Inflammatory Chemokine Expression via Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells by Hiroshi Tanaka, Tadaatsu Imaizumi

“…RIG-I and melanoma differentiation-associated gene 5 (MDA5) are members of the RNA helicase family in the cytosol, and both act as pathogen recognition receptors. …”
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hsa_circWDR37_016 Regulates Hypoxia-Induced Proliferation of Pulmonary Arterial Smooth Muscle Cells by Shan-Shan Li, Shuang Liang, Yao Long, Xu Chen, Xin Jin

“…Our previous clinical studies have demonstrated the importance of the downregulated circRNA in PAH. However, the role of upregulated circRNAs is still elusive. …”
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Iron-mediated post-transcriptional regulation in Toxoplasma gondii. by Megan A Sloan, Adam Scott, Dana Aghabi, Lucia Mrvova, Clare R Harding

“…The accumulation of transcript is likely driven by an increased reporter mRNA stability under low iron. Interestingly, we find iron-mediated changes in mRNA stability in around 400 genes. …”
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Application of Bioinformatics Tools for the Prediction of Helper MicroRNAs for Improvement of Oncolytic Virus Efficacy by Nasrin Rastegarvand, Hoorieh Soleimanjahi, Ehsan Arefian, Mahmoud Reza Pourkarim

“…So, the main aim of this bioinformatic study is to check which microRNA is able to target some reovirus inhibitory proteins. …”
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Alterations in Mucin-Associated Gene Expression on the Ocular Surface in Active and Stable Stages of Atopic and Vernal Keratoconjunctivitis by Mariko Horinaka, Jun Shoji, Akiko Tomioka, Yukiko Tonozuka, Noriko Inada, Satoru Yamagami

“…To evaluate the presence of ocular surface mucin in patients with atopic and vernal keratoconjunctivitis (AKC/VKC), we investigated the mRNA expression levels of SAM-pointed domain-containing ETS-like factor (SPDEF) and mucin-related genes on the ocular surface. …”
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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression by Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Størling, Thomas Mandrup-Poulsen

“…Transient knockdown of Myc also prevented IL-1β-induced apoptosis as well as caspase 3 cleavage. JNK2 shRNA potentiated IL-1β-induced apoptosis and caspase 3 cleavage, whereas JNK3 shRNA did not affect IL-1β-induced β-cell death compared to nonsense shRNA expressing INS-1 cells. …”
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Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases by Chang Youn Lee, Ran Kim, Onju Ham, Jihyun Lee, Pilseog Kim, Seokyeon Lee, Sekyung Oh, Hojin Lee, Minyoung Lee, Jongmin Kim, Woochul Chang

“…Various studies have recently reported increased therapeutic potential of transplantation of microRNA- (miRNA-) overexpressing stem cells or small-molecule-treated cells. …”
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RETRACTED ARTICLE: Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients by Xiliang Zhang, Hanjie Guo, Xiaolong Li, Wei Tao, Xiaoqing Ma, Yuxing Zhang, Weidong Xiao

“…Methods We used a multi-omics approach combining bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) to study polyamine metabolism. …”
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Impact of COVID-19 vaccination on tinnitus onset and severity: a comprehensive survey study by Anusha Yellamsetty, Egbe-Etu Etu, Shaowen Bao

“…There was no significant difference in tinnitus onset latency between mRNA vaccines (Pfizer and Moderna) and non-mRNA vaccines (Johnson & Johnson). …”
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Gene Expression of Adhesion Molecules in Endothelial Cells from Patients with Peripheral Arterial Disease Is Reduced after Surgical Revascularization and Pharmacological Treatment by Franca Marino, Luigina Guasti, Matteo Tozzi, Laura Schembri, Luana Castiglioni, Elisabetta Molteni, Gabriele Piffaretti, Patrizio Castelli, Marco Cosentino

“…AM mRNA expression was significantly higher in pEC than in cEC. …”
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Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice by Jing Han, Zhenglin Wang, Wei Xing, Yueying Yuan, Yi Zhang, Tiantian Lv, Hongliang Wang, Yonggang Liu, Yan Wu

“…The RNA-seq results were validated by the results of RT-qPCR of 4 genes identified as differentially expressed. …”
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FAM98 Family Proteins Play Distinct Roles in Osteoclastogenesis and Bone Resorption by Lei Wang, Tarun Minocha, Bhaba K. Das, Mikaela D. Kunika, Aarthi Kannan, Ling Gao, Subburaman Mohan, Weirong Xing, Kottayil I. Varughese, Haibo Zhao

“…While the knockdown of Fam98c by a specific short-hairpin RNA (shRNA) in osteoclast precursors attenuated osteoclastogenesis, depletion of Fam98b by an shRNA specifically disrupted osteoclast lysosome trafficking and bone resorption with phenotypes similar to Fam98a shRNA-knockdown in our previous study. …”
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Expression Profile of Long Noncoding RNAs and Circular RNAs in Mouse C3H10T1/2 Mesenchymal Stem Cells Undergoing Myogenic and Cardiomyogenic Differentiation by Mingshan Li, Zijie Pei, Hongtao Zhang, Jing Qu

“…In this study, 5-azacytidine- (5-AZA-) treated C3H10T1/2 cells were differentiated into myocyte-like and cardiomyocyte-like cells. Next, ncRNA associated with myogenic and cardiomyogenic differentiation was identified using high-throughput RNA sequencing (RNA-seq) data. …”
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In silico analysis of SNPs and miRNAs of KCTD13, CSDE1, SLC6A1 genes associated with autism spectrum disorder by Kübra Çoruh Kınalı, Ebru Özkan Oktay, Mesut Karahan

“…Micro-RNAs (miRNAs) are short, non-coding RNA molecules that control gene expression after transcription. …”
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Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats by Lin Zhang, Hua Peng, Jin Xu, Yixin Xu, You Yin, Bin He, Jianhua Zhuang

“…At weeks 1, 2, 3, and 4 after modeling, there were no significant differences between the control group and the DOPS group in the mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, p38, and MKP-1 (all P>0.05); the mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, and p38 were significantly increased, while the phosphorylation of MKP-1 was decreased in the model group compared with the control group. …”
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Survivin is Highly Expressed and Promotes Cell Survival in Malignant Peritoneal Mesothelioma by Nadia Zaffaroni, Aurora Costa, Marzia Pennati, Cinzia De Marco, Emanuela Affini, Maria Madeo, Roberta Erdas, Antonello Cabras, Shigeki Kusamura, Dario Baratti, Marcello Deraco, Maria Grazia Daidone

“…MPM cells were transfected with a small-interfering RNA (siRNA) targeting survivin mRNA and analyzed for survivin expression, growth rate, and ability to undergo spontaneous and drug (cisplatin, doxorubicin)-induced apoptosis. …”
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Transitioning from wet lab to artificial intelligence: a systematic review of AI predictors in CRISPR by Ahtisham Fazeel Abbasi, Muhammad Nabeel Asim, Andreas Dengel

“…Abstract The revolutionary CRISPR-Cas9 system leverages a programmable guide RNA (gRNA) and Cas9 proteins to precisely cleave problematic regions within DNA sequences. …”
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Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression by Daphne Wijnbergen, Mridul Johari, Ozan Ozisik, Peter A.C. ‘t Hoen, Friederike Ehrhart, Anaïs Baudot, Chris T. Evelo, Bjarne Udd, Marco Roos, Eleni Mina

“…These subnetworks are related to antigen processing and presentation, chemokine-mediated signaling, immune response-signal transduction, rRNA processing, and mRNA splicing. An interesting finding is that the antigen processing and presentation subnetwork links the underexpressed miR-16-5p to overexpressed HLA genes by negative expression correlation. …”
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Troglitazone and Δ2Troglitazone Enhance Adiponectin Expression in Monocytes/Macrophages through the AMP-Activated Protein Kinase Pathway by Jaw-Shiun Tsai, Lee-Ming Chuang, Ching-Shih Chen, Chan-Jung Liang, Yuh-Lien Chen, Ching-Yu Chen

“…TG induced adiponectin mRNA expression through a PPARγ-dependent pathway whereas Δ2TG enhanced adiponectin mRNA expression through a PPARγ-independent pathway in THP-1 cells. …”
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Analysis of Microarray-Identified Genes and MicroRNAs Associated with Idiopathic Pulmonary Fibrosis by Lichao Fan, Xiaoting Yu, Ziling Huang, Shaoqiang Zheng, Yongxin Zhou, Hanjing Lv, Yu Zeng, Jin-Fu Xu, Xuyou Zhu, Xianghua Yi

“…The aim of this study was to identify potential microRNAs and genes associated with idiopathic pulmonary fibrosis (IPF) through web-available microarrays. The microRNA microarray dataset GSE32538 and the mRNA datasets GSE32537, GSE53845, and GSE10667 were downloaded from the Gene Expression Omnibus (GEO) database. …”
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