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  1. 3801

    Cancer Stem Cell Marker Endoglin (CD105) Induces Epithelial Mesenchymal Transition (EMT) but Not Metastasis in Clear Cell Renal Cell Carcinoma by Junhui Hu, Wei Guan, Libin Yan, Zhangqun Ye, Lily Wu, Hua Xu

    Published 2019-01-01
    “…The knockdown of CD105 by RNA interference led to the downregulation of N-cadherin and the upregulation of E-cadherin and reduced motility and invasiveness of CD105(+) cells. …”
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    Article
  2. 3802

    PPIH is a novel diagnostic biomarker associated with immune infiltration in cholangiocarcinoma by Jun Ye, Zhitao Chen, Chuan Zhang, Rui Xie, Haini Chen, Peng Ren

    Published 2025-02-01
    “…Results Our findings indicate that overexpression of PPIH mRNA in CHOL is associated with poor prognosis, with increased PPIH protein levels observed in CHOL tissues. …”
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    Article
  3. 3803

    Harnessing the diversity of a lettuce wild relative to identify anthocyanin-related genes transcriptionally responsive to drought stress by Inés Medina-Lozano, Inés Medina-Lozano, Jérôme Grimplet, Jérôme Grimplet, Aurora Díaz, Aurora Díaz

    Published 2025-01-01
    “…A transcriptomic study in the variety ‘Romired’ and the wild relative Lactuca homblei was conducted to understand the increase in anthocyanins (only significant in L. homblei) in response to drought previously observed. RNA-seq revealed more differentially expressed genes (DEGs), especially upregulated, in the wild species, in which the most abundant and significant GO terms were involved in regulatory processes (including response to water). …”
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    Article
  4. 3804

    Effect of chikungunya, Mayaro and Una virus coinfection on vector competence of Aedes aegypti mosquitoes by Tessa M. Visser, Haidong D. Wang, Sandra R. Abbo, Chantal B.F. Vogels, Constantianus J.M. Koenraadt, Gorben P. Pijlman

    Published 2025-06-01
    “…Mosquitoes were incubated for ten days at 28 °C and 70 % humidity. After RNA extractions from mosquito bodies and saliva, the presence and relative quantity of each virus in coinfected mosquitoes was determined. …”
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    Article
  5. 3805

    Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype by Xinzhi Xu, Tianwen Qiu, Kexin Sun, Xue Han, Junxia Huang, Xiuyuan Wang, Jianchao Ge, Ji Yang

    Published 2025-02-01
    “…Transcriptomic data from skin samples was utilized to assess immune infiltration and investigate the correlation between protein and mRNA levels of biomarkers. Additionally, the prognostic value and clinical significance of identified biomarkers were validated through follow-up studies of DM patients and immunofluorescence analysis of skin tissues. …”
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    Article
  6. 3806

    Transcriptomics Analysis Reveals Differences in Purine and Phenylpropanoid Biosynthesis Pathways Between <i>Camellia sinensis</i> var. Shuchazao and <i>Camellia ptilophylla</i> by Waqar Khan, Peng Zheng, Binmei Sun, Shaoqun Liu

    Published 2024-12-01
    “…Shuchazao (SCZ) and <i>Camellia ptilophylla</i> (CAF)) and identified diversity in the gene expression levels and major regulatory transcription factors (TFs) for the characterization of purine alkaloids and phenylpropanoid biosynthesis pathways. The RNA-seq analysis of two species (SCZ and CAF) revealed the differences in caffeine and catechins synthesis. …”
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    Article
  7. 3807

    Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder by Dalia Moore, Brittney M. Meays, Lepakshe S. V. Madduri, Farah Shahjin, Subhash Chand, Meng Niu, Abrar Albahrani, Chittibabu Guda, Gurudutt Pendyala, Howard S. Fox, Sowmya V. Yelamanchili

    Published 2019-01-01
    “…We previously have identified an evolutionary young miRNA, miR-1290, to be essential in neural stem cell proliferation and neuronal differentiation. …”
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    Article
  8. 3808

    Involvement of Neuropeptide Y within Paraventricular Nucleus in Electroacupuncture Inhibiting Sympathetic Activities in Hypertensive Rats by Qi Zhang, Yingying Tan, Xin Wen, Fangfang Li

    Published 2022-01-01
    “…The results showed that the enhanced arterial BP and sympathetic activities were effectively reduced by 30 days of EA treatment, and baroreflex sensitivity was improved in 2K1C hypertensive rats. The level of NPY mRNA and protein expression in the PVN was markedly upregulated by EA treatment in 2K1C rats. …”
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    Article
  9. 3809

    Transcription factor KLF2 is associated with the dysfunctional status of NK cells and the prognosis of pediatric B-ALL patients by Fang Wu, Huimin Xu, Benshan Zhang

    Published 2025-01-01
    “…We also analyzed published single-cell RNA sequencing (scRNAseq) data from B-ALL and normal bone marrow samples using unsupervised clustering. …”
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    Article
  10. 3810

    A comprehensive pan-cancer analysis of RNF187 in human tumors by Xuezhong Zhang, Xuebin Zhang, Tonggang Liu, Kaihui Sha

    Published 2025-01-01
    “…Our investigation also unveiled correlations between RNA modification of RNF187 across various cancer types. …”
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    Article
  11. 3811

    Recent advances of nanovaccines on cancer theranostics by Xiaobing Yuan, Xiaobing Yuan, Xiaobing Yuan, Tianyou Xu, Mubashir Hussain, Bin Liu, Jianwei Zhu, Jianwei Zhu

    Published 2025-02-01
    “…We believe that polymer nanoparticle-based nanovaccines have the most widespread applications currently, while liposome nanovaccines using mRNA are expected to see greater development in the future. …”
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    Article
  12. 3812

    Re-identification of Strains from Aspergillus Section Aspergillus and Description of Three Unrecorded Species from Korea by Anbazhagan Mageswari, Daseul Lee, Le Dinh Thao, Donghun Kang, Dong-Hyun Kim, Seung-Beom Hong

    Published 2024-09-01
    “…In this study, 108 strains from the section Aspergillus, originating from Korea and conserved at the Korean Agricultural Culture Collection, were subjected to re-identification using a combined dataset that included partial sequences of β-tubulin (BenA), Calmodulin (CaM), and RNA polymerase II second largest subunit (RPB2) genes, along with their morphological characteristics. …”
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    Article
  13. 3813

    hUC-MSCs Attenuate Acute Graft-Versus-Host Disease through Chi3l1 Repression of Th17 Differentiation by Weijiang Liu, Fulin Yuan, Haitao Bai, Yuanlin Liu, Xue Li, Yang Wang, Yi Zhang

    Published 2022-01-01
    “…To reveal their potential immunosuppressive molecules, we used RNA sequencing to analyze gene expression in different tissue-derived MSCs, including human bone marrow, umbilical cord, amniotic membrane, and placenta, and found that chitinase-3-like protein 1 (Chi3l1) was highly expressed in human umbilical cord mesenchymal stem cells (hUC-MSCs). …”
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  14. 3814

    N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis by Bin Ma, Jing Li, Wen-Ke Yang, Mei-Gui Zhang, Xiao-Dong Xie, Zhong-Tian Bai

    Published 2021-01-01
    “…However, the specific targets and detailed mechanisms still need to be clarified. Screening with RNA-Seq in Huh7 cells treated with FO revealed that 317 genes were modulated, of which 188 genes were upregulated and 129 genes were downregulated. …”
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    Article
  15. 3815

    Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB by Bai Y, Wang X, Wang B

    Published 2025-01-01
    “…The study also demonstrated that PDGFB was linked to RNA and DNA stemness in 15 and 36 tumor types, respectively, and had a positive association with tumor lymphocyte infiltration. …”
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    Article
  16. 3816

    Isolation and Identification of Some Probiotic Bacteria and Their Potential Role in Improving Immune Response and Resistance of Nile Tilapia (Oreochromis niloticus) in Comparison w... by Mosleh M. Abomughaid

    Published 2020-01-01
    “…The potential probiotic based on the in vitro antimicrobial activity test was identified as P. putida using routine and gel electrophoresis and 16S rRNA sequencing. During the first and the second month of experiment, there was a highly significant increase in the survival percent of the experimental fish in both treated groups with probiotics. …”
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    Article
  17. 3817

    Expression of P450arom and Estrogen Receptor Alpha in the Oviduct of Chinese Brown Frog (Rana dybowskii) during Prehibernation by Ji Weng, Yuning Liu, Ying Xu, Ruiqi Hu, Haolin Zhang, Xia Sheng, Gen Watanabe, Kazuyoshi Taya, Qiang Weng, Meiyu Xu

    Published 2015-01-01
    “…ERα was expressed in stromal tissue and epithelial cells in both periods, whereas ERβ could not be detected. The mean protein and mRNA levels of P450arom and ERα were significantly higher in prehibernation as compared to the breeding period. …”
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    Article
  18. 3818

    Sophocarpine inhibits the proliferation and induces apoptosis of glioblastoma cells through regulating the miR-21/PTEN/PI3K/AKT axis by Feng Si, Qian Wang, Fei Chen, Xiangdong Lu

    Published 2025-02-01
    “…CCK-8 was applied to analyze cell toxicity and proliferation. qRT-PCR and western blot were used to measure RNA and protein expressions, respectively. Cell cycle and cell apoptosis were determined by flow cytometry assay. …”
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  19. 3819

    Pan-cancer analysis shows that TNFSF4 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including liver cancer by Zhaoda Deng, Lincheng Li, Zihe Meng, Guineng Zeng, Rui Cao, Rong Liu

    Published 2025-01-01
    “…Therefore, comprehensive bioinformatics analysis of pan-cancer was performed to determine the mechanisms through which TNFSF4 regulates tumorigenesis. Methods RNA-seq data for 33 cancers were analyzed from UCSC XENA database. …”
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  20. 3820

    Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer by Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo

    Published 2021-10-01
    “…Using a CRISPR/Cas9-based SAM (synergistic activation mediator) library against a focus group of lncRNAs, we identify Lnc-DC as a candidate lncRNA. Further analysis suggests that Lnc-DC is able to reduce tamoxifen-induced apoptosis by upregulation of anti-apoptotic genes such as Bcl2 and Bcl-xL. …”
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    Article