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    Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome by Mengnan Chen, Dongmei Sun, Siu-Pok Yee, Zhaoyang Yuan, Li Lin, Bing Cui, Yi Wang, Chao Liu, Peihong Liu

    Published 2025-01-01
    “…The Fam20c D446N allele replaced the WT Fam20c by 3.6Kb Col1a1-Cre to get the conditional knock-in mice, and by Hprt-cre to get conventional knock-in mice, respectively. Results The radiology, serum biochemistry and immunohistochemistry indicated that all conditional and most conventional Fam20c D446N knock-in mice displayed hypophosphatemic rickets with the increased Fgf23 and deceased Dmp1 expression, which survived to adulthood. …”
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    Analysis of panel physician inquiries to U.S. TB Centers of Excellence, 2018–2022 by E. Leithead IV, S. Subramanian, K. Pimenta, N.D. Goswami, A. Patrawalla, A. Lardizabal, C. Haley, L. Chen, L. Armitige, B. Seaworth, B. Sylvester, R. Bhavaraju

    Published 2024-11-01
    “…Diagnostic questions (n = 104, 48.4%) included mycobacterial culture, smear, and radiology interpretation. Treatment tailoring inquiries involved optimizing the initial regimen (n = 89, 41.4%) or modifying existing regimens (n = 26, 12.1%). …”
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