Multi-omics unveils strain-specific neuroactive metabolite production linked to inflammation modulation by Bacteroides and their extracellular vesicles by Basit Yousuf, Walid Mottawea, Galal Ali Esmail, Nazila Nazemof, Nour Elhouda Bouhlel, Emmanuel Njoku, Yingxi Li, Xu Zhang, Zoran Minic, Riadh Hammami

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Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

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FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy by Liang Zhao, Long Sun, Kaili Fu, Qin Lin, Xiaoyuan Chen, Qicong Luo, Hua Wu, Jianhao Chen, Yangfan Zhou, Yizhen Pang, Guoqiang Su, Haojun Chen

“…We recently reported on a novel dimeric FAP-targeting radiopharmaceutical, 68Ga/177Lu-DOTA-2P(FAPI)2, which demonstrated increased tumor uptake and prolonged retention in various cancers. …”
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Apoptotic PET Imaging of Rat Pulmonary Fibrosis With [F]ML-8 by Ying Xiong MM, Dahong Nie BM, Shaoyu Liu PhD, Hui Ma BM, Shu Su BM, Aixia Sun PhD, Jing Zhao MD, PhD, Zhanwen Zhang PhD, Xianhong Xiang MD, PhD, Ganghua Tang MD, PhD

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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

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Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer by Li Wen, Chengxue He, Yanhui Guo, Nina Zhou, Xiangxi Meng, Yuwen Chen, Cheng Ma, Hua Zhu, Zhi Yang, Lei Xia

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Synthesis, Novel Crystal Structure, and β-Amyloid Binding Property of Re(I) (tricarbonyl)+ EHIDA Analogue by Yang Yang, Jia Xin Zhang, Lin Zhu, Huabei Zhang

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Significance of nuclear medicine methods for diagnosis and predicting the course of renal transplantation complications by M.V. Satyr, I.V. Noverko, T.I. Pantus, M.S. Zagriichuk

“…It is related to the implementation of high-quality 3-dimentional visualization, newest radiopharmaceuticals. We conclude the importance of the nuclear medicine as an element of multidisciplinary approach in transplantology.…”
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Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy by La Dong, Rui Zhou, Jinyun Zhou, Ke Liu, Chentao Jin, Jing Wang, Chenxi Xue, Mei Tian, Hong Zhang, Yan Zhong

“…In this review, we focused on the pathological mechanisms of MSA, summarized relevant targets and radiopharmaceuticals, and discussed the clinical applications and future perspectives of PET molecular imaging in MSA.…”
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A Novel Copolymer-Based Functional SPECT/MR Imaging Agent for Asialoglycoprotein Receptor Targeting by Pu Zhang MS, Zhide Guo MS, Deliang Zhang MS, Chang Liu MS, Guibing Chen MM, Rongqiang Zhuang PhD, Manli Song MS, Hua Wu PhD, Xianzhong Zhang PhD

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Synthesis of Poly[APMA]-DOTA-Cu Conjugates for Interventional Radionuclide Therapy of Prostate Cancer: Assessment of Intratumoral Retention by Micro–Positron Emission Tomography by Jianchao Yuan, Yezi You, Xin Lu, Otto Muzik, David Oupicky, Fangyu Peng

“…To develop new radiopharmaceuticals for interventional radionuclide therapy of locally recurrent prostate cancer, poly[ N -(3-aminopropyl)methacrylamide] [poly(APMA)] polymers were synthesized by free radical precipitation polymerization in acetonedimethylsulfoxide using N,N ‘-azobis(isobutyronitrile) as the initiator. …”
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Penile Cancer: Innovations in Ultrastructural and Vibrational Markers by Joel Félix Silva Diniz-Filho, Ana Caroline Muniz Silva, Antônio Augusto Lima Teixeira, Bruna Larissa Nolêto Sousa, Ralph Santos-Oliveira, Gyl Eanes Barros Silva, Clenilton Costa dos Santos, Luciana Magalhães Rebelo Alencar

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Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel F-Folate Radiotracer by Adrienne Müller, Katharina Beck, Zoran Rancic, Cristina Müller, Cindy R. Fischer, Thomas Betzel, Philipp A. Kaufmann, Roger Schibli, Stefanie D. Kramer, Simon M. Ametamey

“…Selectively targeting FR-β-positive macrophages through folate-based radiopharmaceuticals may be useful for noninvasive imaging of plaque inflammation.…”
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Optimisation of low and ultra-low dose scanning protocols for ultra-extended field of view PET in a real-world clinical setting by Johanna Ingbritsen, Jason Callahan, Hugh Morgan, Melissa Munro, Robert E. Ware, Rodney J. Hicks

“…The Siemens Biograph Vision Quadra (Quadra), with an AFOV of 106cm, potentially allows use of significantly lower administered radiopharmaceuticals as well as reduced scan times. The aim of this study was to optimise acquisition protocols for routine clinical imaging with FDG on the Quadra the prioritisation of reduced activity given physical infrastructure constraints in our facility. …”
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On the reduction of imaging time-points for dosimetry in radionuclide therapy by Johan Gustafsson, Jan Taprogge

“…These formulae have the potential to be used for optimization of dosimetry measurement schemes for established and new radiopharmaceuticals as long as the mean and dispersion of biological half-lives are known in the patient population.…”
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Real-time trajectory imaging of alpha particles emitted from actinium-225 and its daughter radionuclides by Seiichi Yamamoto, Masao Yoshino, Kenji Shirasaki, Kohei Nakanishi, Kei Kamada, Akira Yoshikawa, Jun Kataoka

“…Abstract In targeted alpha-particle therapy, actinium-225 (Ac-225) has emerged as a radionuclide of potential, driving extensive efforts to develop innovative radiopharmaceuticals. High-resolution imaging of alpha particles is required for precisely detecting alpha-emitting radionuclides in cellular environments and small organs. …”
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CALCULATION STUDIES OF SPATIAL DISTRIBUTION OF THE ABSORBED DOSE RATE FOR VARIOUS SEEDS by N. A. Nerozin, A. P. Pyshko, V. V. Shapovalov

“…Conducting computational studies of dosimetric characteristics of microsources with the radionuclide I‑125, pilot production of which is established in the research and production complex of isotope and radiopharmaceuticals, JSC “State Scientific Centre of the Russian Federation — Institute for Physics and Power Engineering named after A. …”
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In silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nAChRs) for nicotine addiction treatment by Taufik Muhammad Fakih, Aden Dhana Rizkita, Sintia Ayu Dewi, Muchtaridi Muchtaridi

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Up-to-Date Imaging for Parathyroid Tumor Localization in MEN1 Patients with Primary Hyperparathyroidism: When and Which Ones (A Narrative Pictorial Review) by Valentina Berti, Francesco Mungai, Paolo Lucibello, Maria Luisa Brandi, Carlo Biagini, Alessio Imperiale

“…Radionuclide imaging, especially PET/CT using radiopharmaceuticals like [¹⁸F]FCH, shows promising results in localizing parathyroid tumors, particularly in patients with MEN1. …”
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Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer by Benchao Zheng, Hongbo Wang, Shiyi Zhai, Jiangsheng Li, Kuangda Lu

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