Bone-Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer: Evolving Paradigms by Joelle El-Amm, Ashley Freeman, Nihar Patel, Jeanny B. Aragon-Ching

“…While several radiopharmaceuticals were approved for pain palliation in mCRPC including strontium and samarium, alpharadin is the first radiopharmaceutical to show significant overall survival benefit. …”
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Folate Receptor–Targeted Single-Photon Emission Computed Tomography/Computed Tomography to Detect Activated Macrophages in Atherosclerosis: Can It Distinguish Vulnerable from Stabl... by Leah C.J. Winkel, Harald C. Groen, Bibi S. van Thiel, Cristina Müller, Antonius F.W. van der Steen, Jolanda J. Wentzel, Marion de Jong, Kim Van der Heiden

“…We investigated the feasibility of a folate-based radiopharmaceutical ( 111 In-EC0800) with high-resolution animal single-photon emission computed tomography/computed tomography (SPECT/CT) to differentiate between stable and vulnerable atherosclerotic plaques in apolipoprotein E 7 mice in which we can induce plaques with the characteristics of stable and vulnerable plaques by placing a flow-modifying cast around the common carotid artery. …”
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Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals by Najwa D. Aljehani, Levi Tamming, Muhammad Yasir Khan, Rwaa H. Abdulal, Mohamed A. Alfaleh, Aishah Ghazwani, Asalah Helal, Reem M. Alsulaiman, Mohammad A. Sanki, Khalid Alluhaybi, Farah Ayman Sukareh, Rahaf H. Alharbi, Faris H. Alyami, M-Zaki ElAssouli, Salima Shebbo, Wesam H. Abdulaal, Abdullah Algaissi, Ahmad Bakur Mahmoud, Mohammad Basabrain, Diana Duque, Jegarubee Bavananthasivam, Wangxue Chen, Lisheng Wang, Simon Sauve, Turki S. Abujamel, Tarfa Altorki, Rowa Alhabbab, Anh Tran, Xuguang Li, Anwar M. Hashem

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Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo by Desheng CHEN, Qinggang HUANG, Shiwei CAO, Zhi QIN

“…99mTc derived from 99Mo，stands as the preeminent radiopharmaceutical employed extensively in medical diagnostics worldwide. …”
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Quality of computed tomography image versus dose in hybrid studies: preliminary results in phantom by Adlin López Díaz, Armando del Pozo Almaguer, Adalberto Machado Tejeda, Karla Batista Ramó, Carlos F Calderón Marín, Leonel Torres Aroche

“…<p><strong>Background:</strong> hybrid studies produce a total radiation dose that is the result of the dose imparted by the radiopharmaceutical and that emitted by the computed tomography, therefore optimization is essential.…”
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Emerging Role of PET in the Diagnosis and Staging of Lung Cancer by Geoffery Coates, Stephen J Skehan

“…Malignant tumours demonstrate increased uptake of FDG, a positron-emitting radiopharmaceutical. This increased FDG uptake in tumours can be seen using PET. …”
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Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

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The Role of Dynamic Renal Scintigraphy in Detecting Vesicoureteral Reflux Diagnosed by Voiding Cystourethrogram by İlhan Çiftci, Gonca Kara Gedik, Farise Yılmaz, Fatma Özcan Sıkı, Hasan Önner, Mehmet Sarıkaya

“…Tc-99m MAG-3 was used in infants and Tc-99m DTPA radiopharmaceutical in children over one year old. According to VCUG findings, VUR grades were grouped as grade I-II-III low-grade VUR and IV-V high-grade VUR. …”
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Granzyme B PET Imaging Stratifies Immune Checkpoint Inhibitor Response in Hepatocellular Carcinoma by Julian L. Goggi, Boominathan Ramasamy, Yun Xuan Tan, Siddesh V. Hartimath, Jun Rong Tang, Peter Cheng, Rasha Msallam, Ann-Marie Chacko, You Yi Hwang, Edward G. Robins

“…FACS indicated significant changes in the immune environment including a decrease in immune suppressive CD4+ T regulatory cells and increases in tumour-associated GZB+ NK+ cells, which correlated well with tumour radiopharmaceutical uptake. While the immune response to ICI therapies differs in HCC compared to many other cancers, [18F]AlF-mNOTA-GZP retention is able to stratify response to ICI therapy associated with tumour infiltrating GZB+ NK+ cells in this complex tumour microenvironment.…”
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Investigating the significance of SPECT/CT-SUV for monitoring 177Lu-PSMA-targeted radionuclide therapy: a systematic review by Tahani O. Alkahtani

“…This imaging technique determines the radiopharmaceutical distribution and internal dosimetry in patients who receive TRT. …”
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Advantages and challenges of using arterial spin labelling MRI to monitor cerebral blood flow in multi-centre clinical trials of neurodegenerative disease: Experience from the RADA... by Lina Jarutyte, Jan Petr, Nicholas Turner, Patrick G. Kehoe, Henk-Jan Mutsaerts, David L. Thomas

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Can Radiomics of Dynamic PET Imaging with 11C-methionine Predict EGFR Amplification Status in Glioblastoma? by Gleb DANILOV, Andrey POSTNOV, Diana KALAEVA, Nina VIKHROVA, Tatyana KOBYAKOVA

“…Three datasets were used to predict EGFR amplification status via machine learning: 1) Radiomic features calculated as time series for each image biomarker; 2) Dynamic tumor-to-normal brain ratio (T/N) of radiopharmaceutical uptake - time series of T/N peak for 26 frames; 3) Static T/N - peak, max, and average T/N for static images. …”
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Preliminary Assessment of Reference Region Quantification and Reduced Scanning Times for [18F]SynVesT-1 PET in Parkinson’s Disease by Kelly Smart, Carme Uribe, Kimberly L. Desmond, Sarah L. Martin, Neil Vasdev, Antonio P. Strafella

“…While [18F]SynVesT-1 has been proven to be a powerful radiopharmaceutical for PET imaging of neurodegenerative disorders such as Parkinson’s disease (PD), its currently validated acquisition and quantification protocols are invasive and technically challenging in these populations due to the arterial sampling and relatively long scanning times. …”
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Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics by Lorraine Gaenaelle Gé, Mathias Bogetoft Danielsen, Aaraby Yoheswaran Nielsen, Mathias Lander Skavenborg, Niels Langkjær, Helge Thisgaard, Christine J. McKenzie

“…In conclusion, [⁵⁷Co]Co-TZTPEN-GE11 shows poor pharmacokinetics in a mouse model and is, therefore, not deemed suitable as a targeting radiopharmaceutical for EGFR.…”
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Detection Performance of 99mTc in Albira SI Small-Animal SPECT-CT by Jie TANG, Dong XU, Qianyue HU, Bo ZHANG, Wei LI, Lizhen WANG, Huixin YU, Fukuan ZHAO

“…Small-animal single-photon emission computed tomography-X-ray computed tomography (SPECT-CT) is an advanced imaging tool for preclinical research of single-photon radiopharmaceuticals. Its detection performance is the foundation of image quality and the reliability of experimental data. …”
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Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column by Mohammad S. El-Shahawi, Hassan Alwael, Abdulaziz A. Alsibaai, Abdelgany Hamza, Faisal K. Algethami, Fatmah M. Alshareef, Sanaa H. El-Khouly, Neven Eweda

“…There is growing demand for separation of 90Y carrier free from 90Sr coexisting to produce high purity 90Y essential for radiopharmaceutical uses. Thus, in this context the sorption profiles of Y3+ and Sr2+ from aqueous solutions containing diethylenetriaminepenta acetic acid (DTPA), ethylenediaminetetra-acetic acid (EDTA), acetic acid, citric acid, or NaCl onto Chelex-100 (anion ion exchange) solid sorbent were critically studied for developing an efficient and low-cost methodology for selective separation of Y3+ from Sr2+ ions (1.0 × 10−5 M). …”
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Comparison of ZnS(Ag) Scintillator and Proportional Counter Tube for Alpha Detection in Thin-Layer Chromatography by Marc Pretze, Jan Wendrich, Holger Hartmann, Robert Freudenberg, Ralph A. Bundschuh, Jörg Kotzerke, Enrico Michler

“…A difference was observed when measuring TLC with the AR-2000 in different modes; (4) <b>Conclusions</b>: The MiniScanPRO+ is fast, does not require additional equipment and can also measure the gamma spectrum, which may be important for some radiopharmaceutical production sites and regulatory authorities. …”
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PET imaging of 52Mn labeled DOTATATE and DOTAJR11 by James M. Omweri, Hailey A. Houson, Shannon E. Lynch, Volkan Tekin, Anna G. Sorace, Suzanne E. Lapi

“…Abstract Manganese-52 is gaining interest as an isotope for PET imaging due to its desirable decay and chemical properties for radiopharmaceutical development. Somatostatin receptor 2 (SSTR2) is significantly overexpressed by neuroendocrine tumors (NETs) and is an important target for nuclear imaging and therapy. …”
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Segmentation of Dynamic Total-Body [18F]-FDG PET Images Using Unsupervised Clustering by Maria K. Jaakkola, Maria Rantala, Anna Jalo, Teemu Saari, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco López-Picón, Riku Klén

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Do you know your PSMA-tracer? Variability in the biodistribution of different PSMA ligands and its potential impact on defining PSMA-positivity prior to PSMA-targeted therapy by Jan Heilinger, Katrin Sabine Roth, Henning Weis, Antonis Fink, Jasmin Weindler, Felix Dietlein, Philipp Krapf, Klaus Schomäcker, Bernd Neumaier, Markus Dietlein, Alexander Drzezga, Carsten Kobe

“…Abstract Background In clinical practice, several radiopharmaceuticals are used for PSMA-PET imaging, each with distinct biodistribution patterns. …”
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