Involvement of Mechanistic Target of Rapamycin (mTOR) in Valine Orexigenic Effects in Rainbow Trout by Sara Comesaña, Mauro Chivite, Ayelén M. Blanco, María Alborja-Valado, Jessica Calo, Marta Conde-Sieira, José L. Soengas

“…However, it is not clear which precise mechanisms link the activation of mTOR and the alteration in feed intake levels since we did not observe changes in mRNA levels of appetite-regulatory neuropeptides as well as in the phosphorylation status and levels of integrative proteins.…”
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Spontaneous Clearance of Hepatitis C after Liver and Renal Transplantation by CH Dale, P Burns, M McCutcheon, R Hernandez-Alejandro, PJ Marotta

“…To date, no reports of spontaneous clearance of HCV RNA have been reported in a multiorgan transplant recipient. …”
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Epithelial mesenchymal transition and cancer stem cell markers in oral epithelial dysplasia and oral squamous cell carcinoma by Burcu Tokozlu, Özlem Özer Yücel, Sibel E. Gültekin, Leyla Arslan Bozdağ

“…OSCC cases showed significantly higher CD133 immunoreactivity and inflammation scores and significantly decreased E-cadherin expression compared to OED and OEH groups. Snail mRNA up-regulation was seen in 100% of the OSCC cases followed by 85% for OED cases and 82.5% OEH cases among those that displayed positive mRNA expression by RT-qPCR. …”
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High Levels of 17β-Estradiol Are Associated with Increased Matrix Metalloproteinase-2 and Metalloproteinase-9 Activity in Tears of Postmenopausal Women with Dry Eye by Guanglin Shen, Xiaoping Ma

“…Tear MMP-2 and MMP-9 concentrations (P<0.001), as well as the MMP-9 mRNA expression in conjunctival samples (P=0.02), were significantly higher in dry eye subjects than in controls. …”
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Complete Whole-Genome Sequence of Streptomyces sp. MUM 178J, a Potential Anti-Vibrio Agent by Ke-Yan Loo, Loh Teng-Hern Tan, Kah-Ooi Chua, Priyia Pusparajah, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law, Vengadesh Letchumanan

“…MUM 178J consists of 6,699,249 bp with a G+C content of 71.3%. 66 tRNA genes and 18 rRNA genes were also predicted to be present within the genome. …”
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Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction by Heyu Meng, Lihong Li, Jianjun Ruan, Yanqiu Chen, Zhaohan Yan, Jinsha Liu, Xiangdong Li, Cuiying Mao, Ping Yang

“…However, the AMI group had 0.885 times lower NUMB mRNA expression than the SCAD group P<0.05. Conclusion. …”
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Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression. by Ankita Chavan, Lena Skrutl, Federico Uliana, Melanie Pfister, Franziska Brändle, Laszlo Tirian, Delora Baptista, Dominik Handler, David Burke, Anna Sintsova, Pedro Beltrao, Julius Brennecke, Madhav Jagannathan

“…Interestingly, we find that multiple components of the transposon-silencing piRNA pathway are associated with D1 and Prod in embryos. …”
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Assembly and characterization of the complete mitogenome of Bauhinia purpurea (Leguminosae) by Siqi Xie, Yong Chen, Danjing Zheng, Shukai Luo, Shiyuan Meng, Yan Zhong

“…A total of 35 protein-coding genes, 16 tRNA genes, and 3 rRNA genes were identified in the mitogenome. …”
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Spatiotemporal Pattern of Neuroinflammation After Impact-Acceleration Closed Head Injury in the Rat

“…We found an early upregulation of IL-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math>, IL-6, and TNF-<mml:math alttext="$alpha$"> <mml:mi>&#x03B1;</mml:mi> </mml:math> mRNA between 1h and 7h after injury; the expression of iNOS mRNA only revealed a significant increase at 4h. …”
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Cloning, Characterization and Expression Pattern of the Ovarian Cytochrome P450 Cyp19a1aGene in Gonadal Developmental Period of Cobaltcap Silverside Hypoatherina tsurugae by Dilip Kumar Bej

“…The upregulation of the cyp19a1a transcription factor is required for granulosa cell differentiation and ovarian maintenance. 1630 bp of cyp19a1 mRNA transcript of Hypoatherina tsurugae was cloned and sequenced. …”
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Identification of sea snake meat adulteration in meat products using PCR-RFLP of mitochondrial DNA by Sunutcha Suntrarachun, Lawan Chanhome, Montri Sumontha

“…To distinguish between sea snake species, the PCR products of cytochrome b (Cyt b), 12S and 16S rRNA were sequenced and cut with different restriction endonuclease, Alu I and Hinf I. …”
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Seroprevalence of hepatitis E virus infection in blood donors from Piauí State, Northeast Brazil by João Paulo da Silva-Sampaio, Raniela Borges Sinimbu, Julia Trece Marques, Abilio Francisco de Oliveira Neto, Livia Melo Villar

“…Prevalences of anti-HEV IgG and IgM were 1.35 % and 0.11 %, respectively. None HEV-RNA was detected. This study demonstrated low prevalence of HEV infection in blood donors in this region.…”
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Nitric Oxide and Prostaglandins Potentiate the Liver Regeneration Cascade by Jodi M Schoen Smith, W Wayne Lautt

“…The NO donor s-nitroso-n-acetylpenicillamine, the phosphodiesterase V antagonist zaprinast (ZAP) and PGI2 each potentiated c-fos messenger RNA expression, an index of initiation of the liver regeneration cascade, following PHx. …”
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Integrating Prior Knowledge Using Transformer for Gene Regulatory Network Inference by Guangzheng Weng, Patrick Martin, Hyobin Kim, Kyoung Jae Won

“…Here, this work presents GRNPT, a novel Transformer‐based framework that integrates large language model (LLM) embeddings from publicly accessible biological data and a temporal convolutional network (TCN) autoencoder to capture regulatory patterns from single‐cell RNA sequencing (scRNA‐seq) trajectories. GRNPT significantly outperforms both supervised and unsupervised methods in inferring GRNs, particularly when training data is limited. …”
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Identification and Characterization of Arcanobacterium canis from Companion Animals in Germany and The United Kingdom by Siti Gusti Ningrum, Antonia Kreitlow, Christoph Lämmler, Ellen Prenger-Berninghoff, Christa Ewers, Geoffrey Foster, Madeleine Plötz, Amir Abdulmawjood

“…Both isolates were analyzed using culture methods, biochemical analysis, MALDI-TOF MS, real-time PCR amplification and sequencing of the 16S rRNA gene, and rpoB, gap, and tuf genes. The findings showed that the isolates P5197-15 and M214-96-1 obtained from companion animals were successfully characterized and confirmed to species level by real-time PCR amplification and sequencing of the 16S rRNA gene, as well as the genes of rpoB, gap, and tuf. …”
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Altered ERK1/2 Signaling in the Brain of Learned Helpless Rats: Relevance in Vulnerability to Developing Stress-Induced Depression by Yogesh Dwivedi, Hui Zhang

“…In frontal cortex and hippocampus of LH rats, we found that mRNA and protein expressions of ERK1 and ERK2 were significantly reduced, which was associated with their reduced activation and phosphorylation in cytosolic and nuclear fractions, where ERK1 and ERK2 target their substrates. …”
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Complete genome of mangrove-derived anti-MRSA streptomycete, Streptomyces pluripotens MUSC 135T by Hooi-Leng Ser, Kok-Gan Chan, Wen-Si Tan, Wai-Fong Yin, Bey-Hing Goh, Nurul-Syakima Ab Mutalib, Learn-Han Lee

“…A total of 6,404 open reading frames (ORFs) were predicted, along with 18 rRNA and 69 tRNA genes. Using bacteriocin mining tool, BAGEL detected eights gene clusters associated with bacteriocin production including lanthipeptides and linear azol(in)e-containing peptides (LAPs). …”
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Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles by Qiong Pan, Ya-Qian Li, Ke Guo, Min Xue, Yu Gan, Kejian Wang, Da-Bao Xu, Qiu-Yun Tu

“…Fecal samples were collected for 16S ribosomal RNA (rRNA) quantitative arrays and bioinformatics analysis. …”
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Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury by Zhu Y, Xu G

“…Notably, some medications such as Rituximab and Sparsentan, may simultaneously target multiple downstream mechanisms, Furthermore, exploring molecular strategies for established medications and developing novel treatments guided by biomarkers such as Anti-CD40 antibody, blood microRNA, urinary microRNA, and tumor necrosis factor-alpha (TNF-α) may provide additional therapeutic avenues for patients with FSGS.Keywords: focal segmental glomerulosclerosis, podocyte injury, targeted therapies, biomarkers…”
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Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson’s Disease by Wei Quan, Jia Li, Li Liu, Qinghui Zhang, Yidan Qin, Xiaochen Pei, Jiajun Chen

“…We analyzed the differentially expressed genes and function enrichment analysis of the two sets of data and found that the expression of the m6A-modification gene HNRNPC was significantly downregulated in the PD group, and it played an important role in DNA metabolism, RNA metabolism, and RNA processing and may be involved in PD. …”
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