MicroRNA-541-3p/Rac2 signaling bridges radiation-induced lung injury and repair by Jiandong Zhang, Lei Ma, Limin He, Quanxiao Xu, Yan Ding, Lidong Wang

“…Background: While radiation-induced lung injury decreases quality of life and suppresses efficacy of radiotherapy, to date, the relationship between radiation-induced lung injury and repair remains unclear. …”
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Overweight and obesity among adolescents: health-conscious behaviours, acceptance, and the health behaviours of their parents by Anna Lewandowska, Grzegorz Rudzki, Tomasz Lewandowski, Anna Bartosiewicz, Michał Próchnicki, Aleksandra Stryjkowska-Góra, Barbara Laskowska, Małgorzata Sierpińska, Sławomir Rudzki, Sergii Pavlov

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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…This knowledge may help to optimize the combination of the selected IMQ dose with e.g. chemotherapy or radiotherapy to elicit synergistic effect in cancer treatment. …”
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Comprehensive analysis of peripheral dose in electron beam therapy with a Varian TrueBeam Linac by Kapil Dev Maharaj, Mahsheed Sabet, Joshua Dass, Mounir Ibrahim, Talat Mahmood, Pejman Rowshanfarzad

“…Conclusions: This study highlights the importance of considering peripheral doses in electron radiotherapy. It is important to note the impact on healthy tissues beyond the treatment area to ensure patient safety and prevent the long-term side effects of treatment. …”
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The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer by Mustafa Kandaz, Atalay Balsak, Hatice Bengü Çobanoğlu

“…Methods: Ninety-seven patients with NPC who received adjuvant radiotherapy between 1998 and 2022 were analyzed retrospectively. …”
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Modeling dose uncertainty in cone-beam computed tomography: Predictive approach for deep learning-based synthetic computed tomography generation by Cédric Hémon, Lucía Cubero, Valentin Boussot, Romane-Alize Martin, Blanche Texier, Joël Castelli, Renaud de Crevoisier, Anaïs Barateau, Caroline Lafond, Jean-Claude Nunes

“…Background and purpose:: Cone-beam computed tomography (CBCT) is essential in image-guided radiotherapy (RT) for patient positioning and daily dose calculation. …”
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Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma by Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen

“…Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common malignant urological tumor, and regrettably, and is insensitive to chemotherapy and radiotherapy, resulting in poor patient outcomes. DBF4 plays a critical role in DNA replication and participates in various biological functions, making it an attractive target for cancer treatment. …”
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Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Zaid Ahmed Shamsi, Vlad Paraoan, Chang Kim, Sarah Raihanah Saifuddin, Thomas D A Cosker, Duncan Whitwell, Christopher L M H Gibbons, Dionisios Stavroulias, Francesco DiChiara

“…Standard practice currently comprises wide surgical excision, often accompanied by adjuvant chemotherapy and/or radiotherapy. This approach necessitates a multidisciplinary team, ideally in specialised cancer centres. …”
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Time without PSA recurrence after radical prostatectomy as a predictor of future biochemical recurrence, metastatic disease and prostate cancer death: a prospective Scandinavian co... by Mats Steinholtz Ahlberg, Hans-Olov Adami, Hans Garmo, Lars Holmberg, Anna Bill-Axelson, Ove Andren, Gunnar Steineck, Jan-Erik Johansson

“…Four patients were excluded due to surgery-related death (n=1) or salvage radiotherapy or hormonal treatment within 6 weeks from surgery (n=3).Primary outcome measures Cumulative incidences and absolute differences in metastatic disease and prostate cancer death.Results We analysed 302 patients with complete follow-up during a median of 24 years. …”
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En plaque meningioma of the temporal bone: A systematic review on the imaging and management of a rare tumor by Arianna Burato, Giuseppe Maruccio, Livio Presutti, Ignacio Javier Fernandez, Gabriele Molteni, Giulia Molinari

“…Forty-four percent of patients were sent to definitive surgical treatment, 44 % to follow-up while 8 % received radiotherapy. Conclusions: Meningioma en plaque (MEP) is a rare tumour, particularly when it originates within the temporal bone. …”
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Lactoferrin Modulates Radiation Response Under Hypoxic Conditions, Possibly Through the Regulation of ROS Production in a Cell Type-Specific Manner by Daitoku Murakami, Takahiro Fukazawa, Michihito Kyo, Mutsumi Miyauchi, Shigehiro Ono, Tomonao Aikawa, Nobuyuki Hirohashi, Keiji Tanimoto

“…However, the effects of LF and its mechanisms in anticancer therapies, especially in radiotherapy against cancer cells under hypoxic conditions, are not well-determined. …”
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A High-Salt Diet Disturbs the Development and Function of Natural Killer Cells in Mice by Xiaokang Zeng, Yan Li, Weibiao Lv, Xinhuai Dong, Chong Zeng, Liming Zeng, Zibo Wei, Xu Lin, Yanning Ma, Qiang Xiao

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Trends in survival of patients with stage I/II Burkitt lymphoma in the United States: A SEER database analysis by Ze‐Long Liu, Pan‐Pan Liu, Xi‐Wen Bi, De‐Xin Lei, Yu Wang, Zhi‐Ming Li, Wen‐Qi Jiang, Yi Xia

“…Older age and race of black were correlated with poorer OS in multivariate analysis, whereas sex, primary sites, and application of radiotherapy did not significantly influence OS. In conclusion, the prognosis of patients with limited‐stage BL has improved in the 2002‐2014 era, but the outcome was still much poorer in elderly patients, which needs to be improved by identifying newly molecular‐targeted drugs and developing novel personalized therapeutic approaches.…”
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Deep unsupervised clustering for prostate auto-segmentation with and without hydrogel spacer by Hengrui Zhao, Biling Wang, Michael Dohopolski, Ti Bai, Steve Jiang, Dan Nguyen

“…In recent years, hydrogel spacers have been used in some prostate cancer patients receiving radiotherapy to separate the prostate and the rectum to better spare the rectum while achieving adequate dose coverage on the prostate. …”
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Symptomatic Pituitary Metastasis as Initial Manifestation of Renal Cell Carcinoma: Case Report and Review of Literature by Gunjan Y. Gandhi, Russell Fung, Patrick E. Natter, Raafat Makary, K. C. Balaji

“…He subsequently received fractionated stereotactic radiotherapy to the pituitary gland. He is presently stable with no radiological evidence of progression or new intracranial disease on subsequent imaging. …”
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Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells by Tim Heemskerk, Celebrity Groenendijk, Marta Rovituso, Ernst van der Wal, Wouter van Burik, Konstantinos Chatzipapas, Danny Lathouwers, Roland Kanaar, Jeremy M.C. Brown, Jeroen Essers

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Case report: Successful treatment of hyperbaric oxygen for radiation-induced hemorrhagic cystitis in a 95-year-old patient with bladder cancer by Li Lin, Li Lin, Man He, Yanyan Zeng, Xiaoxiao Ni, Yequn Guo, Xiaojuan Xie, Lingling Sun, Huai Huang

“…However, there is a lack of reported data addressing the applicability of HBOT in very elderly patients (over 90 years old) with severe bleeding necessitating multiple blood transfusions.Case presentationThe patient is a 95-year-old male who suffered from severe hematuria due to RHC after 33 sessions of radiotherapy for muscle-invasive bladder cancer (T2N0M0, stage: II). …”
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Application of large language models in disease diagnosis and treatment by Xintian Yang, Tongxin Li, Qin Su, Yaling Liu, Chenxi Kang, Yong Lyu, Lina Zhao, Yongzhan Nie, Yanglin Pan, Yuanyuan Ji

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Associations Between Patient-Reported Nutritional Status, Toxicity, and Survival in Limited-Stage SCLC by Evgenia Taranova, Marianne Aanerud, MD, PhD, Tarje O. Halvorsen, MD, PhD, Kristin T. Killingberg, MD, PhD, Marit Slaaen, MD, PhD, Bjørn H. Grønberg, MD, PhD

“…We investigated whether nutritional status and weight loss were associated with treatment outcomes in a randomized trial of thoracic radiotherapy (TRT) in LS SCLC (NCT02041845, N = 170). …”
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An Update of the Appropriate Treatment Strategies in Anaplastic Thyroid Cancer: A Population-Based Study of 735 Patients by Nai-si Huang, Xiao Shi, Bo-wen Lei, Wen-jun Wei, Zhong-wu Lu, Peng-cheng Yu, Yu Wang, Qing-hai Ji, Yu-long Wang

“…By directly comparing eight treatment modalities, we found that surgery+radiotherapy RT±chemotherapy was the most effective treatment strategy. surgery+chemotherapy and RT+chemotherapy had comparable results (hazard ratio HR=1.461, 95% confidential interval (CI): 0.843-2.531, P=0.177). …”
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