Alternative RNA Splicing in Cardiac Diseases by Junli Gao, Yanan Zhang, Meiyu Hu, Tao He, Xiaohang Yin, Tian Hao, Guoping Li, Junjie Xiao

Get full text

RNA Splicing: A New Player in the DNA Damage Response by Silvia C. Lenzken, Alessia Loffreda, Silvia M. L. Barabino

“…In this review, we illustrate several different mechanisms through which pre-mRNA splicing and genomic stability can influence each other. …”
Get full text

Targeting RNA splicing modulation: new perspectives for anticancer strategy? by Xuemei Lv, Xiaoyu Sun, Yang Gao, Xinyue Song, Xiaoyun Hu, Lang Gong, Li Han, Miao He, Minjie Wei

“…Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tumors. …”
Get full text

Changes in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain by Xiaojie Yue, Lei Zhu, Zhigang Zhang

Subjects: Get full text

RNA splicing: a split consensus reveals two major 5′ splice site classes by Matthew T. Parker, Sebastian M. Fica, Gordon G. Simpson

Get full text

Genetic ancestry concordant RNA splicing in prostate cancer involves oncogenic genes and associates with recurrence by Muthana Al Abo, Wen-Chi Foo, Lauren E. Howard, Shannon McGue, Bonnie Lacroix, Julie Kephart, Angela Clayton, Blair Thornburg, Monika Anand, Michael B. Rothberg, Shannon J. McCall, Jiaoti Huang, Thomas A. Esther, Judd W. Moul, Michael N. Ferrandino, Thomas J. Polascik, Cary N. Robertson, Brant A. Inman, Andrew J. Armstrong, Yuan Wu, Terry Hyslop, Daniel J. George, Steven R. Patierno, Jennifer A. Freedman

“…Transcriptomic analysis identified differential alternative RNA splicing events (ARSs) between Black and White PCa patients. …”
Get full text

HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis by Hong Wang, Dong Qian, Jiabei Wang, Yao Liu, Wenguang Luo, Hongyan Zhang, Jingjing Cheng, Heng Li, Yang Wu, Wuhan Li, Jing Wang, Xia Yang, Tianzhi Zhang, Dong Han, Qinyao Wang, Chris Zhiyi Zhang, Lianxin Liu

Get full text

Transcriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas. by Victoria E S Armero, Marie-Pier Tremblay, Andréa Allaire, Simon Boudreault, Camille Martenon-Brodeur, Cyntia Duval, Mathieu Durand, Elvy Lapointe, Philippe Thibault, Maude Tremblay-Létourneau, Jean-Pierre Perreault, Michelle S Scott, Martin Bisaillon

“…Multiple human diseases including cancer have been associated with a dysregulation in RNA splicing patterns. In the current study, modifications to the global RNA splicing landscape of cellular genes were investigated in the context of Epstein-Barr virus-associated gastric cancer. …”
Get full text

The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis by Kun Meng, Yuying Li, Xiaoyi Yuan, Hui-Min Shen, Li-Ling Hu, Danya Liu, Fujin Shi, Dandan Zheng, Xinyu Shi, Nengqiao Wen, Yun Cao, Yun-Long Pan, Qing-Yu He, Chris Zhiyi Zhang

“…Here, we show that the novel protein TPM3P9, encoded by the lncRNA tropomyosin 3 pseudogene 9, exhibits oncogenic activity in clear cell renal cell carcinoma (ccRCC) by enhancing oncogenic RNA splicing. Overexpression of TPM3P9 promotes cell proliferation and tumor growth. …”
Get full text

Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro by Imran H. Chowdhury, Hema P. Narra, Abha Sahni, Kamil Khanipov, Casey L. C. Schroeder, Jignesh Patel, Yuriy Fofanov, Sanjeev K. Sahni

“…This study illustrates the genome-wide regulation of endothelial lncRNA splice variants in response to LPS and provides a foundation for further investigations of differentially expressed lncRNA transcripts in endothelial responses to LPS and pathophysiology of sepsis/septic shock.…”
Get full text

RAS, a Pentatricopeptide Repeat Protein, Interacts with OsTRX z to Regulate Chloroplast Gene Transcription and RNA Processing by Zhennan Qiu, Shiyong Wen, Peinan Sun, Dongdong Chen, Chunmiao Wang, Xiliang Song, Liying Xiao, Peiliang Zhang, Dongying Zhao, Cuiping Wen, Peiyan Guan, Xuechu Du, Yinghui Sun, Chenshan Xu, Jian Song

Subjects: Get full text

Identifying novel heterozygous PI4KA variants in fetal abnormalities by Chen Cheng, Fan Yang, Xinlin Chen, Sheng Zhao

Subjects: Get full text

Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA by Rayan Najjar, Xiaoxing Wang, Jose Mario Bello Pineda, Hugh Alessi, Alison Bays, Robert K. Bradley, James N. Jarvis, Tomas Mustelin

“…Objective To test whether messenger RNA (mRNA) splicing is altered in neutrophils from patients with systemic lupus erythematosus (SLE) and can produce neoantigens. …”
Get full text

DNA-Encoded Chromatin Structural Intron Boundary Signals Identify Conserved Genes with Common Function by Justin A. Fincher, Gary S. Tyson, Jonathan H. Dennis

“…The regulation of metazoan gene expression occurs in part by pre-mRNA splicing into mature RNAs. Signals affecting the efficiency and specificity with which introns are removed have not been completely elucidated. …”
Get full text

Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages. by Judith A Smith, Mike Khan, Diogo D Magnani, Jerome S Harms, Marina Durward, Girish K Radhakrishnan, Yi-Ping Liu, Gary A Splitter

“…Consistent with previous reports, XBP1 mRNA splicing was largely MyD88-dependent. However, up regulation of CHOP, and ERdj4 was completely MyD88 independent. …”
Get full text

The functional insight into the genetics of cardiovascular disease: results from the post-GWAS study by L. O. Bryzgalov, E. E. Korbolina, I. S. Damarov, T. I. Merkulova

“…A significant impact on binding sites of thirteen TFs including those involved in blood cells formation, hematopoiesis, macrophage function, inflammation, and vasoconstriction was found in K562 cells. 21 rSNP gene targets and 5 partners predicted by PPI were enriched for spliceosome and endocytosis KEGG pathways, endosome sorting complex and mRNA splicing REACTOME pathways. Related Gene Ontology terms included mRNA splicing and processing, endosome transport and protein catabolic processes. …”
Get full text

Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives by Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li

“…Abstract RNA pseudouridylation, a dynamic and reversible post‐transcriptional modification found in diverse RNA species, is crucial for various biological processes, including tRNA homeostasis, tRNA transport, translation initiation regulation, pre‐mRNA splicing, enhancement of mRNA translation, and translational fidelity. …”
Get full text

Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis by ZHANG Zongwen, FENG Li, FAN Zhisong

“…Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes, including embryonic development of the nervous and reproductive systems. hnRNPH1 is highly expressed in various tumor tissues and tumor cells, and its overexpression correlates with poor prognosis in patients. hnRNPH1 enhances tumor cell proliferation and metastasis through the regulation of alternative splicing of genes, modulation of gene expression, formation of fusion genes with other genes, and involvement in epigenetic regulation.Recent studies have shown that hnRNPH1 could serve as a potential biomarker for certain tumors, and hnRNPH1-targeting drugs show preliminary efficacy in a mouse model of melanoma. …”
Get full text

Comprehensive transcriptomic analysis reveals turnip mosaic virus infection and its aphid vector Myzus persicae cause large changes in gene regulatory networks and co-transcription... by Venura Herath, Clare L. Casteel, Jeanmarie Verchot

“…This study also shows that gene expressions are regulated through alternative pre-mRNA splicing and the use of alternative transcription start and termination sites. …”
Get full text

DDX1 is required for non-spliceosomal splicing of tRNAs but not of XBP1 mRNA by Teruhiko Suzuki, Satoko Takagi, Junta Funada, Yuka Egawa, Mana Yamakawa, Takahiko Hara

“…These results indicate that RTCB is required for the splicing of both tRNA and XBP1 mRNA, whereas the DDX1 enzymatic activity is specifically required for tRNA splicing in vivo.…”
Get full text