The Role of MicroRNAs in Cardiac Stem Cells by Nima Purvis, Andrew Bahn, Rajesh Katare

“…MicroRNAs (miRs) are small, noncoding RNA molecules that regulate gene expression at the posttranscriptional level. …”
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Aptamers: A Feasible Technology in Cancer Immunotherapy by M. M. Soldevilla, H. Villanueva, F. Pastor

“…Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity. …”
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CXCR2 Is Essential for Radiation-Induced Intestinal Injury by Initiating Neutrophil Infiltration by Jing Hu, Qian Ji, Fei Chen, Xiaoqin Gong, Chuansheng Chen, Kaijun Zhang, Ye Hua, Jinlei Wang, Rongkun Li, Xu Wang, Chunhua Dai, Ye Tian

“…Neutrophils, known as an important part of the immune system, are the most abundant leukocyte population in peripheral blood, but excessive recruitment will lead to tissue/organ injury. RNA sequencing showed that ionizing radiation significantly increased the expression of characteristic genes of neutrophils in intestinal tissues compared with liver and lung tissues. …”
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ELOE: A WEB APPLICATION FOR ESTIMATION OF GENE TRANSLATION ELONGATION EFFICIENCY by V. S. Sokolov, B. S. Zuraev, S. A. Lashin, Yu. G. Matushkin

“…In addition, the program identifies preferential codons in a genome and defines the distribution of stability of potential secondary structures in 5′ and 3′ regions of mRNA. EloE can be useful in preliminary estimation of translation elongation efficiency of genes in organisms for which experimental data are not available yet. …”
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COVID-19 Vaccination Associated Bilateral Pulmonary Embolism: Cause or Coincidence by John Omotola Ogunkoya, Marion Itohan Ogunmola, Akinwale Folarin Ogunlade, Akindele Emmanuel Ladele

“…The patient had the booster dose of moderna (mRNA) COVID-19 vaccine a month before the onset of symptoms. …”
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Combination of Oxalobacter Formigenes and Veillonella Parvula in Gastrointestinal Microbiota Related to Bile-Acid Metabolism as a Biomarker for Hypertensive Nephropathy by Xin Li, Li Wang, Shaojun Ma, Shaohui Lin, Chunyan Wang, Haiya Wang

“…Sequencing, bioinformatics, and statistical analysis were performed on the 16S rRNA gene of the subjects’ stool samples. This research study showed the differences of intestinal flora as biomarkers in hypertension patients with and without nephropathy; it investigated the relationship of the differences in the intestinal microbiota with bile-acid metabolism; it also explored bile-acid metabolism mechanism of intestinal microbiota differences in hypertension with or without nephropathy. …”
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Theoretical investigation on models of circadian rhythms based on dimerization and proteolysis of PER and TIM by Jifa Jiang, Qiang Liu, Lei Niu

“…By imposing assumptions that the dimerization reactions were fast and dimeric proteins were in rapid equilibrium, they reduced the model to a pair of nonlinear ordinary differential equations of mRNA and total protein concentrations. Then they used phase plane analysis tools to investigate circadian rhythms. …”
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Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species‐dependent pathways in A549 lung cancer cells and in vitro evaluations by Qi Zhang, Feng Ruan, Maonan Yang, Qinghui Wen

“…Interestingly, chaetocin exhibits a significant level of CD47 that down‐regulates the expression of CD47 at mRNA levels. PBMC biocompatibility study revealed that chaetocin is non‐toxic to normal cells. …”
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P2X7 Receptor Function in Bone-Related Cancer by Elena Adinolfi, Francesca Amoroso, Anna Lisa Giuliani

“…This paper summarizes recent findings on expression and function of P2X7 receptor for extracellular ATP in primary and metastatic bone cancers. Search of mRNA expression microchip databases and literature analysis demonstrate a high expression of P2X7 in primary bone tumors as well as in other malignancies such as multiple myeloma, neuroblastoma, breast, and prostate cancer. …”
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Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation by Fanwen Wang, Xinle Zou, Huilin Zheng, Tianci Kong, Duanqing Pei

“…Epicardium could also integrate and invade into mouse heart with SNAI1 expression, and give birth to numerous cardiomyocyte-like cells. Single-cell RNA seq unveils the heterogeneity and multipotency exhibited by epicardium-derived-cells and fetal-like epicardium. …”
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The Role of the Pathoanatomical Diagnosis «Chronic Gastritis» in the System of Personified Cancer Prevention by A. V. Kononov

“…Biopsy diagnosis of chronic gastritis combined with the evaluation of gene structure (genetic polymorphism) and epigenomic mechanisms (microRNA) allows the risk of gastric cancer to be ranked in a particular patient even with early precancerous changes in the gastric mucosa. …”
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Resistance and resilience of soil microbiomes under climate change by Julia A. Boyle, Bridget K. Murphy, Ingo Ensminger, John R. Stinchcombe, Megan E. Frederickson

“…We exposed in situ soil microbial communities to multiple rounds of heat, drought, or heat and drought treatments, and profiled microbial communities with 16S rRNA and ITS amplicon sequencing during and after these climatic changes. …”
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Captivity Reduces Diversity and Shifts Composition of the Great Bustard (Otis tarda dybowskii) Microbiome by Zhiyuan Lu, Zhucheng Wang, Hexue Jia, Derong Meng, Dayong Wu

“…Therefore, this study utilized high‐throughput sequencing of the 16S rRNA and Internal Transcribed Spacer (ITS) genes to compare the gut bacterial and fungal microbiota of great bustards in different environments. …”
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miRNAs and Melanoma: How Are They Connected? by Adriana Taveira da Cruz, Miriam Galvonas Jasiulionis

“…miRNAs are non-coding RNAs that bind to mRNA targets and disturb their stability and/or translation, thus acting in gene posttranscriptional regulation. …”
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Gene Technology for Papaya Ringspot Virus Disease Management by Md. Abul Kalam Azad, Latifah Amin, Nik Marzuki Sidik

“…The concept of pathogen-derived resistance has been employed for the development of transgenic papaya, using a coat protein-mediated, RNA-silencing mechanism and replicase gene-mediated transformation for effective PRSV disease management. …”
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Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations by James Freeman, Sabrina Salberg, Melanie Noel, Richelle Mychasiuk

“…Numerous overlapping neurological pathways are implicated in both PTSD and chronic pain; many of which are susceptible to epigenetic modification, such as DNA methylation, histone modifications, and RNA regulation. Hence, epigenetic changes related to pain perception, inflammation, and neurotransmission may influence an individual’s predisposition to chronic pain conditions. …”
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Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticles by Mingqing Yang, Lining Xu, Weiyu Wang

“…This indicated that RPM-ELNs could be internalized by hepatoma cells effectively and inhibit their proliferation and migration in vitro. RNA sequencing and qPCR experiments were performed, and the results of bioinformatic analyses revealed that RPM-ELNs could globally regulate expression levels of numerous genes associated with cancer and the cell cycle. …”
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Transglutaminase 2 Induces Deficits in Social Behavior in Mice by Amanda Crider, Talisha Davis, Anthony O. Ahmed, Lin Mei, Anilkumar Pillai

“…Our preliminary findings using postmortem human brain samples found increases in TG2 mRNA and protein levels in the middle frontal gyrus of subjects with autism spectrum disorder. …”
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Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis by Jingbin Zhou, Zhihong Zhao, Chen He, Feng Gao, Yu Guo, Feng Qu, Yujie Liu

“…Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages. …”
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Comparative analysis of antibiotic resistance genes between fresh pig manure and composted pig manure in winter, China. by Shuai Huang, Minghui Xing, Haifeng Wang

“…Notably, tetB-01, blaOCH, and blaOXY were the most abundant in composted pig manure compared to fresh manure. Additionally, 16S rRNA species profiling revealed that the composting process significantly altered the microbial community structure, with an increased abundance of Firmicutes and a decreased abundance of Bacteroidetes in composted pig manure. …”
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