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3761
Development of a Novel Prognostic Model for Lung Adenocarcinoma Utilizing Pyroptosis-Associated LncRNAs
Published 2025-01-01“…This study successfully established a LUAD prognostic model based on pRLs, which provides new insights into lncRNA-based LUAD diagnosis and treatment strategies.…”
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3762
Comparative Study on the Effects of Four Plant Protein Sources on the Liver and Intestinal Health of Largemouth Bass, Micropterus salmoides
Published 2024-01-01“…The contents of total bile acid, lipid, and collagen in the liver were increased, and the mRNA expression levels of genes encoding inflammatory factors and enzymes involved in de novo fatty acid synthesis and bile acid synthesis were upregulated. …”
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3763
Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology
Published 2022-01-01“…The expression of IL-16, frequency of macrophages (a source of IL-16) and expression of microRNA (miR) 125a-5p (a regulator of IL-16 gene) were performed by immunohistochemistry, immunoblotting, and gene expression assays. …”
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3764
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells
Published 2024-12-01“…Using bioinformatics analyses, miR-134-3p was found, in this investigation, to be a crucial microRNA that targets <i>INHBA</i> in sheep GCs. Furthermore, when the follicular diameter expanded, there was a discernible decline in miR-134-3p expression. …”
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3765
Bioprospecting and molecular characterization of laccase producing bacteriafrom industrial contaminated sites
Published 2019-04-01“…Two cultures PHP7 and PKD5 were selected for molecular characterization was carried out using 16S rRNA gene technology of PHP7 revealed as <em>Bacillus cereus</em> (KU878970.1).Partial amplification of laccase gene contain conserved domain of multicopper oxidase family. …”
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3766
Effect of Black Cumin on the Expression of Genes Related to Lipid Metabolism in Adipose Tissue: A Mouse Model Study
Published 2024-02-01“…After anesthetizing the mice, their adipose tissue was collected. Total RNA was extracted, and after the qualification by agarose gel electrophoresis, cDNA was synthesized. …”
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3767
Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan
Published 2025-01-01“…Furthermore, we demonstrated that triplet combination could induce a remarkable response in the T-DXd–refractory setting, which could be explored in future clinical trials in HR+ and HER2-activated (by RNA or protein overexpression, amplification, and mutation) patients. …”
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3768
A Benzochalcone Derivative, (E)-1-(2-hydroxy-6-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one (DK-512), Inhibits Tumor Invasion through Inhibition of the TNFα-Induced NF-κB/MMP-...
Published 2016-01-01“…DK-512 significantly reduced tumor necrosis factor-α- (TNFα-) induced MMP-9 mRNA expression through the inhibition of RelA nuclear factor- (NF-) κB transcription factor. …”
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3769
Characterization of Streptomyces Isolates Associated with Estuarine Fish Chanos chanos and Profiling of Their Antibacterial Metabolites-Crude-Extract
Published 2020-01-01“…Based on the morphological, physiological, and biochemical characterization, as well as 16S rRNA partial sequencing, all of the four isolates belonged to Streptomyces. …”
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3770
Identification and validation of hub gene TNFAIP6 of fibroblast-like synoviocytes in rheumatoid arthritis
Published 2025-02-01“…RT-qPCR and Western blot assay demonstrated that TNFAIP6 was significantly highly expressed at mRNA and protein levels in MH7A cells stimulated with 10 ng/mL TNF-α when compared to the cells treated with PBS (P<0.05). …”
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3771
Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice
Published 2023-01-01“…Correlation analyses revealed that the Th17 cell percentages were positively correlated with the serum TgAb titers, Notch pathway-related mRNA expression levels, and IL-17A concentrations in EAT mice (all P<0.05). …”
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3772
<i>Macrostomum lignano</i> as a model to study the genetics and genomics of parasitic flatworms
Published 2021-03-01“…M. lignano has a number of convenient biological and experimental properties, such as fast reproduction, easy and non-expensive laboratory culturing, optical body transparency, obligatory sexual reproduction, annotated genome and transcriptome assemblies, and the availability of modern molecular methods, including transgenesis, gene knockdown by RNA interference, and in situ hybridization. All this makes M. lignano amenable to the most modern approaches of forward and reverse genetics, such as transposon insertional mutagenesis and methods of targeted genome editing by the CRISPR/Cas9 system. …”
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3773
Human reference microbiome profiles of different body habitats in healthy individuals
Published 2025-02-01“…Blood, saliva, and stool samples were subjected to 16S rRNA sequencing. Reference intervals of alpha diversity indices were calculated. …”
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3774
Adaptation of Archaeal Communities to Summer Hypoxia in the Sediment of Bohai Sea
Published 2025-01-01“…In this study, the diversity, composition, and distribution of archaeal community in sediment along an inshore–offshore transect across the oxygen‐depleted area in the Bohai Sea were investigated in June, July, and August of 2021 by employing high‐throughput sequencing of 16S rRNA gene. Results indicated that the archaeal communities were dominated by Thermoproteota (80.61%), Asgardarchaeota (8.70%), and Thermoplasmatota (5.27%). …”
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3775
Knockdown of Adra2a Increases Secretion of Growth Factors and Wound Healing Ability in Diabetic Adipose-Derived Stem Cells
Published 2022-01-01“…Therefore, the purpose of this study was to investigate whether the elevated Adra2a is involved in the diminished wound-healing capabilities of T2D ASCs. RNA-seq was used to compare the transcriptomic profiles of T2D and normal ASCs. …”
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3776
Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma
Published 2018-01-01“…Our observations in cancer databases that PLXNC1 is upregulated in HCC led us to investigate the expression profile of Plexin C1 mRNA and protein in HCC cell lines and tissues. Methods. …”
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3777
Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation
Published 2013-01-01“…Single nucleotide polymorphisms (SNPs) in microRNA genes may be associated with susceptibility to HCC. …”
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3778
Activating Transcription Factor 5 Promotes Tumorigenic Capability in Cervical Cancer Through the Wnt/β-Catenin Signaling Pathway
Published 2025-01-01“…Knockdown ATF5 expression in cervical cancer cell lines was constructed using lentivirus-mediated shRNA to explore the role of ATF5 in cervical cancer through cell viability, transwell, and wound healing experiments. …”
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3779
Discovery of two novel Flavobacterium species with potential for complex polysaccharide degradation
Published 2025-01-01“…Through comprehensive analyses, including 16S rRNA gene sequencing, whole-genome sequencing, and detailed morphological, physiological, and chemotaxonomic characterizations, these strains have been identified as new species within the genus Flavobacterium. …”
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3780
Intraspinal Grafting of Serotonergic Neurons Modifies Expression of Genes Important for Functional Recovery in Paraplegic Rats
Published 2018-01-01“…Here, we analyzed the mRNA of 5-HT2A and 5-HT7 receptors (encoded by Htr2a and Htr7 genes, resp.) in motoneurons innervating tibialis anterior (TA) and gastrocnemius lateralis (GM) hindlimb muscles and the tail extensor caudae medialis (ECM) muscle in intact as well as spinal rats. …”
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