Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK-Targeting Drugs in Psor... by Martina Morelli, Claudia Scarponi, Laura Mercurio, Francesco Facchiano, Sabatino Pallotta, Stefania Madonna, Giampiero Girolomoni, Cristina Albanesi

“…Thus, JAK targeting appears to be a reasonable strategy to treat psoriasis. Tofacitinib is an inhibitor of JAK proteins, which, similarly to SOCS, impedes JAK phosphorylation. …”
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Attitudes and adherence to changes in nutrition and physical activity following surgery for prostate cancer: a qualitative study by Richard M Martin, Raj Persad, J Athene Lane, Ellie Shingler, Luke A Robles, Edward Rowe, Anthony Koupparis, Amit Bahl, Constance Shiridzinomwa, Lucy McGeagh

“…They believed their diet and level of PA were reasonable before being randomised to their interventions. …”
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Snail Shells Adsorbent for Copper Removal from Aqueous Solutions and the Production of Valuable Compounds by Redouane Ouafi, Meryem Asri, Anass Omor, Mustapha Taleb, Zakia Rais

“…The removal of Cu(II) was reasonably fast to be completed within a time frame of 90 min. …”
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Genetic Variation for Wild Populations of the Rare and Endangered Plant <i>Glyptostrobus pensilis</i> Based on Double-Digest Restriction Site-Associated DNA Sequencing by Yongrong Huang, Yu Li, Xiaojie Hong, Suzhen Luo, Dedan Cai, Xiangxi Xiao, Yunpeng Huang, Yushan Zheng

“…The clustering was consistent with those obtained from the PCA. The main reasons for the endangerment of <i>G. pensilis</i> are likely to be poor natural regeneration, human disturbances, and climatic factors. …”
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Computer-assisted total bilateral knee arthroplasty for a patient with severe hyperextension in residual poliomyelitis: a case report by Valery Y. Murylev, Semen S. Alekseev, Grigory A. Kukovenko, Pavel M. Elizarov, Dmitriy O. Golubkin, Aleksey V. Muzychenkov

“…Total knee arthroplasty in patients in the residual stage of poliomyelitis is a technically difficult job. The reasons for this are anatomical features and therefore difficulties in an implant choice and conflicting results. …”
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Model Analyses of Changes in Spring Surface Ozone Concentrations over Shandong Province in the Period of 2014–2017 by Jialin Li, Juzhen Cai, Houfeng Liu, Xiao Han, Yongfu Xu, Xiaofang Cai, Meigen Zhang

“…Measurements at 14 stations in Shandong Province showed that the monthly mean O3 concentrations in the late spring (May) increased by 22.2 µg m−3 from 2014 to 2017. To investigate the reasons of the increase of O3 in springtime from 2014 to 2017, the changes of O3 concentrations due to meteorological conditions and emissions in May were studied based on ambient measurements and simulations with the RAMS-CMAQ modeling system. …”
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Allograft Reconstruction of the Extensor Mechanism after Resection of Soft Tissue Sarcoma by Daniel A. Müller, Giovanni Beltrami, Guido Scoccianti, Pierluigi Cuomo, Francesca Totti, Rodolfo Capanna

“…The replacement of the extensor mechanism by an allograft is a reasonable option, allowing wide margins and restoration of active extension in most patients. …”
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CanKiwi: A Mechanistic Competition Model of Kiwifruit Bacterial Canker Disease Dynamics by Oussama Hadj Abdelkader, Hadjer Bouzebiba, Miguel G. Santos, Danilo Pena, António Pedro Aguiar, Susana M. P. Carvalho

“…The results show that the proposed model can simulate reasonably well the functional part of the vine in both the healthy case and the disease case without plant defense mechanisms in which the bacteria are always dominant under favorable environmental conditions. …”
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Research on Mechanical Properties of Cement Emulsified Asphalt Mortar Under the Influence of Water-to-Cement Ratios and Water-Reducing Agent by Ce Zhao, Huacheng Jiao, Bing Zhou, Fei Liu, Feilin Zhang, Yong Luo, Jie Yuan

“…As the dosage of water-reducing agent increases, both the compressive strength and flexural strength of CA mortar first increase and then decrease, with a reasonable range of water-reducing agent dosage being between 0.2% and 1.0%, and 0.5% is most appropriate. …”
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Multi-Scale Modeling and Optimization of Single-Layer Reticulated Shell Structures Using Multi-Point Constraint and Variable Density Methods by Xianjie Wang, Yongdang Chen, Zhaoyi Wang, Yue Tang, Xin Wang, Chengpeng Lu

“…The research shows that reasonable cross-section value and grouping of members can effectively reduce the steel consumption without compromising the overall stability performance. …”
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Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liqui... by Malihe Khoeini Sharifabadi, Mohammad Saber-Tehrani, Syed Waqif Husain, Ali Mehdinia, Parviz Aberoomand-Azar

“…The calibration curves obtained for studied drugs show reasonable linearity (R2>0.99) and the limit of detection (LODs) ranged between 2 and 7 ng/mL. …”
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Evaluation of risk factors for incidental parathyroidectomy during thyroidectomy by Çağrı Büyükkasap, Aydın Yavuz, Hüseyin Göbüt, Kürşat Dikmen, Hasan Bostancı

“…This situation increases with thyroidectomies performed for malignant reasons and lymph node dissection. Moreover, although incidental parathyroidectomy causes postoperative biochemical hypocalcemia, its effect on symptomatic hypocalcemia is low.…”
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Long-term indwelling trans-anal ileus tube placement and nursing management for an elderly patient with intestinal obstruction (1例高龄肠梗阻患者长期留置经肛型肠梗阻导管的护理体会)... by ZHANG Jia (张佳), SUN Xin (孙鑫)

“…The key points of care are to improve the fixing method to prevent the tube dislocation; Protect the skin and prevent the occurrence of pressure ulcers; Keep the tube unobstructed to ensure effective drainage; Develop a diet plan to meet nutritional intake; Exercise reasonably to prevent complications; Strengthen psychological care and promote the recovery of the patient. …”
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Acceptability and Future Considerations for Telegenetic Counseling After the COVID Pandemic: Interviews with Genetic Counselors, Clinicians, and Patients by Meghan C. Martinez MPH, Nina Szwerinski MS, Su-Ying Liang PhD, Sharon Chan MPH, Monique de Bruin MD, Cheryl D. Stults PhD

“…This qualitative evaluation elicited feedback from genetic counselors, referring clinicians, and patients from a single healthcare organization to understand the user-driven reasons for overall satisfaction and experience. We conducted 22 in-depth, semi-structured interviews with participants from all 3 groups between February 2022 and February 2023. …”
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Genetic Diversity and Structure of a Critically Endangered Ornamental Species, <i>Rhododendron farinosum</i>, with Extremely Small Populations by Fengjuan Li, Linyuan Fan, Jingli Zhang, Wen Liu, Wei Li, Yongpeng Ma, Hong Ma

“…<i>Rhododendron farinosum</i> is an endangered ornamental species with extremely small populations located in northeastern Yunnan Province. To unravel the reasons behind the endangerment of this species and provide guidance for the rational conservation of this species, this study obtained a large number of SNP loci by using double-digest restriction-site-associated DNA sequencing (ddRAD-seq) to evaluate the genetic diversity and genetic structure of <i>R. farinosum</i>, as well as to infer the population history of this species. …”
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Quantifying the Spatiotemporal Evolution of Radiation Belt Electrons Scattered by Lower Band Chorus Waves: An Integrated Model by Weixin Chen, Song Fu, Xin Ma, Binbin Ni, Deyu Guo, Qiongyue Zhang, Xiangyuan Tong, Yibo Zhao, Xing Cao, Zheng Xiang, Yuan Lei

“…Incorporating the effect of radiation electron drift, we further use the 2‐D Fokker‐Planck equation to simulate the variations of electron phase space density in different MLT sectors at a fixed L, and find that the integrated model replicates reasonably the multi‐MeV electron acceleration at L = 4.5 during the period from the main phase to the early recovery phase of the storm. …”
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Paramedic Recognition of Sepsis in the Prehospital Setting: A Prospective Observational Study by Robert S. Green, Andrew H. Travers, Edward Cain, Samuel G. Campbell, Jan L. Jensen, David A. Petrie, Mete Erdogan, Gredi Patrick, Ward Patrick

“…Using a novel prehospital sepsis screening tool, paramedic recognition of sepsis had greater specificity than sensitivity with reasonable accuracy.…”
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Mothers at the Intersection of Trauma, Addiction, and Involvement with the Criminal Legal System: An Analysis of Multiple Case Studies by Monica Solinas-Saunders PhD, Maureen L. Petrunich-Rutherford PhD, Mark D. Thomas PhD, Natasha R. Brown PhD, Kevin L. McElmurry PhD, Melissa A. Jones PhD, Abigail M. Cognetti BSc, Lytina Andrews BSc, Amira Zahabi BSc

“…Across these life transitions, participants emphasized the relevance of traumatic experiences and mental health disorders as main reasons for their drug addiction. For each theme highlighted in the narrative of each case, a connection to all other participants was made to summarize the findings in the whole sample. …”
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Urinary glucose detection with spiral shape hollow core photonic crystal fiber: Towards improved diabetes management by Md. Safiul Islam, A.H.M. Iftekharul Ferdous, Md. Jakir Hossen, Abdullah Al Mamun, Khalid Sifulla Noor, Diponkar Kundu, Md. Galib Hasan

“…Acute diabetes treatment and follow-up rely on urine glucose detection since it provides a non-invasive, reasonably priced means to assess glucose levels and regulate the progression of the disease. …”
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Are tropical oceanic islands overlooked? Knowledge gaps regarding the vulnerability of amphibians to global anthropogenic threats by Renoir J. Auguste, Amy E. Deacon, Mark F. Hulme

“…We discuss potential reasons for these knowledge gaps and recommend ways to address them, such as more equitable distribution of resources and provision of training and research opportunities for island-based biologists.…”
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