T Cell Repertoire and Inflammatory Bowel Disease by Kenneth Croitoru, David KH Wong, Maria E Baca-Estrada

“…Using monoclonal antibodies to T cell receptor variable-gene products or polymerase chain reaction analysis of variable-gene mRNA expression, the mucosal T cell repertoire has been examined in humans. …”
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Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis by Wenpin Qin, Zhangyu Ma, Guo Bai, Wen Qin, Ling Li, Dongxiao Hao, Yuzhu Wang, Jianfei Yan, Xiaoxiao Han, Wen Niu, Lina Niu, Kai Jiao

“…Here, we report on a hydrogel for extracellular RNA scavenging and releasing bevacizumab to block neurovascularization at the osteochondral interface, thereby mitigating OA pain and disease progression. …”
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Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway by Wang Naizhi, Feng Tao, Liu Xiaona, Liu Qin

“…Cell migration and invasion were analyzed by wound healing assay and transwell assay. MiRNA-206 expression was detected by real-time PCR. …”
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Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion by Katsuya Sakimura, Tatsuya Maekawa, Shin-ichi Kume, Takeshi Ohta

“…To get an insight into the mechanism underlying the impaired melatonin secretion in SDT fatty rats, the expression of arylalkylamine N-acetyltransferase (Aanat) and acetylserotonin O-methyltransferase (Asmt) mRNA, which encode the rate-limiting enzymes for melatonin synthesis, was investigated in the pineal gland. …”
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Multilocus phylogenies reveal three new truffle-like taxa and the traces of interspecific hybridization in Octaviania (Boletaceae, Boletales) by Takamichi Orihara, Rosanne Healy, Adriana Corrales, Matthew E. Smith

“…Here we describe two new species in subgenus Octaviania, O. tenuipes and O. tomentosa, from temperate to subtropical evergreen Fagaceae forests in Japan based on morphological observation and robust multilocus phylogenetic analyses (nrDNA ITS and partial large subunit [LSU], translation elongation factor 1-α gene [TEF1] and the largest subunit of RNA polymerase II gene [RPB1]). Based on specimens from the Americas as well as studies of the holotype, we also taxonomically re-evaluate O. asterosperma var. potteri. …”
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miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT by Pengyu Jing, Nianlin Xie, Nan Zhao, Ximing Zhu, Pei Li, Guizhou Gao, Haizhou Dang, Zhongping Gu

“…The interaction of miR-24-3p and KLF8 was demonstrated by luciferase reporter activity assay, in vitro migration and invasion studies, and in vivo metastatic studies. miR-24-3p level was downregulated in LUAD and negatively associated with KLF8 mRNA expression. miR-24-3p controls LUAD metastasis by directly targeting KLF8 and inducing Snail and E-cadherin expressions. …”
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Successful Antiviral Treatment with Direct-Acting Antivirals for Hepatitis C Virus Infection during Peritransplant Period in a Kidney Transplant Recipient by Giovanni Varotti, Ferdinando Dodi, Ernesto Paoletti, Andrea Bruno, Iris Fontana

“…The 8-week DAA therapy was carried out without interruption. All HCV-RNA level controls resulted undetectable. On postoperative day 15, the patient was discharged and remains in healthy condition with normal renal function and HCV negative after 18 months of follow-up. …”
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Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing by Sabrina Valente, Carmen Ciavarella, Emanuela Pasanisi, Francesca Ricci, Andrea Stella, Gianandrea Pasquinelli

“…This study was aimed at verifying whether HGF/SF influences proliferation, migration, and angiogenesis on mesenchymal stem cells isolated from human arteries (hVW-MSCs). hVW-MSCs were exposed to NIBSC HGF/SF (2.5, 5, 10, and 70 ng/mL) from 6 hrs to 7 days. HGF and c-MET mRNA and protein expression, cell proliferation (Alamar Blue and Ki–67 assay), migration (scratch and transwell assays), and angiogenesis (Matrigel) were investigated. hVW-MSCs displayed stemness features and expressed HGF and c-MET. …”
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Health benefits of Grifola frondosa polysaccharide on intestinal microbiota in type 2 diabetic mice by Xiaoxiang Gao, Dan Liu, Luying Gao, Yuezhen Ouyang, Yuxi Wen, Chao Ai, Yuqing Chen, Chao Zhao

“…The changes of microbiota in faeces of the diabetic mice upon high fat diet were determined and the V3 region of the 16S rRNA was sequenced by Illumina MiSeq high-throughput sequencing platform. …”
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Genome Sequencing of a Mung Bean Plant Growth Promoting Strain of P. aeruginosa with Biocontrol Ability by Devaraj Illakkiam, Manoharan Shankar, Paramasivan Ponraj, Jeyaprakash Rajendhran, Paramasamy Gunasekaran

“…The draft genome of PGPR2 encoded 6803 open reading frames, of which 5314 were genes with predicted functions, 1489 were genes of known functions, and 80 were RNA-coding genes. Strain specific and core genes of P. aeruginosa PGPR2 that are relevant to rhizospheric habitat were identified by pangenome analysis. …”
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Advancements in nanosensors for cancer detection by Dinesh Bhatia, Tania Acharjee, Monika Bhatia

“…Since they are more effective than conventional techniques, point-of-care (PoC) biosensors—such as innovative nano-sensing devices for exosomal micro-RNA analysis—are becoming increasingly popular. …”
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Characterization and genome analysis of a novel phage BP15 infecting Vibrio parahaemolyticus by Te-Ken Hsu, Yi-Yin Chen, Shiao-Wen Li, Hui-Yu Shih, Hsin-Yiu Chou, Jeff Chia-Kai Hsu, Han-Ching Wang, Li-Li Chen

“…Phage BP15 possessed a circular double-stranded DNA of 59,584 bp with a G + C content of 46.7% and lacked tRNA genes, virulence genes, and lysogeny genes. …”
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Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea by Katsuo Tomoyose, Yuka Okada, Takayoshi Sumioka, Masayasu Miyajima, Kathleen C. Flanders, Kumi Shirai, Tomoya Morii, Peter S. Reinach, Osamu Yamanaka, Shizuya Saika

“…Immunohistochemistry showed that immunoreactivity for active form of TGFβ1 and VEGF was detected in subepithelial stroma at the site of cauterization in both genotypes of mice, but the immunoreactivity seemed less marked in mice lacking TRPV1. mRNA expression of VEGF and TGFβ1 in a mouse cornea was suppressed by the loss of TRPV1. …”
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Effects of Bile Acids on Growth Performance, Hepatopancreatic Antioxidant Capacity, Intestinal Immune-Related Gene Expression, and Gut Microbiota of <i>Penaeus vannamei</i> by Yun Zhao, Duanduan Chen, Hui Wang

“…Furthermore, BA supplementation increased the activity of antioxidant-related enzymes in the hepatopancreas and enhanced the mRNA expression levels of gut-associated immune genes. …”
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Genotype B of deformed wing virus and related recombinant viruses become dominant in European honey bee colonies by Fabrice Sircoulomb, Eric Dubois, Frank Schurr, Pierrick Lucas, Marina Meixner, Alicia Bertolotti, Yannick Blanchard, Richard Thiéry

“…These data and the sequencing of the viral RNA provide a first insight into DWV diversity, with a clear dominance of DWV-B and recombinants (A/B) in Europe. …”
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Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques by Li Zheng, Qingdan Ye, Mengmeng Wang, Fan Sun, Qiang Chen, Xiaoping Yu, Yufeng Wang, Pei Liang

“…Nucleic acid aptamers are single-stranded oligonucleotides that are selected through exponential enrichment (SELEX) technology from synthetic DNA/RNA libraries. These aptamers can specifically recognize and bind to target molecules, serving as specific recognition elements. …”
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Antilipotoxicity Activity of Osmanthus fragrans and Chrysanthemum morifolium Flower Extracts in Hepatocytes and Renal Glomerular Mesangial Cells by Po-Jung Tsai, Mei-Ling Chang, Ching-Mei Hsin, Chung-Chieh Chuang, Lu-Te Chuang, Wen-Huey Wu

“…OF and CM also suppressed the mRNA expression of interleukin- (IL-) 1β, IL-6, IL-8, tumor necrosis factor- (TNF-) α, and transforming growth factor- (TGF-) β by HepG2 cells treated with conditioned medium derived from lipopolysaccharide-treated THP-1 monocytes. …”
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Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity by Radwa El- Sayed Mahmoud Marie, Noha M. Abd El-Fadeel, Yara El-Sayed Marei, Lina M. Atef

“…Methods. CD70 and CD27 mRNA expressions were evaluated by a quantitative real-time polymerase chain reaction in scalp biopsies from 40 AA patients (both AA lesions and non-lesional areas) and 40 healthy controls (HCs). …”
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Exosomes in neuron-glia communication: A review on neurodegeneration by Naeimeh Akbari-Gharalari, Sina Khodakarimi, Farshad Nezhadshahmohammad, Mohammad Karimipour, Abbas Ebrahimi-Kalan, Jiagian Wu

“…Despite their small size, they carry diverse cargo, including RNA, proteins, and lipids. Internalization by recipient cells raises concerns about potential disruptions to cellular functions. …”
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The Role of IL-17 Promotes Spinal Cord Neuroinflammation via Activation of the Transcription Factor STAT3 after Spinal Cord Injury in the Rat by Shaohui Zong, Gaofeng Zeng, Ye Fang, Jinzhen Peng, Yong Tao, Keke Li, Jingmin Zhao

“…RT-PCR was used to analyze the mRNA expression of IL-17 and IL-23p19 in the spleen tissue. …”
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