Molecular characterization and lineage analysis of canine astrovirus strains from dogs with gastrointestinal disease in Ecuador based on ORF-2 gene analysis by Anthony Loor-Giler, Anthony Loor-Giler, Silvana Santander-Parra, Sara Castillo-Reyes, Martín Campos, Martín Campos, Renan Mena-Perez, Renan Mena-Perez, Santiago Prado-Chiriboga, Santiago Prado-Chiriboga, Luis Nunez, Luis Nunez

“…Canine Astrovirus (CaAstV) part of the Astroviridae family and genus Mamastrovirus, is a linear RNA virus with a genome of approximately 6.6 kb with three open reading frames (ORF): ORF1a and ORF1b, which code for the most conserved non-structural proteins, and ORF2, which code for the capsid protein, the most variable region of the genome. …”
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Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7 by Deepa Singh, Tushar Kushwaha, Rajkumar Kulandaisamy, Vikas Kumar, Kamal Baswal, Saras H. Tiwari, Arkadyuti Ghorai, Manoj Kumar, Saroj Kumar, Soumya De, Aparoy Polamarasetty, Deepak Sehgal, Madhumohan R. Katika, Suresh Gadde, Marceline Côté, Sarala R. Kayampeta, Mohan Babu Appaiahgari, Krishna K. Inampudi

“…RdRp is a critical component of an RNA virus life cycle. Among coronaviruses, NSP12, along with one copy of NSP7 and two copies of NSP8, forms the RdRp holoenzyme and exhibits polymerase activity. …”
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An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode by Xiaoying Jia, Xuping Jing, Ming Li, Minli Gao, Yao Zhong, Entao Li, Yang Liu, Rui Li, Guoqiang Yao, Qiaojie Liu, Minmin Zhou, Yuxia Hou, Linfeng An, Yibao Hong, Shanshan Li, Jiancun Zhang, Wei Wang, Kaiming Zhang, Peng Gong, Sandra Chiu

“…Abstract By targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases. However, most ribose-modified NAs do not present broad-spectrum features, likely due to differences in ribose-RdRP interactions across virus families. …”
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Landscape of respiratory syncytial virus by Yuping Duan, Zimeng Liu, Na Zang, Bingbing Cong, Yuqing Shi, Lili Xu, Mingyue Jiang, Peixin Wang, Jing Zou, Han Zhang, Ziheng Feng, Luzhao Feng, Lili Ren, Enmei Liu, You Li, Yan Zhang, Zhengde Xie, Jing Ni

“…Respiratory syncytial virus (RSV) is an enveloped, negative-sense, single-stranded RNA virus of the Orthopneumovirus genus of the Pneumoviridae family in the order Mononegavirales. …”
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Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection by Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Jinkang Li, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Yu He, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng

“…Avian reovirus (ARV), a double-stranded RNA virus, frequently induces immunosuppression in poultry, leading to symptoms such as irregular bleeding and spleen necrosis in infected ducks. …”
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A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus. by Alexei Yu Kostygov, Danyil Grybchuk, Senne Heeren, Evgeny S Gerasimov, Donnamae Klocek, Aditya Reddy, Jovana Sádlová, Lenka Pacáková, Alain Kohl, František Stejskal, Petr Volf, Jean-Claude Dujardin, Vyacheslav Yurchenko

“…The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. …”
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Community structure of heritable viruses in a Drosophila-parasitoids complex by Varaldi, Julien, Lepetit, David, Burlet, Nelly, Faber, Camille, Baretje, Bérénice, Allemand, Roland

“…After two lab generations, putative DNA and RNA viruses were purified and sequenced. Our analysis revealed the presence of 53 viruses (including 37 new viruses), the great majority of which were RNA viruses. …”
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Viruses Seen by Our Cells: The Role of Viral RNA Sensors by Elias A. Said, Nicolas Tremblay, Mohammed S. Al-Balushi, Ali A. Al-Jabri, Daniel Lamarre

“…The role of the innate immune response in detecting RNA viruses is crucial for the establishment of proper inflammatory and antiviral responses. …”
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Synthesis and Antiviral Evaluation of 5-(4-Aryl-1,3-butadiyn-1-yl)-uridines and Their Phosphoramidate Pronucleotides by Evan Saillard, Otmane Bourzikat, Koffi Assa, Vincent Roy, Luigi A. Agrofoglio

“…The emergence of RNA viruses driven by global population growth and international trade highlights the urgent need for effective antiviral agents that can inhibit viral replication. …”
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Preventing Foodborne Illness: Norovirus by Keith R. Schneider, Renée M. Goodrich, Michael J. Mahovic, Rajya Shukla

“…Noroviruses (family Caliciviridae, genus Norovirus) are a group of non-enveloped, single-stranded RNA viruses found worldwide, with humans being the only known host. …”
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Flaviviruses—Induced Neurological Sequelae by Samantha Gabrielle Cody, Awadalkareem Adam, Andrei Siniavin, Sam S. Kang, Tian Wang

“…Flaviviruses, a group of single-stranded RNA viruses spread by mosquitoes or ticks, include several significant neurotropic viruses, such as West Nile virus (WNV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Zika virus (ZIKV). …”
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Preventing Foodborne Illness: Norovirus by Keith R. Schneider, Renée M. Goodrich, Michael J. Mahovic, Rajya Shukla

“…Noroviruses (family Caliciviridae, genus Norovirus) are a group of non-enveloped, single-stranded RNA viruses found worldwide, with humans being the only known host. …”
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Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids by Leah Liu Wang, Javier Seravalli, Brett Eaton, Yi Liu, Michael R. Holbrook, Wen-Jian Lan, Shi-Hua Xiang

“…Filoviruses, mainly consisting of the two genera of <i>Ebolavirus</i> and <i>Marburgvirus</i>, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates. …”
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Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolutionResearch in context by Yanan Li, Ru Xu, Fenglei Quan, Yonghua Wu, Yige Wu, Yongyuan Zhang, Yan Liang, Zhenzhong Zhang, Hua Gao, Ruijie Deng, Kaixiang Zhang, Jinghong Li

“…Summary: Background: The widespread and evolution of RNA viruses, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights the importance of fast identification of virus subtypes, particularly in non-laboratory settings. …”
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Discovery of novel tepovirus genomes with a nucleic acid-binding protein homolog by systematic analysis of plant transcriptome data by Dongjin Choi, Hyerin Park, Seungwoo Baek, Myeung Seok Choi, Sylvain Legay, Gea Guerriero, Jean-François Hausman, Yoonsoo Hahn

“…Some plant RNA viruses in the family Betaflexiviridae encode a nucleic acid-binding protein (NABP) that facilitates infection by suppressing the host RNA silencing response. …”
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A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

“…Our understanding of the RNA catalytic mechanism will be beneficial for ribozyme’s biotechnological applications and as potential therapeutics against RNA viruses.…”
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Effects of tissue type and season on the detection of regulated sugarcane viruses by high throughput sequencing by Stephen Bolus, Kate Wathen-Dunn, Samuel C. Grinstead, Xiaojun Hu, Martha Malapi, Dimitre Mollov

“…Using HTS on ribosomal depleted total RNA samples, we reliably detected RNA viruses in all tissue types and across all seasons, but we failed to confidently detect DNA viruses in some samples. …”
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Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…Interestingly, B cells also express some innate sensors, like TLR7 and TLR9, and may respond to bacterial hypomethylated CpG motifs and single-stranded RNA viruses. Intracellular nucleic acid sensing TLRs play an important role in the pathogenesis of Systemic Lupus Erythematosus (SLE). …”
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Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5’ untranslated region by Zhichao Tang, Shalakha Hegde, Siyuan Hao, Manikandan Selvaraju, Jianming Qiu, Jingxin Wang

“…Abstract One of the hallmarks of RNA viruses is highly structured untranslated regions (UTRs) which are often essential for viral replication, transcription, or translation. …”
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Viral RNA polymerase as a SUMOylation decoy inhibits RNA quality control to promote potyvirus infection by Linhao Ge, Mingxuan Jia, Hongying Shan, Weifang Gao, Lu Jiang, Hongguang Cui, Xiaofei Cheng, Marilyne Uzest, Xueping Zhou, Aiming Wang, Fangfang Li

“…Abstract Potyvirids are the largest group of plant RNA viruses. Pelota, a core component of RNA quality controls (RQC), promotes the degradation of potyvirids’ genomic RNA by recognizing a specific G1-2A6-7 motif. …”
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