A phase I, randomized, placebo‐controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults by Xiaomeng Mao, Xiaohan Hua, Chengyi Wu, Xiaoyun Ge, Jie Zhang, Xiaojie Wu, Robert J. Kubiak, Ulrika Wählby Hamrén, Tonya Villafana, Georgios Christou, Jannine Green, Therese Takas, Yuwen Jin

“…Abstract Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in infants worldwide. Nirsevimab, an extended half‐life monoclonal antibody against RSV, is approved in China for the prevention of RSV lower respiratory tract disease in infants; however, global nirsevimab trials did not enroll Chinese infants. …”
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An Integrated Approach for Conducting long-term PM2.5 Exposure and Health Impact Assessments for Residents of a City-scale by Ming-Shing Ho, Ming-Yeng Lin, Chih-Da Wu, Jung-Der Wang, Li-Hao Young, Hui-Tsung Hsu, Bing-Fang Hwang, Perng-Jy Tsai

“…By reference to the results obtained from MMS9yr, using AQMS9yr and h_LUR9yr would respectively lead to the underestimation of the attributed fraction (AFs) ~21%–36% and 18%–26% for the 5 disease burdens, including ischemic heart disease, stroke, chronic obstructive pulmonary disease, lung cancer, and lower respiratory tract infection. The above results clearly indicate the importance of using the integrating approach on conducting EA and HIA.…”
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Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: pro... by Suzana Shahar, Kalavathy Ramasamy, Norhayati Ibrahim, Nur Nadia Mohamad Habibullah, Munirah Ismail, Mohd Zul Amin Kamaruddin, Shirley Gee Hoon Tang, Mohd Faisal Abdul Hamid

“…Given the global prevalence and impact of upper respiratory tract infections (URTIs) on productivity and healthcare costs, YBG has shown promise as a potential therapeutic and preventive strategy for recurrent respiratory tract infections. …”
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Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? by Jeremy Horwood, Alastair D Hay, Patricia Jane Lucas, Clare Clement, Peter S Blair, Jodi Taylor, Christie Cabral, Martin C Gulliford, Jenny Ingram, Padraig Dixon, Nick Francis, Athene Lane, Grace Young, Elizabeth Beech, Penny Seume, Scott Bevan, Sam T Creavin

“…We investigated barriers and facilitators to running a more efficient design.Design An RCT aiming to reduce antibiotic prescribing among children presenting with acute cough and a respiratory tract infection (RTI) with a clinician-focused intervention, embedded at the practice level. …”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Safety (exposure-adjusted incidence rates/100 patient-years (EAIRs)) and efficacy outcomes (binary: non-responder imputation (NRI) and observed case (OC); continuous: multiple imputation (MI)) are presented through 256 weeks.Results From Weeks 0–256, 289/303 (95.4%) patients had ≥1 treatment-emergent adverse event (TEAE); most frequent were nasopharyngitis (21.8%) and upper respiratory tract infection (14.5%). The EAIR of fungal infections was 7.4 (Candida infections: 2.6; oral candidiasis: 2.2); none systemic. …”
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Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience by Antonella Gambadauro, Salvatore Mollica, Emanuela Rosa, Federica Xerra, Alessandra Li Pomi, Mariella Valenzise, Maria Francesca Messina, Agata Vitale, Eloisa Gitto, Malgorzata Wasniewska, Giuseppina Zirilli, Sara Manti

“…Background: Bronchiolitis is the most common cause of lower respiratory tract infection (LRTI) in the first year of life. …”
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Safe, effective and cost-effective oxygen saturation targets for children and adolescents with respiratory distress: protocol for a randomised controlled trial (OxyKids study) by Jolita Bekhof, Eleni-Rosalina Andrinopoulou, J Bosmans, Gerard Koppelman, Karlijn J van Stralen, Anja Vaessen-Verberne, Sam Louman, Caroline Brackel, Arvid W A Kamps, Ismé de Kleer, Walter Balemans, Mirjam Scheffer, Marianne Brouwer, Marije van den Beukel, Mariëlle W H Pijnenburg, Annemie L M Boehmer

“…A total of 560 children aged 6 weeks to 12 years admitted with a diagnosis of bronchiolitis, viral wheeze or lower respiratory tract infection will be recruited and equally randomised into an intervention or usual care arm. …”
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Belimumab versus telitacicept in sequential treatment after rituximab for refractory lupus nephritis: a real-world multicentre study by Fei Han, Hong Pan, Yi Yang, Jianghua Chen, Jing Xue, Lan Lan, Yiting Chen, Pingping Ren, Yaomin Wang, Xin Lei, Jianhang Xu, Xiaochan Chen, Qiankun Zhang, Junni Wang, Nan Shi, Liangliang Chen, Lie Jin

“…Major adverse effects included immunoglobulin deficiency, respiratory tract infection and urinary tract infection. No death occurred.Conclusions The sequential treatment of belimumab or telitacicept following RTX may represent a promising therapeutic approach in the management of refractory lupus nephritis. …”
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Perbandingan Efektivitas Daya Hambat Kotrimoksazol Generik dan Paten terhadap Pertumbuhan Bakteri Escherichia coli sebagai Penyebab Infeksi Saluran Kemih secara In Vitro by Puti Anggun Sari, Erly ., Dessy Arisanty

“…<br />Kata kunci: Escherichia coli, infeksi saluran kemih, sensitivitas, antibiotika, generik, paten</p><p>Abstract<br />Urinary tract infection is one of the infections that are often found after a respiratory tract infection. The major cause of urinary tract infections is Escherichia coli. …”
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Early Postoperative Safety of Total Hip Arthroplasty in Systemic Lupus Erythematosus Patients by YANG Xingdong, YU Muyang, XU Yiming, ZHU Wei, HU Mingwei, WENG Xisheng, FENG Bin

“…Within 30 days postoperatively, 18 cases (6.67%) experienced major complications, including 2 cases (0.74%) of upper respiratory tract infection, 2 cases (0.74%) of pulmonary infection, 3 cases (1.11%) of urinary tract infection, 2 cases (0.74%) of other systemic infection, 5 cases (1.85%) of poor wound healing, 1 case (0.37%) of wound infection, 1 case (0.37%) of gastrointestinal complications, 1 cases (0.37%) of shock, and 1 case (0.37%) of SLE flare-up. …”
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Recommendation for the use of respiratory syncytial virus vaccines by Ping-Ing Lee, Yhu-Chering Huang, Ching-Chuan Liu, Shee-Uan Chen, Po-Ren Hsueh, Shih-Chi Ku, Po-Yen Chen, Chih-Jung Chen, Yi-Tsung Lin, Chun-Yi Lu, Nan-Chang Chiu, Hsin Chi, Yee-Chun Chen, Feng-Yee Chang, Muh-Yong Yen, Chin-Te Lu, Kuang-Yao Yang, Cheng-Hsun Chiu, Kao-Pin Hwang, Wen-Sen Lee, Ting-Yu Yen, Jen-Fu Hsu, Ying-Chin Lin, Ya-Li Hu, Tzou-Yien Lin

“…RSV is also a significant viral pathogen for adults with respiratory tract infection.Vaccines targeting the pre-fusion protein of RSV, including recombinant and mRNA vaccines, are now available. …”
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A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

“…Summary: Background: Although COVID-19 is predominantly a respiratory tract infection, current antibody treatments are administered by systemic dosing. …”
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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…LP is difficult to differentiate from other similar diseases without pathological evidence, such as upper respiratory tract infection (URTI), pneumonia, cryptogenic organizing pneumonia (COP), pulmonary alveolar proteinosis (PAP), lung mucinous adenocarcinoma and pulmonary edema. …”
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The Appearance of Antiphage Antibodies in Sera of Patients Treated with Phages by Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Maciej Żaczek, Ryszard Międzybrodzki, Andrzej Górski

“…<b>Background</b>: Bacteriophages are neutralized by the sera of patients undergoing phage therapy (PT), particularly during local or concomitant local and oral phage administration in bone infections, soft tissue infections, or upper respiratory tract infections. <b>Methods:</b> The antiphage activity of the sera (AAS) level of 27 patients with bacterial infections such as bone infections, soft tissue infections, or upper respiratory tract infections undergoing PT was performed using the plate phage neutralization test. …”
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Nutrient conditions affect antimicrobial pharmacodynamics in Pseudomonas aeruginosa by Maik Kok, Thomas Hankemeier, J. G. Coen van Hasselt

“…ABSTRACT The infectious microenvironment in chronic respiratory tract infections is characterized by substantial variability in nutrient conditions, which may impact colonization and treatment response of pathogens. …”
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Phenotypes, Risk Factors, and Mechanisms of Adult-Onset Asthma by Pinja Ilmarinen, Leena E. Tuomisto, Hannu Kankaanranta

“…Genetic factors, atopy, and early respiratory tract infections are well-recognized factors predisposing to childhood-onset asthma. …”
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Remarkably Few Sputum Cultures from People with Parkinson’s Disease during Hospital In-Patient Admission by Richard W. Walker, Joel English, Grace Tan, Annette Fisher, William K. Gray

“…Although respiratory tract infections can be a common complication in people with Parkinson’s disease (PD), there is little published data on the nature of such infections in this patient group. …”
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Isolated absent pulmonary valve with intact ventricular septum in a young child: A rare case report by Damandeep Singh, Aprateem Mukherjee, Sanjeev Kumar, Sivasubramanian Ramakrishnan

“…This report presents a case of such rarity involving a young child with recurrent lower respiratory tract infections.…”
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Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency by Gülsüm Alkan, Sevgi Keles, İsmail Reisli

“…Most patients presented with recurrent infections, including upper respiratory tract infections (n=8), lower respiratory tract infections (n=9), and gastroenteritis (n=5). …”
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A Case of Prolonged Cholestatic Hepatitis Induced by Azithromycin in a Young Woman by Caterina Maggioli, Luca Santi, Giacomo Zaccherini, Vittoria Bevilacqua, Francesca Giunchi, Paolo Caraceni

“…Azithromycin, a semisynthetic macrolides, is frequently prescribed for the treatment of middle ear and upper respiratory tract infections, bronchitis, and community-acquired pneumonia. …”
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