Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. by Monica G Ferrini, Andrea Abraham, Revecca Millán, Leslie Graciano, Sriram V Eleswarapu, Jacob Rajfer

“…NO intracellular content, nitrite formation and cGMP content in culture media, nitric oxide synthase (NOS) isoforms and mRNA content, pro-inflammatory cytokines, and PAI-1 expression and activity were measured. …”
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A Classification of Basic Helix-Loop-Helix Transcription Factors of Soybean by Karen A. Hudson, Matthew E. Hudson

“…Evidence is presented that the vast majority (281) of these 319 soybean bHLH genes are expressed at the mRNA level. Of these soybean bHLH genes, 67% were found to exist in two or more homeologous copies. …”
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A Case of TAFRO Syndrome Developed after COVID-19 Vaccination by Hitomi Hirose, Hitoshi Suzuki, Yukako Umezawa, Masako Iwasaki, Hiromitsu Fukuda, Hisatsugu Takahara, Shigeki Tomita, Yusuke Suzuki

“…TAFRO syndrome that progresses after the COVID-19 mRNA vaccination has not yet been reported. A 45-year-old man developed fever, gross hematuria, renal dysfunction, pleural effusions, and ascites immediately after vaccination. …”
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Nanomédicaments pour le traitement de maladies graves et recherches duales by Couvreur, Patrick

“…They have also contributed to groundbreaking discoveries, including the introduction of the first mRNA vaccine (against COVID-19), and have improved certain imaging and diagnostic techniques, too. …”
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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS by Pamela Milani, Stella Gagliardi, Emanuela Cova, Cristina Cereda

“…Considering that changes in SOD1 mRNA levels have been associated with sporadic ALS (SALS), a molecular understanding of the processes involved in the regulation of SOD1 gene expression could not only unravel novel regulatory pathways that may govern cellular phenotypes and changes in diseases but also might reveal therapeutic targets and treatments. …”
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Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway by Simon C. M. Kwok

“…Incubation of PC-3 cells with 10 μM ZnPP for 4 h showed only a slight induction of HO-1 mRNA and protein, but the induction was high after 16 h and was maintained through 48 h of incubation. …”
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VEGF Spliced Variants: Possible Role of Anti-Angiogenesis Therapy by Caroline Hilmi, Mélanie Guyot, Gilles Pagès

“…Surgical nephrectomy remains the most efficient curative treatment for patients with noninvasive disease, while VEGF targeting has resulted in varying degrees of success for treating metastatic disease. VEGF pre-mRNA undergoes alternative splicing generating pro-angiogenic isoforms. …”
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Evolution by natural selection is a scientific law and not just a theory by Daniel J.M. Crouch, Walter F. Bodmer

“…The developing knowledge of prokaryotic microorganisms and the discovery of DNA or RNA as the fundamental basis of inheritance in all living organisms, together with Mendel’s laws, now provide the four basic conditions for evolution by natural selection, namely reproduction that is stable, but allows for variation that can increase fitness in the broadest sense. …”
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Biophysical and Structural Studies on the Capsid Protein of the Human Immunodeficiency Virus Type 1: A New Drug Target? by José L. Neira

“…It is caused by a retrovirus, HIV, whose mature capsid (enclosing the RNA with other proteins) is formed by the assembly of several hundred copies of a protein, CA*. …”
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Complication of Salmonella Bacteremia in a Case of Treated Fungal Endophthalmitis by J. Malathi, M. Sowmiya, Vikas Khetan, K. Lily Therese, H. N. Madhavan

“…However, Salmonella typhi was isolated from both specimens, which was confirmed by Polymerase chain reaction targeting the 16SrRNA gene, sequencing, and random amplification of polymorphic DNA showed that they belonged to the same clone. …”
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Astragaloside IV Treats Parkinson’s Disease by Regulating the Proliferation and Differentiation of NSCs through the SHH–Nurr1 Pathway by Zicong Wu, Jianing Zhang, Han Gao, Wentao Li

“…Meanwhile, western blotting, immunofluorescence, and real-time PCR were utilized to detect protein expression both in vivo and in vitro. Furthermore, siRNA assay was used to verify the association between SHH and Nurr1 and to investigate whether AS-IV exerts its effects through this pathway. …”
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Spatial integration of multi-omics single-cell data with SIMO by Penghui Yang, Kaiyu Jin, Yue Yao, Lijun Jin, Xin Shao, Chengyu Li, Xiaoyan Lu, Xiaohui Fan

“…Unlike previous tools, SIMO not only integrates spatial transcriptomics with single-cell RNA-seq but expands beyond, enabling integration across multiple single-cell modalities, such as chromatin accessibility and DNA methylation, which have not been co-profiled spatially before. …”
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Culturable Bacterial Communities Related to Different Larval Stages of Sanys irrosea (Guenee, 1852) (Lepidoptera: Noctuoidae) by Elif Sevim, Ali Sevim

“…The bacterial flora of different development stages of S. irrosea was studied by culture dependent techniques and the isolated bacteria was identified by 16S rRNA sequencing and phylogenetic analysis. A total of 22 bacterial isolates were obtained from different instar larvae of the insect and were identified. …”
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Uropygial gland microbiota of nearctic−neotropical migrants vary with season and migration distance by Leanne A. Grieves, Gregory B. Gloor

“…By sampling 473 birds at a single stopover location during spring and fall migration and using 16S rRNA sequencing, we demonstrate that season, followed by migration distance, had the strongest influence on uropygial gland microbial community composition. …”
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The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse by Maria-Eleni Xypolita, Mubeen Goolam, Elizabeth K. Bikoff, Elizabeth J. Robertson, Arne W. Mould

“…Moreover Blimp1 mutant females are refractory to RU486 induced decidual shedding. RNA-seq together with immunostaining experiments strongly suggest that the failure to up-regulate expression of the matrix metalloprotease Mmp10 in combination with insufficient suppression of BMP signalling, likely explain Blimp1-dependent phenotypic changes. …”
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Primary Peritonitis: An Index Case of Mycoplasma hominis Infection in a Healthy Female by Sabrina Drexel, Daniel Tseng

“…The peritoneal fluid was eventually sent for 16 s ribosomal analysis, which discovered Mycoplasma hominis RNA. Her antibiotics were narrowed, and she eventually made a full recovery. …”
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Influence of Light Intensity on Tobacco Responses to Drought Stress by Brwa Rasool

“…A transcriptome profiling analysis of the tobacco responses to light intensity highlights the increased abundance of a large group of drought-related transcripts including DROUGHT-RESPONSIVE ELEMENT BINDING FACTORS (DREBs), C-REPEAT/DROUGHT-RESPONSIVE BINDING FACTOR 1 (CBF1), GLYCINE-RICH RNA BINDING PROTEINS (GRPs), WRKY33 and MYCs transcription factors, as well as zeaxanthin epoxidase, which play as a regulator of plant responses to water deficient condition. …”
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Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice by Sean E. Thatcher, Manisha Gupte, Nicholas Hatch, Lisa A. Cassis

“…Deficiency of ACE2 in bone marrow cells significantly increased mRNA abundance of F4/80 and TNF-α in the SVF isolated from visceral adipose tissue of HF-fed chimeric mice, supporting increased presence of inflammatory macrophages in adipose tissue. …”
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New information on insect nematodes from Iran: report of Distolabrellus veechi (Nematoda: Mesorhabditidae) as new species and male of Oscheius tipulae (Nematoda: Rhabditidae) by Parissa Jalalinasab, Ramin Heydari, Reza Talaei-Hassanloui, Ebrahim Shokoohi, Javad Karimi

“…Molecular identification was carried out through molecular analysis, encompassing the D2-D3 expansion segment of 28S, ITS, and 18S genes of rRNA. The phylogenetic analyses placed these nematodes within their respective clades with high bootstrap support, confirming their identity. …”
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Mechanism of Gene Amplification via Yeast Autonomously Replicating Sequences by Shelly Sehgal, Sanjana Kaul, M. K. Dhar

“…The amplification promoting sequences were chosen from the Saccharomyces cerevisiae ARS, 5S rRNA regions of Plantago ovata and P. lagopus, proposed sites of replication pausing at Ste20 gene locus of S. cerevisiae, and the bend DNA sequences within fragile site FRA11A in humans. …”
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