Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…Bing Liu,1– 3,* Zhiyao Bao,1– 3,* Wei Chen,1– 3,* Xiaotong Xi,4,5,* Xiao Ge,1– 3 Jun Zhou,1– 3 Xiaoyan Zheng,6 Peipei Zhang,4,5 Wanglong Deng,4,5 Ran Ding,4,5 Min Zhou,1– 3 Jie Fang7 1Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 2Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 3Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, 200025, People’s Republic of China; 4State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostics Co., Ltd., Nanjing Simcere Medical Laboratory Science Co., Ltd., Nanjing, 210018, People’s Republic of China; 5Nanjing Simcere Medical Laboratory Science Co., Ltd., Nanjing, 210018, People’s Republic of China; 6Department of Pulmonary and Critical Care Medicine, Zhoushan Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Zhoushan, 316000, People’s Republic of China; 7Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Fang, Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin 2nd Road, Shanghai, 200025, People’s Republic of China, Email fj40517@rjh.com.cn Min Zhou, Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin 2nd Road, Shanghai, 200025, People’s Republic of China, Email doctor_zhou_99@163.comBackground: Targeted next-generation sequencing (tNGS) is a high-throughput and cost-effective diagnostic alternative for pneumonia, with the ability to simultaneously detect pathogens, antimicrobial resistance genes, and virulence genes. …”
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Changes in infant respiratory pathogens pre-, during, and post-COVID-19 non-pharmacological interventions in Beijing by Tongying Han, Yajuan Wang, Di Zhang, Ying Li, Li Zhang, Jin Yan, Chi Li, Shengnan Yang, Litao Guo, Huijuan Yan

“…Understanding the prevalence of respiratory pathogens before and after the epidemic is particularly important for the prevention and control of respiratory diseases in infants.…”
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Host-microbe computational proteomic landscape in oral cancer revealed key functional and metabolic pathways between Fusobacterium nucleatum and cancer progression by Camila Paz Muñoz-Grez, Mabel Angélica Vidal, Tamara Beatriz Rojas, Luciano Esteban Ferrada, Felipe Andrés Zuñiga, Agustin Andrés Vera, Sergio Andrés Sanhueza, Romina Andrea Quiroga, Camilo Daniel Cabrera, Barbara Evelyn Antilef, Ricardo Andrés Cartes, Milovan Paolo Acevedo, Marco Andrés Fraga, Pedro Felipe Alarcón-Zapata, Mauricio Alejandro Hernández, Alexis Marcelo Salas-Burgos, Francisco Tapia-Belmonte, Milly Loreto Yáñez, Erick Marcelo Riquelme, Wilfredo Alejandro González, Cesar Andrés Rivera, Angel Alejandro Oñate, Liliana Ivonne Lamperti, Estefanía Nova-Lamperti

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Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study by Thomas Lee, Sandeep Singh, Phyo Kyaw Myint, Sheila Jones, Ben Carter, Susan Moug, Terry Quinn, Michael Thomas, Emma Bhatti, Angeline Price, Fenella Barlow-Pay, Siobhan Duffy, Lyndsay Pearce, Arturo Vilches-Moraga, Michael Stechman, Philip Braude, Emma Mitchell, Alessia Verduri, Kathryn McCarthy, Jonathan Hewitt, Charlotte Davey, Kiah Lunstone, Alice Cavenagh, Charlotte Silver, Thomas Telford, Rebecca Simmons, Dolcie Paxton, Francis Rickard, Mark Holloway, James Hesford, Tarik Jichi, Norman Galbraith, Jenny Edwards, Carly Bisset, Ross Alexander, Abigail Ingham, Roxanna Short, Aine McGovern, Jemima Collins, Eilidh Bruce, Alice Einarsson, Enrico Clini, Giovanni Guaraldi, Madeline Garcia, Shefali Sangani, Thomas Kneen, George Kyriakopoulos, Denise Tan

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MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies by Bu-Fu Tang, Wang-Ting Xu, Shi-Ji Fang, Jin-Yu Zhu, Rong-Fang Qiu, Lin Shen, Yang Yang, Qiao-You Weng, Ya-Jie Wang, Jia-Yi Ding, Xiao-Jie Zhang, Wei-Qian Chen, Li-Yun Zheng, Jing-Jing Song, Biao Chen, Zhong-Wei Zhao, Min-Jiang Chen, Jian-Song Ji

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SECTM1 acts as an immune-related biomarker of poor prognosis and promotes cancer progression by modulating M2 macrophage polarization in esophageal squamous cell carcinoma by Pengzhou Kong, Pengzhou Kong, Pengzhou Kong, Ye Jiao, Ye Jiao, Meng Sun, Meng Sun, Zhinan Zhou, Zhinan Zhou, Yingying Zhang, Yingying Zhang, Xin Yang, Xin Yang, Jing Ren, Jing Ren, Mengyuan Yang, Mengyuan Yang, Yanyan Dong, Yanyan Dong, Yanyan Dong, Bin Song

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Phosphorus-solubilizing fungi promote the growth of Fritillaria taipaiensis P. Y. Li by regulating physiological and biochemical reactions and protecting enzyme system–related gene... by Yueheng Wang, Lin Yuan, Lin Yuan, Yuhan Wang, Jiaqi Lang, Mingyan Ye, Qingqiu Liu, Qiang Ma, Nong Zhou

“…Li is a plant used to treat respiratory diseases such as pneumonia, bronchitis, and influenza. …”
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Acute exacerbations in patients with progressive pulmonary fibrosis by Michael Kreuter, Elizabeth A. Belloli, Elisabeth Bendstrup, Stefania Cerri, Kevin R. Flaherty, Shane Shapera, Jin Woo Song, Heiko Mueller, Klaus B. Rohr, Yasuhiro Kondoh, on behalf of the INBUILD trial investigators, S. Quadrelli, M. Otaola, M.A. Bergna, P. Elias, G. Arce, A. Cazaux, J. Guiot, B. Bondue, C. Dahlqvist, L. Homik, S. Shapera, A. Cantin, M. Kolb, M. Salinas Fénero, R. Maturana Rozas, A. Silva Orellana, Z. Xu, Q. Luo, J. Kang, H. Cai, S. Marchand-Adam, E. Bergot, A. Gamez-Dubuis, F. Riviere, R. Kessler, H. Nunes, C. Marquette, L. Wemeau, S. Jouneau, F. Lebargy, B. Crestani, V. Cottin, M. Reynaud-Gaubert, S. Blaas, F. Bonella, W. Randerath, J. Hetzel, D. Koschel, M. Kreuter, A. Prasse, D. Skowasch, S. Stieglitz, R. Refini, S. Cerri, A. Pesci, S. Tomassetti, C. Vancheri, F. Varone, N. Sakamoto, S. Abe, H. Hayashi, T. Saito, T. Suda, H. Kitamura, M. Okamoto, Y. Kondoh, S. Makino, T. Takeuchi, Y. Yamada, C. Kono, Y. Inoue, H. Sugiura, K. Kishi, H. Takaya, H. Yamauchi, K. Ichikado, K. Tomii, H. Takahashi, S. Izumi, T. Kawamura, Y. Nishioka, Y. Miyazaki, J.W. Song, J.S. Park, Y. Kim, E. Jassem, J. Kus, W. Piotrowski, A. Barczyk, D. Ziora, E. Bazdyrev, S. Moiseev, S. Avdeev, M. Ilkovich, V. Yakusevich, C. Valenzuela, O. Acosta, M. Martínez, L. Gómez, M. Molina-Molina, D.M. Castillo Villegas, M. Aburto, J.A. Rodríguez Portal, A. Villar, A. León Jiménez, J. Sauleda, M. Arias, P. Beirne, H. Stone, B. Hope-Gill, N. Hirani, N. Chaudhuri, A. Gifford, L. Jones, L. Morrison, D. Antin-Ozerkis, N. Bhatt, T. Kulkarni, T. Moua, N. Ettinger, L. Pitts, S. Veeraraghavan, M. Padilla, E.R. Fernández Pérez, G. Giessel, M. Strek, S. Danoff, J. Burk, M. Rossman, N. Patel, E. Belloli, D. Hotchkin, S. Weigt, M.B. Scholand, R. Kaner, B. Sigal, Z. Safdar, L. Tolle, R. Martinez, M. Glassberg, R. Hallowell, J. Golden, M. Schwartz, E. Britt, L. Morrow, Y. Mageto, K. Buch, S. Chaaban, H. Poonyagariyagorn, D. Dilling, O. Shlobin, K. Thavarajah, A. Nambiar, I. Rosas, R. Bascom, J. Oldham, S. Schmidt, J. Dematte D'Amico, J. Falk, C. Glazer, G. Criner

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Perspectives from the 2nd International Post-Tuberculosis Symposium: mobilising advocacy and research for improved outcomes by B.W. Allwood, R. Nightingale, G. Agbota, S. Auld, G.P. Bisson, A. Byrne, R. Dunn, D. Evans, G. Hoddinott, G. Günther, Z. Islam, J.C. Johnston, G. Kalyatanda, C. Khosa, S. Marais, G. Makanda, O.M. Mashedi, J. Meghji, C. Mitnick, C. Mulder, E. Nkereuwem, O. Nkereuwem, O.B. Ozoh, A. Rachow, K. Romanowski, J.A. Seddon, I. Schoeman, F. Thienemann, N.F. Walker, D.T. Wademan, R. Wallis, M.M. van der Zalm

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Impact of variations in airborne microbiota on pneumonia infection: An exploratory study by Li Zhou, Chenchen Song, Lianlian Zhao, Zhi Guo, Yuhan Lei, Yunlin Han, Kai Gao, Yanfeng Xu, Zhiguang Xiang, Baicun Li, Jianguo Guo

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The Bioethics-CSR Divide by Caio Caesar Dib

“…., the use of tropical medicine to assist colonial expeditions) but it resurfaced in the political agenda recently after the pandemics of AIDS and respiratory diseases.[19] Bioethics has been accused from the inside of ignoring matters beyond the patient-provider relationship,[20] including those related to public health and/or governance. …”
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