Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

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Investigating the significance of SPECT/CT-SUV for monitoring 177Lu-PSMA-targeted radionuclide therapy: a systematic review by Tahani O. Alkahtani

“…This imaging technique determines the radiopharmaceutical distribution and internal dosimetry in patients who receive TRT. …”
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Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics by Lorraine Gaenaelle Gé, Mathias Bogetoft Danielsen, Aaraby Yoheswaran Nielsen, Mathias Lander Skavenborg, Niels Langkjær, Helge Thisgaard, Christine J. McKenzie

“…In conclusion, [⁵⁷Co]Co-TZTPEN-GE11 shows poor pharmacokinetics in a mouse model and is, therefore, not deemed suitable as a targeting radiopharmaceutical for EGFR.…”
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Detection Performance of 99mTc in Albira SI Small-Animal SPECT-CT by Jie TANG, Dong XU, Qianyue HU, Bo ZHANG, Wei LI, Lizhen WANG, Huixin YU, Fukuan ZHAO

“…Small-animal single-photon emission computed tomography-X-ray computed tomography (SPECT-CT) is an advanced imaging tool for preclinical research of single-photon radiopharmaceuticals. Its detection performance is the foundation of image quality and the reliability of experimental data. …”
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Comparison of ZnS(Ag) Scintillator and Proportional Counter Tube for Alpha Detection in Thin-Layer Chromatography by Marc Pretze, Jan Wendrich, Holger Hartmann, Robert Freudenberg, Ralph A. Bundschuh, Jörg Kotzerke, Enrico Michler

“…A difference was observed when measuring TLC with the AR-2000 in different modes; (4) <b>Conclusions</b>: The MiniScanPRO+ is fast, does not require additional equipment and can also measure the gamma spectrum, which may be important for some radiopharmaceutical production sites and regulatory authorities. …”
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PET imaging of 52Mn labeled DOTATATE and DOTAJR11 by James M. Omweri, Hailey A. Houson, Shannon E. Lynch, Volkan Tekin, Anna G. Sorace, Suzanne E. Lapi

“…Abstract Manganese-52 is gaining interest as an isotope for PET imaging due to its desirable decay and chemical properties for radiopharmaceutical development. Somatostatin receptor 2 (SSTR2) is significantly overexpressed by neuroendocrine tumors (NETs) and is an important target for nuclear imaging and therapy. …”
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Segmentation of Dynamic Total-Body [18F]-FDG PET Images Using Unsupervised Clustering by Maria K. Jaakkola, Maria Rantala, Anna Jalo, Teemu Saari, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco López-Picón, Riku Klén

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Multi-omics unveils strain-specific neuroactive metabolite production linked to inflammation modulation by Bacteroides and their extracellular vesicles by Basit Yousuf, Walid Mottawea, Galal Ali Esmail, Nazila Nazemof, Nour Elhouda Bouhlel, Emmanuel Njoku, Yingxi Li, Xu Zhang, Zoran Minic, Riadh Hammami

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Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

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Apoptotic PET Imaging of Rat Pulmonary Fibrosis With [F]ML-8 by Ying Xiong MM, Dahong Nie BM, Shaoyu Liu PhD, Hui Ma BM, Shu Su BM, Aixia Sun PhD, Jing Zhao MD, PhD, Zhanwen Zhang PhD, Xianhong Xiang MD, PhD, Ganghua Tang MD, PhD

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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

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Synthesis, Novel Crystal Structure, and β-Amyloid Binding Property of Re(I) (tricarbonyl)+ EHIDA Analogue by Yang Yang, Jia Xin Zhang, Lin Zhu, Huabei Zhang

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Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy by La Dong, Rui Zhou, Jinyun Zhou, Ke Liu, Chentao Jin, Jing Wang, Chenxi Xue, Mei Tian, Hong Zhang, Yan Zhong

“…In this review, we focused on the pathological mechanisms of MSA, summarized relevant targets and radiopharmaceuticals, and discussed the clinical applications and future perspectives of PET molecular imaging in MSA.…”
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Penile Cancer: Innovations in Ultrastructural and Vibrational Markers by Joel Félix Silva Diniz-Filho, Ana Caroline Muniz Silva, Antônio Augusto Lima Teixeira, Bruna Larissa Nolêto Sousa, Ralph Santos-Oliveira, Gyl Eanes Barros Silva, Clenilton Costa dos Santos, Luciana Magalhães Rebelo Alencar

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Optimisation of low and ultra-low dose scanning protocols for ultra-extended field of view PET in a real-world clinical setting by Johanna Ingbritsen, Jason Callahan, Hugh Morgan, Melissa Munro, Robert E. Ware, Rodney J. Hicks

“…The Siemens Biograph Vision Quadra (Quadra), with an AFOV of 106cm, potentially allows use of significantly lower administered radiopharmaceuticals as well as reduced scan times. The aim of this study was to optimise acquisition protocols for routine clinical imaging with FDG on the Quadra the prioritisation of reduced activity given physical infrastructure constraints in our facility. …”
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On the reduction of imaging time-points for dosimetry in radionuclide therapy by Johan Gustafsson, Jan Taprogge

“…These formulae have the potential to be used for optimization of dosimetry measurement schemes for established and new radiopharmaceuticals as long as the mean and dispersion of biological half-lives are known in the patient population.…”
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Real-time trajectory imaging of alpha particles emitted from actinium-225 and its daughter radionuclides by Seiichi Yamamoto, Masao Yoshino, Kenji Shirasaki, Kohei Nakanishi, Kei Kamada, Akira Yoshikawa, Jun Kataoka

“…Abstract In targeted alpha-particle therapy, actinium-225 (Ac-225) has emerged as a radionuclide of potential, driving extensive efforts to develop innovative radiopharmaceuticals. High-resolution imaging of alpha particles is required for precisely detecting alpha-emitting radionuclides in cellular environments and small organs. …”
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Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer by Benchao Zheng, Hongbo Wang, Shiyi Zhai, Jiangsheng Li, Kuangda Lu

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