Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites by Brian J. Parrett, Satoko Yamaoka, Michael A. Barry

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Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice by Yu Yang, Yu Chen, Changju Liu, Su Wang, Yijing Zhao, Wen Cao, Kun Wang

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Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2 by Niti Yashvardhini, Amit Kumar, Deepak Kumar Jha

“…In the present study, B- and T-cell immune epitopes were identified for RdRp (RNA-dependent RNA polymerase) protein using immunoinformatic techniques, which is proved to be a rapid and efficient method to explore the candidate peptide vaccine. …”
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Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation by Ayla Valinezhad Orang, Reza Safaralizadeh, Mina Kazemzadeh-Bavili

“…It was primarily acknowledged that miRNAs result in gene expression repression at both the level of mRNA stability by conducting mRNA degradation and the level of translation (at initiation and after initiation) by inhibiting protein translation or degrading the polypeptides through binding complementarily to 3′UTR of the target mRNAs. …”
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Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors by Gang Li, Jing Zhang, Bentuo Zhang, Dan Wang, Zequn Wang, Yan Pan, Lijie Ma

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MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses by Yupei Zhang, Songhui Zhai, Shugang Qin, Yuting Chen, Kepan Chen, Zhiying Huang, Xing Lan, Yaoyao Luo, Guohong Li, Hao Li, Xi He, Meiwan Chen, Zhongwei Zhang, Xingchen Peng, Xin Jiang, Hai Huang, Xiangrong Song

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Construction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke. by Meimei Xu, Shan Yuan, Xing Luo, Mengsi Xu, Guangze Hu, Zhe He, Xinyuan Yang, Rui Gao

“…This led to the establishment of a comprehensive lncRNA-miRNA-mRNA regulatory network comprising 12 lncRNAs, 16 sponge miRNAs, and 191 target mRNAs. …”
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The miRNA‐mRNA Regulatory Network in Human Hepatocellular Carcinoma by Transcriptomic Analysis From GEO by Razieh Heidari, Vahideh Assadollahi, Seyedeh Negar Marashi, Fatemeh Elahian, Seyed Abbas Mirzaei

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A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis by Jiwei Xue, Fanfan Xie, Junmei Xu, Yuan Liu, Yu Liang, Zhining Wen, Menglong Li

“…MicroRNA (miRNA) plays an important role in the degradation and inhibition of mRNAs and is a kind of essential drug targets for cancer therapy. …”
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Viral RNA polymerase as a SUMOylation decoy inhibits RNA quality control to promote potyvirus infection by Linhao Ge, Mingxuan Jia, Hongying Shan, Weifang Gao, Lu Jiang, Hongguang Cui, Xiaofei Cheng, Marilyne Uzest, Xueping Zhou, Aiming Wang, Fangfang Li

“…Abstract Potyvirids are the largest group of plant RNA viruses. Pelota, a core component of RNA quality controls (RQC), promotes the degradation of potyvirids’ genomic RNA by recognizing a specific G1-2A6-7 motif. …”
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MicroRNA Dysregulation in Cystic Fibrosis by Paul J. McKiernan, Catherine M. Greene

“…Their involvement in the pathogenesis of CF lung disease stems from the fact that their expression is altered in vivo in the CF lung due to intrinsic and extrinsic factors; to date defective chloride ion conductance, endoplasmic reticulum stress, inflammation, and infection have been implicated in altering endogenous miRNA expression in this setting. Here, the current state-of-the-art and biological consequences of altered microRNA expression in cystic fibrosis are reviewed.…”
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RNA methylation in neurodevelopment and related diseases by Xia Wenjuan, Liu Yue, Lu Jiafeng, Cheung Hoi-Hung, Meng Qingxia, Huang Boxian

Subjects: “…RNA methylation…”
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Micro-RNA Expression and Function in Lymphomas by Sukhinder K. Sandhu, Carlo M. Croce, Ramiro Garzon

“…In this paper, we attempt to describe the expression of miRNAs and their function in lymphomas and discuss potential miRNA-based therapies in the diagnosis and treatment of lymphomas.…”
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Alternative RNA Splicing in Cardiac Diseases by Junli Gao, Yanan Zhang, Meiyu Hu, Tao He, Xiaohang Yin, Tian Hao, Guoping Li, Junjie Xiao

“…Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention, or the selection of alternative splice sites modify transcript isoforms, which can consequently affect RNA molecules, including mRNA and non-coding RNAs, in terms of their localization, regulation, and overall function. …”
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MicroRNA Profiling in Cartilage Ageing by Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter Clegg, Yongxiang Fang, Andy Cremers, Pieter Emans, Tim Welting, Mandy Peffers

“…Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. …”
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mRNA vaccines as cancer therapies by Shaoxiong Huang, Haiying Que, Manni Wang, Xiawei Wei, Yanjie Yin

“…This review provides an in-depth analysis of messenger RNA (mRNA) vaccines as a therapeutic approach for cancer immunotherapy, focusing on their molecular biology, classification, mechanisms, and clinical studies. …”
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Long Noncoding RNA Regulation of Pluripotency by Alessandro Rosa, Monica Ballarino

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The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis by Kun Meng, Yuying Li, Xiaoyi Yuan, Hui-Min Shen, Li-Ling Hu, Danya Liu, Fujin Shi, Dandan Zheng, Xinyu Shi, Nengqiao Wen, Yun Cao, Yun-Long Pan, Qing-Yu He, Chris Zhiyi Zhang

“…Here, we show that the novel protein TPM3P9, encoded by the lncRNA tropomyosin 3 pseudogene 9, exhibits oncogenic activity in clear cell renal cell carcinoma (ccRCC) by enhancing oncogenic RNA splicing. …”
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The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5 by Abdullah Shah, Farooq Rashid, Hassaan Mehboob Awan, Shanshan Hu, Xiaolin Wang, Liang Chen, Ge Shan

“…DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism. …”
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Integrated Analysis of mRNA and lncRNA Expression Profiles Reveals Regulatory Networks Associated with Decompensated Cirrhosis by Li Zhang, Xiaoyu Fang, Suhua Wang, Shasha Ma, Jinyan Zhang, Xiang Dong, Jing Dai, Chuanmiao Liu, Yu Gao

“…Four patients with decompensated cirrhosis and four controls with liver cirrhosis were recruited in this study. RNA was isolated from peripheral blood mononuclear cells, and RNA-seq was used for transcriptome analysis. …”
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