Picking interstitial lung disease out of the myositis haystack by Jennifer Hannah, Harsha Gunawardena

“…The hallmark CTD-IIM ILD subgroup is antisynthetase syndrome, characterized by autoantibodies to tRNA synthetases. Muscle weakness is not universally present and parenchymal lung disease can predominate. …”
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Characterizing the hindgut microbiome in healthy and ketotic cows by Zhihua Ju, Rongling Li, Wenhao Liu, Qiang Jiang, Jinpeng Wang, Yaran Zhang, Xiuge Wang, Yao Xiao, Chunhong Yang, Xiaochao Wei, Yaping Gao, Jinming Huang

“…In this study, the hindgut microbial communities of ketotic and healthy cows were compared and analyzed using 16S rRNA sequencing. Community composition analysis reveal that the predominant phyl in both groups were Bacteroidetes and Firmicutes. …”
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Clinical Significance of NKD Inhibitor of WNT Signaling Pathway 1 (NKD1) in Glioblastoma by Lijun Li, Ruiying Gao, Weizhong Huangfu, Fang Zhang, Ruixia Wang

“…Here, we aimed to investigate expression and function of NKD inhibitor of Wnt signaling pathway 1 (NKD1), an antagonist of Wnt-beta-catenin signaling pathways, in glioblastoma. Methods. The mRNA level of NKD1 was firstly retrieved from TCGA glioma dataset to evaluate its correlation with clinical characteristics and its value in prognosis prediction. …”
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The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment by Tao Huang, Gang Zhu, Fan Chen

“…HNRNPA2B1 is a member of the HNRNP family, which is associated with telomere function, mRNA translation, and splicing, and plays an important role in tumor development. …”
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Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy by Amandeep Singh, Nayere Zaeri, Immanuel K. Ho

“…Laboratory data showed HCV RNA of 4,515,392 IU/mL, HCV genotype 1a, with normal LFTs. …”
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Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis by Liliana R. Balahura, Aida Selaru, Sorina Dinescu, Marieta Costache

“…Therefore, dysregulations of miRNA expressions have been correlated with inflammation during tumor development. …”
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Transcriptomics profiling of Parkinson’s disease progression subtypes reveals distinctive patterns of gene expression by Carlo Fabrizio, Andrea Termine, Carlo Caltagirone

“…Design This is a retrospective longitudinal cohort study utilizing the Parkinson’s Progression Markers Initiative (PPMI) database. Methods Whole blood RNA-Sequencing data underwent differential gene expression analysis, followed by multiple pathway analyses. …”
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Gut Microbiota Variations between Henoch-Schonlein Purpura and Henoch-Schonlein Purpura Nephritis by Fang Zhou, Qimin Shao, Lihong Jia, Chunyan Cai

“…Fecal samples were collected and analyzed by sequencing the V3-V4 region of the 16S rRNA gene. The diversity of the fecal gut microbiota was compared between the patient groups. …”
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Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation by Katja C. Weisel, Frank Bautz, Gabriele Seitz, Sedat Yildirim, Lothar Kanz, Robert Möhle

“…In our study, we provide evidence that also in human neutrophils, expression (cell surface and mRNA), chemotactic and signaling functions of the homing-related chemokine receptor CXCR4 are upregulated during aging in vitro, independent of addition of stimulatory cytokines (TNF, IL-1, IL-8, G-CSF). …”
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Exosomes in Human Immunodeficiency Virus Type I Pathogenesis: Threat or Opportunity? by Sin-Yeang Teow, Alif Che Nordin, Syed A. Ali, Alan Soo-Beng Khoo

“…Depending on their cellular origins, the membrane-bound exosomes packed a variety of functional proteins and RNA species. These microvesicles are secreted into the extracellular space to facilitate intercellular communication. …”
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A Unique Trinucleotide-Bloc Mutation-Based Two SARS-CoV-2 Genotypes with Potential Pathogenic Impacts by Mustak Ibn Ayub

“…Computational analysis and literature review suggest that this bloc mutation would bring 203–204: RG (arginine-glycine)>KR (lysine-arginine) amino acid changes in the nucleocapsid (N) protein affecting the SR (serine-arginine)-rich motif of the protein, a critical region for the transcription of viral RNA and replication of the virus. Thus, 28881–28883: GGG > AAC bloc mutation is expected to modulate the pathogenicity of SARS-CoV-2. …”
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PAI-1 Expression Is Required for HDACi-Induced Proliferative Arrest in ras-Transformed Renal Epithelial Cells by Stephen P. Higgins, Craig E. Higgins, Paul J. Higgins

“…The addition of a stable, long half-life, recombinant PAI-1 mutant to PAI-1-deficient v-K-ras-/c-Ha-ras-transformants or to PAI-1 functionally null, NaB-resistant, 4HH cells (engineered by antisense knockdown of PAI-1 mRNA transcripts) resulted in marked cytostasis in the absence of NaB. …”
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Inherited Paediatric Motor Neuron Disorders: Beyond Spinal Muscular Atrophy by Hooi Ling Teoh, Kate Carey, Hugo Sampaio, David Mowat, Tony Roscioli, Michelle Farrar

“…Common pathophysiologies include abnormalities in axonal architecture and function, RNA processing, and protein quality control. This review incorporates an overview of the clinical manifestations, genetics, and pathophysiology of inherited paediatric motor neuron disorders beyond classic SMN1-related spinal muscular atrophy and describes recent advances in next generation sequencing and its clinical application. …”
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Supramolecular Biopolymers for Tissue Engineering by Rosario Pérez-Pedroza, Alan Ávila-Ramírez, Zainab Khan, Manola Moretti, Charlotte A. E. Hauser

“…Macromolecular structures are commonly found in living systems such as proteins, DNA/RNA, and polysaccharides. Bioorganic chemistry allows the generation of sequence-specific supramolecular units like SBPs that can be tailored for novel applications in tissue engineering (TE). …”
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Signaling Crosstalk between PPARγ and BMP2 in Mesenchymal Stem Cells by Ichiro Takada, Yoshiko Yogiashi, Shigeaki Kato

“…Although BMP2 did not interfere with PPARγ-mediated adipogenesis, BMP2 increased mRNA expression levels of PPARγ target genes (such as Fabp4 and Nr1h3) when cells were first treated with troglitazone (TRO). …”
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Epithelial to Mesenchymal Transition Relevant Subtypes with Distinct Prognosis and Responses to Chemo- or Immunotherapies in Osteosarcoma by Yang Zhou, Gai Li, Hu Li, Fuchong Lai, Pingguo Duan, Ming Cheng

“…This study retrospectively curated the RNA expression profiling of osteosarcoma patients from the TARGET and GSE21257 cohorts. …”
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BNT162b2 Vaccination during Pregnancy Protects Both the Mother and Infant: Anti-SARS-CoV-2 S Antibodies Persistently Positive in an Infant at 6 Months of Age by Chetna Mangat, Natasa Milosavljevic

“…Vaccinations are the most important intervention for controlling the ongoing coronavirus disease (COVID-19) pandemic, caused by the SARS-CoV-2 virus. BNT162b2 is an mRNA-based vaccine, which is promising and safe for use during pregnancy, as it could help prevent SARS-CoV-2 infection and its complications during pregnancy. …”
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Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers by Ruohua Li, Cuixia Zhou, Kejun Ye, Haihui Chen, Mengjia Peng

“…Protein-protein interaction networks were constructed to identify key genes, and regulatory networks involving transcription factors, miRNAs, and RNA-binding proteins were established. Differential expression was validated with receiver operating characteristic curve analyses, and immune infiltration was assessed.ResultsSix energy metabolism-related genes were identified. …”
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CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases by Christos Liaskos, Eirini I. Rigopoulou, Timoklia Orfanidou, Dimitrios P. Bogdanos, Christos N. Papandreou

“…Human CUZD1 is mapped at chromosome 10q26.13 and the loss of this region is a frequent event in various malignant tumours. mRNA overexpression of CUZD1 has been noted in ovarian cancer and serum levels of CUZD1 are elevated in women with ovarian cancer and patients suffering from pancreatic cancer. …”
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Impacts of host phylogeny, diet, and geography on the gut microbiome of rodents. by Sufia Akter Neha, John D Hanson, Jeremy E Wilkinson, Robert D Bradley, Caleb D Phillips

“…Colon samples were examined from rodents that were collected from 7 different localities in Texas and Oklahoma which were characterized using 16S rRNA gene amplicon sequencing targeting the V1-V3 variable regions. …”
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