Production of Platinum Atom Nanoclusters at One End of Helical Plant Viruses by Yuri Drygin, Olga Kondakova, Joseph Atabekov

“…Results suggest that the Pt-NPs are bound concurrently to the terminal protein subunits and the 5′ end of encapsidated TMV RNA. Thus, a special structure of tobacco mosaic virus and potato X virus particles with nanoparticles of platinum, which looks like a push-pin with platinum head and virus needle, was obtained. …”
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Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study by Yuhua He, Shilin Gao, Lili Jiang, Jie Yang

“…BackgroundThis study was designed to characterize gut microbiota changes of the patients with gastric cancer before and after the gastrectomy during their hospital staying periods.Methods16S ribosomal RNA (rRNA) gene sequencing was used to evaluate differences in gut microbiota among patients with gastric cancer before and after the gastrectomy by comparing gut microbiota α diversity, β diversity, and structure composition at different taxonomic levels.ResultsA total of 120 fecal specimens were collected from 60 patients. …”
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Sequencing and annotation of the complete mitochondrial genome of a threatened labeonine fish, by Mohammad Nazrul Islam, Shirin Sultana, Md. Jobaidul Alam

“…The complete mitochondrial genome was 16,597 bp in size, which formed a circular double-stranded DNA molecule containing a total of 37 mitochondrial genes (13 protein-coding genes, 2 ribosomal RNA genes, and 22 transfer RNA genes) with two non-coding regions, an origin of light strand replication (OL) and a displacement loop (D-loop), similar structure with other fishes of Teleostei. …”
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Calculation of Free Energy Consumption in Gene Transcription with Complex Promoter Structure by Lifang Huang, Peijiang Liu, Kunwen Wen, Jianshe Yu

“…Then, we show that the numbers of the ON and OFF states of a promoter can reduce energy consumption of the gene system and the Fano factor of mRNA, and in contrast to other regulatory ways, the cooperative binding of transcription factors to DNA sites always reduces energy consumption but amplifies the mRNA noise. …”
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miR-214-3p Deficiency Enhances Caspase-1-Dependent Pyroptosis of Microglia in White Matter Injury by Liufang He, Tingyan Wei, Yong Huang, Xueli Zhang, Dongbo Zhu, Huazhen Liu, Zhangxing Wang

“…The expression of microRNA miR-214-3p was largely reduced in the microglia of WMI mice compared to controls. …”
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snRNP: Rich Nuclear Bodies in Hyacinthus orientalis L. Microspores and Developing Pollen Cells by K. Zienkiewicz, E. Bednarska

“…In all cases, a strong accumulation of snRNP-indicating molecules including TMG cap, Sm proteins and U2 snRNA, was observed in the examined nuclear bodies. …”
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The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review by Martina Barchitta, Andrea Maugeri, Annalisa Quattrocchi, Ottavia Agrifoglio, Antonella Agodi

“…Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. …”
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Gene Therapy for Glioblastoma Multiforme by Smit Shah, Joshua Green, Shantelle A. Graff, Qi Li, John D. Heiss

“…It reviews promising DNA transgenes, RNA inhibitors, and vectors for anti-GBM therapy. …”
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Higher-Order Chromatin Regulation of Inflammatory Gene Expression by Jin-Wen Xu, Shuang Ling, Jun Liu

“…When an inflammatory process is triggered, NF-κB binds to enhancers or superenhancers, triggering the transcription of enhancer RNA (eRNA), driving the chromatin of the NF-κB-binding gene locus to construct transcriptional factories, and forming intra- or interchromosomal contacts. …”
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miR-155: An Important Role in Inflammation Response by Jingyan Hu, Songli Huang, Xiaoli Liu, Yuan Zhang, Shengli Wei, Xiuhua Hu

“…MicroRNAs (miRNAs) are a class of small, mature, noncoding RNA that lead to posttranscriptional gene silencing to regulate gene expression. miRNAs are instrumental in biological processes such as cell development, cell differentiation, cell proliferation, and cell apoptosis. …”
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Fluo-Cast-Bright: a deep learning pipeline for the non-invasive prediction of chromatin structure and developmental potential in live oocytes by Xiangyu Zhang, Claudia Baumann, Rabindranath De La Fuente

“…Importantly, transcriptome analysis following non-invasive selection revealed that meiotically competent oocytes exhibit a higher expression of transcripts associated with RNA and protein nuclear export, maternal mRNA deadenylation, histone modifications, chromatin remodeling and signaling pathways regulating microtubule dynamics during the metaphase-I to metaphase-II transition. …”
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The effect of COVID-19 and COVID-19 vaccines on chronic spontaneous urticaria: single center experience by Öner Özdemir, Ümmügülsüm Dikici

“…As a result, omalizumab had to be started in 3/8 patients after mRNA vaccination due to CSU exacerbation or treatment failure. …”
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Comparison of characteristics and immune responses between paired human nasal and bronchial epithelial organoids by Lu Zhu, Wenhao Yang, Jiaxin Luo, Danli Lu, Yanan Hu, Rui Zhang, Yan Li, Li Qiu, Zelian Chen, Lina Chen, Hanmin Liu

“…Whole exome sequencing revealed that over 99% of single nucleotides were shared between the NO and matched BO and there was a 95% overlap in their RNA transcriptomes. RNA sequencing analysis of differentially expressed genes indicated a significant reduction in the immune response in NO. …”
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Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Lung Epithelial Cells by Yueguo Wang, Zhenxing Ding, Youhui Tu, Xu Wu, Wenying Zhang, Shuang Ji, Jilong Shen, Li Zhang, Huimei Wu, Guanghe Fei

“…NADPH enzymatic activity and production of ROS, prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) were assessed simultaneously. The small interfering RNA (siRNA) or plasmid targeting Nox4 was used to downregulate or upregulate Nox4, and the lentiviral vector encoding Poldip2 was used to downregulate or upregulate Poldip2. …”
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CD300E+ macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients by Tao Yang, Yuan Zhang, Chujun Duan, Hui Liu, Dong Wang, Qingshan Liang, Xiao Chen, Jingchang Ma, Kun Cheng, Yong Chen, Ran Zhuang, Jikai Yin

“…Obvious liver regeneration was observed after splenectomy in cirrhotic patients. Single-cell RNA sequencing (scRNA-seq) was performed on three paired liver tissues from patients before and after surgery to explore the immune microenvironment map and the characteristics of liver regeneration-associated macrophages (RAMs). scRNA-seq analysis revealed that the composition of hepatic immune cells changed after splenectomy; among these changes, the proportion of CD300E+ RAMs significantly increased after surgery, and high expression levels of functional genes associated with cell proliferation promoted liver regeneration. …”
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Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions by Joanna Budna, Mariusz Kaczmarek, Agata Kolecka-Bednarczyk, Łukasz Spychalski, Piotr Zawierucha, Joanna Goździk-Spychalska, Michał Nowicki, Halina Batura-Gabryel, Jan Sikora

“…TGF-β and IL-10 concentrations were measured using human TGF-β1 and IL-10 ELISA kit. Relative mRNA expression of studied genes was analyzed by real-time PCR. …”
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Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis by Cheng Tang, Su-Xia Sun, Chao Gu, Chao-Juan Li, Jin Xu, Ke-Lei Su, Dan-Dan Zhou, Kuai Yu, Qing-Ling Xiao, Xiao-Li Chen

“…Abstract Background Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. …”
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Spontaneous tumor regression following COVID-19 vaccination by Hui Dai, Renata Ferrarotto, Myrna Godoy, Diana Bell, Shiaw-Yih Lin, Daniel J McGrail, Luana Guimaraes de Sousa, Kaiyi Li, Mario L Marques-Piubelli, Cipriano Gonzalez, Sammy Ferri-Borgogno, Jared Burks

“…Insight: This case suggests that the mRNA-1273 COVID-19 vaccine stimulated anticancer immunity and tumor regression.…”
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PPARα: A Master Regulator of Bilirubin Homeostasis by Cyril Bigo, Jenny Kaeding, Diala El Husseini, Iwona Rudkowska, Mélanie Verreault, Marie Claude Vohl, Olivier Barbier

“…Similar positive regulations were also observed with the 3 PPARα ligands in CASMCs where HO-1 mRNA and protein levels were increased. In HH and HepG2 cells, both UGT1A1 and MRP2 transcripts were also accumulating. …”
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Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion by Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R. Hof, Goran Šimić

“…The proposed molecular mechanisms by which C9orf72 repeat expansions induce neurodegenerative changes are C9orf72 loss-of-function through haploinsufficiency, RNA toxic gain-of-function, and gain-of-function through the accumulation of toxic dipeptide repeat proteins. …”
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