Immunization with Complete Freund’s Adjuvant Reveals Trained Immunity-like Features in A/J Mice by Kiruthiga Mone, Shraddha Singh, Fatema Abdullatif, Meghna Sur, Mahima T. Rasquinha, Javier Seravalli, Denise K. Zinniel, Indranil Mukhopadhyay, Raul G. Barletta, Teklab Gebregiworgis, Jay Reddy

“…Fourth, epigenetic analysis revealed histone enrichment in the promoter region of TNF-α, in the CFA group, but to a lesser degree than the BCG group. …”
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Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata. by Taiga Miyazaki, Hironobu Nakayama, Yohsuke Nagayoshi, Hiroshi Kakeya, Shigeru Kohno

“…Microarray analysis revealed that the transcriptional response to ER stress is not mediated by Ire1, but instead is dependent largely on calcineurin signaling and partially on the Slt2 MAPK pathway. …”
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Additions to <i>Macgarvieomyces</i> in Iran: Morphological and Phylogenetic Analyses Reveal Six New Species by Abdollah Ahmadpour, Youbert Ghosta, Fatemeh Alavi, Zahra Alavi, Esmaeil Hashemlou, Jaturong Kumla, Samantha C. Karunarathna, Nakarin Suwannarach

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Lipidomic analysis reveals metabolism alteration associated with subclinical carotid atherosclerosis in type 2 diabetes by Maria Barranco-Altirriba, Joana Rossell, Núria Alonso, Ralf J. M. Weber, Emilio Ortega, Gavin R. Lloyd, Marta Hernandez, Oscar Yanes, Jordi Capellades, Catherine Winder, Alexandra Junza, Mireia Falguera, Josep Franch-Nadal, Warwick B. Dunn, Alexandre Perera-Lluna, Esmeralda Castelblanco, Didac Mauricio

“…We discovered several features significantly associated with SCA in individuals with T1D, but only one sterol could be partially annotated. Conclusions We revealed a significant disruption of lipid metabolism associated with SCA in subjects with T2D, and a larger SCA-associated disruption in former/current smokers with T2D and individuals with T2D who do not undergo lipid-lowering treatment. …”
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Multi-omics joint analysis reveals the mechanism of flower color and fragrance variation in Lilium cernuum by Shaopeng Chen, Zhiqun Chen, Qianqian Zhuang, Hewen Chen

“…Concurrently, phenylpropanoid pathway inhibition reduced p-coumaric acid synthesis, diminishing downstream anthocyanins and volatile compounds (eugenol/methyleugenol).DiscussionOur multi-omics approach reveals that flower color loss in L. cernuum var. album results from synergistic effects of transcriptional regulation and metabolic flux redirection. …”
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Unlocking STEM Pathways: Revealing STEM Choices and Science Teachers Empowering Black Queer Students by Arsene Frederic Jr., Madison Fitzgerald-Russell, William Shelton, Mario I. Suárez, Jason C. Garvey

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Single-cell analysis reveals the spatiotemporal effects of long-term electromagnetic field exposure on the liver by Mingming Zhang, Zhichun Lv, Lingping Zhao, Quan Zeng, Yunqiang Wu, Junnian Zhou, Jiafei Xi, Xuetao Pei, Haiyang Wang, Changyan Li, Wen Yue

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Combined analysis of the metabolome and transcriptome reveals the mechanism of Red heart Chinese fir heartwood formation by Cuiping Li, Kaiyong Huang, Kuipeng Li

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Integrated transcriptomic and metabolomic analysis of goose epididymis reveals molecular markers associated with sperm mobility by Xiaofang Ren, Ke Jiang, Jiaxin Yin, Zhigang Ma, Zhifeng Chen, Kun Yang, Shengjun Liu

“…Integration of transcriptomic and metabolomic data revealed critical gene-metabolite pairs, including CNDP1–citric acid, implicated in SM regulation. …”
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Genomic insights reveal community structure and phylogenetic associations of endohyphal bacteria and viruses in fungal endophytes by Efraín Escudero-Leyva, Michal Belle, Abolfazl DadkhahTehrani, James N. Culver, Marcelo Araya-Salas, Joseph P. Kutza, Natasha Goldson, Max Chavarría, Priscila Chaverri

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Integrated Deterministic and Probabilistic Methods Reveal Heavy Metal-Induced Health Risks in Guizhou, China by Qinju Li, Dashuan Li, Zelan Wang, Dali Sun, Ting Zhang, Qinghai Zhang

“…Moreover, Target-Organ Toxicity Dose (TTD) revealed soil HMs as a higher risk to hematological health, with notable health risks posed by Pb in children. …”
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Fungal frontiers in toxic terrain: Revealing culturable fungal communities in Serpentine paddy fields of Taiwan by Kai-Wen Cheng, Jiue-in Yang, Piroonporn Srimongkol, Marc Stadler, Aphichart Karnchanatat, Hiran A. Ariyawansa

“…These isolates were grouped into 79 strains based on colony morphology and were subsequently evaluated through morphological and multi-locus phylogenetic analyses. The results revealed that 60% of the strains belong to the class Dothideomycetes, followed by 21% in Sordariomycetes and 19% in Eurotiomycetes. …”
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Multiomics integration and machine learning reveal prognostic programmed cell death signatures in gastric cancer by Zihao Bai, Hao Wang, Jingru Han, Jia An, Zhaocong Yang, Xuming Mo

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Transcriptome analysis reveals changes in lignin and flavonoid biosynthesis in Serendipita indica colonized Tartary buckwheat by Wenjing Wang, Shanpu Zhong, Wuyao Tang, Xingmei Zhou, Shengjie Li, Binhan Ding, Tao Wang, Tongliang Bu, Zizhong Tang, Qingfeng Li

“…Genetic expression analysis of lignin and flavonoid biosynthesis pathways in colonized S. indica showed a comparison between lignin biosynthesis pathway genes in colonized S. indica and those in uncolonized S. indica in Tartary buckwheat. Research revealed a decrease in certain genes linked to lignin synthesis and an increase in others associated with flavonoid biosynthesis in both colonized and uncolonized S. indica Tartary buckwheat. …”
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Simulation of Neurotrophin Receptor Transmembrane Helix Interactions Reveals Active States and Distinct Signaling Mechanisms by Christina Athanasiou, Ainara Claveras Cabezudo, Alexandros Tsengenes, Rebecca C. Wade

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Single-cell RNAseq reveals adverse metabolic transcriptional program in intrahepatic cholangiocarcinoma malignant cells by Christophe Desterke, Raquel Francés, Claudia Monge, Yuanji Fu, Agnès Marchio, Pascal Pineau, Jorge Mata-Garrido

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Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma by Xiao-Shuai Yuan, Long-Xiang Cao, Ye-Ji Hu, Fei-Chao Bao, Zhi-Tian Wang, Jin-Lin Cao, Ping Yuan, Wang Lv, Jian Hu

“…Lung cancer, of which non-small cell lung cancer accounts for 80%, remains a leading cause of cancer-related mortality and morbidity worldwide. Our study revealed that the expression of WD repeat containing antisense to P53 (WRAP53) is higher in lung-adenocarcinoma specimens than in specimens from adjacent non-tumor tissues. …”
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Acute pancreatitis revealing duodenal papilla MALT lymphoma: a case report and review of the literature by Wafa Dahmani, Houssem Hassan, Aya Hammami, Aida Ben Slama, Ahlem Brahem, Hanene Jaizri, Nour Elleuch, Mehdi Ksiaa

“…We present the case of a 70-year-old woman who initially presented with obstructive jaundice and acute pancreatitis, ultimately revealing a diagnosis of MALT lymphoma at the duodenal papilla. …”
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Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity by Yue Fang, Lingjie Meng, Jun Xia, Yasuhiro Gotoh, Tetsuya Hayashi, Keizo Nagasaki, Hisashi Endo, Yusuke Okazaki, Hiroyuki Ogata

“…Previously reported long-term observations revealed that these viruses display seasonal fluctuations in abundance. …”
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Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis. by Britta Stadelmann, Reto Rufener, Denise Aeschbacher, Markus Spiliotis, Bruno Gottstein, Andrew Hemphill

“…Dose-response assays revealed that only 2 compounds, namely MMV665807 and MMV665794, exhibited an EC50 value below 5 μM. …”
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