Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi by Mireia Larrosa-Godall, Joshua X. D. Ang, Philip T. Leftwich, Estela Gonzalez, Lewis Shackleford, Katherine Nevard, Rob Noad, Michelle A. E. Anderson, Luke Alphey

“…Molecular analysis indicated that the gRNA expressing insertion disrupted normal splicing of dsx. …”
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Th1/Th2 Dichotomy in Obese Women with Gestational Diabetes and Their Macrosomic Babies by A. Seck, A. Hichami, S. Doucouré, F. Diallo Agne, H. Bassène, A. Ba, C. Sokhna, N. A. Khan, A. Samb

“…T lymphocytes were purified from the total blood with Ficoll-Paque. The mRNA expression of inflammatory markers in T cells was determined by RT-qPCR. …”
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Effects of Glycyrrhizin (GL) Supplementation on Survival, Growth Performance, Expression of Feeding-Related Genes, Activities of Digestive Enzymes, Antioxidant Capacity, and Expres... by Yuntao Wang, Wenxuan Xu, Jianmin Zhang, Jiahui Liu, Zhen Wang, Yongtao Liu, Kangsen Mai, Qinghui Ai

“…Compared with the control, the mRNA expression of orexigenic factor genes including neuropeptide Y (npy) and agouti-related protein (agrp) were significantly increased in larvae fed the diet with 0.005% GL, while the mRNA expression of anorexigenic factor genes including thyrotropin-releasing hormone (trh), cocaine and amphetamine regulated transcript (cart), and leptin receptor (lepr) were significantly decreased in larvae fed the diet with 0.005% GL (P<0.05). …”
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The expression profile of genes associated with behavior, stress, and adult neurogenesis along the hippocampal dorsoventral axis in tame and aggressive foxes by Yu. V. Alexandrovich, E. V. Antonov, S. G. Shikhevich, A. V. Kharlamova, L. V. Meister, Y. V. Makovka, D. V. Shepeleva, R. G. Gulevich, Yu. E. Herbeck

“…In tame foxes, significantly elevated mRNA levels were recorded for several genes: CYP26B1 for cytochrome P450 26B1 and ADRA1A for α1A adrenergic receptor in the dorsal hippocampus, whereas the level of NR3C2 mRNA for mineralocorticoid receptor was higher in the ventral. …”
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Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism by Yoshimichi Takeda, Masashi Demura, Mitsuhiro Kometani, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Shin-ichi Horike, Makiko Meguro-Horike, Takashi Yoneda, Yoshiyu Takeda

“…PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11B1 was quantified using real-time PCR. …”
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CircCCT2/miR-146a-5p/IRAK1 axis promotes the development of head and neck squamous cell carcinoma by Long He, Lanruo Li, Liting Zhao, Xiaoya Guan, Yujia Guo, Qi Han, Huina Guo, Hongliang Liu, Chunming Zhang

“…Mechanistically, functioning as a competitive endogenous RNA (ceRNA) or miRNA sponge, circCCT2 binds directly to miR-146a-5p and increases interleukin-1 receptor-associated kinase 1 (IRAK1) levels, which enhances the malignant development of HNSCC by driving epithelial-mesenchymal transition (EMT). …”
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BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia by Xu Sang, Yongping Zhang, Fang Fang, Li Gao, Yanfang Tao, Xiaolu Li, Zimu Zhang, Jianwei Wang, Yuanyuan Tian, Zhiheng Li, Di Yao, Yumeng Wu, Xinran Chu, Kunlong Zhang, Li Ma, Lihui Lu, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Zhen Zhang, Jian Pan, Shaoyan Hu

“…The effect of GNE-987 on AML cells was analyzed in vivo. RNA-seq (RNA sequencing) and ChIP-seq (chromatin immunoprecipitation sequencing) validated the function and molecular pathways of GNE-987 in processing AML. …”
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Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth by Li-Yan Zhang, Tian-Tian Li, Hong-Xin Liao, Jin-Rui Wen, Hong-Yan Nie, Fu-Rong Xu, Xiao-Yun Liu, Xian Dong

“…However, the direct relationship between menthone and histone acetylation in inhibiting F. proliferatum remains nebulous. Our RNA sequencing (RNA-seq) analysis identified 7,332 differentially expressed genes (DEGs) between the control and menthone-treated groups, 3,442 upregulated and 3,880 downregulated, primarily enriched in pathways related to ribosome biogenesis and energy metabolism. …”
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Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management by Bhargav Shreevatsa, Bhargav Shreevatsa, Abhigna Nagaraj, Chandan Dharmashekar, Anisha Jain, Bhavana Harendra, Siddesh V. Siddalingegowda, Haneen A. Al-Mazroua, Sheikh F. Ahmad, Shashanka K. Prasad, Chandrashekar Srinivasa, Chandan Shivamallu, Shiva Prasad Kollur

“…The ASOs were optimized with a focus on stability, binding affinity, and specificity towards AXL mRNA while minimizing off-target effects. To investigate ASO-mRNA interactions and gauge their ability to alter AXL expression, Molecular Docking was performed. …”
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Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery by Yinjie Zhang, Baibing Yang, Joy M. Davis, Madeline M. Drake, Mamoun Younes, Qiang Shen, Zhongming Zhao, Yanna Cao, Tien C. Ko

“…Pancreatic RNAs were extracted for RNA-seq and quantitative (q) PCR validation. Using RNA-seq, we identified a total of 3,600 differentially expressed genes (DEGs) in CP versus CON and 166 DEGs in CPR versus CONR. …”
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Different Activity of the Biological Axis VEGF-Flt-1 (fms-Like Tyrosine Kinase 1) and CXC Chemokines between Pulmonary Sarcoidosis and Idiopathic Pulmonary Fibrosis: A Bronchoalveo... by Katerina M. Antoniou, Giannoula Soufla, Athanasia Proklou, George Margaritopoulos, Christiana Choulaki, Rena Lymbouridou, Katerina D. Samara, Demetrios A. Spandidos, Nikolaos M. Siafakas

“…A statistically significant increase has been detected in VEGF mRNA expression in IPF in comparison with pulmonary sarcoidosis (𝑃=.03). …”
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Biochemical, ecological and molecular characterization of Xenorhabdus anantnagensis associated with Steinernema anantnagense from India: evaluating nematode efficacy against Helico... by Krishnapriya Okram, Aashaq Hussain Bhat, Ladoi Drema

“…KP_CU, exhibited 100% similarity in its 16S rRNA sequence with Xenorhabdus anantnagensis XENO-2T, suggesting conspecificity. …”
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Effect of 2,4-Thiazolidinedione on Limousin Cattle Growth and on Muscle and Adipose Tissue Metabolism by M. Arévalo-Turrubiarte, L. González-Dávalos, A. Yabuta, J. D. Garza, J. L. Dávalos, O. Mora, A. Shimada

“…Expression of PPAR mRNA was measured in liver and muscle (PPARα, -δ, and -γ) and SC adipose tissue (γ) by real-time PCR. …”
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True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair by Nicolas Le May, Jean-Marc Egly, Frédéric Coin

“…In the absence of a genotoxic attack, the promoters of RNA polymerases I- and II-dependent genes recruit XPA, XPC, XPG, and XPF to initiate gene expression. …”
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SPOP Inhibition of Endometrial Carcinoma and Its Clinicopathological Relationship by Qing Zhu, Guanghui Zhang, Mingyang Tang, Rumin Zheng, Huaiyong Gan

“…After upregulating the SPOP expression by RNA activation in EC cell lines, the abilities of proliferation, migration, and invasion of cells were significantly inhibited.…”
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LINC00626 drives tamoxifen resistance in breast cancer cells by interaction with UPF1 by Hui Yuan, Lianbang Zhou, Wei Hu, Min Yang

“…LINC00626 is a novel ERα-regulated long non-coding RNA (lncRNA) that has not yet been examined for its potential contribution to endocrine therapy resistance. …”
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Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism by Xiaoya Wang, Kang Zhang, Jingyan Zhang, Guowei Xu, Zhiting Guo, Xiaorong Lu, Chunhua Liang, Xueyan Gu, Liping Huang, Shuqi Liu, Lei Wang, Jianxi Li

“…We assessed pulmonary changes, inflammation, oxidative stress, and macrophage and neutrophil activation levels, then we analyzed the gut microbiota through 16S rRNA and analyzed metabolomics profile by UPLC-QTOF/MS. …”
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A contribution to Porogramme (Polyporaceae, Agaricomycetes) and related genera by Wei-Lin Mao, Ying-Da Wu, Hong-Gao Liu, Yuan Yuan, Yu-Cheng Dai

“…Our molecular phylogeny based on the internal transcribed spacer (ITS), the large subunit nuclear ribosomal RNA gene (nLSU), the translation elongation factor 1-α gene (TEF1), and the largest subunit of RNA polymerase II (RPB1) demonstrates six clades are formed among Porogramme and related genera. …”
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Absence of the Genetic Marker IS6110 from a Strain of Mycobacterium tuberculosis Isolated in Ontario by Susan T Howard, Matthew T Oughton, Albert Haddad, Wendy M Johnson

“…Sequence data from the 16S rRNA gene and the 16S/23S rRNA gene spacer confirmed that the strain was a member of the M tuberculosis complex, and analysis of the mpcA and pncA genes supported the identification of the strain as M tuberculosis rather than Mycobacterium bovis. …”
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The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms by Shumei Jin, Mixia Zhang, Yan Gao, Xuebin Zhang, Guangzhi Cui, Yanjun Zhang

“…Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.…”
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