Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-κB Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury by Deng H, Fan Q, Huang L, Ouyang W, Zhu W

“…Haihong Deng,1,* Qisen Fan,2,* Lichao Huang,1 Wenbo Ouyang,1 Wendian Zhu3 1Department of Anesthesiology, The First People’s Hospital of Zhaoqing, Zhaoqing City, Guangdong Province, People’s Republic of China; 2Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province, People’s Republic of China; 3Department of Hepatobiliary Surgery, The First People’s Hospital of Zhaoqing, Zhaoqing City, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wendian Zhu, Department of Hepatobiliary Surgery, The First People’s Hospital of Zhaoqing, NO. 9 Donggang East Road, Duanzhou District, Zhaoqing City, Guangdong Province, People’s Republic of China, Email Zq2860676@163.comBackground: Myocardial ischemia/reperfusion (I/R) injury significantly impacts the recovery of ischemic heart disease patients. …”
Get full text

The Utility of Synovial Fluid Interleukin-10 in Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Cohort Study by Zou Y, Yang Y, Yang J, Zhang Y, Zhao C, Qin L, Hu N

“…Yinshuang Zou,1– 3,* Yaji Yang,1,3,* Jianye Yang,1,3 Yanhao Zhang,4 Chen Zhao,1,3 Leilei Qin,1,3 Ning Hu1,3 1Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Orthopedics, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434000, People’s Republic of China; 3Laboratory of Orthopedics, Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 4National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, 400038, People’s Republic of China*These authors contributed equally to this workCorrespondence: Leilei Qin; Ning Hu, Email qinleilei@stu.cqmu.edu.cn; huning@cqmu.edu.cnBackground: Diagnosing chronic periprosthetic joint infection (PJI) is challenging. …”
Get full text

Risk factors and early prediction of cardiorenal syndrome type 3 among acute kidney injury patients: a cohort study by Hui Lin, Xiaoyu Guo, Mengzhu Wang, Xiaole Su, Xi Qiao

Get full text

Acupuncture Dosage and Its Correlation with Effectiveness in Patients with Chronic Stable Angina: A Systematic Review and Meta-Analysis of Randomized Controlled Trial by Huang D, Li Y, Zheng X, Hu J, Tang H, Yin Y, Wu Z, Kong L

“…Dajun Huang,1,* Yanwei Li,1,* Xiaoyan Zheng,2,3,* Jinming Hu,1 Hanzhang Tang,1 Yongjun Yin,1 Zhou Wu,1 Lingqiu Kong1 1Department of Cardiovascular Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Clinical Research Center for Acupuncture and Moxibustion in Sichuan province, Sichuan JinXin Xinan Women’s and Children’s Hospital, Chengdu, People’s Republic of China; 3Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingqiu Kong; Zhou Wu, Department of Cardiovascular Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Address: No. 39 Shi’er Qiao Road, Chengdu, Sichuan, 610023, People’s Republic of China, Email klq521@163.com; 1209293923@qq.comObjective: This systematic review aimed to compare the efficacy of various acupuncture dosages for Chronic Stable Angina (CSA) using randomized controlled trials (RCTs), addressing the unclear relationship between dosage and effectiveness despite acupuncture’s potential.Methods: We searched eight bibliographic databases from inception to October 31, 2024, evaluating RCTs comparing acupuncture to placebo or standard care for CSA patients, focusing on angina attack frequency as the primary outcome. …”
Get full text

Droplet and creaming stability of fish oil-loaded gelatin/surfactant-stabilized emulsions depends on both the adsorption ways of emulsifiers and the adjusted pH by Ting Zhang, Mengzhen Ding, Xichang Wang, Jian Zhong

Get full text

Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

“…Jingyi Tang,1,2,* Yingnan Hu,1,3,* Jintao Fang,1,* Weihan Zhu,1,* Wenjun Xu,1 Dian Yu,1 Zhipeng Zheng,4 Qiujing Zhou,4 Huiying Fu,4 Wei Zhang1,4 1The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China; 2Lanxi Hospital of Traditional Chinese Medicine, Jinhua, 321100, People’s Republic of China; 3The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510510, People’s Republic of China; 4The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Zhang; Huiying Fu, Email zhangweils1968@163.com; fhy131@126.comBackground: Huanglian-ejiao decoction (HED) is a Chinese traditional medicinal formula evolved from the Shanghan Lun (Treatise on Febrile Diseases). …”
Get full text

Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway by Shi Y, Tang Y, Sun Z, Sui P, Shao Y, Wang Z, Zhang J, Gao M

“…Yingxu Shi,1 Yu Tang,2 Zhiwei Sun,3 Ping Sui,4 Yiming Shao,4 Zhonghao Wang,4 Jian Zhang,1 Ming Gao1 1Department of Trauma Orthopedics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272007, People’s Republic of China; 2Pharmaceutical Department, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272007, People’s Republic of China; 3Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; 4Department of Clinical Medicine, Jining Medical University, Jining, Shandong, 272067, People’s Republic of ChinaCorrespondence: Ming Gao, Department of Trauma Orthopedics, Affiliated Hospital of Jining Medical University, No. 129 hehua Road, Jining, Shandong, 272007, People’s Republic of China, Tel + 86-0537-0298202, Email gaoming3661@mail.jnmc.edu.cnPurpose: Osteosarcoma (OS) is the most common malignant tumor associated with poor patient outcomes and a limited availability of therapeutic agents. …”
Get full text

Establishment and Clinical Application of Rh Blood Group Bank in the East China Region by Jin Y, Fu X, Xie S, Liu Z, Xu Z, Wang M, Wang Y, Lu R, Wang L

“…Yiming Jin,1,* Xiaoyan Fu,2,* Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, People’s Republic of China; 3Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingling Wang; Rong Lu, Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China, Email linglingwang0716@163.com; cv-25a@163.comPurpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.Patients and Methods: A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. …”
Get full text

LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Yajuan Yan,1,* Ting Duan,1,* Xiaonan Xue,1,* Xiaojuan Yang,2 Miao Liu,2 Bin Ma,3,4 Xiangguo Duan,2 Chunxia Su1 1Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Inspection, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 3Department of Surgery, The First People’s Hospital of Yinchuan, Yinchuan, Ningxia, People’s Republic of China; 4The Second School of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunxia Su; Xiangguo Duan, Email chunxiasu@qq.com; duanxiangguo@nxmu.edu.cnBackground: Colorectal cancer (CRC) is a highly malignant and aggressive gastrointestinal tumor. …”
Get full text

Poor Glycemic Control in Carbapenem-Resistant Klebsiella pneumoniae Infections: Impact on Epidemiological Features, Mortality Risks, and Polymyxin Resistance by Wang Q, Yan T, Ma C, Teng X, Shen C, Wang N, Yu K, Chu W, Zhou Q, Liu Z

“…Qiuyan Wang,1 Tao Yan,1 Chengcheng Ma,1 Xuan Teng,1 Chengyin Shen,2 Na Wang,3 Kexue Yu,1 Wenwen Chu,1 Qiang Zhou,1 Zhou Liu1,4 1Department of Clinical Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, People’s Republic of China; 3Institute of Health Sciences and Technology, Institutes of Physical and Information Technology, Anhui University, Hefei, Anhui, People’s Republic of China; 4Department of Clinical Laboratory Center, Anhui Chest Hospital, Hefei, Anhui, People’s Republic of ChinaCorrespondence: Zhou Liu, Email liuzhou0112@ahmu.edu.cnPurpose: This study aims to investigate the relationship between glycemic control and epidemiological characteristics of patients infected with carbapenem-resistant Klebsiella pneumoniae (CRKP), to identify mortality risk factors associated with CRKP infection, and to evaluate the impact of glucose on the resistance of CRKP to polymyxin and serum killing.Patients and Methods: Clinical cases of 218 patients infected with CRKP were collected from a large tertiary public hospital in Anhui Province. …”
Get full text

Glycemic Management of Patients with Hospital Hyperglycemia: A Retrospective Cohort Study on Adults Admitted in the Non-ICU Wards by Zheng R, Zeng X, Shen R, Wang Y, Liu J, Zhang M

“…Ruoxuan Zheng,1,2 Xiangman Zeng,1 Ruiting Shen,1 Yueqiu Wang,1 Jing Liu,1,3 Mingchen Zhang1 1Department of Endocrinology and Metabolism, Ningbo No.2 hospital, Ningbo, Zhejiang Province, People’s Republic of China; 2School of Medicine, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 3Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang Province, People’s Republic of ChinaCorrespondence: Mingchen Zhang, Department of Endocrinology and Metabolism, Ningbo No.2 hospital, Ningbo, Zhejiang Province, People’s Republic of China, Email zhangmc1015@163.comPurpose: To identify the key populations for Hospital Hyperglycemia (HH) management and to assess recent trends in the management of HH.Patients and Methods: This retrospective study analyzed 1,136,092 point-of-care blood glucose (POC-BG) measurements from 40,758 patients with HH in non-intensive care unit (non-ICU) wards at Ningbo No.2 hospital from January 2020 to December 2022. …”
Get full text

GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia by Lai L, Wu H, Peng L, Zhang Z, Wu X, Zheng S, Su Z, Chu H

“…Lingzhi Lai,1 Hao Wu,1 Liang Peng,2 Zhen Zhang,3 Xinfan Wu,1 Shuo Zheng,3 Zekang Su,3 Hongxing Chu3 1Maoming People’s Hospital, Maoming, Guangdong, People’s Republic of China; 2The First People’s Hospital of Guiyang, Guiyang, Guizhou, People’s Republic of China; 3Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Hongxing Chu, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, People’s Republic of China, Tel +86-13533856675, Email chuhongxing22@smu.edu.cnPurpose: Limb ischemia is a refractory disease characterized by insufficient angiogenesis and tissue necrosis. …”
Get full text

Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…Yunfu Chen,1,* Guangling Tang,1,* Jun Lu,1,* Sijie Tang,1 Xinglong Xiong,1 Chao Chen,1 Lijian Pei,2 Jing Shi1 1Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guizhou, People’s Republic of China; 2Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Shi, Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China, Tel +86-18685034016, Email shijing81@gmc.edu.cn Lijian Pei, Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China, Email hazelbeijing@vip.163.comBackground: The neuropathic pain side induced by Vincristine severely limit its clinical application. …”
Get full text

Association of Adverse Perinatal Outcomes with Blood Components Transfusion in Patients with Acute Fatty Liver of Pregnancy by Pan X, Chu R, Qiao X, Zhang X, Li L, Zhang W

“…Xiyu Pan,1 Ran Chu,2 Xu Qiao,3 Xianru Zhang,3 Li Li,1 Wenxia Zhang1 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong Province, People’s Republic of China; 2Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, People’s Republic of China; 3Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, Shandong Province, People’s Republic of ChinaCorrespondence: Li Li; Wenxia Zhang, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong Province, 250012, People’s Republic of China, Tel +8615153187102 ; +8615165113326, Email bzlily@163.com; WxZhangpxy@163.comPurpose: To investigate the rare obstetric emergency with no specific treatments called acute fatty liver of pregnancy. …”
Get full text

Traditional Chinese Medicine Ion Introduction Therapy Reduces the Incidence of Acute Exacerbation of Idiopathic Pulmonary Fibrosis: A Prospective Cohort Study by Wang Y, Xu B, Wang J, Li S, Xie Y

“…Yan Wang,1,2 Baichuan Xu,1,2 Jiajia Wang,1,3,4 Suyun Li,1,3,4 Yang Xie1,3,4 1National Regional Traditional Chinese Medicine (Lung Disease) Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 2The First Clinical College of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, People’s Republic of China; 3Henan University of Traditional Chinese Medicine Respiratory Disease Diagnosis and Treatment and New Drug Research and Development Provincial and Ministry Co-Built Collaborative Innovation Center, Zhengzhou, Henan, 450046, People’s Republic of China; 4Henan Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Respiratory Diseases, Zhengzhou, Henan, 450046, People’s Republic of ChinaCorrespondence: Yang Xie; Suyun Li, Email xieyanghn@163.com; lisuyun2000@126.comObjective: To evaluate the effectiveness and safety of traditional Chinese medicine (TCM) ion introduction therapy in the treatment of patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF).Methods: This study adopts a prospective cohort study design, with 60 AE-IPF patients as the research subjects. …”
Get full text

Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis by Wei B, Wang S, Li S, Gu Q, Yue Q, Tang Z, Zhang J, Liu W

“…Bowen Wei,1,2,* Siwei Wang,1,2,* Suiran Li,1,2,* Qingxiang Gu,3 Qingyun Yue,4 Zhuo Tang,1,2 Jiamin Zhang,1,2 Wei Liu1,2 1Department of Rheumatism and Immunity, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, People’s Republic of China; 3Center of Preventive Treatment of Disease, Cangzhou Hospital of Integrated Traditional Chinese and Western of Hebei Province, Cangzhou, Hebei, People’s Republic of China; 4School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Liu, Email fengshiliuwei@163.comBackground: Ankylosing spondylitis (AS) is a chronic autoimmune disease characterized by inflammation of the sacroiliac joints and spine. …”
Get full text

Sanming Model of Medical Service Integration: Impact on Medical Expenditures, Service Provision, and Resource Allocation in China by Lin K, Liu X, Xiang L, Luo F

“…Kunhe Lin,1,* Xiao Liu,2,* Li Xiang,1 Fei Luo3 1Department of Health Management, School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Medical Affairs, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 3Department of Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Luo, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, People’s Republic of China, Email 267115670@qq.comBackground: Fragmentation of healthcare services has been a central issue, contributing to escalating medical expenditures and service provision, thereby exacerbating the waste of limited medical resources. …”
Get full text

Serum Ferritin Levels in Pregnancy and Their Association with Gestational Diabetes Mellitus: A Prospective Longitudinal Study by Qin Z, Du Y, Wang Z, Qin X, Wu H, Yu X, Zhao C, Mo L, Huang B

“…Zhenhua Qin,1 Yao Du,1 Zidi Wang,1 Xianfeng Qin,1 Hongchi Wu,1 Xiangyuan Yu,1 Chaochao Zhao,1 Lei Mo,2 Bo Huang1 1Guangxi Key Laboratory of Diabetic Systems Medicine, Guangxi Key Laboratory of Environmental Exposomics and Life-Course Health, Guangxi Health Commission Key Laboratory of Health and Care for Life-Course, School of Public Health, Guilin Medical University, Guilin, Guangxi, People’s Republic of China; 2Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People’s Republic of ChinaCorrespondence: Bo Huang, Guangxi Key Laboratory of Diabetic Systems Medicine, Guangxi Key Laboratory of Environmental Exposomics and Life-Course Health, Guangxi Health Commission Key Laboratory of Health and Care for Life-Course, School of Public Health, Guilin Medical University, Guilin, Guangxi, 541199, People’s Republic of China, Tel +86-773-5591452, Email Bo.Huang@glmc.edu.cn Lei Mo, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, People’s Republic of China, Email 50442117@qq.comObjective: Elevated serum ferritin (SF) levels are associated with oxidative stress (OS) and systemic inflammation in various disorders. …”
Get full text

Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects by Li H, Wei D, Cao H, Han Y, Li L, Liu Y, Qi J, Wu X, Zhang Z

“…Han Li,1,* Dongsheng Wei,2,* Huimin Cao,2 Yelei Han,1 Luzhen Li,1 Yuting Liu,1 Jiajie Qi,1 Xinyue Wu,1 Zhe Zhang2,3 1The First School of Clinical Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China; 2Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China; 3Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhe Zhang, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Shenyang, 110032, People’s Republic of China, Tel +86-18102459155, Email pedtrainzhzh7676@163.comPurpose: Myocardial infarction (MI) is a prevalent cardiovascular disorder affecting individuals worldwide. …”
Get full text

Characteristics and Associated Factors of Insomnia Among the General Population in the Post-Pandemic Era of COVID-19 in Zhejiang, China: A Cross-Sectional Study by Da M, Mou S, Hou G, Shen Z

“…Miao Da,1 Shaoqi Mou,2 Guangwei Hou,3 Zhongxia Shen1 1Department of Sleep Medicine Center, Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, People’s Republic of China; 2Department of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Psychiatry, Yuyao Third People’s Hospital, Ningbo City, Zhejiang Province, People’s Republic of ChinaCorrespondence: Zhongxia Shen, Department of Sleep medicine center, Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, 2088 East Tiaoxi Road, Huzhou, Zhejiang, People’s Republic of China, Tel +860572-2132661, Email snowszx@sina.comObjective: This study aimed to analyze the changes in insomnia characteristics among the general population and explore associated factors during the COVID-19 pandemic and post-pandemic periods.Methods: A cross-sectional study was conducted using an anonymous online survey. …”
Get full text