Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro by Feng Tian, Qiang Lu, Jie Lei, Yunfeng Ni, Nianlin Xie, Daixing Zhong, Guang Yang, Shaokui Si, Tao Jiang

“…Such modulation between TRAF6 and SIGIRR could affect cytokine secretion and exacerbate the immune response; the IL-8, NFKB1, and NFKBIA mRNA levels were reduced after SIGIRR overexpression. …”
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Transmembrane and Ubiquitin-Like Domain-Containing 1 Promotes Glioma Growth and Indicates Unfavorable Prognosis by Yinggang Liu, Changcheng Cai, Ke Wu, Libo Hu

“…We conducted a comprehensive analysis using two cohorts: a retrospective glioma cohort from our hospital and The Cancer Genome Atlas (TCGA) cohort. The mRNA levels of TMUB1 were assessed through reverse transcription-quantitative polymerase chain reaction (RT-qPCR). …”
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The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy by Gabriela De Nardi Sanches-da-Silva, Luiza Fonseca Sales Medeiros, Fabio Mitsuo Lima

“…The CRISPR- (clustered regularly interspaced short palindromic repeat-) Cas system is a genome-editing method which uses a guide RNA, a complementary sequence to the interested site, recruiting a nuclease that can break the viral or the host cell genetic material. …”
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Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis by Georg Auburger, Suzana Gispert, Nadine Brehm

“…The strongest effects were documented for the adhesion modulator CMAS, the mRNA decapping/deadenylation factor PATL1, and the synaptic plasticity mediator CRTC1/TORC1. …”
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Enhanced Expression of ABCB1 and Nrf2 in CD133-Positive Cancer Stem Cells Associates with Doxorubicin Resistance by Shinji Goto, Tsuyoshi Kawabata, Tao-Sheng Li

“…Unexpectedly, silencing CD133 by siRNA only partially enhanced the cytotoxicity of DXR, but did not obviously change the expression of ABCB1 and the accumulation of DXR in CD44+CD133+ cells. …”
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Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor by Madison Mograbi, Michael S. Stump, David T. Luyimbazi, Mohammad H. Shakhatreh, Douglas J. Grider

“…The pseudotumor additionally demonstrated EBV-encoded RNA (EBER) positivity typical of IPT-like FDCT. …”
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Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation by Filipa I. Baptista, Célia A. Aveleira, Áurea F. Castilho, António F. Ambrósio

“…Exposure of retinal neural cell cultures to high glucose upregulated both mRNA and protein levels of IL-1β. High glucose decreased microglial and macroglial cell proliferation, whereas IL-1β increased their proliferation. …”
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Bauhinia coccinea extract prevents memory loss induced by scopolamine through activation of antiapoptotic and antioxidant pathways in mice by Eunjin Sohn, Bu-Yeo Kim, Yu Jin Kim, Joo-Hwan Kim, Soo-Jin Jeong

“…Furthermore, EEBC significantly reduced malondialdehyde levels and activated catalase in SCO-administered brains. Quantitative RNA sequencing showed involvement of lipid metabolism in EEBC memory function regulation. …”
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Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via Caspase BmICE. by Maoshuang Ran, Jialing Bao, Boning Li, Yulian Shi, Wenxin Yang, Xianzhi Meng, Jie Chen, Junhong Wei, Mengxian Long, Tian Li, Chunfeng Li, Guoqing Pan, Zeyang Zhou

“…An immunofluorescent assay demonstrated that upon infection with N. bombycis, NbSPN14 was initially found in the B. mori cell cytoplasm and then became enriched in the host cell nucleus. Overexpression and RNA-interference (RNAi) of NbSPN14 in B. mori' embryo cell confirmed that NbSPN14 inhibited host cells apoptosis. …”
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Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study by Reham Alfaraj, Zainab Alabdulsalam, Zahrah Alfaraj, Hawraa Alsunni, Hussain Alhawaj, Omar Omar, Hatem Abuohashish

“…The molecular analysis of dorsal root ganglia suggested that CAF upregulated the mRNA expression of the Nav1.3, Nav1.7, and Nav1.8 sodium channel subtypes. …”
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Selective cultivation of bacterial strains with lipolytic and hydrocarbon-oxidizing activity from bottom sediments of the Ob River, Western Siberia by A. I. Gerasimchuk, D. A. Ivasenko, A. A. Kasymova, Yu. A. Frank

“…The phylogenetic position of the obtained bacterial isolates was determined based on the analysis of 16S rRNA gene sequences. The strains isolated on selective media belonged to representatives of the genera Pseudomonas and Aeromonas (Gammaproteobacteria), and the genus Microvirgula (Betaproteobacteria). …”
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The influence of follicular fluid on the regulation of apoptosis and related genes during IVM of camel oocytes by A.A. Ammari, AR. Alhimaidi, K.N. Yaseen, B.O. Almutairi, R.A. Amran, A. AL-juaimlan, A. Rady

“…Consequently, the follicular fluid from camels had a substantial effect on the mRNA transcript level of the BCL2 gene, which is related to apoptosis. …”
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Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis by Zhijun Jiao, Wenhong Wang, Jie Ma, Shengjun Wang, Zhaoliang Su, Huaxi Xu

“…Exposure of RA FLSs to TNF-α (10 ng/ml) led to increase of Hes-1, a target gene of Notch signaling, and a marked upregulation of Notch 2, Delta-like 1, and Delta-like 3 mRNA levels. Blockage of Notch signaling by a γ-secretase inhibitor (DAPT) inhibited IL-6 secretion of RA FLSs in response to TNF-α while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response. …”
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Gene Expression Changes in Venous Segment of Overflow Arteriovenous Fistula by Yasuhiro Hashimoto, Akiko Okamoto, Hisao Saitoh, Shingo Hatakeyama, Takahiro Yoneyama, Takuya Koie, Chikara Ohyama

“…Venous tissue samples were collected from 6 hemodialysis patients with AV fistulas exposed to overflow and from the normal cephalic veins of 4 other hemodialysis patients. Total RNA was extracted from the venous tissue samples, and gene expression between the 2 groups was compared using Whole Human Genome DNA microarray 44 K. …”
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TMEM100 Modulates TGF-β Signaling Pathway to Inhibit Colorectal Cancer Progression by Huixia Li, Chuan Cheng, Weibo You, Jiujian Zheng, Jie Xu, Peng Gao, Jianping Wang

“…This study investigated the functional mechanism of transmembrane protein 100 (TMEM100) as a tumor inhibitor gene in CRC cells and offered a reference for the treatment of CRC. Methods. The mRNA expression data of CRC were acquired from the TCGA database to mine differentially expressed mRNAs. …”
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Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p by Mei Zheng, Panpan Fan, Pu Yang, Junwen Zheng, Dongchi Zhao

“…The expression level of miR-19a-3p was significantly upregulated in the pNS1 or RSV-treated cells, which was reversed by the NS1 small interfering RNA. In addition, pNS1 also upregulated the expression of 5-LO, interleukin-5 (IL-5), and leukotriene B4 (LTB4), which was also significantly inhibited by the miR-19a-3p antagonists. …”
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Influence of leptin administration to pregnant female mice on obesity development, taste preferences, and gene expression in the liver and muscles of their male and female offsprin... by E. I. Denisova, M. M. Savinkova, E. N. Makarova

“…It also increased the consumption of standard chow and the mRNA levels of genes for the insulin receptor and glucose transporter type 4 in the muscles of both male and female offspring. …”
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An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters by Ryuta Uraki, Mutsumi Ito, Maki Kiso, Kiyoko Iwatsuki-Horimoto, Masafumi Endo, Seiya Yamayoshi, Yoshihiro Kawaoka

“…Vaccination is an essential primary preventative measure. While mRNA vaccines have been widely used worldwide, it is essential that we continue to prepare alternative vaccine modalities. …”
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Trachoma and Ocular Chlamydial Infection in the Era of Genomics by Tamsyn Derrick, Chrissy h. Roberts, Anna R. Last, Sarah E. Burr, Martin J. Holland

“…We focus on the contribution of host and pathogen genetic variation, bacterial ecology of the conjunctiva, and host epigenetic imprinting including small RNA regulation by both host and pathogen in the development of ocular pathology. …”
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Mutations in human prion-like domains: pathogenic but not always amyloidogenic by Andrea Bartolomé-Nafría, Javier García-Pardo, Salvador Ventura

“…Heterogeneous nuclear ribonucleoproteins (hnRNPs) are multifunctional proteins with integral roles in RNA metabolism and the regulation of alternative splicing. …”
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