavonoid synthesis. …”
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Inhibiting CFTR through inh-172 in primary neutrophils reveals CFTR-specific functional defects by Ana Lúcia Da Silva Cunha, Marfa Blanter, Janne Renders, Mieke Gouwy, Natalie Lorent, Mieke Boon, Sofie Struyf, Marianne S. Carlon

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Seascape Genomics of the Smooth Hammerhead Shark Sphyrna zygaena Reveals Regional Adaptive Clinal Variation by D. L. Grobler, J. D. Klein, M. L. Dicken, K. Mmonwa, M. Soekoe, M. vanStaden, S. B. Hagen, S. N. Maduna, A. E. Bester‐van der Merwe

“…Subsequent assessments of putatively adaptive loci revealed a distinctive south to east genetic cline. …”
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Targeting ferroptosis reveals a new strategy for breast cancer treatment: a bibliometric study by Junlin Liu, Rong Tang, Jie Zheng, Ke Luo

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Single-cell RNA sequencing reveals important role of monocytes and macrophages during mucopolysaccharidosis treatment by Gaohui Zhu, Yue Xie, Li Li, Rong Li, Yihong Sun, Ting Zhou, Yupeng Cun

“…Pseudotime, Gene Ontology, and cell-communication analyses revealed unique functions for the different cellular subtypes. …”
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Integrated metagenomics and transcriptomics analysis reveals pathways associated with oral periapical lesions formation and progression by Alaa Muayad Altaie, Thenmozhi Venkatachalam, Kiran Patil, Farah Al-Marzooq, Surendra Singh Rawat, Ali Al Qabbani, Mohammed Amjed Alsaegh, Lakshman P. Samaranayake, Sameh S.M. Soliman, Rifat Hamoudi

“…The sequences of the most abundant bacteria were then analyzed to identify secondary metabolites, pathogenic proteins, and their associated metabolic pathways. The results revealed that Fusobacterium nucleatum was the predominant bacterium in periapical abscesses and radicular cysts, whereas Porphyromonas endodontalis was the most abundant in periapical granulomas. …”
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Genomic Insights Into Red Squirrels in Scotland Reveal Loss of Heterozygosity Associated With Extreme Founder Effects by Melissa M. Marr, Emily Humble, Peter W. W. Lurz, Liam A. Wilson, Elspeth Milne, Katie M. Beckmann, Jeffrey Schoenebeck, Uva‐Yu‐Yan Fung, Andrew C. Kitchener, Kenny Kortland, Colin Edwards, Rob Ogden

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Single-Cell Analysis Reveals Aspirin Restores Intervertebral Disc Integrity via Ferroptosis Regulation by Niu H, Qi H, Zhang P, Meng H, Liu N, Zhang D

“…Molecular docking results revealed a high affinity of aspirin for GPX4. Additionally, aspirin inhibited ferroptosis and ameliorated disc structural damage.Conclusion: The increased proportion of CDKN1A⁺aNPC cells serves as an early warning feature for the progression of IVDD. …”
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Dokdo sea lion Zalophus japonicus genome reveals its evolutionary trajectory before extinction by Jungeun Kim, Asta Blazyte, Jae-Pil Choi, Changjae Kim, Fedor Sharko, Sungwon Jeon, Eun-Mi Kim, Hawsun Sohn, Jong Hee Lee, Hyun Woo Kim, Mi Hyun Yoo, Kyunglee Lee, Artem Nedoluzhko, Jong Bhak

“…Our genome-wide SNP analyses reveal Z. japonicus as the earliest diverged species within its genus, redefining its evolutionary relationship with the California (Z. californianus) and Galapagos (Z. wollebaeki) sea lions. …”
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Integrative pigGTEx resource with GWAS reveals genetic mechanism underlying semen quality in boars by Xuehua Li, Qing Lin, Zhanwei Zhuang, Kai Rao, Zhili Li, Xiuguo Shang, Panjie Xia, Lin Zhu, Zhe Zhang, Yunxiang Zhao

“…By integrating PigGTEx and FAANG resources, we combined TWAS and colocalization analyses to reveal genetic regulation of semen quality traits. …”
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Anxiety and depression screening reveals the importance of advancing mental health support for Haitian healthcare providers by Youri Encelotti Louis, Brooke Betson, Samy Auguste

“…This study was conducted using a self-report questionnaire containing the Generalized Anxiety Disorder-7 and Patient Health Questionnaire-9 screening tools, distributed to Haitian healthcare providers nationwide. The results revealed that 84% of the 106 participants experienced mild to severe symptoms of depression, while 69% reported mild to severe symptoms of anxiety. …”
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Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles by Kirsi Rilla, Arto Koistinen

“…Surprisingly, this method revealed that GFP-HAS3 not only localizes to ruffles but in fact induces dorsal ruffle formation. …”
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Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes by Inez A. Trambas, Lilliana Bowen, Vicki Thallas-Bonke, Matthew Snelson, Karly C. Sourris, Adrienne Laskowski, Michel Tauc, Isabelle Rubera, Guoping Zheng, David C.H. Harris, Phillip Kantharidis, Takahiko Shimizu, Mark E. Cooper, Sih Min Tan, Melinda T. Coughlan

“…Plasma cystatin C, which is a surrogate marker of glomerular filtration was not altered in SODptKO diabetic mice and histological assessment of the kidney cortex revealed no change in kidney fibrosis. Thus, our findings suggest that deletion of SOD2 in the proximal tubular compartment of the kidney induces a more subtle phenotype than expected, shedding light on the involvement of SOD2 and the proximal tubular compartment in the pathogenesis of diabetic kidney disease.…”
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Transcriptomic analysis reveals shared deregulated neutrophil responses in COVID-19 and idiopathic pulmonary fibrosis by Georgios Divolis, Evgenia Synolaki, Rodoula Tringidou, Argyrios Tzouvelekis, Dimitrios T. Boumpas, Panagiotis Skendros, Ioanna-Evdokia Galani

“…Results Our analysis revealed significant transcriptional changes in COVID-19 neutrophils, particularly in pathways involved in immune regulation, inflammation, and antiviral responses. …”
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An Integrated Approach Involving Metabolomics and Transcriptomics Reveals Arsenic-Induced Toxicity in Human Renal Cells by Lin Rong, Xinxin Liang, Xingfang Zhang, Yajun Qiao, Guoqiang Li, Yuancan Xiao, Hongtao Bi, Lixin Wei

“…The results of the metabolome analysis revealed that purine metabolism was the major affected pathway, with 21 DMs enriched within this pathway. …”
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Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase by Julia Andrés-Rodríguez, María-Cristina González-Montero, Nerea García-Fernández, Juan-José Galano-Frutos, Maria-Cristina de Rosa, Patricia Ferreira, María-Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Carlos García-Estrada

“…Furazolidone exhibited the most promising antileishmanial profile, and molecular docking analysis revealed consistency with the strongest TryR uncompetitive inhibitory effect, demonstrating its high affinity for an alternative binding site near the substrate (oxidized trypanothione) pocket. …”
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