Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia by Nikolaos Papadopoulos, Melanie Deutsch, Athanasios Georgalas, Helias Poulakidas, Lazaros Karnesis

“…Laboratory evaluation revealed total bilirubin: 2.7 mg/dL and serum HCV-RNA 137.204 IU/mL. HCV was genotyped as 4. A FibroScan revealed 35.3 kPa. …”
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The role of transposable elements in the ecological morphogenesis under the influence of stress by R. N. Mustafin, E. K. Khusnutdinova

“…Transposons are sources of non-coding RNA, transcription factors binding sites and protein-coding genes due to domestication, exonization, and duplication. …”
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Insights into the gut microbiota characteristics between the organic and traditional feeding chickens based on amplicon and metagenomic sequencing by Wenzhou Zhang, Xiaoru Jian, Siqi Ding, Jiamin Chang, Shouping Ji, Shouping Ji, Yulang Chi, Yulang Chi

“…The intestinal contents of organic and feed chickens were analyzed by 16S rRNA gene and metagenome technology. The results showed that the microbial diversity of organic chickens was significantly higher than that of the feed chickens, especially the key microorganisms, such as Enterococcus, were more abundant in organic chickens. …”
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Meta-Omics Analyses of Conventional and Regenerative Fermented Vegetables: Is There an Impact on Health-Boosting Potential? by Kylene Guse, Qingqing Mao, Chi Chen, Andres Gomez

“…We profiled bacterial and fungal communities via 16S rRNA short-read (V4 region), long-read, and ITS2 sequencing, in tandem with untargeted metabolomics (LC-MS). …”
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CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging by Yun-feng Rui, Min-hao Chen, Ying-juan Li, Long-fei Xiao, Peng Geng, Pei Wang, Zheng-yuan Xu, Xuan-pu Zhang, Guang-chun Dai

“…Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging. CTGF protein and mRNA levels were markedly decreased in the aged TSPCs. …”
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Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation by Shuang Lin, Shanshan Dai, Jiahui Lin, Xiaohe Liang, Weiqi Wang, Weijian Huang, Bozhi Ye, Xia Hong

“…After inhibiting the expression of GSDMD in cardiomyocytes by siRNA, it was found that Ang II-induced hypertrophy was attenuated. …”
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Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization by Zhewei Dong, Yingli Fu, Zhongming Cai, Hao Dai, Yucang He

“…Potent anti-inflammatory substances contained in exosomes include the glycoprotein MFGE8, the cytokines such as prostaglandin E2, IL-6, and IGF, as well as non-coding nucleotides (miR-451a, miR-23, miR-30d-5p, let-7, lncRNA DLEU2, circRps5, Circ-Ptpn4, and mmu_ circ_0001359). …”
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Expressional Subpopulation of Cancers Determined by G64, a Co-regulated Module by Jae-Woong Min, Sun Shim Choi

“…Here, we investigated whether the G64 module genes were also expressed distinctively in different subpopulations of other cancers. RNA sequencing-based transcriptome data derived from 22 cancers, except LADC, were downloaded from The Cancer Genome Atlas (TCGA). …”
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In Vitro Study of Combined Application of Bevacizumab and 5-Fluorouracil or Bevacizumab and Mitomycin C to Inhibit Scar Formation in Glaucoma Filtration Surgery by Yuanyuan Zhang, Shaopin Zhu, Xun Xu, Lei Zuo

“…In addition, the effects of combined drugs on VEGF(R) mRNA in HTFs were detected to explore the possible underlying drug mechanisms. …”
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Bacterial Infections across the Ants: Frequency and Prevalence of Wolbachia, Spiroplasma, and Asaia by Stefanie Kautz, Benjamin E. R. Rubin, Corrie S. Moreau

“…In this study, we used 16S rRNA tag encoded amplicon pyrosequencing to survey bacterial communities of 310 samples representing 221 individuals, 176 colonies and 95 species of ants. …”
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Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model by Tianhang Luo, Jixin Shu, Zhengmao Lu, Ting Han, Guoen Fang, Xuchao Xue

“…Then, we knockdown Cav-1 expression with siRNA or induce Cav-1 expression with proinflammatory factors to evaluate potential effects on EPCs. …”
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Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease by Li JianFang, Zhang PengFei, Zeng XianJing, Liu Rong

“…Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability worldwide, and circRNA dysregulation is functionally associated with COPD. …”
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Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway by Yajuan Lin, Yunpeng Xie, Zhujing Hao, Hailian Bi, Yang Liu, Xiaolei Yang, Yunlong Xia

“…A microfluidic device was used to mimic the vascular environment in the body, and the level of mRNA levels of inflammatory factors was determined by RT-PCR. …”
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Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice by Wei-Jian Zhang, Balz Frei

“…AS-IV also inhibited LPS-induced upregulation of inflammatory gene expression in different organs. Lung mRNA levels of cellular adhesion molecules, MCP-1, TNFα, IL-6, and TLR4 were significantly attenuated, and lung neutrophil infiltration and activation were strongly inhibited, as reflected by decreased myeloperoxidase content, when the mice were pretreated with AS-IV. …”
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Isolation and Identification of Pyrene Mineralizing Mycobacterium spp. from Contaminated and Uncontaminated Sources by Christopher W. M. Lease, Richard H. Bentham, Sharyn E. Gaskin, Albert L. Juhasz

“…Three pyrene-degrading microorganisms isolated from the corresponding enrichment cultures had broad substrate ranges, however, isolates could be differentiated based on surfactant, phenol, hydrocarbon and PAH utilisation. 16S rRNA analysis identified all three isolates as Mycobacterium sp. …”
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Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry by Vaibhav P. Pai, Laura N. Vandenberg, Douglas Blackiston, Michael Levin

“…Bilateral misexpression of a depolarizing channel mRNA affects primarily the right eye, revealing an additional functional asymmetry in the control of eye patterning by Vmem. …”
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Bacterial Colonization in the Airways and Intestines of Twin and Singleton Preterm Neonates: A Single-Center Study by Jiawei Yao, Tao Ai, Lei Zhang, Wei Tang, Zijin Chen, Yuedong Huang, Yinghong Fan

“…These specimens were analyzed using 16S rRNA deep sequencing to study the alpha and beta diversities and community structures of airway and intestinal bacteria and predict their metabolic functions. …”
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Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis by Jieyang Yu, Hongping Li, Jingjie Zhao, Yanhua Huang, Chunlei Liu, Pengfei Yang, Dinggui Lu, Jian Song, Lingzhang Meng

“…Their gut microbial community profiles were analyzed by 16S rRNA gene sequencing using the Illumina MiSeq system. …”
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Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response by Shikui Xu, Aixue Zuo, Zengjun Guo, Chunping Wan

“…Th1 cell differentiation assay was performed, and mRNA expression in interferon-γ-related signaling was examined by q-PCR analysis. …”
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Myricetin exposure reduces PC differentiation in vitro in primary human B cells by Shabirul Haque, Betty Diamond

“…Quantification of PCs (CD27 + + , CD38 +) was obtained by flow cytometry. The expression of mRNA was measured by qPCR. Ig secretion in culture supernatant was measured by ELISA. …”
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