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Fitness landscape of a dynamic RNA structure.
Published 2021-02-01“…RNA structures are dynamic. As a consequence, mutational effects can be hard to rationalize with reference to a single static native structure. …”
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The myriad roles of RNA structure in the flavivirus life cycle
Published 2024-12-01“…Herein, we highlight advances in our understanding of flavivirus RNA structural elements through the lens of their impact on the viral life cycle. …”
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Unveiling RNA structure-mediated regulations of RNA stability in wheat
Published 2024-11-01“…Our findings indicate that the 3’ UTR structure and homoeolog preference for RNA structural motifs can influence mRNA stability, leading to subgenomic RNA decay imbalance. …”
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RNA structure in alternative splicing regulation: from mechanism to therapy
Published 2024-07-01“…Its regulation is multifactorial, with RNA structure exerting a significant impact. …”
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The role of RNA structural motifs in RNA-lipid raft interaction
Published 2025-02-01“…Abstract Here, we sought to determine the role of specific RNA structural motifs in the interaction of RNA with model lipid vesicles containing liquid-ordered domains (RAFT liposomes). …”
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Advances in solid-state NMR methods for studying RNA structures and dynamics
Published 2025-02-01“…Ribonucleic acid (RNA) structures and dynamics play a crucial role in elucidating RNA functions and facilitating the design of drugs targeting RNA and RNA-protein complexes. …”
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Systematic benchmarking of deep-learning methods for tertiary RNA structure prediction.
Published 2024-12-01“…Experimental methods for determining RNA structures are labour-intensive, expensive, and time-consuming. …”
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REDalign: accurate RNA structural alignment using residual encoder-decoder network
Published 2024-11-01“…While various computational strategies for RNA structural alignment exist, they often come with high computational complexity. …”
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Mechanism of modified mRNA structure in COVID-19 vaccines for inducing neutralizing antibodies
Published 2024-10-01Get full text
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Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation
Published 2014-12-01Subjects: Get full text
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Ensemble refinement of mismodeled cryo-EM RNA structures using all-atom simulations
Published 2025-05-01“…An analysis of all RNA-containing structures deposited in the Protein Data Bank reveals that this issue affects most cryo-EM structures in the 2.5–4 Å range. Thus, RNA structures determined by cryo-EM require careful handling, and our method may be broadly applicable to other RNA systems.…”
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Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries
Published 2024-05-01“…Abstract The large-scale analysis of small-molecule binding to diverse RNA structures is key to understanding the required interaction properties and selectivity for developing RNA-binding molecules toward RNA-targeted therapies. …”
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A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions
Published 2025-02-01“…We determined the structure of a representative viral RNA-ribosome complex using cryoelectron microscopy (cryo-EM). 3D classification and variability analyses reveal that the viral RNA structure can sample a range of conformations while remaining tethered to the ribosome, enabling the ribosome to find a reinitiation start site within a limited range of mRNA sequence. …”
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CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure
Published 2023-04-01Get full text
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The Unpaved Road of Non-Coding RNA Structure–Function Relationships: Current Knowledge, Available Methodologies, and Future Trends
Published 2025-03-01“…The subjacent reasons for this relative lack of information regarding RNA structure are related to the specific chemical nature of RNA molecules and the limitations of the currently available methods for structural characterization of biomolecules. …”
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Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR
Published 2025-06-01Subjects: Get full text
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Correction: CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure
Published 2025-03-01Get full text
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Efficient translation initiation dictates codon usage at gene start
Published 2013-06-01Subjects: Get full text
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