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    Adverse events and overall health and well-being after COVID-19 vaccination: interim results from the VAC4COVID cohort safety study by Thomas M MacDonald, Andrew Duncan, Amy Rogers, Greg Guthrie, Alex Doney, Steve Morant, Isla Mackenzie, Evelien Rooke, Rebecca Barr, Filippo Pigazzani, Krists Zutis

    Published 2022-06-01
    “…Objectives To describe the incidence of adverse events (AEs), reactogenicity symptoms, menstrual changes and overall self-rated improvement in health and well-being after COVID-19 vaccination.Design VAC4COVID is an ongoing prospective, active observational, post-authorisation cohort safety study (PASS) of UK-approved vaccines for COVID-19 disease.Setting The study is conducted through a secure website (www.vac4covid.com) by MEMO Research, University of Dundee, UK.Participants 16 265 adult (18 years or older) UK residents with a valid email address and internet access.Interventions Any UK-authorised COVID-19 vaccination.Main outcome measures The outcomes reported in this interim analysis include AEs, reactogenicity-type AEs (headache, fatigue, muscle or joint pain, fever, nausea, dizziness or local vaccine reaction), menstrual changes and reported improvement in overall health and well-being.Results 11 475 consented participants (mean age 54.8 years) provided follow-up data between 2 February and 5 October 2021 (mean follow-up duration 184 days), by which date 89.2% of participants had received two vaccine doses. 89.8% of 5222 participants who completed a follow-up questionnaire in the 7 days after any COVID-19 vaccination reported no AEs. …”
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