Synergistic Activations of REG Iα and REG Iβ Promoters by IL-6 and Glucocorticoids through JAK/STAT Pathway in Human Pancreatic β Cells by Akiyo Yamauchi, Asako Itaya-Hironaka, Sumiyo Sakuramoto-Tsuchida, Maiko Takeda, Kiyomi Yoshimoto, Tomoko Miyaoka, Takanori Fujimura, Hiroki Tsujinaka, Chikatsugu Tsuchida, Hiroyo Ota, Shin Takasawa

“…Furthermore, small interfering RNA-mediated targeting of STAT3 blocked the IL-6+Dx-induced expression of REG Iα and REG Iβ. …”
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Identification of a Ferroptosis-Related Signature Associated with Prognosis and Immune Infiltration in Adrenocortical Carcinoma by Xi Chen, Lijun Yan, Feng Jiang, Yu Lu, Ni Zeng, Shufang Yang, Xianghua Ma

“…Our study aimed to establish a ferroptosis-related signature with prognostic value in ACC. RNA-seq data and corresponding clinical characteristics for ACC were downloaded from TCGA and GEO databases. …”
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Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma by Chuyu He, Xuejuan Wang, Yi-Shiou Chiou, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

“…Targeting TFF3 with an interfering RNA plasmid or a small-molecule inhibitor (AMPC) inhibited these oncogenic characteristics, highlighting the therapeutic potential of targeting TFF3 in ER+HER2+ MC. …”
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Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP by Min Kyeong Kim, Kyong-Ah Yoon, Eun Young Park, Jungnam Joo, Eun Young Lee, Hyeon-Seok Eom, Sun-Young Kong

“…Previous studies have revealed that the transcription of IL10 mRNA and its protein expression may be infl uenced by several single-nucleotide polymorphisms in the promoter and intron regions, including rs1800896, rs1800871, and rs1800872. …”
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Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. by Selma Hurem, Leonardo Martín Martín, Dag Anders Brede, Eystein Skjerve, Rasoul Nourizadeh-Lillabadi, Ole Christian Lind, Terje Christensen, Vidar Berg, Hans-Christian Teien, Brit Salbu, Deborah Helen Oughton, Peter Aleström, Jan Ludvig Lyche

“…Molecular responses analyzed by RNA-seq at gastrulation (5.5 hpf transcriptome) indicate that the radiation induced adverse effects occurred during the earliest stages of development. …”
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Bile acids in the lower airways is associated with airway microbiota changes in chronic obstructive pulmonary disease: an observational study by Peter A B Wark, Siobhain Mulrennan, Stephen Stick, Yuben P Moodley, Kristy S Nichol, Jose A Caparros-Martin, Montserrat Saladié, S Patricia Agudelo-Romero, F Jerry Reen, Fergal O’Gara

“…We profiled the BAL microbiota using an amplicon sequencing approach targeting the V3-V4 region of the 16S rRNA gene.Results Detection of BAs in BAL was more likely at the earliest clinical stages of COPD and was independent of the degree of airway obstruction. …”
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Migration of primordial germline cells is negatively regulated by surrounding somatic cells during early embryogenesis in Drosophila melanogaster by N. V. Dorogova, A. S. Khruscheva, Iu. A. Galimova, D. Yu. Oshchepkov, D. E. Maslov, E. D. Shvedkina, K. A. Akhmetova, S. A. Fedorova

“…We identified the myc, Hph, stat92E, Tre-1, and hop genes, whose RNA interference leads to premature active PGC migration at stages 4–7 of embryogenesis. …”
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Specific types of male infertility are correlated with T cell exhaustion or senescence signatures by Giada Amodio, Giorgia Giacomini, Luca Boeri, Massimiliano Raffo, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Fausto Negri, Anna Maria Ferrara, Alessia d’Arma, Francesca Romana Santoni de Sio, Luca Pagliardini, Enrico Papaleo, Eugenio Ventimiglia, Massimo Alfano, Francesco Montorsi, Andrea Salonia, Silvia Gregori

“…Here, by combining multiparameter phenotyping and scRNA-seq, we delineate the immune status of infertile men both at the semen and systemic levels. …”
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miR-133b在甲基苯丙胺诱导PC12细胞凋亡中的调控作用 by 刘海莉, 王洪杰, 扈燕来, 孙晋浩, 董晓光

“…【目的】探讨小分子非编码RNA 133b在甲基苯丙胺（MA）导致神经元毒性损伤中的表达变化及其对神 经细胞凋亡的调控作用。…”
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Promising markers of CIMP+ colon tumors identified on the basis of TCGA data analysis by G. S. Krasnov, A. D. Beniaminov, R. A. Tychko, G. A. Puzanov, R. O. Novakovskiy, A. V. Kudryavtseva, A. A. Dmitriev

“…To verify the obtained data in independent sampling, first, the quantitative PCR was used to assess the relative mRNA level of the AMOTL1, ZNF43, ZNF134, and CHFR genes in 30 paired (tumor/histologically normal tissue) colon samples. …”
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Epidemiological and molecular characterization of investigation of Mycoplasma gallisepticum of goose origin in Guangdong (China) by Nan Zhang, Yixin Jia, Weihuo Li, Yangshuo Li, Jingyi Liang, Zhaofeng Yao, Sheng Yuan, Hong Yang, Huanzhong Ding, Yuanyuan Zhou

“…Despite high genomic similarities between geese and chickens MG strains, significant differences were found in the 16S rRNA and mgc2 genes. The mgc2 gene typing results revealed that the clinical strain of MG in goose was of the H∼M type, distinct from the reference strain of MG in chickens (A∼G type). …”
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Molecular Mechanism of Germinated Foxtail Millet Bioactive Peptides in Attenuating Copper-induced Oxidative Damage in Caenorhabditis elegans by Huiqi ZHANG, Xiao CHEN, Xueling JIN, Jingjing LI, Juanli YUAN, Jinyan GAO, Hongbing CHEN, Yong WU

“…Furthermore, the mechanism of action of GRBPs was explored through genomic and transcriptomic sequencing techniques (RNA-seq) and untargeted metabolomics analysis. Antioxidant-related genes were validated by reverse transcription and real-time quantitative PCR (qPCR). …”
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Integrative analysis of 5-methylcytosine associated signature in papillary thyroid cancer by Ying Ding, Xinying Li, Wenlong Wang, Lei Cai

“…This study aims to explore the regulation mechanism of m5C RNA methylation-related long noncoding RNAs (m5C-lncRNAs) in papillary thyroid cancer (PTC). …”
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Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin by Craig A. Swearingen, John H. Sloan, Grace M. Rhodes, Robert W. Siegel, Nico Bivi, Yuewei Qian, Robert J. Konrad, Michael Boffa, Marlys Koschinsky, John Krege, Giacomo Ruotolo, Stephen J. Nicholls, Laura F. Michael, Yi Wen

“…Muvalaplin phase I multiple ascending dose study samples and lepodisiran, a small-interfering RNA that lowers Lp(a), phase I single ascending dose study samples were analyzed using the intact Lp(a) assay and commercial assays. …”
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Unveiling the Effect of Age and IgE Level on Alopecia Areata: Insights from Comparative RNAseq Analysis by Liu H, Yang S, Xian H, Liu Y, Zhang Y, Chen Y, Xu Y, Liu J, Yang B, Luo Y

“…Moreover, pediatric AA patients with atopic predisposition often exhibit elevated IgE levels, early onset, and a poor prognosis.Purpose: This study aimed to investigate the impact of age and IgE levels on AA by conducting RNA sequencing on scalp samples from AA patients with atopic predisposition, age-matched healthy controls, and AA samples with varying IgE levels.Patients and Methods: We employed the single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm in conjunction with gene expression analysis to assess immune infiltration. …”
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Graphene nanomaterial-based electrochemical biosensors for salivary biomarker detection: A translational approach to oral cancer diagnostics by D. Mahalakshmi, J. Nandhini, G. Meenaloshini, E. Karthikeyan, KK Karthik, J. Sujaritha, Vandhana, V, C. Ragavendran

“…We discuss the unique advantages of saliva as a diagnostic medium and highlight the key salivary biomarkers associated with oral cancer, including proteins, DNA, and RNA. Various electrochemical detection techniques, such as cyclic voltammetry, differential pulse voltammetry, electrochemical impedance spectroscopy, field-effect transistors, amperometry, chronoamperometry, and photoelectrochemical methods, are explored in the context of graphene-based biosensors. …”
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Inhalation of patchouli essential oil alleviates airway inflammation in cigarette smoke-induced COPD mice by Yan Zhang, Rui Cao, Duo Wang, Qiulin Yue, Le Su, Kunlun Li, Baojun Li, Lin Zhao, Song Zhang

“…Furthermore, PEO treatment reduced the levels of inflammatory factors IL-6, IL-1β, and TNF-α, and reversed the CS-induced elevation of mRNA levels of these factors. Additionally, PEO treatment significantly countered cigarette smoke-induced COPD via the NF-κB signaling pathway in mice; Our result has shown that inhalation of PEO can substantially alleviate the increase in inflammatory factors, mitigate lung function impairment, and reduce airway remodeling in cigarette smoke-induced COPD mice.…”
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自发性高血压大鼠TGFβ1/ Smad7通路与心室纤维化的关系 by 高修仁, 翟原生, 彭龙云, 何旭瑜, 郭小刚, 朱莺莺

“…与SHR14周龄组相比，SHR22周龄组的心室质量指数、心肌羟脯氨酸的含量、Ⅰ型和Ⅲ型胶原均明显增加（P<0.01）；在mRNA 水平或蛋白水平，心肌中的TGFβ1的表达上调，smad7的表达下调。[结论]在一定的时间窗内，自发性高血压大鼠血压的升高及心肌纤维化随着病程的进展而发展，同时伴随着TGFβ1的表达上调，smad7的表达下调。…”
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Identification of tacrolimus-related genes in familial combined hyperlipidemia and development of a diagnostic model using bioinformatics analysis by Yuan Xu, Hongfei He, Haiyang Li

“…Finally, we examined the regulatory network of screened key genes that interact with RNA-binding proteins, potential drugs, small-molecule compounds, and transcription factors. …”
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The landscape of rare mitochondrial DNA variants in sudden cardiac death: A potential role for ATP synthase by Elena Luppi, Monica De Luise, Carla Bini, Guido Pelletti, Gaia Tioli, Ivana Kurelac, Luisa Iommarini, Susi Pelotti, Giuseppe Gasparre

“…No known or novel mtDNA pathogenic variants were found. Two rRNA and 8 missense variants were rarer than polymorphisms as they had a frequency lower than 1% in population databases. 5/8 missense variants clustered in ATP synthase genes and 4/8 missense variants were previously detected in patients with suspected mitochondriopathy. …”
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