Effect of Relocation, Social Housing Changes, and Diarrhea Status on Microbiome Composition of Juvenile Cynomolgus Macaques (<i>Macaca fascicularis</i>) by Keely McGrew, Nicole Monts de Oca, Therese A. Kosten

“…Samples were assessed via 16S rRNA next-generation sequencing for a microbiome analysis and by ELISA for cortisol levels. …”
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An Exploration of Gene-Gene Interactions and Their Effects on Hypertension by Ying Meng, Susan Groth, Jill R. Quinn, John Bisognano, Tong Tong Wu

“…Three detected genes were recognized by previous studies, and the other 5 loci/genes (MAN1A1, LMO3, NPAP1/SNRPN, DNAL4, and RNA5SP455/KRT8P5) were novel findings, which had no strong main effect on hypertension and could not be easily identified by single-locus genome-wide studies. …”
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PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes by Hyun-keun Kim, Seonung Lim, Min-Jung Bae, Wonwoo Lee, Sunyoung Kim

“…PG102 increased the expression of IL-37 at both mRNA and protein levels presumably by enhancing the phosphorylation of Smad3, ERK, and p38. …”
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Quantification and discovery of PCR inhibitors found in food matrices commonly associated with foodborne viruses by Cassandra Suther, Matthew D. Moore

“…RT-qPCR reactions containing different amounts of genomic bacteriophage MS2 RNA, a norovirus surrogate, were spiked with different concentrations of pectin (0.0625%–0.25% w/V), glycogen (1.25%–10%), and hemocyanin (0.0625%–0.25%). …”
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Pan-Cancer Analysis of the Cuproptosis-Related Gene DLD by Jiahui Lin, Guowei Wang, Sha Cheng, Yanan Hu, Huan Li, Wanjiang Feng, Xiaoming Liu, Canxia Xu

“…The relationship of DLD with immune microenvironment immunomodulators, immune checkpoints, tumor mutational load (TMB), microsatellite instability (MSI), and oncology drug sensitivity was explored by correlation analysis. Results. The mRNA and protein expression of DLD differs in most cancers. …”
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Long-Term Consequences of Hepatitis C Viral Clearance on the CD4 (+) T Cell Lymphocyte Course in HIV/HCV Coinfected Patients by J. Dazley, R. Sison, J. Slim

“…The aim of this study was to investigate the impact of HCV-RNA clearance by standard anti-HCV therapy on long-term CD4 cells recovery in HIV/HCV patients on successful combined antiretroviral therapy. …”
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N-Oxalylglycine-Conjugated Hyaluronic Acid as a Macromolecular Prodrug for Therapeutic Angiogenesis by Andrew H. DeMaria, Jeoung Soo Lee, Ken Webb

“…Normal human dermal fibroblasts (NHDFs) cultured with HA-NOG exhibited HIF-1α accumulation in the cell nucleus and dose-dependent increases in mRNA expression levels of three direct HIF transcriptional targets. …”
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A two-strain HIV-1 mathematical model to assess the effects of chemotherapy on disease parameters by Tinevimbo Shiri, Winston Garira, Senelani D. Musekwa

“…There is a drastic increase of CD4+ T cells during the first few weeks of treatment, followed by a gradual increase, and these increases are strictly by clonal expansion of preexisting CD4+ T cells. Plasma HIV RNA dramatically decline to zero levels during the first week of drug administration. …”
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Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit Model by Victoria Lövljung, Mathias Waldén, Mikael Sandell, Peter Damberg, Staffan Holmin, Fabian Arnberg Sandor

“…The trans-vessel wall device (TW-device) is a new endovascular tool for precise and safe delivery of various payloads (cells, viral, modified RNA, chemotherapy, growth factors) in oncology and regenerative medicine. …”
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Adenine, a key player in biology and medicinal chemistry by Fillion, Alexandra, Vichier-Guerre, Sophie, Arimondo, Paola Barbara

“…In addition of being one of the four nucleobases constituting DNA and RNA, adenine is also contained in many biological molecules (ATP, SAM, NAD, cAMP, coA ...) that have fundamental roles in the functioning of living systems, e.g. energy source, cofactors of enzymes and proteins. …”
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Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance by Zengfang Wang, Ruizhen Yang, Jiaojiao Zhang, Pingping Wang, Zengyan Wang, Jian Gao, Xue Liu

“…EVs contain tens to thousands of different RNA, proteins, small molecules, DNA fragments, and bioactive lipids. …”
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Preliminary Study on the Impact of Ruminal Ciliate Inoculation in Fauna-Free Conditions on the Ruminal Fermentation and Ciliate–Prokaryote Association In Vitro by Geonwoo Kim, Woohyung Lee, Tansol Park

“…Using QIIME2 to analyze 16S rRNA gene sequences, the study revealed group-specific effects on methane production, volatile fatty acids (VFAs), and microbial diversity. …”
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Metagenomic dna isolation from sheep feces and pcr detection of several rumen bacteria by Arif Yavuz, Dilek Özgün Ekiz, İlhami Kenger, Uğur Çömlekcioğlu

“…Anaerovibrio lipolytica, Fibrobacter succinogenes, Prevotella bryantii, Prevotella ruminicola, Ruminobacter amylophilus, Ruminococcus albus, Ruminococcus flavefaciens, Streptococcus bovis, Selenomonas ruminantium and Succinovibrio dextrinosolvens were screened using metagenomic DNA with polymerase chain reaction and spesific primers. Reaction of 16S rRNA region with SphI was carried out to confirm the absence of R. amylophilus, R. albus and S. dextrinosolvens.…”
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Aging-regulated TUG1 is dispensable for endothelial cell function. by Anna Theresa Gimbel, Susanne Koziarek, Kosta Theodorou, Jana Felicitas Schulz, Laura Stanicek, Veerle Kremer, Tamer Ali, Stefan Günther, Sandeep Kumar, Hanjoong Jo, Norbert Hübner, Lars Maegdefessel, Stefanie Dimmeler, Sebastiaan van Heesch, Reinier A Boon

“…TUG1 knockdown did slightly and significantly decrease cumulative sprout length upon vascular endothelial growth factor A stimulation in human umbilical vein endothelial cells (HUVECs), though TUG1-silenced HUVECs displayed no transcriptome-wide mRNA expression changes explaining this effect. Further, ectopic expression of the highly conserved and recently discovered 153 amino acid protein translated from certain TUG1 transcript isoforms did not alter angiogenic sprouting in vitro. …”
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Functional genomic imaging (FGI), a virtual tool for visualization of functional gene expression modules in heterogeneous tumor samples by Xinlei Chen, Youbing Guo, Xiaorong Gu, Danyi Wen

“…To this end, we developed functional genomic imaging (FGI), a visualization tool designed to assist clinicians in interpreting RNA-Seq results from patient samples. FGI uses weighted gene co-expression network analysis (WGCNA), followed by a modified Phenograph clustering algorithm to identify co-expression gene clusters. …”
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Drosophila Torsin Protein Regulates Motor Control and Stress Sensitivity and Forms a Complex with Fragile-X Mental Retardation Protein by Phuong Nguyen, Jong Bok Seo, Hyo-Min Ahn, Young Ho Koh

“…Downregulation of Drosophila Torsin (DTor) by DTor-specific inhibitory double-stranded RNA (RNAi) induced abnormal locomotor behavior and increased susceptibility to H2O2. …”
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The Role of the Key Differentially Mutated Gene FGFR3 in the Immune Microenvironment of Bladder Cancer by Jun Jiang, Yan Zhan, Jun Li

“…In this work, we downloaded the RNA-seq expression profiles and somatic mutation data of 433 bladder cancer cases from The Cancer Genome Atlas (TCGA) and then employed a comprehensive bioinformatics approach to evaluate them. …”
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Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution by Xiaohui Tong, Nianjun Yu, Rongchun Han, Tongsheng Wang

“…As a type III ribonuclease (RNase III) specifically cleaving double-stranded RNA substrates into short fragments, Dicer is indispensable in a range of physi/pathologic processes, e.g., nutrient deprivation, hypoxia, or DNA damage. …”
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Acetylation Modification Improves Immunoregulatory Effect of Polysaccharide from Seeds of Plantago asiatica L. by Le-Ming Jiang, Shao-Ping Nie, Dan-Fei Huang, Zhi-Hong Fu, Ming-Yong Xie

“…The endocytosis activity of DCs was attenuated by Ac-PLCPs treatment (P<0.01), while the mRNA expressions of chemokine receptors CCR7 and CXCR4 in DCs were significantly increased (P<0.01). …”
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Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…C-233 increased both supernatant HIV RNA and p24 expression ex vivo after treatment of CD4+ T cells from ART-suppressed people with HIV. …”
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