Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury by Jessica M. Herrera, Yun Weng, Tyler J. Lieberthal, Marcus Paoletti, Tammy T. Chang

“…Upon DDC-induced liver injury, mice with hepatocyte-specific deletion of ROCK1 alone (R1 KO) or ROCK2 alone (R2 KO) demonstrated minimal differences compared to WT. …”
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Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial. by Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John E Walker, Tim Matheson, Matthew McLaughlin, Jennifer Jain, Eric Vittinghoff, Steven L Batki

“…Future research may be needed to continue to explore the potential utility of 5-HT2cR agonists.…”
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Low Circulating TRAIL Levels Are Associated with Increase of Resistin and Lipocalin-2/ngal Adipokines in Postmenopausal Women by Veronica Tisato, Paola Secchiero, Gloria Bonaccorsi, Carlo Bergamini, Pantaleo Greco, Giorgio Zauli, Carlo Cervellati

“…Low serum TRAIL concentration (deciles I–IV) was significantly and inversely correlated with resistin and lipocalin 2/ngal levels (r=−0.502 and p<0.001 and r=−0.360 and p<0.01, resp.). …”
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Predicting the exposure of mycophenolic acid in children with autoimmune diseases using a limited sampling strategy: A retrospective study by Ping Zheng, Ting Pan, Ya Gao, Juan Chen, Liren Li, Yan Chen, Dandan Fang, Xuechun Li, Fei Gao, Yilei Li

“…The predictive performance of the Wide&Deep model using four and three blood concentration points was similar (R 2 ≈ 1 for four points; R 2 = 0.95 for three points). …”
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Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraep... by Fei Chen, Jinghe Lang, Peter Hillemanns, Youzhong Zhang, Zoltán Novák, Long Sui, Ling Han, Christian Dannecker, Ctirad Mokráš, Zhixue You

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Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis by Fang-Chen Gong, Ran Ji, Yu-Ming Wang, Zhi-Tao Yang, Ying Chen, En-Qiang Mao, Er-Zhen Chen

“…Differentially expressed genes (DEGs) were identified using R packages (Affy and limma). Functional enrichment of the DEGs was analyzed with the DAVID database. …”
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Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT3AR and 5-HT3BR Expression in the Rat Brain by Fang Li, Jizhen Feng, Dongmei Gao, Jieqiong Wang, Chunhong Song, Sheng Wei, Mingqi Qiao

“…As compared to control rats, the 5-HT3R channel current in the model group was significantly higher; the 5-HT3R channel current in hippocampal neurons treated with serum from Shuyu group rats was significantly lower than that in those treated with model group serum. …”
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Future climate change impacts on common bean (Phaseolus vulgaris L.) phenology and yield with crop management options in Amhara Region, Ethiopia by Adem Mohammed, Estifanos Feleke

“…The RMSE, R2 and d-index values for days to physiological maturity were 3.19 days, 0.70 and 0.87, respectively while the values for grain yield were 113.7 kg ha−1, 0.95 and 0.89 for the respective parameters. …”
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Morphological and molecular characterization of a Sarcocystis bovifelis-like sarcocyst in American beef by Aditya Gupta, Larissa S. de Araujo, Andrew Hemphill, Asis Khan, Benjamin M. Rosenthal, Jitender P. Dubey

“…Molecular characterization was attempted employing genetic markers: 18S rRNA, 28S rRNA, cox1, ITS1, gapdh1, ron3, and rpoB. …”
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Kinetics of Organic Biodegradation and Biogas Production in the Pilot-Scale Moving Bed Biofilm Reactor (MBBR) for Piggery Wastewater Treatment by Thi Ha Nguyen, Manh Khai Nguyen, Thi Hoang Oanh Le, Thanh Tu Bui, Trong Hieu Nguyen, Truong Quan Nguyen, Anh van Ngo

“…About COD degradation kinetics, in comparison to the first- and second-order kinetics and the Monod model, Stover–Kincannon model showed the best fit with R2 0.98 and a saturation value constant (KB) and a maximum utilization rate (Umax) of 52.40 g/L day and 82.65 g/L day, respectively. …”
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Determining Factors and Zootechnical Output of Biosecurity Practices in Fish Farms in the Wouri Division, Cameroon by Fonkwa Georges, Makombu Judith Georgette, Kamdem Alex Henri, Kametieu Djamou Franck, Nack Jacques, Awah-Ndukum Julius, Tomedi Eyango Minette, Tchoumboue Joseph

“…The CR and AR were significantly higher for the isolation component (CR = 60.17 ± 19.81%; AR = 60.17 ± 25.68%) followed by traffic control (CR = 53.53 ± 25.87%; AR = 53.53% ± 34.86) and sanitation (CR = 27.70 ± 19.70%; AR = 29.84 ± 26.00%). A strong (R2 = 0.725), positive, and significant (p=0.019) linear relationship was found between the level of education of fish farmers and the biosecurity compliance rate while the health status of fish was weakly (R2 = 0.207), positively, and significantly (p=0.017) influenced by the compliance rate. …”
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Spatiotemporal dynamics of carbon sequestration capacity and its determinants in rubber plantation ecosystems of Hainan Island by Yinghe An, Zhixiang Wu, Runqing Zhang, Xiang Zhang, Zhenghong Tan, Zhongyi Sun

“…The results reveal that the model accurately captures the trends and seasonality of Gross Primary Productivity (GPP) (R2=0.88, RMSE=1.19 g C m−2 d −1) and Ecosystem Respiration (RECO) (R2=0.87, MSE=0.94 g C m−2 d −1). …”
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Forty-two-year frequencies of river buffaloes calving in the Terecay ranch, Venezuela by Renny Jesús Becerra, Inés Valentina Reggeti-Gómez, Francisco Miguel Reggeti Gómez, Néstor Simón Montiel-Urdaneta

“…The equation of the polynomial regression analysis was y = -3.0656x4 + 64.363x3 - 360.05x2 + 417.41x + 810.37 with an R² = 0.9571. With this R² value, it can be inferred that the calving behavior will be maintained during these 42 years. …”
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Don’t mind the gap: reframing the Perren strain rule for fracture healing using insights from virtual mechanical testing by Maham Tanveer, Karina Klein, Brigitte von Rechenberg, Salim Darwiche, Hannah L. Dailey

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Performance evaluation of the Qiagen BK virus ASR on the NeuMoDx system by Amorce Lima, Luciano Soares, Caroline Simmons, Laura Rowe, Dominic Uy, Deanna Becker, Suzane Silbert

“…Results: The assay exhibited a strong linear correlation (R² = 0.9985) with the reference panel and an excellent analytical accuracy (R² = 0.9976). …”
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Early-Phase Recovery of Cardiorespiratory Measurements after Maximal Cardiopulmonary Exercise Testing in Patients with Chronic Obstructive Pulmonary Disease by Marie Bellefleur, David Debeaumont, Alain Boutry, Marie Netchitailo, Antoine Cuvelier, Jean-François Muir, Catherine Tardif, Jérémy Coquart

“…T1/4V˙O2 significantly differed between groups (p<0.01; 58±18 s in CG, 79±26 s in COPDI-II group, and 121±34 s in COPDIII-IV) and was significantly correlated with forced expiratory volume in one second in COPD patients (p<0.001, r=0.53) and with peak power output (p<0.001, r=0.59). …”
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Central Obesity and Associated Factors among Adult Patients on Antiretroviral Therapy (ART) in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia by Adnan Kemal, Mohammed Ahmed, Melese Sinaga Teshome, Kalkidan Hassen Abate

“…Being female, increased BMI, low CD4 count, AZT + 3TC + EFV, ABC + 3TC + ATV/r-based regimen, and abnormal blood pressure were associated with central obesity. …”
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Discovery of a New Cyanobacterial Genus (<em>Paludothrix</em> gen. nov.) from the Sanyang Wetland in Eastern China, Reflecting the Latest Taxonomic Status in Coleofasciculaceae by Yangyang Wu, Yao Cheng, He Zhang, Ruozhen Geng, Peng Xiao, Baiyu Cui, Renhui Li

“…The findings from morphological analysis, 16S rRNA gene sequencing, and the identification of the 16S-23S ITS rRNA region have led to the discovery of a new genus, <i>Paludothrix</i>, which is categorized within the family <i>Coleofasciculaceae</i>. …”
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Area under the Curve-Based Dosing of Vancomycin in Critically Ill Patients Using 6-Hour Urine Creatinine Clearance Measurement by Bita Shahrami, Farhad Najmeddin, Saeideh Ghaffari, Atabak Najafi, Mohammad Reza Rouini, Mojtaba Mojtahedzadeh

“…Data analysis revealed that CL6 h had a stronger correlation with CLvan rather than CLCG (r = 0.823 vs. 0.594; p<0.001 vs. 0.003). The relationship between CLvan and CL6 h was utilized to develop the following equation for estimating CLvan: CLvan (mL/min) = ─137.4 + CL6 h (mL/min) + 2.5 IBW (kg) (R2 = 0.826, p<0.001). …”
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Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis by LijiangTao, Minjuan He, Yisheng Lu, Jie Zheng, Yili Ye

“…The levels of CXCL12 and S100A12 in PB of knee OS were positively correlated with WOMAC score (r=0.767, 0.521, respectively, P<0.05); see Figure 1. …”
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