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Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy
Published 2025-02-01“…Xiaoyu Ma, Ni Chen, Peiyuan Zeng, Yuqian He, Tao Zhang, Yu Lu, Ziyu Li, Jin Xu, Jingcan You, Youkun Zheng, Liqun Wang, Mao Luo, Jianbo Wu Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy; Luzhou Municipal Key Laboratory of Thrombosis and Vascular Biology Southwest Medical University, Luzhou, 646000, People’s Republic of ChinaCorrespondence: Jianbo Wu, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China, Tel/Fax +0086-830-3161702, Email jbwucn1996@yahoo.comBackground: Natural photosensitizers hold potential for photodynamic therapy (PDT) but are often limited by poor visible light absorption. …”
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Longitudinal Associations Between Sleep Disturbance Trajectories and Internet Gaming Disorder Mediated by Self-Control: A Six-Wave Longitudinal Investigation
Published 2025-01-01“…Hongping Liu,* Xiaofei Qiao,* Xuliang Shi College of Education, Hebei University, Baoding, Hebei Province, 071002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuliang Shi, Associate Professor at the College of Education, Hebei University, Baoding, 071002, People’s Republic of China, Email shixl163@163.comObjective: The present study aims to analyze the heterogeneous trajectories of sleep disturbance (SD) among college students and to examine whether self-control mediates the association between sleep disturbance trajectories and Internet gaming disorder (IGD).Methods: A total of 4352 students were initially invited to participate, and 4191 (Mage = 19.12, SD = 0.98; 46.9% females) students were included as valid respondents at the first time-point. …”
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Correlation of Aspergillus fumigatus Sensitization with Mucus Plugging in COPD
Published 2025-01-01“…Ying Luo,1,2 Jiaqi Ren,1,2 Long Liang,1,2 Jingge Qu,1,2 Chun Chang,1,2 Yongchang Sun1,2 1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, People’s Republic of China; 2Research Center for Chronic Airway Diseases, Peking University Health Science Center, Beijing, People’s Republic of ChinaCorrespondence: Chun Chang; Yongchang Sun, Email doudou_1977@163.com; suny@bjmu.edu.cnBackground: Both Aspergillus fumigatus sensitization and mucus plugs are associated with poor clinical outcomes in COPD. …”
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Mixed Pulmonary Infection, Asthma, and Nephrotic Syndrome in a Patient Diagnosed with Selective IgA Deficiency: A Case Report
Published 2025-01-01“…Chenxi Yan, Junke Qiu, Xiaohong Pan, Xiaoqin Huang, Lei Pan, Caihong Wang, Minjie Mao Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang, 310003, People’s Republic of ChinaCorrespondence: Minjie Mao, Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine, 208 huancheng East Road, Gongshu District, Hangzhou, 310003, People’s Republic of China, Tel +86 15825500408, Email maominjie0909@163.comAbstract: Patients with selective IgA deficiency could have various clinical presentations ranging from asymptomatic to severe respiratory or gastrointestinal tract infection, as well as autoimmune disease and allergic reactions. …”
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Mitochondria-Targeting Type-I Photodynamic Therapy Based on Phenothiazine for Realizing Enhanced Immunogenic Cancer Cell Death via Mitochondrial Oxidative Stress
Published 2025-01-01“…Zeyu Duan,1,* Lie Li,1,* Qiyu Zhan,1 Jian Chen,1 Qiyan Li,1 Ruiyuan Liu,1,* Yinuo Tu2,* 1Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, People’s Republic of China; 2Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510095, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ruiyuan Liu; Yinuo Tu, Email ruiyliu@smu.edu.cn; tuyinuo@gzhmu.edu.cnPurpose: Photo-immunotherapy faces challenges from poor immunogenicity and low response rate due to hypoxic microenvironment. …”
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Observations of Microlensed Images with Dual-field Interferometry: On-sky Demonstration and Prospects
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Science-fiction et traduction en Chine continentale : d’outils pour le progrès à outils de soft power
Published 2024-12-01“…Drawing first on the polysystem theory and then on Lefevere’s notion of patronage, this article sets out to highlight the role played by translation, firstly in the popularisation of the genre in Mainland China and in its evolution and definition, in order to explore how an “imported” genre has been continually reworked and brought to the fore at each period ; and secondly as a tool for “re-exporting” the genre, which is now fairly well assimilated, from the People’s Republic of China to other countries, with the Chinese government promoting science fiction as a soft power tool designed to tell the country’s “bright future”.…”
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A Nomogram for Predicting Overall Survival in Primary Central Nervous System Lymphoma: A Retrospective Study
Published 2025-02-01“…Yunan Ling,* Xiaqi Miao,* Xiang Zhou,* Jingjing Ma, Zhiguang Lin, Qing Li, Mengxue Zhang, Yan Ma, Bobin Chen Department of Hematology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bobin Chen, Department of Hematology, Huashan Hospital, Fudan University, 12 Urumuqi Road (Middle), Shanghai, 200040, People’s Republic of China, Email bbchen@fudan.edu.cnPurpose: Current prognostic scoring systems for newly diagnosed primary central nervous system lymphoma (PCNSL), such as IELSG prognostic score and MSKCC prognostic score, are widely used but have limitations in clinical practice. …”
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Development and Validation of a Nosocomial Infection Nomogram Model in the NICU: A Novel and Nurse-Led Way to Prediction in Preterm Infants
Published 2025-01-01“…Yanyan Shang,* Ling Chen,* Xindie Hu, Keqian Zhang, Qian Cheng, Xiaoyu Shui, Zhiyue Deng Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiyue Deng; Xiaoyu Shui, Department of Neonatology, Renmin Hospital of Wuhan University, Wuchang District, Jiefang Road, No. 99, Wuhan, Hubei, 430060, People’s Republic of China, Tel +86 18086403090, Email 2015302180361@whu.edu.cn; 15926276672@163.comPurpose: Nosocomial infections (NI) are a leading cause of mortality in preterm infants in the Neonatal Intensive Care Unit (NICU). …”
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Tumor-Educated Platelets lncRNA-STARD4-AS1 and ELOA-AS1 as Potential Novel Biomarkers for the Early Diagnosis of Non-Small Cell Lung Cancer
Published 2025-01-01“…ChangLiang Luo, Zhongyuan Lin, Fangfang Huang, Leping Ning, Yulin Yuan Department of Clinical Laboratory, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of ChinaCorrespondence: Leping Ning; Yulin Yuan, Department of Clinical Laboratory, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People’s Republic of China, Email ningleping@126.com; yuanyulin@126.comPurpose: (Tumor-educated platelets) TEPs have emerged as active players in all steps of tumorigenesis, confrontation of platelets with tumor cells via transfer of tumor-associated biomolecules and results in the sequestration of such biomolecules. …”
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Factors Influencing Background Parenchymal Enhancement in Breast Contrast-Enhanced Mammography: A Retrospective Study
Published 2025-02-01“…Jing Xue,1 Tianyun Qu,1 Zhigang Li,1 Bo Shi,1 Guang Yang,1 Xiaocui Rong,1 Yazhou Li,1 Guoquan Lin,2 Yong Ping1 1Department of Radiology; Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China; 2Department of General Surgery; Botou Hospital, Cangzhou City, Hebei Province, 062150, People’s Republic of ChinaCorrespondence: Yong Ping, Email Ulrica150sci@163.comObjective: To evaluate the association between background parenchymal enhancement (BPE) level and extent on contrast-enhanced mammography (CEM) with age, menopausal status, breast density, and menstrual cycle phase in women. …”
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Chronic Stress Mediates Inflammatory Cytokines Alterations and Its Role in Tumorigenesis
Published 2025-01-01“…Zhihan Liu,* Meng Lei,* Yanxia Bai Department of Otorhinolaryngology-Head & Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanxia Bai, Department of Otorhinolaryngology-Head & Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China, Tel +86 85323965, Email yanxiabai@xjtufh.edu.cnIntroduction: Prolonged psychological stress is closely associated with cancer due to its role in promoting the release of stress hormones through the sustained activation of the sympathetic-adrenal-medullary system. …”
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Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging
Published 2025-01-01“…Yu Zhang,1,2 Fan Liu,2,3,* Chuntao Shao,2,* Jun Huang,3 Guoping Yan1 1College of Chemical and Material Engineering, Quzhou University, Quzhou, Zhejiang Province, 324000, People’s Republic of China; 2School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, 430205, People’s Republic of China; 3School of Chemical and Biomolecular Engineering, University of Sydney, NSW, 2006, Australia*These authors contributed equally to this workCorrespondence: Guoping Yan, Tel +86 570 8028560, Email guopingyan@qzc.edu.cnBackground: Precise intraoperative tumor delineation is essential for successful surgical outcomes. …”
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Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage
Published 2025-02-01“…Dehong Wu,1,* Mengdi Yin,2,* Dandan Cao,2,* Xiafeng Zhang,2 Yichun Zhu,2 Ying Wei,2 Yiling Li,2 Chengping Wen,2 Jia Zhou2 1Department of Rheumatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, People’s Republic of China; 2Institute of Basic Research in Clinical Medicine, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jia Zhou; Chengping Wen, Email zhoujia@zcmu.edu.cn; chengpw2010@126.comBackground: Rheumatoid arthritis (RA) is a chronic autoimmune disease and increasing evidence suggests that disturbances in the composition and function of gut microbiota are potentially implicated in the progression of RA. …”
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The Prediction Model of High-Frequency Ultrasound Combined with Artificial Intelligence-Assisted Scoring System Improved the Diagnosis of Sclerosing Adenosis and Early Breast Cance...
Published 2025-02-01“…Bingxin Ma,1 Gang Wu,1 Haohui Zhu,1 Yifei Liu,1 Wenjia Hu,1 Jing Zhao,1 Yinlong Liu,1 Qiuyu Liu2 1Department of Ultrasound, Henan Provincial People’s Hospital, Zhengzhou, 450000, People’s Republic of China; 2Department of Pathology, Henan Provincial People’s Hospital, Zhengzhou, 450000, People’s Republic of ChinaCorrespondence: Gang Wu, Email drwugang325@126.com; Haohui Zhu, Email zhh761126@163.comObjective: The study aimed to apply an artificial intelligence (AI)-assisted scoring system, and improve the diagnostic efficiency of Sclerosing adenosis and early breast cancer.Methods: This study retrospectively collected adenopathy patients (156 cases) and early breast cancer patients (150 cases) in Henan Provincial People’s Hospital from August 2020 to April 2023.Results: The area under the curve of the model constructed by clinical ultrasound features and combined AI features to predict and identify the two in the training group was 0.89 and 0.94, respectively. …”
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Prenatal Counseling and Diagnosis of COX20 Gene-Related Mitochondrial Complex IV Deficiency: A Case Report and Literature Review
Published 2025-01-01“…Junyou Su,1,* Lingdong Zeng,2,* Hongfei Chen,1 Junru Tong,1 Yan Chen,1 Lingling Huang,1 Li Deng,1 Yan Huang1 1Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, People’s Republic of China; 2Department of Pediatrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Deng; Yan Huang, Email dengli@gxmu.edu.cn; huangyanHY2020@163.comBackground: COX20-related mitochondrial complex IV deficiency is a rare autosomal recessive metabolic disorder that arises from biallelic loss-of-function mutations. …”
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Elevated Fasting C-Peptide Levels Correlate with Increased 10-Year Risk of Atherosclerotic Cardiovascular Disease in Newly Diagnosed Type 2 Diabetes Patients
Published 2025-01-01“…Xiao-Yun Zha, Chang-Shun Wei, Jia-Jia Dong, Jin-Zhi Wu, Liang-Xiao Xie, Ze-Hong Xu, Hua-Qiang Zheng, Duo-Bin Huang, Peng-Bin Lai The First Department of Endocrinology and Metabolism, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, 363000, People’s Republic of ChinaCorrespondence: Peng-Bin Lai, The First Department of Endocrinology and Metabolism, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, 363000, People’s Republic of China, Tel +8613709398727, Email 13709398727@163.comPurpose: This study aims to analyze the impact of serum C-peptide levels in patients with newly diagnosed type 2 diabetes (T2DM) on the 10-year risk of atherosclerotic cardiovascular disease (ASCVD).Patients and Methods: A total of 1923 patients with newly diagnosed T2DM were selected and categorized into four groups based on the interquartile range of fasting C-peptide (FCP) levels: Q1 group (FCP≤ 0.568 ng/mL), Q2 group (0.568 < FCP≤ 0.751 ng/mL), Q3 group (0.751 < FCP≤ 0.980 ng/mL), and Q4 group (FCP > 0.980 ng/mL). …”
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A Preliminary Screening Tool for High-Risk Frailty in Older Adults Patients with Pulmonary Tuberculosis
Published 2025-01-01“…Hui-Juan Li, Yue-Ying Zhou, He-He Yu, Jian Jiang, Yu-Wei Cai Department of Infectious Diseases, Wenzhou Central Hospital, Wenzhou, People’s Republic of ChinaCorrespondence: Yue-Ying Zhou, Department of Infectious Diseases, Wenzhou Central Hospital, No. 252 Baili East Road, Lucheng District, Wenzhou City, 325000, People’s Republic of China, Tel +86-0577-88882121, Email zhouyueying25@163.comObjective: To understand the current status and analyse the factors influencing frailty in older adults patients with pulmonary tuberculosis.Methods: This retrospective case-control study included 204 older adults patients with pulmonary tuberculosis. …”
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