A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation by Yukinori Ikeda, Makoto Kondo, Jun-ichi Suehiro, Hiroko Oshima, Sau Yee Kok, Kazuki Takahashi, Joris Pauty, Dong Wang, Hiroyuki Sakurai, Tetsuro Watabe, Masanobu Oshima, Yukiko T. Matsunaga

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Tensor decomposition reveals concurrent evolutionary convergences and divergences and correlations with structural motifs in ribosomal RNA. by Chaitanya Muralidhara, Andrew M Gross, Robin R Gutell, Orly Alter

“…We find, in support of our hypothesis that, first, the significant eigenpositions reveal multiple similarities and dissimilarities among the taxonomic groups. …”
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Spatial cell graph analysis reveals skin tissue organization characteristic for cutaneous T cell lymphoma by Suryadipto Sarkar, Anna Möller, Anne Hartebrodt, Michael Erdmann, Christian Ostalecki, Andreas Baur, David B. Blumenthal

“…The resulting protein abundance maps were then analyzed via scoring functions to quantify the heterogeneity of the individual cells’ neighborhoods within spatial graphs inferred from the cells’ positions in the tissue samples. Our analyses reveal characteristic patterns of skin tissue organization in CTCL as compared to AD and PSO, including a combination of increased local entropy and egophily in T-cell neighborhoods. …”
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Proteomic profiling reveals common and region-specific protein signatures underlying tumor heterogeneity in cholangiocarcinoma by Sirinya Sitthirak, Sittiruk Roytrakul, Arporn Wangwiwatsin, Nisana Namwat, Poramate Klanrit, Hasaya Dokduang, Prakasit Sa-ngiamwibool, Attapol Titapan, Apiwat Jareanrat, Vasin Thanasukarn, Natcha Khuntikeo, Luke Boulter, Watcharin Loilome

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Reversion of a RND transporter pseudogene reveals latent stress resistance potential in Brucella ovis. by Thomas Kim, Bongjin Hong, Rosemary Northcote, Thomas V O'Halloran, Erika Lisabeth, Richard R Neubig, Aretha Fiebig, Sean Crosson

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Epitope Analysis of Hypothetical Proteins in Leptospira interrogans Serovar Lai Reveals Potential Diagnostic Markers by Elangovan Saranya, Mohandass Ramya

“…Epitope probability of the potential proteins was compared with the standard diagnostic marker, LipL32. The comparison revealed that a protein (UniProt ID D4YW28) has better immunogenic potential than the gold standard marker, LipL32. …”
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Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information by Rubén Mollá-Albaladejo, Manuel Jiménez-Caballero, Juan Antonio Sanchez-Alcaniz

“…Further data analysis has revealed that a pair of neurons in the SEZ, expressing the neuropeptide Leucokinin (SELK neurons), receive simultaneous input from GRNs sensing bitter (potentially toxic) and sweet (nutritious) information. …”
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Morphology and multigene phylogeny reveals five new species of Hydnaceae (Cantharellales, Basidiomycota) from China by Qian Zhou, Chengbin Qian, Chuyun Zhang, Qidong Su, Yiliang Li, Shihui Zhang, Nian Mu, Taimin Xu, Hongmin Zhou, Changlin Zhao

“…The topology based on these sequences revealed that Burgella albofarinacea was closely related to B. flavoparmeliae, and B. fissurata was grouped with B. lutea. …”
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Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques by Danielle E. Campbell, Xiaofen Wu, Lindsey R. Hall, Dylan Lawrence, Jerome M. Molleston, Lawrence A. Schriefer, Lindsay Droit, James S. Weagley, Benjamin S. Olson, Joanna Rimmer, Miles Parkes, Scott A. Handley, Megan T. Baldridge

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Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients by Tobias Jooss, Katharina Maier, Lena-Marie Reichardt, Bianca Hindelang, Lönna Süberkrüb, Kim Lena Hamberger, Jasmin Maria Bülow, Konrad Schuetze, Florian Gebhard, Marco Mannes, Rebecca Halbgebauer, Lisa Wohlgemuth, Markus Huber-Lang, Borna Relja, Christian B. Bergmann

“…Patients with favorable physical performative outcome revealed higher functional T cell specific Interferon γ (IFN-γ) and IL-17 (8 hours) and lower IL-10 production (day 5) and higher CD8 T cell concentrations. …”
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Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Changes in Primary Angiitis of the Central Nervous System by Lu P, Cui L, Zhang L, Wang H, Yin L, Tian D, Zhang X

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Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients by Gao Z, Xie X, Liu F, Xu T, Zhang N, Zhang X, Li Y, Kong Y, Lv D, Wu T

“…Structural and functional analyses of WM were assessed using fractional anisotropy (FA) and amplitude of low-frequency fluctuation (ALFF), respectively, to explore WM alterations in FMS patients.Results: Structural analysis revealed altered FA values in the left corticospinal tract (CST), right cingulate/hippocampus, right fornix/stria terminalis (FX/ST), superior occipitofrontal fasciculus (SOFF), right superior corona radiata (SCR), right posterior corona radiata (PCR), sagittal stratum, and left medial lemniscus (ML) in FMS patients. …”
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Differential interactions of ToLCNDV with different betasatellites reveal complex viral dynamics in N. benthamiana. by Zafar Iqbal, Muhammad Shafiq, Sajed Ali, Mudassar Fareed Awan, Muhammad Farhan Sarwar, Imran Amin, Muhammad Shafiq Shahid, Rob W Briddon

“…Infectious clones of ToLCNDV (either DNA-A [TA] alone or with DNA-B [TB]) were co-inoculated with each betasatellite clone. Results revealed intriguing complexity and variability in interactions: betasatellite with TA/TB affected TB accumulation, suggesting a competition between them, while TA levels increased only in the presence of TB, not apparently with Bβ. …”
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Morphological and phylogenetic analyses reveal new species and records of Fusarium (Nectriaceae, Hypocreales) from China by Congcong Ai, Qiyun Liu, Yaling Wang, Zhaoxue Zhang, Duhua Li, Yun Geng, Xiuguo Zhang, Jiwen Xia

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RNAi dynamics in Juvenile Fasciola spp. Liver flukes reveals the persistence of gene silencing in vitro. by Paul McVeigh, Erin M McCammick, Paul McCusker, Russell M Morphew, Angela Mousley, Abbas Abidi, Khalid M Saifullah, Raman Muthusamy, Ravikumar Gopalakrishnan, Terry W Spithill, John P Dalton, Peter M Brophy, Nikki J Marks, Aaron G Maule

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Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis by Raquel A. Martínez García de la Torre, Julia Vallverdú, Zhenqing Xu, Silvia Ariño, Raquel Ferrer-Lorente, Laura Zanatto, Maria Mercado-Gómez, Beatriz Aguilar-Bravo, Paloma Ruiz-Blázquez, Maria Fernandez- Fernandez, Artur Navarro-Gascon, Albert Blasco-Roset, Paula Sànchez-Fernàndez-de-Landa, Joan Pera, Damia Romero-Moya, Paula Ayuso Garcia, Celia Martínez Sánchez, Laura Sererols Viñas, Paula Cantallops Vilà, Carmen I. Cárcamo Giráldez, Andrew McQuillin, Marsha Y. Morgan, Daniel Moya-Rull, Núria Montserrat, Delphine Eberlé, Bart Staels, Bénédicte Antoine, Mikel Azkargorta, Juan-José Lozano, Maria L. Martínez-Chantar, Alessandra Giorgetti, Félix Elortza, Anna Planavila, Marta Varela-Rey, Ashwin Woodhoo, Antonio Zorzano, Isabel Graupera, Anna Moles, Mar Coll, Silvia Affo, Pau Sancho-Bru

“…Notably, RORA expression correlates negatively with liver fibrosis and HSCs activation markers in patients with liver disease. This study reveals that RORA regulates cell metabolic plasticity, important for mesoderm differentiation, pericyte quiescence, and fibrosis, influencing cell commitment and disease.…”
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Correction: Computational gene expression analysis reveals distinct molecular subgroups of T-cell prolymphocytic leukemia. by PLOS One Staff

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Comparative analysis of chloroplast genomes reveals molecular evolution and phylogenetic relationships within the Papilionoideae of Fabaceae by Qian Qin, Yanjing Dong, Jialong Chen, Bo Wang, Yuxin Peng, XinPeng Zhang, Xiaoyun Wang, Jinxiang Zeng, Guoyue Zhong, Shouwen Zhang, Xiaolang Du

“…Genetic characteristic analysis revealed a plentiful presence of SSR loci, with single-nucleotide repeats and dinucleotide (A/T) repeats being the most predominant. …”
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Multidimensional pan-cancer analysis reveals the impact of PPIA on tumor epigenetic modifications and immune regulation by Yuanqian Yao, Xueqing Gong, Hui Li

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Whole Exome Sequencing Reveals Rare Variants in Genes Associated with Metabolic Disorders in Women with PCOS by Priyal Sharma, Ashutosh Halder, Manish Jain, Manish Tripathi

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