Real-world outcomes of the CROSS regimen in patients with resectable esophageal or gastro-esophageal junction adenocarcinoma: a nationwide cohort study in the NetherlandsResearch i... by Hanneke van Laarhoven, Rob Verhoeven, Mark van Berge Henegouwen, Nadia Haj Mohammad, Richard van Hillegersberg, Marije Slingerland, Christina T. Muijs, Bas Wijnhoven, Bianca Mostert, Laurens Beerepoot, Grard Nieuwenhuijzen, Sarah Derks, Peter S.N. van Rossum

“…Findings: Of the 4765 included patients, 4170 (87.5%) completed the full CROSS regimen of radiotherapy and chemotherapy. A pCR was observed in 704 (20.5%) of 3439 patients who underwent surgical resection within 16 weeks after completing the CROSS regimen. …”
Get full text

Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models by Andrea Mancini, Alessandro Colapietro, Loredana Cristiano, Alessandra Rossetti, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Héctor Perez-Montoyo, Marc Yeste-Velasco, Jose Alfon, Carles Domenech, Claudio Festuccia

“…Finally, we investigated the combination of ABTL0812 with the standard of care treatments for GBM radiotherapy and temozolomide in an orthotopic model, detecting that ABTL0812 potentiates the efficacy of both treatments and that the strongest effect is obtained with the triple combination of ABTL0812+radiotherapy+temozolomide.ConclusionsOverall, the present study demonstrated the anticancer efficacy of ABTL0812 as single agent and in combination with the GBM standard of care treatments in models of glioblastoma and supports the clinical investigation of ABTL0812 as a potential novel therapy for this aggressive brain tumor type.…”
Get full text

The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study by Donghoon Kang, Gi-June Min, Tong Yoon Kim, Young-Woo Jeon, Yukyung Cho, Jae Myung Park, Joo Hyun O, Byung-Ock Choi, Gyeongsin Park, Seok-Goo Cho

“…Of the eight patients without VCE, seven and one received radiotherapy and observation, respectively. Nine of the 23 patients (39.1%) received systemic treatment based on positive VCE results. …”
Get full text

USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…Background: Radiotherapy is a major modality for esophageal cancer (ESCA) treatment, yet radioresistance severely hampers its therapeutic efficacy. …”
Get full text

Left Vocal Cord Paralysis Detected by PET/CT in a Case of Lung Cancer by Ali Ozan Oner, Adil Boz, Evrim Surer Budak, Gulnihal Hale Kaplan Kurt

“…After completing chemotherapy and radiotherapy against the primary mass in the left lung, the patient underwent a second PET/CT examination for evaluation of treatment response. …”
Get full text

Treatment of primary esophageal lymphomas: A review by Joe El Khoury, Remy Daou, Neal Kim, Josiane Bou Eid, Brandon Imber, Joachim Yahalom, Carla Hajj

“…This literature review provides a comprehensive overview of the use of available treatment options for primary esophageal lymphoma, including surgery, radiotherapy, and chemotherapy. The review also highlights the current knowledge gaps that need to be addressed through further research. …”
Get full text

Primary Angiosarcoma of the Spleen: An Oncological Enigma by Myoteri Despoina, Dellaportas Dionysios, Ayiomamitis Georgios, Strigklis Konstantinos, Kouroumpas Efstratios, Zizi-Sermpetzoglou Adamantia

“…As with other sarcomas, surgery is the only curative approach, while chemo- and radiotherapy have poor results. Prognosis remains dismal.…”
Get full text

The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis by Alexandra Arcilla Xin Hui Sim, Jia Ying Cheam, Jodi Woan-Fei Law, Vengadesh Letchumanan, Yatinesh Kumari, Satoshi Ogawa, Sunny Hei Wong, Kok-Gan Chan, Loh Teng-Hern Tan

“…Although early detection improves the survival rate to around 90%, late detection would mean the need to use chemotherapy or radiotherapy, especially if surgery is not feasible. 5-fluorouracil (5-FU) is one of the common anti-cancer drugs used in treating CRC. …”
Get full text

LLM-driven multimodal target volume contouring in radiation oncology by Yujin Oh, Sangjoon Park, Hwa Kyung Byun, Yeona Cho, Ik Jae Lee, Jin Sung Kim, Jong Chul Ye

“…We validate our proposed LLMSeg within the context of breast cancer radiotherapy using external validation and data-insufficient environments, which attributes highly conducive to real-world applications. …”
Get full text

Radiofrequency Ablation in the Management of Advanced Stage Thymomas: A Case Report on a Novel Multidisciplinary Therapeutic Approach by Panagiotis Paliogiannis, Carlo Pala, Renato Versace, Claudio Pusceddu

“…Successively, the patient underwent adjuvant radiotherapy. As a result of this multidisciplinary treatment, complete and stable response was obtained. …”
Get full text

Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion by Sherif Ali Eltawansy, Ryane Panasiti, Samaa Hasanien, Dennis Lourdusamy, David Sharon

“…Work up could not detect the primary lesion and patient was started on radiotherapy and immunotherapy. Conclusion. We present a case of malignant melanoma of unknown primary presenting in an unusual place which is the inguinal lymph node. …”
Get full text

Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis by Catarina Araújo, Cristina Resende, Francisco Pardal, Celeste Brito

“…Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. …”
Get full text

Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

“…Despite aggressive treatment including surgery, adjuvant TMZ-based chemotherapy, and radiotherapy, GBM still has a dismal prognosis: the median survival is 14.6 months from diagnosis. …”
Get full text

Extramedullary Plasmacytoma of the Oral Cavity: A Rare Case in the Buccal Mucosa by Armin Khaleghi, Nafise Shamloo

“…The lesion was treated successfully through a combination of surgical excision and radiotherapy at a dose of 40 Gy. This case underscores the importance of early diagnosis and treatment of EMP, particularly in rare locations, to prevent progression to MM and improve patient outcomes. …”
Get full text

Fluorescence-Guided Resection of Malignant Glioma with 5-ALA by Sadahiro Kaneko, Sadao Kaneko

“…In the future, chemotherapy with new anticancer agents, immunotherapy, and new methods of radiotherapy and gene therapy will be developed; however, ALA will play a key role in malignant glioma treatment before the development of these new treatments. …”
Get full text

An Osteolytic Metastasis of Humerus from an Asymptomatic Squamous Cell Carcinoma of Lung: A Rare Clinical Entity by Anirban Das, Sudipta Pandit, Sibes k. Das, Sumitra Basuthakur, Somnath Das

“…Systemic cytotoxic chemotherapy, local palliative radiotherapy, adequate analgesia, and internal fixation of the affected long bone are different modalities of treatment in this advanced stage of disease. …”
Get full text

A Rare Cause of the Cough: Primary Small Cell Carcinoma of Esophagus—Case Report by Erdal Yekeler, Timur Koca, Semra Vural

“…The case was assumed inoperable, and chemotherapy and radiotherapy were planned. We presented a rare cause of the cough and primary esophageal small cell carcinoma in this paper.…”
Get full text

A Narrative Review on the Pathophysiology and Management for Radiation Cystitis by C. Browne, N. F. Davis, E. Mac Craith, G. M. Lennon, D. W. Mulvin, D. M. Quinlan, Gerard P. Mc Vey, D. J. Galvin

“…Radiation cystitis is a recognised complication of pelvic radiotherapy. Incidence of radiation cystitis ranges from 23 to 80% and the incidence of severe haematuria ranges from 5 to 8%. …”
Get full text

Artificial intelligence across oncology specialties: current applications and emerging tools by Frank Lin, Tim Rattay, John Kang, Evangelia Katsoulakis, Kyle Lafata, Ellen Kim, Christopher Yao, Harsha Nori, Christoph Ilsuk Lee

“…In this review, we provide multidisciplinary perspectives on oncology applications touched by AI—imaging, pathology, patient triage, radiotherapy, genomics-driven therapy and surgery—and integration with existing tools—natural language processing, digital twins and clinical informatics.…”
Get full text

An Optimal Algorithm for Determining Risk Factors for Complex Diseases: Depressive Disorder, Osteoporosis, and Fracture in Young Patients with Breast Cancer Receiving Curative Surg... by Chieh-Yu Liu, Chun-Hung Chang

“…The results revealed that depressive disorder, osteoporosis, and fracture were clustered with liver cirrhosis, chronic obstructive pulmonary disease (COPD), distant metastasis, and primary metastatic and adjuvant therapies, namely, chemotherapy, radiotherapy, tamoxifen, aromatase inhibitors, and trastuzumab. …”
Get full text